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2015 2
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77 results

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Page 1
Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma.
Jansky S, Sharma AK, Körber V, Quintero A, Toprak UH, Wecht EM, Gartlgruber M, Greco A, Chomsky E, Grünewald TGP, Henrich KO, Tanay A, Herrmann C, Höfer T, Westermann F. Jansky S, et al. Nat Genet. 2021 May;53(5):683-693. doi: 10.1038/s41588-021-00806-1. Epub 2021 Mar 25. Nat Genet. 2021. PMID: 33767450
Our work highlights the roles of oncogenic MYCN and loss of TFAP2B in blocking differentiation and may provide the basis for designing therapeutic interventions to overcome differentiation blocks....
Our work highlights the roles of oncogenic MYCN and loss of TFAP2B in blocking differentiation and may provide the basis for designin …
Human Genetics of Ventricular Septal Defect.
Perrot A, Rickert-Sperling S. Perrot A, et al. Adv Exp Med Biol. 2024;1441:505-534. doi: 10.1007/978-3-031-44087-8_27. Adv Exp Med Biol. 2024. PMID: 38884729
Transcription factor AP-2beta in development, differentiation and tumorigenesis.
Raap M, Gierendt L, Kreipe HH, Christgen M. Raap M, et al. Int J Cancer. 2021 Sep 15;149(6):1221-1227. doi: 10.1002/ijc.33558. Epub 2021 Mar 26. Int J Cancer. 2021. PMID: 33720400 Review.
Germline mutation of TFAP2B is known to cause the Char syndrome, an autosomal dominant disorder characterized by facial dysmorphism, patent ductus arteriosus and anatomical abnormalities of the fifth digit. Furthermore, single-nucleotide polymorphisms in TFAP2B were …
Germline mutation of TFAP2B is known to cause the Char syndrome, an autosomal dominant disorder characterized by facial dysmorphism, …
ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma.
Lu Y, Travnickova J, Badonyi M, Rambow F, Coates A, Khan Z, Marques J, Murphy LC, Garcia-Martinez P, Marais R, Louphrasitthiphol P, Chan AHY, Schofield CJ, von Kriegsheim A, Marsh JA, Pavet V, Sansom OJ, Illingworth RS, Patton EE. Lu Y, et al. Cell Rep. 2024 Jul 23;43(7):114406. doi: 10.1016/j.celrep.2024.114406. Epub 2024 Jul 3. Cell Rep. 2024. PMID: 38963759 Free PMC article.
Tumor exosomal circPTBP3 drives gastric cancer peritoneal metastasis via mesothelial-mesenchymal transition.
Dong C, Zhou Y, Shen X, Hu S, Duan K, Chen T, Li W, Sun X, Li P, Wang P, Han Y, Li D, Zhi Q, Zhou J. Dong C, et al. Cell Death Dis. 2025 Jun 11;16(1):444. doi: 10.1038/s41419-025-07749-z. Cell Death Dis. 2025. PMID: 40500263 Free PMC article.
Located in the nucleus, circPTPB3 was found to recruit transcription factor AP-2-beta (TFAP2B) to the serum- and glucocorticoid-inducible kinase 1 (SGK1) promoter sites, thereby initiating its transcription in mesothelial cells. ...
Located in the nucleus, circPTPB3 was found to recruit transcription factor AP-2-beta (TFAP2B) to …
Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views.
Jin C, Luo Y, Liang Z, Li X, Kołat D, Zhao L, Xiong W. Jin C, et al. J Transl Med. 2023 Jun 8;21(1):371. doi: 10.1186/s12967-023-04189-1. J Transl Med. 2023. PMID: 37291585 Free PMC article. Review.
The TFAP2 family consists of five DNA-binding proteins, including TFAP2A, TFAP2B, TFAP2C, TFAP2D and TFAP2E. The importance of TFAP2 in tumor biology is becoming more widely recognized. ...
The TFAP2 family consists of five DNA-binding proteins, including TFAP2A, TFAP2B, TFAP2C, TFAP2D and TFAP2E. The importance of TFAP2 …
TFAP2B mutation and dental anomalies.
Tanasubsinn N, Sittiwangkul R, Pongprot Y, Kawasaki K, Ohazama A, Sastraruji T, Kaewgahya M, Kantaputra PN. Tanasubsinn N, et al. J Hum Genet. 2017 Aug;62(8):769-775. doi: 10.1038/jhg.2017.37. Epub 2017 Apr 6. J Hum Genet. 2017. PMID: 28381879 Free PMC article.
The mutation is predicted to cause an amino-acid substitution p.Val336Ile in the TFAP2B protein. Tfap2b expression during early mouse tooth development supports the association of TFAP2B mutation and dental anomalies. ...In addition, we also found that TFA …
The mutation is predicted to cause an amino-acid substitution p.Val336Ile in the TFAP2B protein. Tfap2b expression during earl …
Transcription factor activating protein 2 beta (TFAP2B) mediates noradrenergic neuronal differentiation in neuroblastoma.
Ikram F, Ackermann S, Kahlert Y, Volland R, Roels F, Engesser A, Hertwig F, Kocak H, Hero B, Dreidax D, Henrich KO, Berthold F, Nürnberg P, Westermann F, Fischer M. Ikram F, et al. Mol Oncol. 2016 Feb;10(2):344-59. doi: 10.1016/j.molonc.2015.10.020. Epub 2015 Nov 7. Mol Oncol. 2016. PMID: 26598443 Free PMC article.
We also found that low TFAP2B expression was strongly associated with CpG methylation of the TFAP2B locus in primary neuroblastomas (n = 105) and demethylation with 5-aza-2'-deoxycytidine resulted in induction of TFAP2B expression in vitro, suggesting that …
We also found that low TFAP2B expression was strongly associated with CpG methylation of the TFAP2B locus in primary neuroblas …
Transcription factor TFAP2B up-regulates human corneal endothelial cell-specific genes during corneal development and maintenance.
Hara S, Kawasaki S, Yoshihara M, Winegarner A, Busch C, Tsujikawa M, Nishida K. Hara S, et al. J Biol Chem. 2019 Feb 15;294(7):2460-2469. doi: 10.1074/jbc.RA118.005527. Epub 2018 Dec 14. J Biol Chem. 2019. PMID: 30552118 Free PMC article.
Furthermore, the TFAP2B protein was expressed both in vivo and in cultured CECs. During mouse development, TFAP2B expression began in the PM at embryonic day 11.5 and then in CECs during adulthood. siRNA-mediated knockdown of TFAP2B in CECs decreased the expr …
Furthermore, the TFAP2B protein was expressed both in vivo and in cultured CECs. During mouse development, TFAP2B expression b …
DNA methylation profile of human dura and leptomeninges.
Maier AD, Christiansen SN, Haslund-Vinding J, Krogager ME, Melchior LC, Scheie D, Mathiesen T. Maier AD, et al. J Neuropathol Exp Neurol. 2023 Jun 20;82(7):641-649. doi: 10.1093/jnen/nlad036. J Neuropathol Exp Neurol. 2023. PMID: 37203418
Samples from foramen magnum showed hypomethylation of TFAP2B compared to those from remaining locations. Thus, the DNA methylation profiles of human meninges are heterogenous in terms of meningeal layer and anatomical location. ...
Samples from foramen magnum showed hypomethylation of TFAP2B compared to those from remaining locations. Thus, the DNA methylation pr …
77 results