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2025 21
2026 7

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Tumor-Derived EBI3 Promotes CD8+ T-cell Exhaustion via STAT4-IL10/CCL5 in Gastric Cancer.
Yan YJ, Liu X, Wang D, Shen Z, Zhang W, Zhang Z, Jia Y, Wang P, Fong Y, Woo Y, Fu W. Yan YJ, et al. Cancer Immunol Res. 2025 Nov 3;13(11):1873-1886. doi: 10.1158/2326-6066.CIR-24-1228. Cancer Immunol Res. 2025. PMID: 40889276
Mechanistically, EBI3 induced T-cell exhaustion by promoting the phosphorylation of STAT4 and upregulating the transcription of downstream target genes CCL5 and IL10. An anti-EBI3 heptapeptide (Val-Tyr-Leu-His-Trp-His-Asp) was developed, which competitively bound EBI3 and …
Mechanistically, EBI3 induced T-cell exhaustion by promoting the phosphorylation of STAT4 and upregulating the transcription of downs …
Clinicopathological significance of JAK2, STAT3, and STAT4 expression in patients with gastric solid-type poorly differentiated adenocarcinoma: a retrospective study.
Umekita S, Kiyozawa D, Honma H, Kohashi K, Taniguchi Y, Kawatoko S, Sasaki T, Ihara E, Oki E, Nakamura M, Ogawa Y, Oda Y. Umekita S, et al. Gastric Cancer. 2025 May;28(3):455-464. doi: 10.1007/s10120-025-01589-8. Epub 2025 Feb 17. Gastric Cancer. 2025. PMID: 39961990
RESULTS: Deficient mismatch repair was found to be associated with high pJAK2 (p = 0.038) and STAT4 (p = 0.023) expression in contrast to proficient mismatch repair. Log-rank analysis revealed high pSTAT3 and low STAT4 expression to be significantly correlated with …
RESULTS: Deficient mismatch repair was found to be associated with high pJAK2 (p = 0.038) and STAT4 (p = 0.023) expression in contras …
Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors.
ElHarouni D, Hernansaiz-Ballesteros R, Peterziel H, Balasubramanian GP, Previti C, Schramm K, Blattner-Johnson M, Kabbe R, Jones BC, Oppermann S, Jones DTW, Pfister SM, Witt O, Saez-Rodriguez J, Oehme I, Jäger N, Schlesner M. ElHarouni D, et al. Cancer Res. 2026 Feb 2;86(3):773-784. doi: 10.1158/0008-5472.CAN-24-1938. Cancer Res. 2026. PMID: 41417259 Free PMC article.
A second signature was specific to a subset of Wilms tumors harboring the SIX1 (Q177R) hotspot mutation that displayed high expression of MGAM, PTPN14, STAT4, and KDM2B and high sensitivity to MEK inhibitors. A patient-specific causal interaction network analysis suggested …
A second signature was specific to a subset of Wilms tumors harboring the SIX1 (Q177R) hotspot mutation that displayed high expression of MG …
Multi-omics analysis of Helicobacter pylori-associated gastric cancer identifies hub genes as a novel therapeutic biomarker.
Mohamed SH, Hamed M, Alamoudi HA, Jastaniah Z, Alakwaa FM, Reda A. Mohamed SH, et al. Brief Bioinform. 2025 May 1;26(3):bbaf241. doi: 10.1093/bib/bbaf241. Brief Bioinform. 2025. PMID: 40445003 Free PMC article.
Furthermore, network analysis identified hub genes, including CXCL1, CCL20, IL12B, and STAT4, which are enriched in immune pathways such as chemotaxis, leukocyte migration, and cytokine signaling. ...
Furthermore, network analysis identified hub genes, including CXCL1, CCL20, IL12B, and STAT4, which are enriched in immune pathways s …
From Skin to Brain: Key Genetic Mediators Associating Cutaneous Inflammation and Neurodegenerative Diseases.
Grech VS, Lotsaris K, Kefala V, Rallis E. Grech VS, et al. Genes (Basel). 2025 Dec 8;16(12):1463. doi: 10.3390/genes16121463. Genes (Basel). 2025. PMID: 41465136 Free PMC article. Review.
Rosacea demonstrates upregulation of neurodegeneration-related proteins SNCA, GSK3B, and HSPA8, together with shared regulatory hubs (PPARG, STAT4, RORA) driving NF-kappaB/IL-17/TNF-dependent inflammation. In atopic dermatitis, rare FLG variants interacting with BACE1 sugg …
Rosacea demonstrates upregulation of neurodegeneration-related proteins SNCA, GSK3B, and HSPA8, together with shared regulatory hubs (PPARG, …
Distinct genetic risk loci between biopsy-proven renal and non-renal lupus: a 10-year longitudinal cohort.
Chan SCW, Lei Y, Yap DYH, Lee PPW, Lai WM, Ying SKY, Leung AMH, Mok CC, Lee KL, Lau CS, Yang W, Li PH. Chan SCW, et al. Rheumatology (Oxford). 2025 Jun 1;64(6):4005-4013. doi: 10.1093/rheumatology/keaf027. Rheumatology (Oxford). 2025. PMID: 39832277
Genome-wide significant variants were identified in HLA, TNFAIP3, BLK and STAT4 loci specifically for LN patients, while STAT4 also remained significant for NLN patients. ...
Genome-wide significant variants were identified in HLA, TNFAIP3, BLK and STAT4 loci specifically for LN patients, while STAT4 …
The association between STAT4 polymorphism and pulmonary arterial hypertension in Chinese patients with primary Sjogren's syndrome.
Hui M, Deng X, Wang J, Qian J, Zhao J, Wang Q, Liu Y, Tian Z, Xu D, Li M, Zeng X. Hui M, et al. Clin Rheumatol. 2025 Sep;44(9):3581-3590. doi: 10.1007/s10067-025-07580-z. Epub 2025 Jul 29. Clin Rheumatol. 2025. PMID: 40731200
RESULTS: In pSS-PAH group, 97.7% of the patients were female and average age of PAH onset was 37.3 10.6 years. The allele frequency of STAT4 rs10168266 was markedly different between pSS-PAH and pSS-non-PAH groups (p = 0.027, OR = 0.547), with the genotypic frequency of …
RESULTS: In pSS-PAH group, 97.7% of the patients were female and average age of PAH onset was 37.3 10.6 years. The allele frequency of …
Deciphering the transcriptomic characteristic of lactate metabolism and the immune infiltration landscape in abdominal aortic aneurysm.
Zhang M, Ying R, Lu S. Zhang M, et al. Biochem Biophys Res Commun. 2025 Aug 30;776:152198. doi: 10.1016/j.bbrc.2025.152198. Epub 2025 Jun 14. Biochem Biophys Res Commun. 2025. PMID: 40532306
Functional enrichment analysis revealed significant enrichment in pathways related to oxidative phosphorylation and energy metabolism. SLC25A4, HBB, and STAT4 were identified as candidate biomarkers for AAA. Immune infiltration analysis revealed distinct immune profiles be …
Functional enrichment analysis revealed significant enrichment in pathways related to oxidative phosphorylation and energy metabolism. SLC25 …
PDGFC facilitates enzalutamide resistance in prostate cancer through activation of the Rap1-MAPK pathway.
Deng B, Chen S, Zhong D, Song G, Liu H, Xie L, Liu Y, Ni R, Shen W, Huang G. Deng B, et al. J Cancer Res Clin Oncol. 2025 Sep 24;151(10):267. doi: 10.1007/s00432-025-06276-w. J Cancer Res Clin Oncol. 2025. PMID: 40993441 Free PMC article.
Luciferase assays and chromatin immunoprecipitation (ChIP) assays were performed to demonstrate the mechanism of signal transducer and activator of transcription 4 (STAT4)-mediated transcriptional regulation of PDGFC. ...Not …
Luciferase assays and chromatin immunoprecipitation (ChIP) assays were performed to demonstrate the mechanism of signal transducer …
27 results