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The transcription of the main gene associated with Treacher-Collins syndrome (TCOF1) is regulated by G-quadruplexes and cellular nucleic acid binding protein (CNBP).
Gil Rosas M, Centola C, Torres M, Mouguelar VS, David AP, Piga EJ, Gomez D, Calcaterra NB, Armas P, Coux G. Gil Rosas M, et al. Sci Rep. 2024 Mar 29;14(1):7472. doi: 10.1038/s41598-024-58255-9. Sci Rep. 2024. PMID: 38553547 Free PMC article.
Given the established role of CNBP in gene regulation during rostral development, we explored the potential for CNBP to modulate TCOF1 transcription. Computational analysis for CNBP binding sites (CNBP-BSs) in the TCOF1 promoter revealed several putati …
Given the established role of CNBP in gene regulation during rostral development, we explored the potential for CNBP to modula …
A KIF1C-CNBP motor-adaptor complex for trafficking mRNAs to cell protrusions.
Moissoglu K, Wang T, Gasparski AN, Stueland M, Paine EL, Jenkins LM, Mili S. Moissoglu K, et al. Cell Rep. 2025 Mar 25;44(3):115346. doi: 10.1016/j.celrep.2025.115346. Epub 2025 Feb 20. Cell Rep. 2025. PMID: 39982819 Free PMC article.
Here, we identify the RNA-binding protein CNBP as a factor required for mRNA localization to protrusions. CNBP binds directly to GA-rich sequences in the 3' UTR of protrusion-targeted mRNAs. CNBP also interacts with KIF1C and is required for KIF1C recruitment …
Here, we identify the RNA-binding protein CNBP as a factor required for mRNA localization to protrusions. CNBP binds directly …
OSBPL10-CNBP axis mediates hypoxia-induced pancreatic cancer development.
Huang Y, Zhang R, Fan S, Shi M, Tang X, Wang X, Deng X. Huang Y, et al. Biofactors. 2025 Jan-Feb;51(1):e2124. doi: 10.1002/biof.2124. Epub 2024 Sep 27. Biofactors. 2025. PMID: 39329194 Free PMC article.
Additionally, OSBPL10 directly bound to CNBP, mediating CNBP expression and ultimately regulating the proliferation and metastasis capacity of pancreatic cancer cells, as well as influencing macrophage polarization. The research emphasized the oncogenic role of OSBP …
Additionally, OSBPL10 directly bound to CNBP, mediating CNBP expression and ultimately regulating the proliferation and metast …
STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer.
Liu X, Chen Y, Li Y, Bai J, Zeng Z, Wang M, Dong Y, Zhou Y. Liu X, et al. Biol Direct. 2024 Jul 30;19(1):59. doi: 10.1186/s13062-024-00506-w. Biol Direct. 2024. PMID: 39080743 Free PMC article.
Employing bioinformatics, we identified lncRNAs associated with ovarian cancer, with a focus on LINC00665 and its interaction with the CNBP mRNA. In situ hybridization, immunohistochemistry, and qPCR were utilized to examine their expression and localization, alongside fun …
Employing bioinformatics, we identified lncRNAs associated with ovarian cancer, with a focus on LINC00665 and its interaction with the CN …
circTADA2A inhibited SLC38A1 expression and suppresses melanoma progression through the prevention of CNBP trans-activation.
Zhang L, Zhang L, Zhang C, Shi S, Cao Z, Shao C, Li J, Yang Y, Zhang X, Wang J, Li X. Zhang L, et al. PLoS One. 2024 Apr 18;19(4):e0301356. doi: 10.1371/journal.pone.0301356. eCollection 2024. PLoS One. 2024. PMID: 38635778 Free PMC article.
Mechanistically, circTADA2A interacted with CNBP, acting to suppress the binding of CNBP to the SLC38A1 promoter and subsequently restrained SLC38A1 transcription, which resulting in repression of melanoma progression. CONCLUSIONS: CircTADA2A suppresses melanoma pro …
Mechanistically, circTADA2A interacted with CNBP, acting to suppress the binding of CNBP to the SLC38A1 promoter and subsequen …
Optical genome mapping enables accurate testing of large repeat expansions.
van der Sanden B, Neveling K, Shukor S, Gallagher MD, Lee J, Burke SL, Pennings M, van Beek R, Oorsprong M, Kater-Baats E, Kamping E, Tieleman AA, Voermans NC, Scheffer IE, Gecz J, Corbett MA, Vissers LELM, Pang AWC, Hastie A, Kamsteeg EJ, Hoischen A. van der Sanden B, et al. Genome Res. 2025 Apr 14;35(4):810-823. doi: 10.1101/gr.279491.124. Genome Res. 2025. PMID: 40113266 Free PMC article.
This study evaluated optical genome mapping (OGM) as an efficient, accurate approach for measuring STR lengths and assessing somatic stability in 85 samples with known pathogenic repeat expansions in DMPK, CNBP, and RFC1, causing myotonic dystrophy types 1 and 2 and cerebe …
This study evaluated optical genome mapping (OGM) as an efficient, accurate approach for measuring STR lengths and assessing somatic stabili …
Lactate bridges mesangial cells to the differentiation of follicular helper T cells in lupus nephritis.
Liu M, Ji H, Lei J, Zheng M, Li L, Zhai X, Wang H, Liu T, Cao Q, Xu L, Wen Z. Liu M, et al. Nat Commun. 2025 Dec 11;17(1):663. doi: 10.1038/s41467-025-67416-x. Nat Commun. 2025. PMID: 41381571 Free PMC article.
Mechanistically, self-DNA-stimulated LN-associated mesangial cells (MC) promote Tfh differentiation by inducing CNBP-mediated MPC1 deficiency, leading to increased lactate production. In turn, elevated lactate levels enhance PCAF-catalyzed BCL6 lactylation and subsequent K …
Mechanistically, self-DNA-stimulated LN-associated mesangial cells (MC) promote Tfh differentiation by inducing CNBP-mediated MPC1 de …
CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA.
Liu Y, Jiang H, Hu K, Zou H, Zhang W, Liu J, Jian X. Liu Y, et al. PLoS One. 2024 Apr 16;19(4):e0298947. doi: 10.1371/journal.pone.0298947. eCollection 2024. PLoS One. 2024. PMID: 38626179 Free PMC article.
Mechanically, circPRMT5 promoted the binding of CNBP to CDK6 mRNA, which enhanced the stability of CDK6 mRNA and facilitated its translation, thereby promoting the progression of osteosarcoma. ...These findings suggest that circPRMT5 promotes osteosarcoma cell malignant ac …
Mechanically, circPRMT5 promoted the binding of CNBP to CDK6 mRNA, which enhanced the stability of CDK6 mRNA and facilitated its tran …
Global dysregulation of circular RNAs in frontal cortex and whole blood from DM1 and DM2.
Srinivasan A, Magner D, Kozłowski P, Philips A, Kajdasz A, Wojciechowski P, Wojciechowska M. Srinivasan A, et al. Hum Genet. 2025 Apr;144(4):417-432. doi: 10.1007/s00439-025-02729-x. Epub 2025 Feb 4. Hum Genet. 2025. PMID: 39903274 Free PMC article.
Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant neuromuscular disorders associated with expansions of microsatellites, respectively, in DMPK and CNBP. Their pathogenesis is linked to the global aberrant alternative splicing (AAS) of many genes and m …
Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant neuromuscular disorders associated with expansions of microsatellite …
From molecular convergence to clinical divergence: Comparative pathogenic mechanisms and therapeutic trajectories in C9orf72-ALS/FTD and myotonic dystrophy.
Alberti C, Parente V, Corti S, Sansone VA. Alberti C, et al. Neurobiol Dis. 2025 Dec;217:107192. doi: 10.1016/j.nbd.2025.107192. Epub 2025 Nov 17. Neurobiol Dis. 2025. PMID: 41260310 Free article. Review.
Short tandem repeat expansions in C9orf72, DMPK, and CNBP genes cause amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) and myotonic dystrophy types 1 and 2 (DM1/DM2), respectively. ...
Short tandem repeat expansions in C9orf72, DMPK, and CNBP genes cause amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) …
14 results