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Structure and genetic variants of thyroglobulin: Pathophysiological implications.
Citterio CE, Rivolta CM, Targovnik HM. Citterio CE, et al. Mol Cell Endocrinol. 2021 May 15;528:111227. doi: 10.1016/j.mce.2021.111227. Epub 2021 Mar 6. Mol Cell Endocrinol. 2021. PMID: 33689781 Review.
Thyroglobulin (TG) plays a main role in the biosynthesis of thyroid hormones (TH), and, thus, it is involved in a wide range of vital functions throughout the life cycle of all vertebrates. ...To this day, 229 variations in the human TG gene have been identif …
Thyroglobulin (TG) plays a main role in the biosynthesis of thyroid hormones (TH), and, thus, it is involved in a wide range o …
The structure of human thyroglobulin.
Coscia F, Taler-Verčič A, Chang VT, Sinn L, O'Reilly FJ, Izoré T, Renko M, Berger I, Rappsilber J, Turk D, Löwe J. Coscia F, et al. Nature. 2020 Feb;578(7796):627-630. doi: 10.1038/s41586-020-1995-4. Epub 2020 Feb 5. Nature. 2020. PMID: 32025030 Free PMC article.
Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for growth, development and the control of metabolism in vertebrates(1,2). Hormone synthesis from TG occurs in the thyroid gland via the iodination and coupling of pairs of t …
Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for growth, development and the control o …
Increased Prevalence of TG and TPO Mutations in Sudanese Children With Congenital Hypothyroidism.
Bruellman RJ, Watanabe Y, Ebrhim RS, Creech MK, Abdullah MA, Dumitrescu AM, Refetoff S, Weiss RE. Bruellman RJ, et al. J Clin Endocrinol Metab. 2020 May 1;105(5):1564-72. doi: 10.1210/clinem/dgz297. J Clin Endocrinol Metab. 2020. PMID: 31867598 Free PMC article.
Our samples and information regarding samples from the literature were used to compare TG (thyroglobulin) and TPO (thyroid peroxidase) mutation rates in the Sudanese population with all populations. ...Genotype prediction based on phenotype includes low or undetecta …
Our samples and information regarding samples from the literature were used to compare TG (thyroglobulin) and TPO (thyroid per …
TSH stimulation of human thyroglobulin and thyroid peroxidase gene transcription is partially dependent on internalization.
Jang D, Eliseeva E, Klubo-Gwiezdzinska J, Neumann S, Gershengorn MC. Jang D, et al. Cell Signal. 2022 Feb;90:110212. doi: 10.1016/j.cellsig.2021.110212. Epub 2021 Dec 9. Cell Signal. 2022. PMID: 34896620 Free PMC article.
The TSH receptor (TSHR) is the major regulator of thyroid hormone biosynthesis in human thyrocytes by regulating the transcription of a number of genes including thyroglobulin (TG) and thyroperoxidase (TPO). Until recently, it was thought that TSHR initiated signal …
The TSH receptor (TSHR) is the major regulator of thyroid hormone biosynthesis in human thyrocytes by regulating the transcription of a numb …
Thyroglobulin as a negative marker for malignancy in canine and human breast tumors.
Hwang SH, Yang Y, Woo SH, Jung JH, Seo D, Kim DY, Kim Y. Hwang SH, et al. Mol Carcinog. 2021 Jul;60(7):455-468. doi: 10.1002/mc.23304. Epub 2021 May 18. Mol Carcinog. 2021. PMID: 34003526
Canine mammary gland tumors (CMTs) are the most common tumor type in female dogs. This study evaluated the expression pattern and role of thyroglobulin (Tg) in CMT and in human breast cancer (HBC). CMT samples were subjected to fine-needle aspiration, primary cell c …
Canine mammary gland tumors (CMTs) are the most common tumor type in female dogs. This study evaluated the expression pattern and role of …
Homology between TSH-R/Tg/TPO and Hashimoto's encephalopathy autoantigens.
Benvenga S, Guarneri F. Benvenga S, et al. Front Biosci (Landmark Ed). 2020 Jan 1;25(2):229-241. doi: 10.2741/4804. Front Biosci (Landmark Ed). 2020. PMID: 31585887 Free article.
We searched for amino acid sequence homologies between these proteins and the three classical thyroid autoantigens (thyroperoxidase (TPO), thyroglobulin (Tg), TSH-receptor (TSH-R)), which are also expressed in the central nervous system (CNS). TSH-R shows homologies …
We searched for amino acid sequence homologies between these proteins and the three classical thyroid autoantigens (thyroperoxidase (TPO), …
Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels.
Pleić N, Babić Leko M, Gunjača I, Boutin T, Torlak V, Matana A, Punda A, Polašek O, Hayward C, Zemunik T. Pleić N, et al. Int J Mol Sci. 2022 Feb 16;23(4):2173. doi: 10.3390/ijms23042173. Int J Mol Sci. 2022. PMID: 35216288 Free PMC article.
Thyroglobulin (Tg) is an iodoglycoprotein produced by thyroid follicular cells which acts as an essential substrate for thyroid hormone synthesis. ...For ST6GAL1 and the newly uncovered genes, we provide physiological and pathophysiological explanations of how their …
Thyroglobulin (Tg) is an iodoglycoprotein produced by thyroid follicular cells which acts as an essential substrate for thyroi …
Association between thyroglobulin polymorphisms and autoimmune thyroid disease: a systematic review and meta-analysis of case-control studies.
Zhang ML, Zhang DM, Wang CE, Chen XL, Liu FZ, Yang JX. Zhang ML, et al. Genes Immun. 2019 Jul;20(6):484-492. doi: 10.1038/s41435-018-0042-z. Epub 2018 Aug 24. Genes Immun. 2019. PMID: 30139952
Emerging evidence revealed that thyroglobulin (TG) contributes to the development of autoimmune disease, and the relationship between TG and autoimmune thyroid disease (AITD) is still controversial. ...We identified all studies that assessed the association b …
Emerging evidence revealed that thyroglobulin (TG) contributes to the development of autoimmune disease, and the relationship …
Thyroglobulin Interactome Profiling Defines Altered Proteostasis Topology Associated With Thyroid Dyshormonogenesis.
Wright MT, Kouba L, Plate L. Wright MT, et al. Mol Cell Proteomics. 2021;20:100008. doi: 10.1074/mcp.RA120.002168. Epub 2020 Dec 8. Mol Cell Proteomics. 2021. PMID: 33581410 Free PMC article.
Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for triiodothyronine and thyroxine hormones. ...While dependencies on individual proteostasis network components are known, the integration of proteostasis pathways mediating Tg protei …
Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for triiodothyronine and thyroxine hormones. ...Whi …
Curating the gnomAD database: Report of novel variants in the thyroid peroxidase gene using in silico bioinformatics algorithms and a literature review.
Molina MF, Pio MG, Scheps KG, Adrover E, Abelleyro MM, Targovnik HM, Rivolta CM. Molina MF, et al. Mol Cell Endocrinol. 2022 Dec 1;558:111748. doi: 10.1016/j.mce.2022.111748. Epub 2022 Aug 20. Mol Cell Endocrinol. 2022. PMID: 35995307 Review.
Thyroid peroxidase (TPO) is a membrane-bound glycoprotein located at the apical side of the thyroid follicular cells that catalyzes both iodination and coupling of iodotyrosine residues within the thyroglobulin molecule, leading to the synthesis of thyroid hormone. ...
Thyroid peroxidase (TPO) is a membrane-bound glycoprotein located at the apical side of the thyroid follicular cells that catalyzes both iod …
29 results