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D-enantiomeric antibiofilm peptides effective against anaerobic Cutibacterium acnes biofilm.
Varin-Simon J, Haney EF, Colin M, Velard F, Gangloff SC, Hancock REW, Reffuveille F. Varin-Simon J, et al. Microbiol Spectr. 2025 Mar 25;13(5):e0252324. doi: 10.1128/spectrum.02523-24. Online ahead of print. Microbiol Spectr. 2025. PMID: 40130849 Free PMC article.
This study aimed to test the effect of synthetic HDPs on Cutibacterium acnes, an anaerobe species involved in 10% of prosthesis joint infections (PJI). ...In this study, we tested the effect of synthetic host defense peptides (HDPs) on Cutibacterium acnes …
This study aimed to test the effect of synthetic HDPs on Cutibacterium acnes, an anaerobe species involved in 10% of prosthesi …
Cutibacterium acnes and its complex host interaction in prosthetic joint infection: Current insights and future directions.
Thoraval L, Varin-Simon J, Ohl X, Velard F, Reffuveille F, Tang-Fichaux M. Thoraval L, et al. Res Microbiol. 2025 Mar-Jun;176(3-4):104265. doi: 10.1016/j.resmic.2024.104265. Epub 2024 Dec 17. Res Microbiol. 2025. PMID: 39701197 Free article. Review.
Cutibacterium acnes is a commensal Gram-positive anaerobic bacterium that can also act as an opportunistic pathogen in various diseases, particularly in prosthetic joint infections (PJI). Throughout this review, we delve into the current understanding of the intrica …
Cutibacterium acnes is a commensal Gram-positive anaerobic bacterium that can also act as an opportunistic pathogen in various …
Cutibacterium acnes strains associated with bone prosthesis infections cannot evade the host immune system.
Thoraval L, Tang-Fichaux M, Guillaume C, Varin-Simon J, Dumortier C, Sergheraert J, Lamret F, Bonhomme M, Laurent F, Josse J, Gangloff SC, Mongaret C, Reffuveille F, Velard F. Thoraval L, et al. Front Immunol. 2024 Nov 27;15:1468709. doi: 10.3389/fimmu.2024.1468709. eCollection 2024. Front Immunol. 2024. PMID: 39664373 Free PMC article.
INTRODUCTION: Cutibacterium acnes is a commensal skin bacterium that is involved in bone prosthesis infections (BPIs) and presents low-grade clinical symptoms. ...In an original infected prosthesis mimetic model, osteoblasts and neutrophils were able to detect C. …
INTRODUCTION: Cutibacterium acnes is a commensal skin bacterium that is involved in bone prosthesis infections (BPIs) and pres …
A novel synthetic synovial fluid model for investigating biofilm formation and antibiotic susceptibility in prosthetic joint infections.
De Bleeckere A, van Charante F, Debord T, Vandendriessche S, De Cock M, Verstraete M, Lamret F, Lories B, Boelens J, Reffuveille F, Steenackers HP, Coenye T. De Bleeckere A, et al. Microbiol Spectr. 2025 Jan 7;13(1):e0198024. doi: 10.1128/spectrum.01980-24. Epub 2024 Nov 29. Microbiol Spectr. 2025. PMID: 39612218 Free PMC article.
In this study, 18 PJI isolates were included belonging to Staphylococcus aureus, coagulase-negative staphylococci, Cutibacterium acnes, Streptococcus spp., Enterococcus spp., Pseudomonas aeruginosa, Escherichia coli, and Candida spp. ...
In this study, 18 PJI isolates were included belonging to Staphylococcus aureus, coagulase-negative staphylococci, Cutibacterium a …
Cutibacterium acnes biofilm formation is influenced by bone microenvironment, implant surfaces and bacterial internalization.
Varin-Simon J, Colin M, Velard F, Tang-Fichaux M, Ohl X, Mongaret C, Gangloff SC, Reffuveille F. Varin-Simon J, et al. BMC Microbiol. 2024 Jul 20;24(1):270. doi: 10.1186/s12866-024-03422-1. BMC Microbiol. 2024. PMID: 39033146 Free PMC article.
However, little is known on the characteristics of Cutibacterium acnes biofilm formation, whereas this species is frequently involved in prosthesis infections. ...CONCLUSION: Taken together, these results evidenced the versatility of C. acnes biofilm, dependi …
However, little is known on the characteristics of Cutibacterium acnes biofilm formation, whereas this species is frequently i …
Comparison of Two Cutibacterium acnes Biofilm Models.
Varin-Simon J, Lamret F, Colin M, Gangloff SC, Mongaret C, Reffuveille F. Varin-Simon J, et al. Microorganisms. 2021 Sep 26;9(10):2035. doi: 10.3390/microorganisms9102035. Microorganisms. 2021. PMID: 34683356 Free PMC article.
The study of biofilms in vitro is complex and often limited by technical problems due to simplified models. Here, we compared C. acnes biofilm formation, from species involved in bone and prosthesis infection, in a static model with a dynamic model. ...
The study of biofilms in vitro is complex and often limited by technical problems due to simplified models. Here, we compared C. acnes …
Bone marrow mesenchymal stem cells offer an immune-privileged niche to Cutibacterium acnes in case of implant-associated osteomyelitis.
Dubus M, Varin J, Papa S, Chevrier J, Quilès F, Francius G, Audonnet S, Mauprivez C, Gangloff SC, Siboni R, Ohl X, Reffuveille F, Kerdjoudj H. Dubus M, et al. Acta Biomater. 2022 Jan 1;137:305-315. doi: 10.1016/j.actbio.2021.10.026. Epub 2021 Oct 20. Acta Biomater. 2022. PMID: 34678484
Considered as some of the most devastating complications, Cutibacterium acnes (C. acnes)-related osteomyelitis are among the hardest infections to diagnose and treat. ...STATEMENT OF SIGNIFICANCE: The interaction of bone commensal C. acnes with bone ma …
Considered as some of the most devastating complications, Cutibacterium acnes (C. acnes)-related osteomyelitis are amon …
Interaction of implant infection-related commensal bacteria with mesenchymal stem cells: a comparison between Cutibacterium acnes and Staphylococcus aureus.
El-Mahdy TS, Mongaret C, Varin-Simon J, Lamret F, Vernet-Garnier V, Rammal H, Mauprivez C, Kerdjoudj H, Gangloff SC, Reffuveille F. El-Mahdy TS, et al. FEMS Microbiol Lett. 2021 Mar 19;368(4):fnab014. doi: 10.1093/femsle/fnab014. FEMS Microbiol Lett. 2021. PMID: 33580963
Staphylococcus aureus and Cutibacterium acnes are involved in several tissue infections and can encounter mesenchymal stem cells (MSCs) during their role in tissue regenerative process. ...Internalization rates ranged between 1.7-6.3% and 0.8-2.7% for C. acnes …
Staphylococcus aureus and Cutibacterium acnes are involved in several tissue infections and can encounter mesenchymal stem cel …
Cutibacterium acnes: the Urgent Need To Identify Diagnosis Markers.
Mongaret C, Velard F, Reffuveille F. Mongaret C, et al. Infect Immun. 2021 Mar 17;89(4):e00753-20. doi: 10.1128/IAI.00753-20. Print 2021 Mar 17. Infect Immun. 2021. PMID: 33468579 Free PMC article. Review.
Cutibacterium acnes role is well described during acne but remains a mystery regarding its implication in bone and prosthesis or cerebrospinal fluid shunt infections. ...
Cutibacterium acnes role is well described during acne but remains a mystery regarding its implication in bone and prosthesis …
11 results