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2024 12
2025 3

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14 results

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Platelet-derived TGF-β1 induces functional reprogramming of myeloid-derived suppressor cells in immune thrombocytopenia.
Wang L, Wang H, Zhu M, Ni X, Sun L, Wang W, Xie J, Li Y, Xu Y, Wang R, Han S, Zhang P, Peng J, Hou M, Hou Y. Wang L, et al. Blood. 2024 Jul 4;144(1):99-112. doi: 10.1182/blood.2023022738. Blood. 2024. PMID: 38574321
Platelet alpha-granules are rich in transforming growth factor beta1 (TGF-beta1), which is associated with myeloid-derived suppressor cell (MDSC) biology. Responders to thrombopoietin receptor agonists (TPO-RAs) revealed a parallel increase in the number of both platelets …
Platelet alpha-granules are rich in transforming growth factor beta1 (TGF-beta1), which is associated with myeloid-derived suppressor cell ( …
Clonal hematopoiesis in patients with autoimmune thrombocytopenia: an international multicenter study.
Fattizzo B, Marchetti A, Bosi A, Gurnari C, Giannotta JA, Pedone GL, Rossi E, Carrai V, Guido A, Brioschi F, Carpenedo M, Crugnola M, Caramazza D, Leuzzi L, Marchetti M, Merati G, Malato S, Vianello F, Patriarca A, Awada H, Bortolotti M, Canzi M, Bolli N, Capecchi M, Chen F, Artoni A, Maciejewski JP, Barcellini W. Fattizzo B, et al. Blood Adv. 2025 Feb 11;9(3):488-495. doi: 10.1182/bloodadvances.2024014984. Blood Adv. 2025. PMID: 39536292 Free PMC article.
Mutated patients were more frequently older males and showed a shorter time from first to second-line therapy, particularly with thrombopoietin receptor agonist (TPO-RA). Additionally, clonal hematopoiesis was associated with increased thrombotic risk (26% vs 8% in NGS-neg …
Mutated patients were more frequently older males and showed a shorter time from first to second-line therapy, particularly with thrombop …
New approaches to standard of care in early-phase myeloproliferative neoplasms: can interferon-α alter the natural history of the disease?
Pasquier F, Pegliasco J, Martin JE, Marti S, Plo I. Pasquier F, et al. Haematologica. 2025 Apr 1;110(4):850-862. doi: 10.3324/haematol.2023.283958. Epub 2024 Oct 24. Haematologica. 2025. PMID: 39445431 Free PMC article. Review.
MPN are caused by three main recurrent mutations, JAK2V617F and mutations in the calreticulin (CALR) and thrombopoietin receptor (MPL) genes. Here, we review the general diagnosis, the complications, and the management of MPN. ...
MPN are caused by three main recurrent mutations, JAK2V617F and mutations in the calreticulin (CALR) and thrombopoietin receptor (MPL …
Relative impact of THPO mutation causing hereditary thrombocythemia.
Kimura H, Onozawa M, Matsukawa T, Goto H, Kondo T, Teshima T. Kimura H, et al. Exp Hematol. 2024 Jun;134:104208. doi: 10.1016/j.exphem.2024.104208. Epub 2024 Mar 26. Exp Hematol. 2024. PMID: 38548144
Each mutation was identified in an independent pedigree, and the differences between the mutations were not compared. We cloned six distinct THPO mutations (THPO c.-47delG, THPO c.-31G>T, THPO c.13G>A, THPO c.13+1G>A, THPO c.13+2 …
Each mutation was identified in an independent pedigree, and the differences between the mutations were not compared. We cloned six distinct …
Lysosomal degradation targets mutant calreticulin and the thrombopoietin receptor in myeloproliferative neoplasms.
Kaur A, Venkatesan A, Kandarpa M, Talpaz M, Raghavan M. Kaur A, et al. Blood Adv. 2024 Jul 9;8(13):3372-3387. doi: 10.1182/bloodadvances.2023011432. Blood Adv. 2024. PMID: 38640435 Free PMC article.
Somatic mutants of calreticulin (CRT) drive myeloproliferative neoplasms (MPNs) via binding to the thrombopoietin receptor (MPL) and aberrant activation of the JAK/STAT pathway. Compared with healthy donors, platelets from mutant CRT-expressing patients with MPN display lo …
Somatic mutants of calreticulin (CRT) drive myeloproliferative neoplasms (MPNs) via binding to the thrombopoietin receptor (MPL) and …
TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signaling.
Yang Y, Cathelin S, Liu ACH, Subedi A, Maher A, Hosseini M, Manikoth Ayyathan D, Vanner R, Chan SM. Yang Y, et al. Nat Commun. 2025 Mar 10;16(1):2384. doi: 10.1038/s41467-025-57614-y. Nat Commun. 2025. PMID: 40064887 Free PMC article.
Mechanistically, we find that TET2 deficiency increases H3K79 dimethylation and expression of Mpl, which encodes the thrombopoietin receptor (TPO-R). Correspondingly, TET2 deficiency is associated with a higher proportion of primitive Mpl-expressing (Mpl(+)) cells in the H …
Mechanistically, we find that TET2 deficiency increases H3K79 dimethylation and expression of Mpl, which encodes the thrombopoietin r …
Thrombopoietin mimetic reduces mouse lung inflammation and fibrosis after radiation by attenuating activated endothelial phenotypes.
English J, Dhanikonda S, Tanaka KE, Koba W, Eichenbaum G, Yang WL, Guha C. English J, et al. JCI Insight. 2024 Nov 8;9(21):e181330. doi: 10.1172/jci.insight.181330. JCI Insight. 2024. PMID: 39513364 Free PMC article.
Here, using a whole thoracic irradiation (WTI) mouse model, we investigated the mechanisms and effectiveness of thrombopoietin mimetic (TPOm) for preventing RILI. We demonstrated that administering TPOm 24 hours before irradiation decreased histologic lung injury score, ap …
Here, using a whole thoracic irradiation (WTI) mouse model, we investigated the mechanisms and effectiveness of thrombopoietin mimeti …
Megakaryocyte maturation involves activation of the adaptive unfolded protein response.
Faiz M, Kalev-Zylinska ML, Dunstan-Harrison C, Singleton DC, Hay MP, Ledgerwood EC. Faiz M, et al. Genes Cells. 2024 Oct;29(10):889-901. doi: 10.1111/gtc.13151. Epub 2024 Aug 13. Genes Cells. 2024. PMID: 39138929 Free PMC article.
We studied the involvement of UPR in human megakaryocytic differentiation using PMA (phorbol 12-myristate 13-acetate)-induced maturation of megakaryoblastic cell lines and thrombopoietin-induced differentiation of human peripheral blood-derived progenitors. Our results dem …
We studied the involvement of UPR in human megakaryocytic differentiation using PMA (phorbol 12-myristate 13-acetate)-induced maturation of …
Discovery of an unconventional lamprey lymphocyte lineage highlights divergent features in vertebrate adaptive immune system evolution.
Huang Y, Liu X, Li S, Li C, Wang HY, Liu Q, Chen JY, Zhang Y, Li Y, Zhang X, Wang Q, Liu K, Liu YY, Pang Y, Liu S, Fan G, Shao C. Huang Y, et al. Nat Commun. 2024 Sep 3;15(1):7626. doi: 10.1038/s41467-024-51763-2. Nat Commun. 2024. PMID: 39227584 Free PMC article.
We further discovered that MPL-L(+) VLRA(+) T-like cells are widely present in the typhlosole, gill, liver, kidney, and skin of lamprey and they proliferate in response to both a T cell mitogen and recombinant human thrombopoietin. These findings provide new insights into …
We further discovered that MPL-L(+) VLRA(+) T-like cells are widely present in the typhlosole, gill, liver, kidney, and skin of lamprey and …
14 results