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SLITRK6 promotes the progression of lung adenocarcinoma by regulating PI3K/AKT/mTOR signaling and Warburg effect.
Yu F, Zhao X, Li M, Meng M. Yu F, et al. Apoptosis. 2023 Aug;28(7-8):1216-1225. doi: 10.1007/s10495-023-01838-0. Epub 2023 May 23. Apoptosis. 2023. PMID: 37219677
To investigate the role of SLITRK6 in lung adenocarcinoma (LUAD) and the underlying mechanism in it, clinical tissues and tissue microarray of LUAD were used to detect the expression of SLITRK6. ...SLITRK6 may serve as a potential therapeutic target for LUAD …
To investigate the role of SLITRK6 in lung adenocarcinoma (LUAD) and the underlying mechanism in it, clinical tissues and tissue micr …
SLITRK6 mutations cause myopia and deafness in humans and mice.
Tekin M, Chioza BA, Matsumoto Y, Diaz-Horta O, Cross HE, Duman D, Kokotas H, Moore-Barton HL, Sakoori K, Ota M, Odaka YS, Foster J 2nd, Cengiz FB, Tokgoz-Yilmaz S, Tekeli O, Grigoriadou M, Petersen MB, Sreekantan-Nair A, Gurtz K, Xia XJ, Pandya A, Patton MA, Young JI, Aruga J, Crosby AH. Tekin M, et al. J Clin Invest. 2013 May;123(5):2094-102. doi: 10.1172/JCI65853. Epub 2013 Apr 1. J Clin Invest. 2013. PMID: 23543054 Free PMC article.
Our molecular investigation in 3 families led to the identification of 3 homozygous nonsense mutations (p.R181X, p.S297X, and p.Q414X) in SLIT and NTRK-like family, member 6 (SLITRK6), a leucine-rich repeat domain transmembr …
Our molecular investigation in 3 families led to the identification of 3 homozygous nonsense mutations (p.R181X, p.S297X, and p.Q414X) in …
A novel mutation in SLITRK6 causes deafness and myopia in a Moroccan family.
Salime S, Riahi Z, Elrharchi S, Elkhattabi L, Charoute H, Nahili H, Rouba H, Kabine M, Bonnet C, Petit C, Barakat A. Salime S, et al. Gene. 2018 Jun 15;659:89-92. doi: 10.1016/j.gene.2018.03.042. Epub 2018 Mar 15. Gene. 2018. PMID: 29551497
Myopia is by far the most common human eye disorder that is known to have a clear heritable component. The analysis of the two exons of SLITRK6 gene in a Moroccan family allowed us to identify a novel single deleterious mutation c.696delG, p.Trp232Cysfs*10 at homozygous st …
Myopia is by far the most common human eye disorder that is known to have a clear heritable component. The analysis of the two exons of S …
Human cytomegalovirus downregulates SLITRK6 expression through IE2.
Liao H, Sato H, Chiba R, Kawai T, Nakabayashi K, Hata K, Akutsu H, Fujiwara S, Nakamura H. Liao H, et al. J Neurovirol. 2017 Feb;23(1):79-86. doi: 10.1007/s13365-016-0475-y. Epub 2016 Aug 16. J Neurovirol. 2017. PMID: 27530937
We also show that HCMV-encoded immediate-early 2 (IE2) proteins mediate this downregulation and their carboxy-terminal region, especially amino acid residue Gln(548), has a critical role. These findings suggest that the downregulation of SLITRK6 expression by IE2 ma …
We also show that HCMV-encoded immediate-early 2 (IE2) proteins mediate this downregulation and their carboxy-terminal region, especi …
The role of SLITRK6 in the pathogenesis of Tourette syndrome: From the conclusion of a family-based study in the Chinese Han population.
Liu W, Zhang X, Deng Z, Li G, Zhang R, Yang Z, Che F, Liu S, Li H. Liu W, et al. J Gene Med. 2020 Jun;22(6):e3173. doi: 10.1002/jgm.3173. Epub 2020 Mar 2. J Gene Med. 2020. PMID: 32037697
Studies in recent years have confirmed the association of SLITRK genes with sensory and neuropsychiatric diseases. To detect whether SLITRK6 is involved in the progress of TS, a family-based association study was performed to explore the possible genetic association betwee …
Studies in recent years have confirmed the association of SLITRK genes with sensory and neuropsychiatric diseases. To detect whether SLIT …
Development of ASG-15ME, a Novel Antibody-Drug Conjugate Targeting SLITRK6, a New Urothelial Cancer Biomarker.
Morrison K, Challita-Eid PM, Raitano A, An Z, Yang P, Abad JD, Liu W, Lortie DR, Snyder JT, Capo L, Verlinsky A, Aviña H, Doñate F, Joseph IB, Pereira DS, Morrison K, Stover DR. Morrison K, et al. Mol Cancer Ther. 2016 Jun;15(6):1301-10. doi: 10.1158/1535-7163.MCT-15-0570. Epub 2016 Mar 4. Mol Cancer Ther. 2016. PMID: 26944921
SLITRK6 is a member of the SLITRK family of neuronal transmembrane proteins that was discovered as a bladder tumor antigen using suppressive subtractive hybridization. ...To explore the possibility of using SLITRK6 as a target for an antibody-drug conjugate ( …
SLITRK6 is a member of the SLITRK family of neuronal transmembrane proteins that was discovered as a bladder tumor antigen usi …
Genetic Spectrum of Syndromic and Non-Syndromic Hearing Loss in Pakistani Families.
Doll J, Vona B, Schnapp L, Rüschendorf F, Khan I, Khan S, Muhammad N, Alam Khan S, Nawaz H, Khan A, Ahmad N, Kolb SM, Kühlewein L, Labonne JDJ, Layman LC, Hofrichter MAH, Röder T, Dittrich M, Müller T, Graves TD, Kong IK, Nanda I, Kim HG, Haaf T. Doll J, et al. Genes (Basel). 2020 Nov 11;11(11):1329. doi: 10.3390/genes11111329. Genes (Basel). 2020. PMID: 33187236 Free PMC article.
A combined exome sequencing, bioinformatics analysis, and gene mapping approach for 21 consanguineous Pakistani families revealed 13 pathogenic or likely pathogenic variants in the genes GJB2, MYO7A, FGF3, CDC14A, SLITRK6, CDH23, and MYO15A, with an overall resolve rate of …
A combined exome sequencing, bioinformatics analysis, and gene mapping approach for 21 consanguineous Pakistani families revealed 13 pathoge …
Genome-Wide CRISPR-Cas9 Screening and Identification of Potential Genes Promoting Prostate Cancer Growth and Metastasis.
Wang W, Yuan D, Jiang K, Li R, Qu H, Jiang FN, Zhong WD, Sun F, Jia Z, Zhu J. Wang W, et al. Curr Cancer Drug Targets. 2022;23(1):71-86. doi: 10.2174/1568009622666220615154137. Curr Cancer Drug Targets. 2022. PMID: 35708078
Fifteen target genes (C1QTNF9B, FAM229A, hsa-mir-3929, KRT23, TARS2, CRADD, GRIK4, PLA2G15, LOXL1, SLITRK6, CDC42EP5, SLC2A4, PTGDS, MYL9 and ACOX2 for the enriched sgRNAs) have been selected for experimental validation, which showed that knock-out of any of these genes le …
Fifteen target genes (C1QTNF9B, FAM229A, hsa-mir-3929, KRT23, TARS2, CRADD, GRIK4, PLA2G15, LOXL1, SLITRK6, CDC42EP5, SLC2A4, PTGDS, …
A homozygous SLITRK6 nonsense mutation is associated with progressive auditory neuropathy in humans.
Morlet T, Rabinowitz MR, Looney LR, Riegner T, Greenwood LA, Sherman EA, Achilly N, Zhu A, Yoo E, O'Reilly RC, Jinks RN, Puffenberger EG, Heaps A, Morton H, Strauss KA. Morlet T, et al. Laryngoscope. 2014 Mar;124(3):E95-103. doi: 10.1002/lary.24361. Epub 2013 Dec 17. Laryngoscope. 2014. PMID: 23946138 Free PMC article.
OBJECTIVES/HYPOTHESIS: SLITRK family proteins control neurite outgrowth and regulate synaptic development. In mice, Slitrk6 plays a role in the survival and innervation of sensory neurons in the inner ear, vestibular apparatus, and retina, and also influences axial …
OBJECTIVES/HYPOTHESIS: SLITRK family proteins control neurite outgrowth and regulate synaptic development. In mice, Slitrk6 pl …
Zonisamide promotes survival of human-induced pluripotent stem cell-derived dopaminergic neurons in the striatum of female rats.
Miyawaki Y, Samata B, Kikuchi T, Nishimura K, Takahashi J. Miyawaki Y, et al. J Neurosci Res. 2020 Aug;98(8):1575-1587. doi: 10.1002/jnr.24668. Epub 2020 Jun 7. J Neurosci Res. 2020. PMID: 32506530 Free PMC article.
The analysis revealed that the expression of SLIT-and NTRK-like protein 6 (SLITRK6) was upregulated in rat striatum treated with ZNS. In conclusion, ZNS promotes the survival of DA neurons after the transplantation of human-iPS cell-derived DA p …
The analysis revealed that the expression of SLIT-and NTRK-like protein 6 (SLITRK6) was upregulated in ra …
23 results