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Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease.
Zhang X, Yang F, Zhan X, Bian T, Xing Z, Lu Y, Shi Y. Zhang X, et al. Mol Cell. 2023 Apr 20;83(8):1328-1339.e4. doi: 10.1016/j.molcel.2023.03.015. Epub 2023 Apr 6. Mol Cell. 2023. PMID: 37028420 Free article.
In humans, this process is mediated by the tRNA splicing endonuclease (TSEN) comprising four subunits: TSEN2, TSEN15, TSEN34, and TSEN54. ...The mature domain of pre-tRNA is recognized by conserved structural elements of TSEN34, TSEN54, and TSEN …
In humans, this process is mediated by the tRNA splicing endonuclease (TSEN) comprising four subunits: TSEN2, TSEN15, …
Recognition and cleavage mechanism of intron-containing pre-tRNA by human TSEN endonuclease complex.
Yuan L, Han Y, Zhao J, Zhang Y, Sun Y. Yuan L, et al. Nat Commun. 2023 Sep 28;14(1):6071. doi: 10.1038/s41467-023-41845-y. Nat Commun. 2023. PMID: 37770519 Free PMC article.
Here we present a 3.2 A-resolution cryo-EM structure of an active human tRNA splicing endonuclease complex bound to an intron-containing pre-tRNA. TSEN54, along with the unique regions of TSEN34 and TSEN2, cooperatively recognizes the mature body of pr …
Here we present a 3.2 A-resolution cryo-EM structure of an active human tRNA splicing endonuclease complex bound to an …
Spliceosome-mediated RNA trans-splicing.
Yang Y, Walsh CE. Yang Y, et al. Mol Ther. 2005 Dec;12(6):1006-12. doi: 10.1016/j.ymthe.2005.09.006. Epub 2005 Oct 12. Mol Ther. 2005. PMID: 16226059 Free article. Review.
Unlike conventional gene therapy, in which exogenous cDNAs are introduced into cells, RNA repair approaches, which are based on spliceosome-mediated pre-mRNA trans-splicing, trans-splicing ribozymes, and tRNA-splicing endonuclease, allow the correction of end …
Unlike conventional gene therapy, in which exogenous cDNAs are introduced into cells, RNA repair approaches, which are based on spliceosome- …
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex.
Hayne CK, Butay KJU, Stewart ZD, Krahn JM, Perera L, Williams JG, Petrovitch RM, Deterding LJ, Matera AG, Borgnia MJ, Stanley RE. Hayne CK, et al. Nat Struct Mol Biol. 2023 Jun;30(6):824-833. doi: 10.1038/s41594-023-00991-z. Epub 2023 May 25. Nat Struct Mol Biol. 2023. PMID: 37231153 Free PMC article.
In eukaryotes, tRNA splicing is initiated by the heterotetrameric tRNA splicing endonuclease (TSEN) complex. All TSEN subunits are essential, and mutations within the complex are associated with a family of neurodevelopmental disorders known as pontocerebella …
In eukaryotes, tRNA splicing is initiated by the heterotetrameric tRNA splicing endonuclease (TSEN) complex. All TSEN s …
New insights into RNA processing by the eukaryotic tRNA splicing endonuclease.
Hayne CK, Sekulovski S, Hurtig JE, Stanley RE, Trowitzsch S, van Hoof A. Hayne CK, et al. J Biol Chem. 2023 Sep;299(9):105138. doi: 10.1016/j.jbc.2023.105138. Epub 2023 Aug 5. J Biol Chem. 2023. PMID: 37544645 Free PMC article. Review.
Through its role in intron cleavage, tRNA splicing endonuclease (TSEN) plays a critical function in the maturation of intron-containing pre-tRNAs. ...
Through its role in intron cleavage, tRNA splicing endonuclease (TSEN) plays a critical function in the maturation of i …
Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN.
Sekulovski S, Sušac L, Stelzl LS, Tampé R, Trowitzsch S. Sekulovski S, et al. Nat Struct Mol Biol. 2023 Jun;30(6):834-840. doi: 10.1038/s41594-023-00992-y. Epub 2023 May 25. Nat Struct Mol Biol. 2023. PMID: 37231152
Heterotetrameric human transfer RNA (tRNA) splicing endonuclease TSEN catalyzes intron excision from precursor tRNAs (pre-tRNAs), utilizing two composite active sites. ...
Heterotetrameric human transfer RNA (tRNA) splicing endonuclease TSEN catalyzes intron excision from precursor tRNAs (p …
Reconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage.
Hayne CK, Schmidt CA, Haque MI, Matera AG, Stanley RE. Hayne CK, et al. Nucleic Acids Res. 2020 Aug 20;48(14):7609-7622. doi: 10.1093/nar/gkaa438. Nucleic Acids Res. 2020. PMID: 32476018 Free PMC article.
In archaea and eukaryotes, tRNA intron removal is catalyzed by the tRNA splicing endonuclease (TSEN) complex. Eukaryotic TSEN is comprised of four core subunits (TSEN54, TSEN2, TSEN34 and TSEN15). ...
In archaea and eukaryotes, tRNA intron removal is catalyzed by the tRNA splicing endonuclease (TSEN) complex. Eukaryoti …
What connects splicing of transfer RNA precursor molecules with pontocerebellar hypoplasia?
Sekulovski S, Trowitzsch S. Sekulovski S, et al. Bioessays. 2023 Feb;45(2):e2200130. doi: 10.1002/bies.202200130. Epub 2022 Dec 14. Bioessays. 2023. PMID: 36517085 Review.
Aberrations in the extensive tRNA biogenesis pathways lead to severe neurological disorders in humans. Mutations in the tRNA splicing endonuclease (TSEN) and its associated RNA kinase cleavage factor polyribonucleotide kinase subunit 1 (CLP1) cause pontocereb …
Aberrations in the extensive tRNA biogenesis pathways lead to severe neurological disorders in humans. Mutations in the tRNA splic …
Pontocerebellar hypoplasia type 2 and TSEN2: review of the literature and two novel mutations.
Bierhals T, Korenke GC, Uyanik G, Kutsche K. Bierhals T, et al. Eur J Med Genet. 2013 Jun;56(6):325-30. doi: 10.1016/j.ejmg.2013.03.009. Epub 2013 Apr 3. Eur J Med Genet. 2013. PMID: 23562994 Review.
Seven different subtypes have been reported (PCH1-7) and mutations in three genes, TSEN2, TSEN34 and TSEN54 encoding three of four subunits of the tRNA splicing endonuclease complex have been found to underlie PCH2, PCH4 and PCH5. ...
Seven different subtypes have been reported (PCH1-7) and mutations in three genes, TSEN2, TSEN34 and TSEN54 encoding three of four su …
Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.
Sekulovski S, Devant P, Panizza S, Gogakos T, Pitiriciu A, Heitmeier K, Ramsay EP, Barth M, Schmidt C, Tuschl T, Baas F, Weitzer S, Martinez J, Trowitzsch S. Sekulovski S, et al. Nat Commun. 2021 Sep 28;12(1):5610. doi: 10.1038/s41467-021-25870-3. Nat Commun. 2021. PMID: 34584079 Free PMC article.
Introns of human transfer RNA precursors (pre-tRNAs) are excised by the tRNA splicing endonuclease TSEN in complex with the RNA kinase CLP1. Mutations in TSEN/CLP1 occur in patients with pontocerebellar hypoplasia (PCH), however, their role in the disease is …
Introns of human transfer RNA precursors (pre-tRNAs) are excised by the tRNA splicing endonuclease TSEN in complex with …
42 results