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1,534 results

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Page 1
The cGAS-STING pathway and cancer.
Samson N, Ablasser A. Samson N, et al. Nat Cancer. 2022 Dec;3(12):1452-1463. doi: 10.1038/s43018-022-00468-w. Epub 2022 Dec 12. Nat Cancer. 2022. PMID: 36510011 Review.
STING: infection, inflammation and cancer.
Barber GN. Barber GN. Nat Rev Immunol. 2015 Dec;15(12):760-70. doi: 10.1038/nri3921. Nat Rev Immunol. 2015. PMID: 26603901 Free PMC article. Review.
Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients.
Frémond ML, Hadchouel A, Berteloot L, Melki I, Bresson V, Barnabei L, Jeremiah N, Belot A, Bondet V, Brocq O, Chan D, Dagher R, Dubus JC, Duffy D, Feuillet-Soummer S, Fusaro M, Gattorno M, Insalaco A, Jeziorski E, Kitabayashi N, Lopez-Corbeto M, Mazingue F, Morren MA, Rice GI, Rivière JG, Seabra L, Sirvente J, Soler-Palacin P, Stremler-Le Bel N, Thouvenin G, Thumerelle C, Van Aerde E, Volpi S, Willcocks S, Wouters C, Breton S, Molina T, Bader-Meunier B, Moshous D, Fischer A, Blanche S, Rieux-Laucat F, Crow YJ, Neven B. Frémond ML, et al. J Allergy Clin Immunol Pract. 2021 Feb;9(2):803-818.e11. doi: 10.1016/j.jaip.2020.11.007. Epub 2020 Nov 18. J Allergy Clin Immunol Pract. 2021. PMID: 33217613 Free article.
BACKGROUND: Gain-of-function mutations in STING1 underlie a type I interferonopathy termed SAVI (STING-associated vasculopathy with onset in infancy). This severe disease is variably characterized by early-onset systemic inflammation, ski …
BACKGROUND: Gain-of-function mutations in STING1 underlie a type I interferonopathy termed SAVI (STING-associated vasculopa …
Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging.
Paul BD, Snyder SH, Bohr VA. Paul BD, et al. Trends Neurosci. 2021 Feb;44(2):83-96. doi: 10.1016/j.tins.2020.10.008. Epub 2020 Nov 10. Trends Neurosci. 2021. PMID: 33187730 Free PMC article. Review.
Whereas it generally mediates immune surveillance and is often neuroprotective, excessive engagement of the system can be deleterious. This is relevant in aging and age-related neurological diseases, where neuroinflammation contributes to disease progression. ...
Whereas it generally mediates immune surveillance and is often neuroprotective, excessive engagement of the system can be deleterious. This …
cGAS in action: Expanding roles in immunity and inflammation.
Ablasser A, Chen ZJ. Ablasser A, et al. Science. 2019 Mar 8;363(6431):eaat8657. doi: 10.1126/science.aat8657. Science. 2019. PMID: 30846571 Review.
Manipulating cGAS or STING may open the door for new therapeutic strategies for the treatment of acute and chronic inflammation relevant to many human diseases....
Manipulating cGAS or STING may open the door for new therapeutic strategies for the treatment of acute and chronic inflammation relevant to …
DNA sensing by the cGAS-STING pathway in health and disease.
Motwani M, Pesiridis S, Fitzgerald KA. Motwani M, et al. Nat Rev Genet. 2019 Nov;20(11):657-674. doi: 10.1038/s41576-019-0151-1. Epub 2019 Jul 29. Nat Rev Genet. 2019. PMID: 31358977 Review.
Moreover, the ability of self-DNA to engage cGAS has emerged as an important mechanism fuelling the development of inflammation and implicating the cGAS-STING pathway in human inflammatory diseases and cancer. This detailed mechanistic and biological understanding is pavin …
Moreover, the ability of self-DNA to engage cGAS has emerged as an important mechanism fuelling the development of inflammation and implicat …
SnapShot: CGAS-STING Signaling.
Galluzzi L, Vanpouille-Box C, Bakhoum SF, Demaria S. Galluzzi L, et al. Cell. 2018 Mar 22;173(1):276-276.e1. doi: 10.1016/j.cell.2018.03.015. Cell. 2018. PMID: 29570996 Free article. Review.
The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential.
Zhang J, Zhang L, Chen Y, Fang X, Li B, Mo C. Zhang J, et al. Front Immunol. 2023 Oct 25;14:1273248. doi: 10.3389/fimmu.2023.1273248. eCollection 2023. Front Immunol. 2023. PMID: 37965345 Free PMC article. Review.
Recent studies have highlighted the involvement of aberrant activation of cGAS-STING contributes to fibrotic lung diseases. This review aims to provide a comprehensive summary of the current knowledge regarding the role of cGAS-STING pathway in pulmonary fibrosis. ...
Recent studies have highlighted the involvement of aberrant activation of cGAS-STING contributes to fibrotic lung diseases. This revi …
1,534 results