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49 results

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Page 1
The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas.
Yu FX, Lee PSY, Yang L, Gao N, Zhang Y, Ljubimov AV, Yang E, Zhou Q, Xie L. Yu FX, et al. Prog Retin Eye Res. 2022 Jul;89:101039. doi: 10.1016/j.preteyeres.2021.101039. Epub 2022 Jan 4. Prog Retin Eye Res. 2022. PMID: 34991965 Free PMC article. Review.
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, with several underlying pathophysiological mechanisms, some of which are still uncertain. The cornea is an avascular tissue and sensitive to hyperglycemia, resulting in several diabetic corne …
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, with several underlying pathophysiological mechanisms, som …
Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis.
Dai C, Me R, Gao N, Su G, Wu X, Yu FX. Dai C, et al. Among authors: yu fx. Invest Ophthalmol Vis Sci. 2021 May 3;62(6):10. doi: 10.1167/iovs.62.6.10. Invest Ophthalmol Vis Sci. 2021. PMID: 33970198 Free PMC article.
We herein investigated their expression and function in mediating corneal innate immunity against Candida albicans infection. METHODS: Gene expression in mouse corneas with or without C. albicans infection was determined by regular RT- and real-time (q)-PCR, Western blot a …
We herein investigated their expression and function in mediating corneal innate immunity against Candida albicans infection. METHODS: Gene …
Toll-like receptors and corneal innate immunity.
Kumar A, Yu FS. Kumar A, et al. Among authors: yu fs. Curr Mol Med. 2006 May;6(3):327-37. doi: 10.2174/156652406776894572. Curr Mol Med. 2006. PMID: 16712478 Free PMC article. Review.
The ocular surface is constantly exposed to a wide array of microorganisms. The ability of the cornea to recognize pathogens as foreign and eliminate them is critical to retain its transparency, hence preservation of sight. ...Here in this review we summarize the current k …
The ocular surface is constantly exposed to a wide array of microorganisms. The ability of the cornea to recognize pathogens as forei …
Lack of Elevated Expression of TGFbeta3 Contributes to the Delay of Epithelial Wound Healing in Diabetic Corneas.
Gao N, Yu FS. Gao N, et al. Among authors: yu fs. Invest Ophthalmol Vis Sci. 2024 Mar 5;65(3):35. doi: 10.1167/iovs.65.3.35. Invest Ophthalmol Vis Sci. 2024. PMID: 38546583 Free PMC article.
RESULTS: Epithelial debridement led to an increased expression of TGFbeta1 and TGFbeta3 in cultured human NL corneas, but only TGFbeta1 in DM corneas. TGFbeta1 and TGFbeta3 inhibition was significantly impeded, but exogenous TGFbeta1 and, more potently, TGFbeta3 pro …
RESULTS: Epithelial debridement led to an increased expression of TGFbeta1 and TGFbeta3 in cultured human NL corneas, but only TGFbet …
Interleukin-36 Receptor Signaling Attenuates Epithelial Wound Healing in C57BL/6 Mouse Corneas.
Chen Q, Gao N, Yu FS. Chen Q, et al. Among authors: yu fs. Cells. 2023 Jun 8;12(12):1587. doi: 10.3390/cells12121587. Cells. 2023. PMID: 37371057 Free PMC article.
IL-36R deficiency also suppressed IL-1beta, IL-1Ra, and ICAM expression in unwounded-DM mice and wounded NL corneas. Opposing IL-1beta and ICAM, the expression of IL-Ra in DM corneas of IL-36R(-/-) mice was augmented. ...Our data suggest that IL-36Ra, similar to IL- …
IL-36R deficiency also suppressed IL-1beta, IL-1Ra, and ICAM expression in unwounded-DM mice and wounded NL corneas. Opposing IL-1bet …
Targeting toll-like receptor signaling as a novel approach to prevent ocular infectious diseases.
Pandey RK, Yu FS, Kumar A. Pandey RK, et al. Among authors: yu fs. Indian J Med Res. 2013 Nov;138(5):609-19. Indian J Med Res. 2013. PMID: 24434316 Free PMC article. Review.
In the last several years, extensive research efforts have provided a considerable wealth of information on the expression and function of TLRs in the eye, with significant implications for better understanding of pathogenesis of infectious eye diseases affecting the cornea …
In the last several years, extensive research efforts have provided a considerable wealth of information on the expression and function of T …
CXCL10 suppression of hem- and lymph-angiogenesis in inflamed corneas through MMP13.
Gao N, Liu X, Wu J, Li J, Dong C, Wu X, Xiao X, Yu FX. Gao N, et al. Among authors: yu fx. Angiogenesis. 2017 Nov;20(4):505-518. doi: 10.1007/s10456-017-9561-x. Epub 2017 Jun 16. Angiogenesis. 2017. PMID: 28623423 Free PMC article.
We previously showed that the chemokine CXCL10 plays a key role in eradicating invading Candida (C.) albicans in C57BL6 mouse corneas. However, even after the clearance of pathogens, infection-induced inflammation and angiogenesis continue to progress in the cornea. …
We previously showed that the chemokine CXCL10 plays a key role in eradicating invading Candida (C.) albicans in C57BL6 mouse corneas …
Growth factors and corneal epithelial wound healing.
Yu FS, Yin J, Xu K, Huang J. Yu FS, et al. Brain Res Bull. 2010 Feb 15;81(2-3):229-35. doi: 10.1016/j.brainresbull.2009.08.024. Epub 2009 Sep 4. Brain Res Bull. 2010. PMID: 19733636 Free PMC article. Review.
Intraepithelial dendritic cells and sensory nerves are structurally associated and functional interdependent in the cornea.
Gao N, Lee P, Yu FS. Gao N, et al. Among authors: yu fs. Sci Rep. 2016 Nov 2;6:36414. doi: 10.1038/srep36414. Sci Rep. 2016. PMID: 27805041 Free PMC article.
Local DC depletion resulted in a significant decrease in corneal sensitivity, an increase in epithelial defects, and a reduced density of nerve endings at the center of the cornea. Post-wound nerve regeneration was also delayed in the DC-depleted corneas. Taken toge …
Local DC depletion resulted in a significant decrease in corneal sensitivity, an increase in epithelial defects, and a reduced density of ne …
IL-17 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas.
Me R, Gao N, Dai C, Yu FX. Me R, et al. Among authors: yu fx. J Immunol. 2020 Jan 1;204(1):169-179. doi: 10.4049/jimmunol.1900736. Epub 2019 Nov 25. J Immunol. 2020. PMID: 31767781 Free PMC article.
The aim of this study was to elucidate the expression and functions of IL-17 in C57BL/6 mouse corneas in response to Pseudomonas aeruginosa infection. We found that P. aeruginosa infection induced and increased signaling of IL-23/23R/17/17R in mouse corneas. ...
The aim of this study was to elucidate the expression and functions of IL-17 in C57BL/6 mouse corneas in response to Pseudomonas aeru …
49 results