Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1992 1
1993 1
1994 1
1995 3
1997 1
1998 2
1999 3
2000 1
2001 1
2002 6
2003 13
2004 15
2005 20
2006 27
2007 29
2008 26
2009 30
2010 27
2011 52
2012 51
2013 52
2014 37
2015 39
2016 43
2017 41
2018 31
2019 31
2020 44
2021 62
2022 42
2023 50
2024 15

Text availability

Article attribute

Article type

Publication date

Search Results

692 results

Results by year

Filters applied: . Clear all
Page 1
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
Gwon Y, Maxwell BA, Kolaitis RM, Zhang P, Kim HJ, Taylor JP. Gwon Y, et al. Science. 2021 Jun 25;372(6549):eabf6548. doi: 10.1126/science.abf6548. Epub 2021 Aug 5. Science. 2021. PMID: 34739333 Free PMC article.
We found that ubiquitinated G3BP1 interacted with the endoplasmic reticulum-associated protein FAF2, which engaged the ubiquitin-dependent segregase p97/VCP (valosin-containing protein). Thus, targeting of G3BP1 weakened the stress granule-specific interactio …
We found that ubiquitinated G3BP1 interacted with the endoplasmic reticulum-associated protein FAF2, which engaged the ubiquitin-dependent s …
Stress granules and neurodegeneration.
Wolozin B, Ivanov P. Wolozin B, et al. Nat Rev Neurosci. 2019 Nov;20(11):649-666. doi: 10.1038/s41583-019-0222-5. Epub 2019 Oct 3. Nat Rev Neurosci. 2019. PMID: 31582840 Free PMC article. Review.
The major signalling pathways regulating SG formation include the mammalian target of rapamycin (mTOR)-eukaryotic translation initiation factor 4F (eIF4F) and eIF2alpha pathways, whereas the pathways regulating SG dispersion and removal are mediated by valosin-containin …
The major signalling pathways regulating SG formation include the mammalian target of rapamycin (mTOR)-eukaryotic translation initiation fac …
VCP/p97 regulates Beclin-1-dependent autophagy initiation.
Hill SM, Wrobel L, Ashkenazi A, Fernandez-Estevez M, Tan K, Bürli RW, Rubinsztein DC. Hill SM, et al. Nat Chem Biol. 2021 Apr;17(4):448-455. doi: 10.1038/s41589-020-00726-x. Epub 2021 Jan 28. Nat Chem Biol. 2021. PMID: 33510452
Here, we have identified the essential protein VCP/p97 (VCP, valosin-containing protein) as a novel regulator of autophagosome biogenesis, where VCP regulates autophagy induction in two ways, both dependent on Beclin-1. ...
Here, we have identified the essential protein VCP/p97 (VCP, valosin-containing protein) as a novel regulator of autoph …
Stress- and ubiquitylation-dependent phase separation of the proteasome.
Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernández-Busnadiego R, Tanaka K, Saeki Y. Yasuda S, et al. Nature. 2020 Feb;578(7794):296-300. doi: 10.1038/s41586-020-1982-9. Epub 2020 Feb 5. Nature. 2020. PMID: 32025036
These foci are transient structures that contain ubiquitylated proteins, p97 (also known as valosin-containing protein (VCP)) and multiple proteasome-interacting proteins, which collectively constitute a proteolytic centre. ...
These foci are transient structures that contain ubiquitylated proteins, p97 (also known as valosin-containing protein …
VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
Pu Z, Duda DG, Zhu Y, Pei S, Wang X, Huang Y, Yi P, Huang Z, Peng F, Hu X, Fan X. Pu Z, et al. J Transl Med. 2022 May 13;20(1):212. doi: 10.1186/s12967-022-03416-5. J Transl Med. 2022. PMID: 35562734 Free PMC article.
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common pathological type of liver cancer. Valosin-containing protein (VCP) is a member of the AAA-ATPase family associated with multiple molecular functions and involved in tumor metastasis and prognosis. …
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common pathological type of liver cancer. Valosin-containing protein …
The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system.
Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS. Saha I, et al. Nat Commun. 2023 Feb 2;14(1):560. doi: 10.1038/s41467-023-36058-2. Nat Commun. 2023. PMID: 36732333 Free PMC article.
Here we show in cell culture and in neurons that the hexameric ATPase valosin-containing protein (VCP) is recruited to ubiquitylated Tau fibrils, resulting in their efficient disaggregation. ...
Here we show in cell culture and in neurons that the hexameric ATPase valosin-containing protein (VCP) is recruited to …
Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases.
Chu S, Xie X, Payan C, Stochaj U. Chu S, et al. Mol Neurodegener. 2023 Aug 7;18(1):52. doi: 10.1186/s13024-023-00639-y. Mol Neurodegener. 2023. PMID: 37545006 Free PMC article. Review.
The AAA(+) ATPase valosin containing protein (VCP) is essential for cell and organ homeostasis, especially in cells of the nervous system. ...
The AAA(+) ATPase valosin containing protein (VCP) is essential for cell and organ homeostasis, especially in cells of …
TOLLIP-mediated autophagic degradation pathway links the VCP-TMEM63A-DERL1 signaling axis to triple-negative breast cancer progression.
Zhang TM, Liao L, Yang SY, Huang MY, Zhang YL, Deng L, Hu SY, Yang F, Zhang FL, Shao ZM, Li DQ. Zhang TM, et al. Autophagy. 2023 Mar;19(3):805-821. doi: 10.1080/15548627.2022.2103992. Epub 2022 Aug 3. Autophagy. 2023. PMID: 35920704 Free PMC article.
Mechanistic investigations revealed that TMEM63A localizes in endoplasmic reticulum (ER) and lysosome membranes, and interacts with VCP (valosin-containing protein) and its cofactor DERL1 (derlin 1). Furthermore, TMEM63A undergoes autophagy receptor TOLLIP-me …
Mechanistic investigations revealed that TMEM63A localizes in endoplasmic reticulum (ER) and lysosome membranes, and interacts with VCP ( …
Valosin Containing Protein (VCP): A Multistep Regulator of Autophagy.
Ferrari V, Cristofani R, Tedesco B, Crippa V, Chierichetti M, Casarotto E, Cozzi M, Mina F, Piccolella M, Galbiati M, Rusmini P, Poletti A. Ferrari V, et al. Int J Mol Sci. 2022 Feb 9;23(4):1939. doi: 10.3390/ijms23041939. Int J Mol Sci. 2022. PMID: 35216053 Free PMC article. Review.
Valosin containing protein (VCP) has emerged as a central protein in the regulation of the protein quality control (PQC) system. ...
Valosin containing protein (VCP) has emerged as a central protein in the regulation of the protein quality control (PQC …
692 results