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Page 1
SLITRK6 mutations cause myopia and deafness in humans and mice.
Tekin M, Chioza BA, Matsumoto Y, Diaz-Horta O, Cross HE, Duman D, Kokotas H, Moore-Barton HL, Sakoori K, Ota M, Odaka YS, Foster J 2nd, Cengiz FB, Tokgoz-Yilmaz S, Tekeli O, Grigoriadou M, Petersen MB, Sreekantan-Nair A, Gurtz K, Xia XJ, Pandya A, Patton MA, Young JI, Aruga J, Crosby AH. Tekin M, et al. J Clin Invest. 2013 May;123(5):2094-102. doi: 10.1172/JCI65853. Epub 2013 Apr 1. J Clin Invest. 2013. PMID: 23543054 Free PMC article.
Our molecular investigation in 3 families led to the identification of 3 homozygous nonsense mutations (p.R181X, p.S297X, and p.Q414X) in SLIT and NTRK-like family, member 6 (SLITRK6), a leucine-rich repeat domain transmembr …
Our molecular investigation in 3 families led to the identification of 3 homozygous nonsense mutations (p.R181X, p.S297X, and p.Q414X) in …
Genome-Wide CRISPR-Cas9 Screening and Identification of Potential Genes Promoting Prostate Cancer Growth and Metastasis.
Wang W, Yuan D, Jiang K, Li R, Qu H, Jiang FN, Zhong WD, Sun F, Jia Z, Zhu J. Wang W, et al. Curr Cancer Drug Targets. 2022;23(1):71-86. doi: 10.2174/1568009622666220615154137. Curr Cancer Drug Targets. 2022. PMID: 35708078
Fifteen target genes (C1QTNF9B, FAM229A, hsa-mir-3929, KRT23, TARS2, CRADD, GRIK4, PLA2G15, LOXL1, SLITRK6, CDC42EP5, SLC2A4, PTGDS, MYL9 and ACOX2 for the enriched sgRNAs) have been selected for experimental validation, which showed that knock-out of any of these genes le …
Fifteen target genes (C1QTNF9B, FAM229A, hsa-mir-3929, KRT23, TARS2, CRADD, GRIK4, PLA2G15, LOXL1, SLITRK6, CDC42EP5, SLC2A4, PTGDS, …
A novel mutation in SLITRK6 causes deafness and myopia in a Moroccan family.
Salime S, Riahi Z, Elrharchi S, Elkhattabi L, Charoute H, Nahili H, Rouba H, Kabine M, Bonnet C, Petit C, Barakat A. Salime S, et al. Gene. 2018 Jun 15;659:89-92. doi: 10.1016/j.gene.2018.03.042. Epub 2018 Mar 15. Gene. 2018. PMID: 29551497
Myopia is by far the most common human eye disorder that is known to have a clear heritable component. The analysis of the two exons of SLITRK6 gene in a Moroccan family allowed us to identify a novel single deleterious mutation c.696delG, p.Trp232Cysfs*10 at homozygous st …
Myopia is by far the most common human eye disorder that is known to have a clear heritable component. The analysis of the two exons of S …
Human cytomegalovirus downregulates SLITRK6 expression through IE2.
Liao H, Sato H, Chiba R, Kawai T, Nakabayashi K, Hata K, Akutsu H, Fujiwara S, Nakamura H. Liao H, et al. J Neurovirol. 2017 Feb;23(1):79-86. doi: 10.1007/s13365-016-0475-y. Epub 2016 Aug 16. J Neurovirol. 2017. PMID: 27530937
We also show that HCMV-encoded immediate-early 2 (IE2) proteins mediate this downregulation and their carboxy-terminal region, especially amino acid residue Gln(548), has a critical role. These findings suggest that the downregulation of SLITRK6 expression by IE2 ma …
We also show that HCMV-encoded immediate-early 2 (IE2) proteins mediate this downregulation and their carboxy-terminal region, especi …
SLITRK6 promotes the progression of lung adenocarcinoma by regulating PI3K/AKT/mTOR signaling and Warburg effect.
Yu F, Zhao X, Li M, Meng M. Yu F, et al. Apoptosis. 2023 Aug;28(7-8):1216-1225. doi: 10.1007/s10495-023-01838-0. Epub 2023 May 23. Apoptosis. 2023. PMID: 37219677
To investigate the role of SLITRK6 in lung adenocarcinoma (LUAD) and the underlying mechanism in it, clinical tissues and tissue microarray of LUAD were used to detect the expression of SLITRK6. ...SLITRK6 may serve as a potential therapeutic target for LUAD …
To investigate the role of SLITRK6 in lung adenocarcinoma (LUAD) and the underlying mechanism in it, clinical tissues and tissue micr …
Intra‑tumor heterogeneity of cancer stem cell‑related genes and their potential regulatory microRNAs in metastasizing colorectal carcinoma.
Urh K, Zidar N, Tomažič A, Boštjančič E. Urh K, et al. Oncol Rep. 2022 Nov;48(5):193. doi: 10.3892/or.2022.8408. Epub 2022 Sep 16. Oncol Rep. 2022. PMID: 36111489
The expression of selected genes (L1TD1, SLITRK6, ST6GALNAC1 and TCEA3) and miRNAs (miR-199a-3p, miR-425-5p, miR-1225-3p, miR-1233-3p and miR-1303) was evaluated using reverse transcription-quantitative PCR. ...The SLITRK6 gene and its regulatory miRNA miR-199a-3p a …
The expression of selected genes (L1TD1, SLITRK6, ST6GALNAC1 and TCEA3) and miRNAs (miR-199a-3p, miR-425-5p, miR-1225-3p, miR-1233-3p …
Genetic Spectrum of Syndromic and Non-Syndromic Hearing Loss in Pakistani Families.
Doll J, Vona B, Schnapp L, Rüschendorf F, Khan I, Khan S, Muhammad N, Alam Khan S, Nawaz H, Khan A, Ahmad N, Kolb SM, Kühlewein L, Labonne JDJ, Layman LC, Hofrichter MAH, Röder T, Dittrich M, Müller T, Graves TD, Kong IK, Nanda I, Kim HG, Haaf T. Doll J, et al. Genes (Basel). 2020 Nov 11;11(11):1329. doi: 10.3390/genes11111329. Genes (Basel). 2020. PMID: 33187236 Free PMC article.
A combined exome sequencing, bioinformatics analysis, and gene mapping approach for 21 consanguineous Pakistani families revealed 13 pathogenic or likely pathogenic variants in the genes GJB2, MYO7A, FGF3, CDC14A, SLITRK6, CDH23, and MYO15A, with an overall resolve rate of …
A combined exome sequencing, bioinformatics analysis, and gene mapping approach for 21 consanguineous Pakistani families revealed 13 pathoge …
Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue.
Aruga J, Yokota N, Mikoshiba K. Aruga J, et al. Gene. 2003 Oct 2;315:87-94. doi: 10.1016/s0378-1119(03)00715-7. Gene. 2003. PMID: 14557068
Slitrk family proteins are characterized as integral membrane proteins that have two leucine-rich repeat (LRR) domains and a carboxy-terminal domain that is partially similar to trk neurotrophin receptor proteins. The LRR domains are similar to those o …
Slitrk family proteins are characterized as integral membrane proteins that have two leucine-rich repeat (LRR) domains and a c …
Integrating Whole-Genome Resequencing and RNA Sequencing Data Reveals Selective Sweeps and Differentially Expressed Genes Related to Nervous System Changes in Luxi Gamecocks.
Zhou J, Chang Y, Li J, Bao H, Wu C. Zhou J, et al. Genes (Basel). 2023 Feb 25;14(3):584. doi: 10.3390/genes14030584. Genes (Basel). 2023. PMID: 36980855 Free PMC article.
Eleven genes that were highly related to nervous system development (CDH18, SLITRK1, SLITRK6, NDST3, ATP23, LRIG3, IL1RAPL1, GADL1, C5orf22, UGT8, WISP1, and WNT9A) appeared in at least four methods and were regarded as the most significant genes under selection. ...Combin …
Eleven genes that were highly related to nervous system development (CDH18, SLITRK1, SLITRK6, NDST3, ATP23, LRIG3, IL1RAPL1, GADL1, C …
A homozygous SLITRK6 nonsense mutation is associated with progressive auditory neuropathy in humans.
Morlet T, Rabinowitz MR, Looney LR, Riegner T, Greenwood LA, Sherman EA, Achilly N, Zhu A, Yoo E, O'Reilly RC, Jinks RN, Puffenberger EG, Heaps A, Morton H, Strauss KA. Morlet T, et al. Laryngoscope. 2014 Mar;124(3):E95-103. doi: 10.1002/lary.24361. Epub 2013 Dec 17. Laryngoscope. 2014. PMID: 23946138 Free PMC article.
OBJECTIVES/HYPOTHESIS: SLITRK family proteins control neurite outgrowth and regulate synaptic development. In mice, Slitrk6 plays a role in the survival and innervation of sensory neurons in the inner ear, vestibular apparatus, and retina, and also influences axial …
OBJECTIVES/HYPOTHESIS: SLITRK family proteins control neurite outgrowth and regulate synaptic development. In mice, Slitrk6 pl …
22 results