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2023 1
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Page 1
Helicases in R-loop Formation and Resolution.
Yang S, Winstone L, Mondal S, Wu Y. Yang S, et al. J Biol Chem. 2023 Nov;299(11):105307. doi: 10.1016/j.jbc.2023.105307. Epub 2023 Sep 29. J Biol Chem. 2023. PMID: 37778731 Free PMC article. Review.
Indeed, numerous helicases such as senataxin (SETX), Aquarius (AQR), WRN, BLM, RTEL1, PIF1, FANCM, ATRX (alpha-thalassemia/mental retardation, X-linked), CasDinG, and several DEAD/H-box proteins are reported to resolve R-loops; while other helicases, such as Cas3 and UPF1, …
Indeed, numerous helicases such as senataxin (SETX), Aquarius (AQR), WRN, BLM, RTEL1, PIF1, FANCM, ATRX (alpha-thalassemia/mental ret …
Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome Protein.
Orren DK, Machwe A. Orren DK, et al. Int J Mol Sci. 2024 Jul 30;25(15):8300. doi: 10.3390/ijms25158300. Int J Mol Sci. 2024. PMID: 39125869 Free PMC article. Review.
Werner syndrome (WS) is an autosomal recessive disease caused by loss of function of WRN. ...Here, we review the genetics, biochemistry, and probably physiological functions of the WRN protein. Although its precise role is unclear, evidence suggests …
Werner syndrome (WS) is an autosomal recessive disease caused by loss of function of WRN. ...Here, we review the geneti …
DNA repair deficiencies and neurodegeneration.
Ropert B, Gallrein C, Schumacher B. Ropert B, et al. DNA Repair (Amst). 2024 Jun;138:103679. doi: 10.1016/j.dnarep.2024.103679. Epub 2024 Apr 16. DNA Repair (Amst). 2024. PMID: 38640601 Free article. Review.
Far less known are the neurodegenerative pathologies in DNA repair deficiency syndromes. Such diseases like Cockayne - or Werner Syndrome are described as progeroid syndromes - diseases that cause the premature ageing of the affected persons, and there are clear imp …
Far less known are the neurodegenerative pathologies in DNA repair deficiency syndromes. Such diseases like Cockayne - or Werner S …
WRN as a Novel Target of Synthetic Lethality: Current Advances and Future Perspectives.
Zhang Y, Zhang J, Tang C, Zhao G, Pan H, Bing T, Li Z, Xu X, Bian J. Zhang Y, et al. J Med Chem. 2025 Jul 10;68(13):13218-13245. doi: 10.1021/acs.jmedchem.5c01114. Epub 2025 Jun 17. J Med Chem. 2025. PMID: 40526642 Review.
Werner syndrome (WS) is an autosomal recessive disorder caused by mutations in the Werner syndrome protein (WRN, also known as RecQ3) gene. ...In this perspective, we provide a critical analysis of WRN's structural and biological features …
Werner syndrome (WS) is an autosomal recessive disorder caused by mutations in the Werner syndrome protein (W …
Targeting the Werner syndrome protein in microsatellite instability cancers: mechanisms and therapeutic potential.
Chen S, Wang Z, Cao Z, Xu M, Zhang Y. Chen S, et al. Clin Exp Med. 2025 Aug 6;25(1):278. doi: 10.1007/s10238-025-01781-1. Clin Exp Med. 2025. PMID: 40767886 Free PMC article. Review.
Microsatellite instability (MSI) is a key feature of cancers with defective DNA mismatch repair, including colorectal, gastric, endometrial, and ovarian cancers. Tumors with MSI depend on the Werner syndrome protein (WRN) for genomic stability, making WRN …
Microsatellite instability (MSI) is a key feature of cancers with defective DNA mismatch repair, including colorectal, gastric, endometrial, …
An overview of RecQ helicases and related diseases.
Yiu TC, Tu J, Cheung HH. Yiu TC, et al. Aging (Albany NY). 2025 Jul 25;17(7):1881-1907. doi: 10.18632/aging.206291. Epub 2025 Jul 25. Aging (Albany NY). 2025. PMID: 40728512 Free PMC article. Review.
Aberrant accumulation of unsolved DNA structures could lead to defects in DNA replication, gene transcription, and unrepaired DNA lesions. Pathogenic mutations on BLM, WRN, and RECQL4 are associated with several pathological conditions, namely Bloom syndrome (BS), Werne …
Aberrant accumulation of unsolved DNA structures could lead to defects in DNA replication, gene transcription, and unrepaired DNA lesions. P …
Werner helicase as a therapeutic target in mismatch repair deficient colorectal cancer.
Hao S, Liu Z, Lenz HJ, Yu J, Zhang L. Hao S, et al. DNA Repair (Amst). 2025 May;149:103831. doi: 10.1016/j.dnarep.2025.103831. Epub 2025 Apr 3. DNA Repair (Amst). 2025. PMID: 40203476 Review.
Recent studies have revealed that MSI cancer cells require Werner (WRN), a RecQ family DNA helicase, for survival. Inhibiting WRN has emerged as a promising approach for targeting MSI CRCs that are insensitive to standard therapies. ...Two of these WRN inhibi …
Recent studies have revealed that MSI cancer cells require Werner (WRN), a RecQ family DNA helicase, for survival. Inhibiting WRN …
Targeting Werner Helicase: A novel combination strategy for MSI colorectal cancer.
Peng N, Xie Z, Wu Y, Xiong Q, Lin J, Yu L, Liu C, Wu G, Zhao L, Zhou R. Peng N, et al. Biochem Pharmacol. 2025 Sep;239:117022. doi: 10.1016/j.bcp.2025.117022. Epub 2025 Jun 3. Biochem Pharmacol. 2025. PMID: 40473227 Review.
Despite advancements in immunotherapy have markedly improved the prognosis of MSI CRC patients over the past two decades, resistance to treatment has emerged as a major clinical challenge. Werner syndrome ATP-dependent helicase (WRN), a member of the RecQ hel …
Despite advancements in immunotherapy have markedly improved the prognosis of MSI CRC patients over the past two decades, resistance to trea …
Drugging the DNA damage response in the clinic: going beyond PARP.
Torrado C, Gonzalez-Ortiz A, Xavier CB, Tan HN, Ngoi NYL, Yap TA. Torrado C, et al. Expert Rev Anticancer Ther. 2026 Jan;26(1):43-58. doi: 10.1080/14737140.2025.2575825. Epub 2025 Oct 25. Expert Rev Anticancer Ther. 2026. PMID: 41086259 Review.
This review summarizes preclinical and clinical data on next-generation DDR inhibitors, including agents targeting ATR, ATM, APE1, DNA-PK, WEE1, CHK1/2, CDC7, PLK4, PKMYT1, Poltheta, USP1, PARG, WRN, and ALC1. It discusses mechanistic rationale, clinical activity, and safe …
This review summarizes preclinical and clinical data on next-generation DDR inhibitors, including agents targeting ATR, ATM, APE1, DNA-PK, W …
Targeting DNA Damage Repair Pathways Beyond PARP Inhibition.
Merry E, Gourley C. Merry E, et al. Target Oncol. 2025 Nov;20(6):937-953. doi: 10.1007/s11523-025-01183-z. Epub 2025 Nov 15. Target Oncol. 2025. PMID: 41240294 Review.
This review summarises the most recent DDR inhibitor clinical evidence, focusing on DDR signalling targets; ATR (ataxia telangiectasia and Rad3-related protein serine/threonine kinase), ATM (ataxia telangiectasia mutated kinase), DNA-PK (DNA-dependent protein kinase), CHK1 (check …
This review summarises the most recent DDR inhibitor clinical evidence, focusing on DDR signalling targets; ATR (ataxia telangiectasia and R …
17 results