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2009 1
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32 results

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Page 1
Genome-scale exon perturbation screens uncover exons critical for cell fitness.
Xiao MS, Damodaran AP, Kumari B, Dickson E, Xing K, On TA, Parab N, King HE, Perez AR, Guiblet WM, Duncan G, Che A, Chari R, Andresson T, Vidigal JA, Weatheritt RJ, Aregger M, Gonatopoulos-Pournatzis T. Xiao MS, et al. Among authors: weatheritt rj. Mol Cell. 2024 Jul 11;84(13):2553-2572.e19. doi: 10.1016/j.molcel.2024.05.024. Epub 2024 Jun 24. Mol Cell. 2024. PMID: 38917794 Free PMC article.
Conversely, fitness-suppressing exons are enriched in nonessential genes, exhibiting lower inclusion levels, and overlap with intrinsically disordered regions and disease-associated mutations. In-depth mechanistic investigation of the screen-hit TAF5 alternative exo …
Conversely, fitness-suppressing exons are enriched in nonessential genes, exhibiting lower inclusion levels, and overlap with intrinsically …
A highly conserved program of neuronal microexons is misregulated in autistic brains.
Irimia M, Weatheritt RJ, Ellis JD, Parikshak NN, Gonatopoulos-Pournatzis T, Babor M, Quesnel-Vallières M, Tapial J, Raj B, O'Hanlon D, Barrios-Rodiles M, Sternberg MJ, Cordes SP, Roth FP, Wrana JL, Geschwind DH, Blencowe BJ. Irimia M, et al. Among authors: weatheritt rj. Cell. 2014 Dec 18;159(7):1511-23. doi: 10.1016/j.cell.2014.11.035. Cell. 2014. PMID: 25525873 Free PMC article.
Alternative splicing (AS) generates vast transcriptomic and proteomic complexity. However, which of the myriad of detected AS events provide important biological functions is not well understood. ...
Alternative splicing (AS) generates vast transcriptomic and proteomic complexity. However, which of the myriad of detected AS events …
Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis.
Han H, Best AJ, Braunschweig U, Mikolajewicz N, Li JD, Roth J, Chowdhury F, Mantica F, Nabeel-Shah S, Parada G, Brown KR, O'Hanlon D, Wei J, Yao Y, Zid AA, Comsa LC, Jen M, Wang J, Datti A, Gonatopoulos-Pournatzis T, Weatheritt RJ, Greenblatt JF, Wrana JL, Irimia M, Gingras AC, Moffat J, Blencowe BJ. Han H, et al. Among authors: weatheritt rj. Mol Cell. 2022 Aug 18;82(16):2982-2999.e14. doi: 10.1016/j.molcel.2022.06.036. Epub 2022 Jul 31. Mol Cell. 2022. PMID: 35914530 Free PMC article.
Alternative splicing (AS) is a critical regulatory layer; yet, factors controlling functionally coordinated splicing programs during developmental transitions are poorly understood. ...Our results describe important roles for previously unknown regulators of neurogenesis a …
Alternative splicing (AS) is a critical regulatory layer; yet, factors controlling functionally coordinated splicing programs during …
Linear motifs: lost in (pre)translation.
Weatheritt RJ, Gibson TJ. Weatheritt RJ, et al. Trends Biochem Sci. 2012 Aug;37(8):333-41. doi: 10.1016/j.tibs.2012.05.001. Epub 2012 Jun 15. Trends Biochem Sci. 2012. PMID: 22705166 Review.
Pretranslational modification by alternative splicing, alternative promoter usage and RNA editing enables the production of multiple protein isoforms from a single gene. ...This article discusses the novel functionality enabled by the addition or removal of SLiM-con …
Pretranslational modification by alternative splicing, alternative promoter usage and RNA editing enables the production of mu …
How do disordered regions achieve comparable functions to structured domains?
Latysheva NS, Flock T, Weatheritt RJ, Chavali S, Babu MM. Latysheva NS, et al. Among authors: weatheritt rj. Protein Sci. 2015 Jun;24(6):909-22. doi: 10.1002/pro.2674. Epub 2015 May 15. Protein Sci. 2015. PMID: 25752799 Free PMC article. Review.
In recent years, it has been established that unstructured, intrinsically disordered regions (IDRs) in proteins are equally crucial elements for protein function, regulation and homeostasis. ...
In recent years, it has been established that unstructured, intrinsically disordered regions (IDRs) in proteins are equally crucial e …
Alu-minating the Mechanisms Underlying Primate Cortex Evolution.
Wang J, Weatheritt R, Voineagu I. Wang J, et al. Among authors: weatheritt r. Biol Psychiatry. 2022 Nov 15;92(10):760-771. doi: 10.1016/j.biopsych.2022.04.021. Epub 2022 May 19. Biol Psychiatry. 2022. PMID: 35981906 Review.
Alus are repetitive elements that contribute extensively to the acquisition of novel genes and the expansion of diverse gene regulatory layers, including enhancers, alternative splicing, RNA editing, and microRNA pathways. By reviewing the impact of Alus on molecular featu …
Alus are repetitive elements that contribute extensively to the acquisition of novel genes and the expansion of diverse gene regulatory laye …
Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2.
Mucha M, Lai Z, McKenzie NJ, Matrà F, Boudes M, Flanigan SF, Alejo-Vinogradova MT, Monger C, Zhang Q, Nimmo D, Healy E, Silva AJ, Angelov D, Reck DM, Holland G, Atmaca ZE, King HE, Hamilton M, Glancy E, Nolan J, Weatheritt RJ, Bell O, Vermeulen M, Davidovich C, Bracken AP. Mucha M, et al. Among authors: weatheritt rj. EMBO J. 2025 Dec;44(23):6979-7020. doi: 10.1038/s44318-025-00616-9. Epub 2025 Oct 30. EMBO J. 2025. PMID: 41168462 Free PMC article.
Control of PRC2 activity is a critical process in development and disease, yet no inhibitory cofactor has been identified in somatic cells. Here, we show that the alternative isoforms of its accessory subunit AEBP2, namely AEBP2(S) (short) and AEBP2(L) (long), perform oppo …
Control of PRC2 activity is a critical process in development and disease, yet no inhibitory cofactor has been identified in somatic cells. …
Classification of intrinsically disordered regions and proteins.
van der Lee R, Buljan M, Lang B, Weatheritt RJ, Daughdrill GW, Dunker AK, Fuxreiter M, Gough J, Gsponer J, Jones DT, Kim PM, Kriwacki RW, Oldfield CJ, Pappu RV, Tompa P, Uversky VN, Wright PE, Babu MM. van der Lee R, et al. Among authors: weatheritt rj. Chem Rev. 2014 Jul 9;114(13):6589-631. doi: 10.1021/cr400525m. Epub 2014 Apr 29. Chem Rev. 2014. PMID: 24773235 Free PMC article. Review. No abstract available.
Controlling entropy to tune the functions of intrinsically disordered regions.
Flock T, Weatheritt RJ, Latysheva NS, Babu MM. Flock T, et al. Among authors: weatheritt rj. Curr Opin Struct Biol. 2014 Jun;26:62-72. doi: 10.1016/j.sbi.2014.05.007. Epub 2014 Jun 12. Curr Opin Struct Biol. 2014. PMID: 24930020 Review.
Intrinsically disordered regions (IDRs) are fundamental units of protein function and regulation. Despite their inability to form a unique stable tertiary structure in isolation, many IDRs adopt a defined conformation upon binding and achieve their function through their i …
Intrinsically disordered regions (IDRs) are fundamental units of protein function and regulation. Despite their inability to form a u …
32 results