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Year Number of Results
2016 3
2017 2
2018 6
2019 5
2020 3
2021 7
2022 6
2023 4
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Page 1
Controversy over the atherogenicity of lipoprotein-X.
Miida T, Hirayama S. Miida T, et al. Curr Opin Endocrinol Diabetes Obes. 2019 Apr;26(2):117-123. doi: 10.1097/MED.0000000000000466. Curr Opin Endocrinol Diabetes Obes. 2019. PMID: 30694826 Review.
Serum Lp-X increases in patients with cholestasis and lecithin-cholesterol acyltransferase deficiency, as well as in those receiving intravenous lipid emulsion. ...
Serum Lp-X increases in patients with cholestasis and lecithin-cholesterol acyltransferase deficiency, as well as in th …
LCAT- targeted therapies: Progress, failures and future.
Yang K, Wang J, Xiang H, Ding P, Wu T, Ji G. Yang K, et al. Biomed Pharmacother. 2022 Mar;147:112677. doi: 10.1016/j.biopha.2022.112677. Epub 2022 Feb 2. Biomed Pharmacother. 2022. PMID: 35121343 Free article. Review.
Because LCAT plays a central role in HDL metabolism and RCT, many animal studies and clinical studies are currently aimed at improving plasma lipid metabolism by increasing LCAT activity in order to find better treatment options for familial LCAT deficiency (FLD), fish …
Because LCAT plays a central role in HDL metabolism and RCT, many animal studies and clinical studies are currently aimed at improving plasm …
Novel therapeutic opportunities for familial lecithin:cholesterol acyltransferase deficiency: promises and challenges.
Vitali C, Rader DJ, Cuchel M. Vitali C, et al. Curr Opin Lipidol. 2023 Apr 1;34(2):35-43. doi: 10.1097/MOL.0000000000000864. Epub 2022 Dec 6. Curr Opin Lipidol. 2023. PMID: 36473023 Review.
PURPOSE OF REVIEW: Genetic lecithin:cholesterol acyltransferase (LCAT) deficiency is a rare, inherited, recessive disease, which manifests as two different syndromes: Familial LCAT deficiency (FLD) and Fish-eye disease (FED), characterized by low HDL-C and co …
PURPOSE OF REVIEW: Genetic lecithin:cholesterol acyltransferase (LCAT) deficiency is a rare, inherited, recessive disease, which manifests a …
HDL and type 2 diabetes: the chicken or the egg?
Xepapadaki E, Nikdima I, Sagiadinou EC, Zvintzou E, Kypreos KE. Xepapadaki E, et al. Diabetologia. 2021 Sep;64(9):1917-1926. doi: 10.1007/s00125-021-05509-0. Epub 2021 Jul 13. Diabetologia. 2021. PMID: 34255113 Review.
Interestingly, different structural alterations in HDL correlate with distinct metabolic abnormalities, as indicated by recent data evaluating the role of apolipoprotein A1 and lecithin-cholesterol acyltransferase deficiency in glucose homeostasis. While it i …
Interestingly, different structural alterations in HDL correlate with distinct metabolic abnormalities, as indicated by recent data evaluati …
Current Status of Familial LCAT Deficiency in Japan.
Kuroda M, Bujo H, Yokote K, Murano T, Yamaguchi T, Ogura M, Ikewaki K, Koseki M, Takeuchi Y, Nakatsuka A, Hori M, Matsuki K, Miida T, Yokoyama S, Wada J, Harada-Shiba M. Kuroda M, et al. J Atheroscler Thromb. 2021 Jul 1;28(7):679-691. doi: 10.5551/jat.RV17051. Epub 2021 Apr 18. J Atheroscler Thromb. 2021. PMID: 33867422 Free PMC article. Review.
The disease appears in two different phenotypes depending on the position of the gene mutation: familial LCAT deficiency (FLD, OMIM 245900) that lacks esterification activity on both HDL and ApoB-containing lipoproteins, and fish-eye disease (FED, OMIM 136120 …
The disease appears in two different phenotypes depending on the position of the gene mutation: familial LCAT deficiency (FLD, OMIM 245900) …
LCAT deficiency: a systematic review with the clinical and genetic description of Mexican kindred.
Mehta R, Elías-López D, Martagón AJ, Pérez-Méndez OA, Sánchez MLO, Segura Y, Tusié MT, Aguilar-Salinas CA. Mehta R, et al. Lipids Health Dis. 2021 Jul 13;20(1):70. doi: 10.1186/s12944-021-01498-6. Lipids Health Dis. 2021. PMID: 34256778 Free PMC article.
BACKGROUND: LCAT (lecithin-cholesterol acyltransferase) deficiency is characterized by two distinct phenotypes, familial LCAT deficiency (FLD) and Fish Eye disease (FED). ...The mean age of diagnosis was 42 16.5 years, with fish …
BACKGROUND: LCAT (lecithin-cholesterol acyltransferase) deficiency is characterized by two distinct phenotypes, familia …
A systematic review of the natural history and biomarkers of primary lecithin:cholesterol acyltransferase deficiency.
Vitali C, Bajaj A, Nguyen C, Schnall J, Chen J, Stylianou K, Rader DJ, Cuchel M. Vitali C, et al. J Lipid Res. 2022 Mar;63(3):100169. doi: 10.1016/j.jlr.2022.100169. Epub 2022 Jan 20. J Lipid Res. 2022. PMID: 35065092 Free PMC article.
Syndromes associated with LCAT deficiency, a rare autosomal recessive condition, include fish-eye disease (FED) and familial LCAT deficiency (FLD). FLD is more severe and characterized by early and progressive chronic kidney disease (CKD). ...
Syndromes associated with LCAT deficiency, a rare autosomal recessive condition, include fish-eye disease (FED) and fam …
Apolipoprotein E isoforms differentially affect LCAT-dependent cholesterol esterification.
Vitali C, Pavanello C, Turri M, Lund-Katz S, Phillips MC, Catapano AL, Baragetti A, Norata GD, Veglia F, Calabresi L. Vitali C, et al. Atherosclerosis. 2023 Oct;382:117266. doi: 10.1016/j.atherosclerosis.2023.117266. Epub 2023 Aug 30. Atherosclerosis. 2023. PMID: 37725860
METHODS: We evaluated the plasma cholesterol esterification rate (CER) in 311 individuals who express functional LCAT and either apoE2, apoE3, or apoE4 and in 28 individuals who also carried LCAT mutations causing selective loss of LCAT alpha-activity (Fish-Eye D …
METHODS: We evaluated the plasma cholesterol esterification rate (CER) in 311 individuals who express functional LCAT and either apoE2, apoE …
Diagnosis and treatment of high density lipoprotein deficiency.
Schaefer EJ, Anthanont P, Diffenderfer MR, Polisecki E, Asztalos BF. Schaefer EJ, et al. Prog Cardiovasc Dis. 2016 Sep-Oct;59(2):97-106. doi: 10.1016/j.pcad.2016.08.006. Epub 2016 Aug 24. Prog Cardiovasc Dis. 2016. PMID: 27565770 Free PMC article. Review.
These patients may have homozygous, compound heterozygous, or heterozygous defects involving the apolipoprotein (APO)AI, ABCA1, or lecithin:cholesterol acyl transferase genes, associated with apo A-I deficiency, apoA-I variants, Tangier disease , familial lecithin:cholesteryl est …
These patients may have homozygous, compound heterozygous, or heterozygous defects involving the apolipoprotein (APO)AI, ABCA1, or lecithin: …
40 results