Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2014 1
2015 30
2016 52
2017 52
2018 50
2019 39
2020 5
Text availability
Article attribute
Article type
Publication date

Search Results

191 results
Results by year
Filters applied: . Clear all
Page 1
Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome.
Yurgelun MB, Allen B, Kaldate RR, Bowles KR, Judkins T, Kaushik P, Roa BB, Wenstrup RJ, Hartman AR, Syngal S. Yurgelun MB, et al. Gastroenterology. 2015 Sep;149(3):604-13.e20. doi: 10.1053/j.gastro.2015.05.006. Epub 2015 May 14. Gastroenterology. 2015. PMID: 25980754 Free PMC article.
We also analyzed data on patients' personal and family history of cancer, including fulfillment of clinical guidelines for genetic testing. RESULTS: Of the 1260 patients, 1112 met National Comprehensive Cancer Network (NCCN) criteria for Lynch s …
We also analyzed data on patients' personal and family history of cancer, including fulfillment of clinical guidelines for …
Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer.
Yurgelun MB, Kulke MH, Fuchs CS, Allen BA, Uno H, Hornick JL, Ukaegbu CI, Brais LK, McNamara PG, Mayer RJ, Schrag D, Meyerhardt JA, Ng K, Kidd J, Singh N, Hartman AR, Wenstrup RJ, Syngal S. Yurgelun MB, et al. J Clin Oncol. 2017 Apr 1;35(10):1086-1095. doi: 10.1200/JCO.2016.71.0012. Epub 2017 Jan 30. J Clin Oncol. 2017. PMID: 28135145 Free PMC article.
Purpose Hereditary factors play an important role in colorectal cancer (CRC) risk, yet the prevalence of germline cancer susceptibility gene mutations in patients with CRC unselected for high-risk features (eg, early age at diagnosis, personal/famil
Purpose Hereditary factors play an important role in colorectal cancer (CRC) risk, yet the prevalence of germline cancer susce …
Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management.
Kanth P, Grimmett J, Champine M, Burt R, Samadder NJ. Kanth P, et al. Am J Gastroenterol. 2017 Oct;112(10):1509-1525. doi: 10.1038/ajg.2017.212. Epub 2017 Aug 8. Am J Gastroenterol. 2017. PMID: 28786406 Review.
Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This narrative r …
Identification of these patients through family history and appropriate genetic testing can provide estimates of can
A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America.
Rossi BM, Palmero EI, López-Kostner F, Sarroca C, Vaccaro CA, Spirandelli F, Ashton-Prolla P, Rodriguez Y, de Campos Reis Galvão H, Reis RM, Escremim de Paula A, Capochin Romagnolo LG, Alvarez K, Della Valle A, Neffa F, Kalfayan PG, Spirandelli E, Chialina S, Gutiérrez Angulo M, Castro-Mujica MDC, Sanchez de Monte J, Quispe R, da Silva SD, Rossi NT, Barletta-Carrillo C, Revollo S, Taborga X, Morillas LL, Tubeuf H, Monteiro-Santos EM, Piñero TA, Dominguez-Barrera C, Wernhoff P, Martins A, Hovig E, Møller P, Dominguez-Valentin M. Rossi BM, et al. BMC Cancer. 2017 Sep 5;17(1):623. doi: 10.1186/s12885-017-3599-4. BMC Cancer. 2017. PMID: 28874130 Free PMC article.
BACKGROUND: Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. ...METHODS: Eleven LS hereditary cancer registries and 34 published LS databases were used to identify unrelate …
BACKGROUND: Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin Amer …
Recent progress in Lynch syndrome and other familial colorectal cancer syndromes.
Boland PM, Yurgelun MB, Boland CR. Boland PM, et al. CA Cancer J Clin. 2018 May;68(3):217-231. doi: 10.3322/caac.21448. Epub 2018 Feb 27. CA Cancer J Clin. 2018. PMID: 29485237 Free PMC article. Review.
The current understanding of familial colorectal cancer was limited to descriptions of affected pedigrees until the early 1990s. ...Recent advances have occurred in our understanding of the epidemiology of this disease, and the advent of broad …
The current understanding of familial colorectal cancer was limited to descriptions of affected pedigrees until the …
Uptake of genetic testing by the children of Lynch syndrome variant carriers across three generations.
Seppälä TT, Pylvänäinen K, Mecklin JP. Seppälä TT, et al. Eur J Hum Genet. 2017 Nov;25(11):1237-1245. doi: 10.1038/ejhg.2017.132. Epub 2017 Aug 23. Eur J Hum Genet. 2017. PMID: 28832568 Free PMC article.
Many Lynch syndrome (LS) carriers remain unidentified, thus missing early cancer detection and prevention opportunities. Tested probands should inform their relatives about cancer risk and options for genetic counselling and predictive ge …
Many Lynch syndrome (LS) carriers remain unidentified, thus missing early cancer detection and prevention opportunities …
Assessment of Tumor Sequencing as a Replacement for Lynch Syndrome Screening and Current Molecular Tests for Patients With Colorectal Cancer.
Hampel H, Pearlman R, Beightol M, Zhao W, Jones D, Frankel WL, Goodfellow PJ, Yilmaz A, Miller K, Bacher J, Jacobson A, Paskett E, Shields PG, Goldberg RM, de la Chapelle A, Shirts BH, Pritchard CC; Ohio Colorectal Cancer Prevention Initiative Study Group. Hampel H, et al. JAMA Oncol. 2018 Jun 1;4(6):806-813. doi: 10.1001/jamaoncol.2018.0104. JAMA Oncol. 2018. PMID: 29596542 Free PMC article.
DESIGN, SETTING, AND PARTICIPANTS: Tumor DNA from 419 consecutive CRC cases undergoing standard universal tumor screening and germline genetic testing when indicated as part of the multicenter, population-based Ohio Colorectal Cancer Prevention …
DESIGN, SETTING, AND PARTICIPANTS: Tumor DNA from 419 consecutive CRC cases undergoing standard universal tumor screening and germlin …
Suspected Lynch syndrome associated MSH6 variants: A functional assay to determine their pathogenicity.
Houlleberghs H, Goverde A, Lusseveld J, Dekker M, Bruno MJ, Menko FH, Mensenkamp AR, Spaander MCW, Wagner A, Hofstra RMW, Te Riele H. Houlleberghs H, et al. PLoS Genet. 2017 May 22;13(5):e1006765. doi: 10.1371/journal.pgen.1006765. eCollection 2017 May. PLoS Genet. 2017. PMID: 28531214 Free PMC article.
To conclusively diagnose LS and enroll patients in appropriate surveillance programs to reduce morbidity as well as mortality, the functional consequences of these variants of uncertain clinical significance (VUS) must be defined. ...We demonstrate the efficacy of t …
To conclusively diagnose LS and enroll patients in appropriate surveillance programs to reduce morbidity as well as mortality, …
Comparison of Prediction Models for Lynch Syndrome Among Individuals With Colorectal Cancer.
Kastrinos F, Ojha RP, Leenen C, Alvero C, Mercado RC, Balmaña J, Valenzuela I, Balaguer F, Green R, Lindor NM, Thibodeau SN, Newcomb P, Win AK, Jenkins M, Buchanan DD, Bertario L, Sala P, Hampel H, Syngal S, Steyerberg EW; Lynch Syndrome prediction model validation study group. Kastrinos F, et al. J Natl Cancer Inst. 2015 Nov 18;108(2):djv308. doi: 10.1093/jnci/djv308. Print 2016 Feb. J Natl Cancer Inst. 2015. PMID: 26582061 Free PMC article. Clinical Trial.
CONCLUSIONS: MMRPro and PREMM1,2,6 can well be used to select CRC patients from genetics clinics or population-based settings for tumor and/or germline testing at a 5% or higher risk. If no MMR deficiency is detected and risk exceeds 15%, we suggest consideri …
CONCLUSIONS: MMRPro and PREMM1,2,6 can well be used to select CRC patients from genetics clinics or population-based settings for tum …
Genetic counseling and cascade genetic testing in Lynch syndrome.
Hampel H. Hampel H. Fam Cancer. 2016 Jul;15(3):423-7. doi: 10.1007/s10689-016-9893-5. Fam Cancer. 2016. PMID: 26969309
It also includes universal tumor screening for Lynch syndrome whereby all individuals with colorectal or endometrial cancer are screened for tumor features of Lynch syndrome at the time of diagnosis. ...Finally, and perhaps most importantly, cas …
It also includes universal tumor screening for Lynch syndrome whereby all individuals with colorectal or endometrial cancer ar …
191 results
Jump to page
Feedback