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Year Number of Results
2021 4
2022 9
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2026 9

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46 results

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IL-4 mediated TAP2 downregulation is a dominant and reversible mechanism of immune evasion and immunotherapy resistance in non-small cell lung cancer.
Ranjan K, Rajendran BK, Deen IU, Costantini A, de Rodas ML, Desai SS, Scallo F, Gianino N, Ferrone S, Schalper KA. Ranjan K, et al. Mol Cancer. 2025 Mar 17;24(1):80. doi: 10.1186/s12943-025-02276-z. Mol Cancer. 2025. PMID: 40091029 Free PMC article.
TAP2 loss in human NSCLCs was associated with reduced TAP2 promoter chromatin accessibility and elevated IL-4 IL-4 expression. Treatment with IL-4 reduced TAP2 levels and the chromatin accessibility of the TAP2 gene promoter in NSCLC cells and reproduc …
TAP2 loss in human NSCLCs was associated with reduced TAP2 promoter chromatin accessibility and elevated IL-4 IL-4 expression. …
IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer.
Wang S, Yang W, Peng T, Zhu C, Dong J, Wang Y, Yuan H, Sun Q, Luan X, Guan X, Zhang W, Qin JJ. Wang S, et al. Nat Commun. 2025 Nov 28;16(1):10733. doi: 10.1038/s41467-025-65762-4. Nat Commun. 2025. PMID: 41315272 Free PMC article.
Mechanistically, UBE2D3 binds the ubiquitin ligase Kelch Like Family Member 13 (KLHL13) to mediate K63-linked polyubiquitination at lysine 245 of transporter 2 (TAP2), resulting in steric hindrance that blocks the transporter. Genetic or pharmacologic …
Mechanistically, UBE2D3 binds the ubiquitin ligase Kelch Like Family Member 13 (KLHL13) to mediate K63-linked polyubiquitination at lysine 2 …
The role of ATP-binding Cassette subfamily B member 6 in the inner ear.
Baril SA, Wilson KA, Shaik MM, Fukuda Y, Umans RA, Barbieri A, Lynch J, Gose T, Myasnikov A, Oldham ML, Wang Y, Zhu J, Fang J, Zuo J, Kalathur RC, Ford RC, Coffin A, Taylor MR, O'Mara ML, Schuetz JD. Baril SA, et al. Nat Commun. 2024 Nov 18;15(1):9885. doi: 10.1038/s41467-024-53663-x. Nat Commun. 2024. PMID: 39557842 Free PMC article.
Dyschromatosis universalis hereditaria-associated mutations in ABCB6 have been reported, but the role of this protein in the inner ear has not been studied. Here we determine a high-resolution (2.93 A) cryo-EM structure of ABCB6 and functionally characterized several dysch …
Dyschromatosis universalis hereditaria-associated mutations in ABCB6 have been reported, but the role of this protein in the inner ear has n …
TAP2 Drives HLA-B 13:01-Linked Dapsone Hypersensitivity Syndrome Tolerance and Reactivity.
Sun L, Wang Z, Liu T, Zhao Q, Yu G, Sun Y, Xue X, You J, Yue Z, Mi Z, Liu H, Zhang F. Sun L, et al. J Invest Dermatol. 2023 May;143(5):722-730.e1. doi: 10.1016/j.jid.2022.10.009. Epub 2022 Oct 29. J Invest Dermatol. 2023. PMID: 37306379 Free article.
However, the pathway of antigen processing and presentation was enriched in patients with DHS, and the gene TAP2 was identified. Expression of TAP2 and its molecular chaperone, TAP1, were validated by quantitative PCR, and in vitro functional experiments were perfor …
However, the pathway of antigen processing and presentation was enriched in patients with DHS, and the gene TAP2 was identified. Expr …
Role of necroptosis-related genes in immune activity and prognosis of colorectal cancer.
Tan L, Wang S, Chang W, Zhang X, Deng R, Yan H, Zhu W, Wang H, Cai Y, Liu Z, Tan Y, Cui J. Tan L, et al. Front Immunol. 2025 Sep 1;16:1619749. doi: 10.3389/fimmu.2025.1619749. eCollection 2025. Front Immunol. 2025. PMID: 40959081 Free PMC article.
RESULTS: A novel signature consisting of eighteen NRGs (CTSB, PAEP, ARL4C, TAP2, WFS1, BATF2, DUSP27, CXCL9, EPHB2, IRF8, CXCL13, GZMB, APOL6, NLRC5, CXCL10, IRF1, HES6, and PTGDR) was successfully established. ...
RESULTS: A novel signature consisting of eighteen NRGs (CTSB, PAEP, ARL4C, TAP2, WFS1, BATF2, DUSP27, CXCL9, EPHB2, IRF8, CXCL13, GZM …
Spotlight on TAP and its vital role in antigen presentation and cross-presentation.
Mantel I, Sadiq BA, Blander JM. Mantel I, et al. Mol Immunol. 2022 Feb;142:105-119. doi: 10.1016/j.molimm.2021.12.013. Epub 2021 Dec 29. Mol Immunol. 2022. PMID: 34973498 Free PMC article. Review.
In the late 1980s and early 1990s, the hunt for a transporter molecule ostensibly responsible for the translocation of peptides across the endoplasmic reticulum (ER) membrane yielded the successful discovery of transporter associated with antigen processing ( …
In the late 1980s and early 1990s, the hunt for a transporter molecule ostensibly responsible for the translocation of peptides acros …
Computational and functional prioritization identifies genes that rescue behavior and reduce tau protein in fly and human cell models of Alzheimer disease.
Stephens MC, Li J, Mair M, Moore J, Zhu K, Tarkunde A, Amoh B, Perez AM, Bhakare A, Guo F, Shulman JM, Al-Ramahi I, Botas J. Stephens MC, et al. Am J Hum Genet. 2025 May 1;112(5):1081-1096. doi: 10.1016/j.ajhg.2025.03.012. Epub 2025 Apr 10. Am J Hum Genet. 2025. PMID: 40215969 Free PMC article.
Reversing the aberrant down- or upregulation of 11 of these genes (MTCH2, ELL, TAP2, HDC, DMWD, MYCL, SLC4A9, ABCA7, CSTF1, PTK2B, and CD2AP) proved neuroprotective in vivo. ...
Reversing the aberrant down- or upregulation of 11 of these genes (MTCH2, ELL, TAP2, HDC, DMWD, MYCL, SLC4A9, ABCA7, CSTF1, PTK2B, an …
Genetic Variants in the ABCB1 and ABCG2 Gene Drug Transporters Involved in Gefitinib-Associated Adverse Reaction: A Systematic Review and Meta-Analysis.
Morau MV, Seguin CS, Visacri MB, Pincinato EC, Moriel P. Morau MV, et al. Genes (Basel). 2024 May 7;15(5):591. doi: 10.3390/genes15050591. Genes (Basel). 2024. PMID: 38790220 Free PMC article.
This systematic review and meta-analysis aimed to verify the association between the genetic variants of adenosine triphosphate (ATP)-binding cassette subfamily B member 1 (ABCB1) and ATP-binding cassette subfamily G member 2 (ABCG …
This systematic review and meta-analysis aimed to verify the association between the genetic variants of adenosine triphosphate (ATP) …
TP53 mutation predicts resistance to immune checkpoint inhibitor-based therapy in intrahepatic cholangiocarcinoma.
Inada H, Kurano S, Miyamoto H, Onishi M, Suzuki Y, Narahara S, Otsuka F, Iio E, Watanabe T, Setoyama H, Nagaoka K, Beppu T, Hayashi H, Tanaka Y. Inada H, et al. J Gastroenterol. 2026 Mar;61(3):325-333. doi: 10.1007/s00535-025-02320-1. Epub 2025 Nov 17. J Gastroenterol. 2026. PMID: 41247518
Spatial transcriptomic profiling revealed a distinct immunosuppressive microenvironment in TP53-mutated tumors marked by poor CD8+ T-cell infiltration, enrichment of CD109+ tumor-associated macrophages, and downregulation of antigen-presentation genes TAP1 and TAP2. CONCLU …
Spatial transcriptomic profiling revealed a distinct immunosuppressive microenvironment in TP53-mutated tumors marked by poor CD8+ T-cell in …
Identification of TAP2 as a novel immune target in human cancers: insights from integrated bioinformatics and experimental approaches.
Yang L, Gui J, Sheng Y, Liu J, Wang C, Fang Z, Huang L, Tu Z, Zhu X, Huang K. Yang L, et al. Eur J Med Res. 2025 Mar 13;30(1):163. doi: 10.1186/s40001-025-02360-6. Eur J Med Res. 2025. PMID: 40075453 Free PMC article.
BACKGROUND: Transporter 2, ATP binding cassette (ABC) subfamily B member (TAP2), encodes a protein within the ABC transporter superfamily. ...RESULTS: TAP2 exhibited aberrantly expression in tumor tissues with genomic alterations. TAP2 si …
BACKGROUND: Transporter 2, ATP binding cassette (ABC) subfamily B member (TAP2), encodes a protein within the ABC tr …
46 results