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2018 1
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Page 1
Identification of Hub Genes and Pathways Associated with Oxidative Stress of Cartilage in Osteonecrosis of Femoral Head Using Bioinformatics Analysis.
Shi W, Zhang X, Xu C, Pang R, Fan Z, Wan X, Jiang Z, Li H, Li Z, Zhang H. Shi W, et al. Cartilage. 2022 Jan-Mar;13(1):19476035221074000. doi: 10.1177/19476035221074000. Cartilage. 2022. PMID: 35118903 Free PMC article.
The top 10 hub genes were JUN, FOXO3, CASP3, JAK2, RELA, EZH2, ABL1, PTGS2, FBXW7, MCL1. Besides, TFAP2A, GATA2, SP1, and E2F1 may be the key regulatory factors of hub genes. ...
The top 10 hub genes were JUN, FOXO3, CASP3, JAK2, RELA, EZH2, ABL1, PTGS2, FBXW7, MCL1. Besides, TFAP2A, GATA2, SP1, and E2F1 may be …
Origin and segregation of the human germline.
Castillo-Venzor A, Penfold CA, Morgan MD, Tang WW, Kobayashi T, Wong FC, Bergmann S, Slatery E, Boroviak TE, Marioni JC, Surani MA. Castillo-Venzor A, et al. Life Sci Alliance. 2023 May 22;6(8):e202201706. doi: 10.26508/lsa.202201706. Print 2023 Aug. Life Sci Alliance. 2023. PMID: 37217306 Free PMC article.
Furthermore, we show that both the PGCs and amnion arise from transcriptionally similar TFAP2A-positive progenitors at the posterior end of the embryo. Notably, genetic loss of function experiments shows that TFAP2A is crucial for initiating the PGC fate without det …
Furthermore, we show that both the PGCs and amnion arise from transcriptionally similar TFAP2A-positive progenitors at the posterior …
Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views.
Jin C, Luo Y, Liang Z, Li X, Kołat D, Zhao L, Xiong W. Jin C, et al. J Transl Med. 2023 Jun 8;21(1):371. doi: 10.1186/s12967-023-04189-1. J Transl Med. 2023. PMID: 37291585 Free PMC article. Review.
The TFAP2 family consists of five DNA-binding proteins, including TFAP2A, TFAP2B, TFAP2C, TFAP2D and TFAP2E. The importance of TFAP2 in tumor biology is becoming more widely recognized. ...
The TFAP2 family consists of five DNA-binding proteins, including TFAP2A, TFAP2B, TFAP2C, TFAP2D and TFAP2E. The importance of TFAP2 …
Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis.
Zhao X, Chen L, Wu J, You J, Hong Q, Ye F. Zhao X, et al. Biol Direct. 2021 Nov 3;16(1):21. doi: 10.1186/s13062-021-00300-y. Biol Direct. 2021. PMID: 34727954 Free PMC article.
Fluorescence in situ hybridization (FISH) assays were performed to determine the subcellular distribution of TFAP2A-AS1 in GC. Mechanism investigations were conducted to explore the downstream genes of TFAP2A-AS1 and the upstream transcription factor of TFAP2A
Fluorescence in situ hybridization (FISH) assays were performed to determine the subcellular distribution of TFAP2A-AS1 in GC. Mechan …
TFAP2A potentiates lung adenocarcinoma metastasis by a novel miR-16 family/TFAP2A/PSG9/TGF-beta signaling pathway.
Xiong Y, Feng Y, Zhao J, Lei J, Qiao T, Zhou Y, Lu Q, Jiang T, Jia L, Han Y. Xiong Y, et al. Cell Death Dis. 2021 Apr 6;12(4):352. doi: 10.1038/s41419-021-03606-x. Cell Death Dis. 2021. PMID: 33824285 Free PMC article.
Meanwhile, we discovered suppressed post-transcriptional silencing of miR-16 family upon TFAP2A partly contributed to TFAP2A upregulation in LUAD. In clinical specimens, we also validated cancer-regulating effect of miR-16 family/TFAP2A/PSG9 axis, especially …
Meanwhile, we discovered suppressed post-transcriptional silencing of miR-16 family upon TFAP2A partly contributed to TFAP2A u …
Long Noncoding RNA TFAP2A-AS1 Suppressed Hepatitis B Virus Replication by Modulating miR-933/HDAC11.
Cheng Y, Shi W, Cui X, Sun L, Nan Y, Yao H, Fan J, Zhu L, Yu L. Cheng Y, et al. Dis Markers. 2022 Apr 18;2022:7733390. doi: 10.1155/2022/7733390. eCollection 2022. Dis Markers. 2022. Retraction in: Dis Markers. 2023 Jun 21;2023:9867801. doi: 10.1155/2023/9867801. PMID: 35478990 Free PMC article. Retracted.
TFAP2A-AS1 acted as a sponge for miR-933 and HDAC11 was one direct target gene for miR-933. Overexpression of TFAP2A-AS1 suppressed cell growth, HBV DNA replication, HbeAg, and HbsAg expression, while knockdown of TFAP2A-AS1 enhanced cell proliferation, HBV D
TFAP2A-AS1 acted as a sponge for miR-933 and HDAC11 was one direct target gene for miR-933. Overexpression of TFAP2A-AS1 suppr
Genetics of anophthalmia and microphthalmia. Part 2: Syndromes associated with anophthalmia-microphthalmia.
Slavotinek A. Slavotinek A. Hum Genet. 2019 Sep;138(8-9):831-846. doi: 10.1007/s00439-018-1949-1. Epub 2018 Oct 30. Hum Genet. 2019. PMID: 30374660 Review.
Less common genetic causes of A/M, including genes involved in BMP signaling [Bone Morphogenetic Protein 4 (BMP4), Bone Morphogenetic Protein 7 (BMP7) and SPARC-related modular calcium-binding protein 1 (SMOC1)], genes involved in the mitochondrial respiratory chain complex [Holo …
Less common genetic causes of A/M, including genes involved in BMP signaling [Bone Morphogenetic Protein 4 (BMP4), Bone Morphogenetic Protei …
DNA Methylation Signatures of Functional Somatic Syndromes: Systematic Review.
Fischer S, Kleinstäuber M, Fiori LM, Turecki G, Wagner J, von Känel R. Fischer S, et al. Psychosom Med. 2023 Oct 1;85(8):672-681. doi: 10.1097/PSY.0000000000001237. Epub 2023 Aug 21. Psychosom Med. 2023. PMID: 37531610
In genome-wide studies in fibromyalgia syndrome, differential methylation in sites related to HDAC4 , TMEM44 , KCNQ1 , SLC17A9 , PRKG1 , ALPK3 , TFAP2A , and LY6G5C was found. CONCLUSIONS: Individuals with chronic fatigue syndrome and fibromyalgia syndrome seem to be chara …
In genome-wide studies in fibromyalgia syndrome, differential methylation in sites related to HDAC4 , TMEM44 , KCNQ1 , SLC17A9 , PRKG1 , ALP …
Long noncoding RNA TFAP2A-AS1 promotes oral squamous cell carcinoma cell growth and movement via competitively binding miR-1297 and regulating TFAP2A expression.
Yang K, Niu Y, Cui Z, Jin L, Peng S, Dong Z. Yang K, et al. Mol Carcinog. 2022 Sep;61(9):865-875. doi: 10.1002/mc.23438. Epub 2022 Jun 22. Mol Carcinog. 2022. PMID: 35730908
TFAP2A promoted OSCC cell growth and migration/invasion, indicating that TFAP2A mediated the effects of TFAP2A-AS1 and miR-1297. TFAP2A-AS1 exerts an oncogenic effect in OSCC via the TFAP2A-AS1/miR-1297/TFAP2A axis, which may provide new
TFAP2A promoted OSCC cell growth and migration/invasion, indicating that TFAP2A mediated the effects of TFAP2A-AS1 and
AP-2α-Mediated Activation of E2F and EZH2 Drives Melanoma Metastasis.
White JR, Thompson DT, Koch KE, Kiriazov BS, Beck AC, van der Heide DM, Grimm BG, Kulak MV, Weigel RJ. White JR, et al. Cancer Res. 2021 Sep 1;81(17):4455-4470. doi: 10.1158/0008-5472.CAN-21-0772. Epub 2021 Jul 1. Cancer Res. 2021. PMID: 34210752 Free PMC article.
In melanoma metastasis, the role of the AP-2alpha transcription factor, which is encoded by TFAP2A, is controversial as some findings have suggested tumor suppressor activity while other studies have shown high TFAP2A expression in node-positive melanoma associated …
In melanoma metastasis, the role of the AP-2alpha transcription factor, which is encoded by TFAP2A, is controversial as some findings …
68 results