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1976 1
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Page 1
Complement deficiency predisposes for meningitis due to nongroupable meningococci and Neisseria-related bacteria.
Fijen CA, Kuijper EJ, Tjia HG, Daha MR, Dankert J. Fijen CA, et al. Clin Infect Dis. 1994 May;18(5):780-4. doi: 10.1093/clinids/18.5.780. Clin Infect Dis. 1994. PMID: 8075270
Inherited complement component C7 or C8 deficiency was found in two persons who had had meningitis due to nongroupable meningococci, and one C8-deficient person had had meningitis caused by Moraxella osloensis. ...This rather high frequency of inherite …
Inherited complement component C7 or C8 deficiency was found in two persons who had had meningitis due to nongro …
Inherited Classical and Alternative Pathway Complement Deficiencies in Children: A Single Center Experience.
Genel F, Erdem SB, Gülez N, Karaman S, Nacaroglu HT, Skattum L, Truedsson L. Genel F, et al. Iran J Immunol. 2018 Dec;15(4):309-320. doi: 10.22034/IJI.2018.39400. Iran J Immunol. 2018. PMID: 30593745 Free article.
BACKGROUND: Primary complement deficiencies are rare diseases. OBJECTIVE: To retrospectively evaluate the clinical and laboratory findings and complications of patients to increase awareness of pediatricians about complement deficiencies, which are rarely encountere …
BACKGROUND: Primary complement deficiencies are rare diseases. OBJECTIVE: To retrospectively evaluate the clinical and laboratory fin …
Functional Complement Analysis Can Predict Genetic Testing Results and Long-Term Outcome in Patients With Complement Deficiencies.
Blazina Š, Debeljak M, Košnik M, Simčič S, Stopinšek S, Markelj G, Toplak N, Kopač P, Zakotnik B, Pokorn M, Avčin T. Blazina Š, et al. Front Immunol. 2018 Mar 21;9:500. doi: 10.3389/fimmu.2018.00500. eCollection 2018. Front Immunol. 2018. PMID: 29619023 Free PMC article. Clinical Trial.
METHODS: CD was confirmed with genetic analyses in patients with C2 deficiency, C8 deficiency, and hereditary angioedema or with repeated functional complement studies and measurement of complement components in other CD. ...CONCLUSION: R …
METHODS: CD was confirmed with genetic analyses in patients with C2 deficiency, C8 deficiency, and hereditary angioedem …
Occurrence of an incomplete C8 molecule in homozygous C8 deficiency in man.
Tschopp J, Esser AF, Spira TJ, Müller-Eberhard HJ. Tschopp J, et al. J Exp Med. 1981 Nov 1;154(5):1599-607. doi: 10.1084/jem.154.5.1599. J Exp Med. 1981. PMID: 6795303 Free PMC article.
We concluded that the dysfunctional C8 protein in the three individuals' serum is identical to the alpha-gamma subunit of normal C8 and that this form of C8 deficiency is distinct from the C8 deficiencies previously reported in which the entire three-chain protein i …
We concluded that the dysfunctional C8 protein in the three individuals' serum is identical to the alpha-gamma subunit of normal C8 and that …
Dysfunctional C8 beta chain in patients with C8 deficiency.
Tschopp J, Penea F, Schifferli J, Späth P. Tschopp J, et al. Scand J Immunol. 1986 Dec;24(6):715-20. doi: 10.1111/j.1365-3083.1986.tb02191.x. Scand J Immunol. 1986. PMID: 3798025
We conclude that the dysfunction in the C8 protein in these two patients resides in the dysfunctional C8 beta chain, and that this form of C8 deficiency is distinct from C8 deficiencies previously reported, in which one or both C8 subunits are lacking....
We conclude that the dysfunction in the C8 protein in these two patients resides in the dysfunctional C8 beta chain, and that this form of …
Molecular, genetic, and functional analysis of homozygous C8 beta-chain deficiency in two siblings.
Kotnik V, Luznik-Bufon T, Schneider PM, Kirschfink M. Kotnik V, et al. Immunopharmacology. 1997 Dec;38(1-2):215-21. doi: 10.1016/s0162-3109(97)00074-x. Immunopharmacology. 1997. PMID: 9476133
C8 deficiency is associated with an increased susceptibility to neisserial infections. ...No hemolytic activities of the classical (CH50) and the alternative (APH50) pathways of complement were measurable, and SC5b-9 protein complexes could not be detected in …
C8 deficiency is associated with an increased susceptibility to neisserial infections. ...No hemolytic activities of the class …
A novel mutation in a patient with a deficiency of the eighth component of complement associated with recurrent meningococcal meningitis.
Arnold DF, Roberts AG, Thomas A, Ferry B, Morgan BP, Chapel H. Arnold DF, et al. J Clin Immunol. 2009 Sep;29(5):691-5. doi: 10.1007/s10875-009-9295-7. Epub 2009 May 12. J Clin Immunol. 2009. PMID: 19434484
INTRODUCTION: Complement component C8 is one of the five terminal complement components required for the formation of the membrane attack complex. ...RESULTS: We report a case of functional and immunochemical deficiency of the complement comp …
INTRODUCTION: Complement component C8 is one of the five terminal complement components required for the formati …
Genetic control of the eighth component of complement.
Raum D, Spence MA, Balavitch D, Tideman S, Merritt AD, Taggart RT, Petersen BH, Day NK, Alper CA. Raum D, et al. J Clin Invest. 1979 Sep;64(3):858-65. doi: 10.1172/JCI109534. J Clin Invest. 1979. PMID: 468996 Free PMC article.
C8 allotypes have been determined for two previously studied families, each with a homozygous C8-deficient propositus. This study suggests that C8 deficiency is a silent or null allele of the C8 structural locus, and that half normal levels of C8 cannot be used as a …
C8 allotypes have been determined for two previously studied families, each with a homozygous C8-deficient propositus. This study suggests t …
C8 beta subunit deficiency in a patient with recurrent neisserial infections.
Fontana L, Tedesco F, De Carolis C, Roncelli L, Teggi A, Paffetti A, Perricone R. Fontana L, et al. Ric Clin Lab. 1987 Jan-Mar;17(1):19-25. Ric Clin Lab. 1987. PMID: 3109005
Since in the last few years some of the patients affected by recurrent meningococcal infections have been recognized to have selective complement deficiencies, the patient's serum was studied for determining the complement function. C8 was found to be present only i …
Since in the last few years some of the patients affected by recurrent meningococcal infections have been recognized to have selective co …
Comparison of isolates of Neisseria gonorrhoeae causing meningitis and report of gonococcal meningitis in a patient with C8 deficiency.
Del Rio C, Stephens DS, Knapp JS, Rice RJ, Schalla WO. Del Rio C, et al. J Clin Microbiol. 1989 May;27(5):1045-9. doi: 10.1128/jcm.27.5.1045-1049.1989. J Clin Microbiol. 1989. PMID: 2473091 Free PMC article.
This is the first reported case of gonococcal meningitis occurring in a patient with a terminal-complement deficiency. Gonococcal meningitis is a rare complication of gonococcal bacteremia. Both defects in host defenses (e.g., terminal-complement deficiency) and org …
This is the first reported case of gonococcal meningitis occurring in a patient with a terminal-complement deficiency. Gonococcal men …
29 results