((grana X[au] Temple University[affiliation])) AND (("1993"[Date - Create] : "3000"[Date - Create])) - Search Results

Year	Number of Results
1993	1
1994	2
1995	3
1996	3
1997	1
1998	4
2000	1
2001	1
2002	2
2003	2
2004	2
2005	2
2006	1
2007	2
2008	2
2009	1
2010	2
2012	2
2013	1
2015	1
2018	1
2019	3
2021	1
2022	1
2023	1
2024	5
2025	1
2026	1

1

Editors' Corner: Suppressor of cytokine signaling 6 (SOCS6) mediates ubiquitination-dependent degradation of SLC7A11 to promote ferroptosis in ovarian cancer.

Graña X. Graña X. Gene. 2026 Feb 10;979:149937. doi: 10.1016/j.gene.2025.149937. Epub 2025 Dec 6. Gene. 2026. PMID: 41360183 No abstract available.

2

Derivation of human primary prostate epithelial cell lines by differentially targeting the CDKN2A locus along with expression of hTERT.

Wasserman JS, Fowle H, Hashmi R, Atar D, Patel KR, Yarmahmoodi A, Macfarlane AW, Tan Y, Cukierman E, Gligorijevic B, Karami A, Whelan KA, Campbell KS, Graña X. Wasserman JS, et al. Among authors: grana x. Sci Rep. 2024 Sep 2;14(1):20409. doi: 10.1038/s41598-024-71306-5. Sci Rep. 2024. PMID: 39223207 Free PMC article.

3

FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs.

Wasserman JS, Faezov B, Patel KR, Kurimchak AM, Palacio SM, Glass DJ, Fowle H, McEwan BC, Xu Q, Zhao Z, Cressey L, Johnson N, Duncan JS, Kettenbach AN, Dunbrack RL Jr, Graña X. Wasserman JS, et al. Among authors: grana x. Nat Commun. 2024 Jul 10;15(1):5776. doi: 10.1038/s41467-024-50015-7. Nat Commun. 2024. PMID: 38982062 Free PMC article.

4

Derivation of human primary prostate epithelial cell lines by differentially targeting the CDKN2A locus along with expression of hTERT.

Wasserman JS, Fowle H, Hashmi R, Atar D, Patel K, Yarmahmoodi A, Macfarlane AW, Tan Y, Cukierman E, Gligorijevic B, Karami A, Whelan KA, Campbell KS, Graña X. Wasserman JS, et al. Among authors: grana x. Res Sq [Preprint]. 2024 May 6:rs.3.rs-4294058. doi: 10.21203/rs.3.rs-4294058/v1. Res Sq. 2024. Update in: Sci Rep. 2024 Sep 2;14(1):20409. doi: 10.1038/s41598-024-71306-5. PMID: 38766032 Free PMC article. Updated. Preprint.

5

Autophagy Contributes to Homeostasis in Esophageal Epithelium Where High Autophagic Vesicle Level Marks Basal Cells With Limited Proliferation and Enhanced Self-Renewal Potential.

Klochkova A, Karami AL, Fuller AD, Parham LR, Panchani SR, Natarajan S, Jackson JL, Mu A, Tan Y, Cai KQ, Klein-Szanto AJ, Muir AB, Tétreault MP, Graña X, Hamilton KE, Whelan KA. Klochkova A, et al. Among authors: grana x. Cell Mol Gastroenterol Hepatol. 2024;18(1):15-40. doi: 10.1016/j.jcmgh.2024.02.018. Epub 2024 Mar 5. Cell Mol Gastroenterol Hepatol. 2024. PMID: 38452871 Free PMC article.

6

4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.

Calbert ML, Chandramouly G, Adams CM, Saez-Ayala M, Kent T, Tyagi M, Ayyadevara VSSA, Wang Y, Krais JJ, Gordon J, Atkins J, Toma MM, Betzi S, Boghossian AS, Rees MG, Ronan MM, Roth JA, Goldman AR, Gorman N, Mitra R, Childers WE, Graña X, Skorski T, Johnson N, Hurtz C, Morelli X, Eischen CM, Pomerantz RT. Calbert ML, et al. Among authors: grana x. Mol Cancer Ther. 2024 May 2;23(5):683-699. doi: 10.1158/1535-7163.MCT-23-0487. Mol Cancer Ther. 2024. PMID: 38064712 Free PMC article.

7

Protocol to assess substrate dephosphorylation by serine/threonine phosphoprotein phosphatases in vitro.

Wasserman JS, Feiser F, Palacio S, Patel K, Gonzalez J, Fowle H, Graña X. Wasserman JS, et al. Among authors: grana x. STAR Protoc. 2023 Jun 16;4(2):102148. doi: 10.1016/j.xpro.2023.102148. Epub 2023 Apr 18. STAR Protoc. 2023. PMID: 37074907 Free PMC article.

8

Expanding the prostate cancer cell line repertoire with ACRJ-PC28, an AR-negative neuroendocrine cell line derived from an African-Caribbean patient.

Valentine H, Aiken W, Morrison B, Zhao Z, Fowle H, Wasserman JS, Thompson E, Chin W, Young M, Clarke S, Gibbs D, Harrison S, McLaughlin W, Kwok T, Jin F, Campbell KS, Horvath A, Thompson R, Lee NH, Zhou Y, Graña X, Ragin C, Badal S. Valentine H, et al. Among authors: grana x. Cancer Res Commun. 2022 Nov;2(11):1355-1371. doi: 10.1158/2767-9764.crc-22-0245. Epub 2022 Nov 7. Cancer Res Commun. 2022. PMID: 36643868 Free PMC article.

9

PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107.

Fowle H, Zhao Z, Xu Q, Wasserman JS, Wang X, Adeyemi M, Feiser F, Kurimchak AN, Atar D, McEwan BC, Kettenbach AN, Page R, Peti W, Dunbrack RL, Graña X. Fowle H, et al. Among authors: grana x. Elife. 2021 Oct 18;10:e63181. doi: 10.7554/eLife.63181. Elife. 2021. PMID: 34661528 Free PMC article.

10

PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilization.

Zhao Z, Kurimchak A, Nikonova AS, Feiser F, Wasserman JS, Fowle H, Varughese T, Connors M, Johnson K, Makhov P, Lindskog C, Kolenko VM, Golemis EA, Duncan JS, Graña X. Zhao Z, et al. Among authors: grana x. Oncogenesis. 2019 Dec 10;8(12):72. doi: 10.1038/s41389-019-0180-9. Oncogenesis. 2019. PMID: 31822657 Free PMC article.

11

Invadopodia-mediated ECM degradation is enhanced in the G1 phase of the cell cycle.

Bayarmagnai B, Perrin L, Esmaeili Pourfarhangi K, Graña X, Tüzel E, Gligorijevic B. Bayarmagnai B, et al. Among authors: grana x. J Cell Sci. 2019 Oct 18;132(20):jcs227116. doi: 10.1242/jcs.227116. J Cell Sci. 2019. PMID: 31533971 Free PMC article.

12

PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer.

Fowle H, Zhao Z, Graña X. Fowle H, et al. Among authors: grana x. Adv Cancer Res. 2019;144:55-93. doi: 10.1016/bs.acr.2019.03.009. Epub 2019 Apr 12. Adv Cancer Res. 2019. PMID: 31349904 Free PMC article. Review.

13

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer.

Zhang H, Pandey S, Travers M, Sun H, Morton G, Madzo J, Chung W, Khowsathit J, Perez-Leal O, Barrero CA, Merali C, Okamoto Y, Sato T, Pan J, Garriga J, Bhanu NV, Simithy J, Patel B, Huang J, Raynal NJ, Garcia BA, Jacobson MA, Kadoch C, Merali S, Zhang Y, Childers W, Abou-Gharbia M, Karanicolas J, Baylin SB, Zahnow CA, Jelinek J, Graña X, Issa JJ. Zhang H, et al. Among authors: grana x. Cell. 2018 Nov 15;175(5):1244-1258.e26. doi: 10.1016/j.cell.2018.09.051. Epub 2018 Oct 25. Cell. 2018. PMID: 30454645 Free PMC article.

14

PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues.

Kurimchak A, Graña X. Kurimchak A, et al. Among authors: grana x. Cell Cycle. 2015;14(1):18-30. doi: 10.4161/15384101.2014.985069. Cell Cycle. 2015. PMID: 25483052 Free PMC article. Review.

15

Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme.

Kurimchak A, Haines DS, Garriga J, Wu S, De Luca F, Sweredoski MJ, Deshaies RJ, Hess S, Graña X. Kurimchak A, et al. Among authors: grana x. Mol Cell Biol. 2013 Aug;33(16):3330-42. doi: 10.1128/MCB.00082-13. Epub 2013 Jun 17. Mol Cell Biol. 2013. PMID: 23775125 Free PMC article.

16

PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in Cancer.

Kurimchak A, Graña X. Kurimchak A, et al. Among authors: grana x. Genes Cancer. 2012 Nov;3(11-12):739-48. doi: 10.1177/1947601912473479. Genes Cancer. 2012. PMID: 23634261 Free PMC article.

17

Complex effects of flavopiridol on the expression of primary response genes.

Keskin H, Garriga J, Georlette D, Graña X. Keskin H, et al. Among authors: grana x. Cell Div. 2012 Mar 29;7:11. doi: 10.1186/1747-1028-7-11. Cell Div. 2012. PMID: 22458775 Free PMC article.

18

B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation.

Jayadeva G, Kurimchak A, Garriga J, Sotillo E, Davis AJ, Haines DS, Mumby M, Graña X. Jayadeva G, et al. Among authors: grana x. J Biol Chem. 2010 Sep 24;285(39):29863-73. doi: 10.1074/jbc.M110.162354. Epub 2010 Jul 27. J Biol Chem. 2010. PMID: 20663872 Free PMC article.

19

Requirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C Mutation.

Reddy HK, Graña X, Dhanasekaran DN, Litvin J, Reddy EP. Reddy HK, et al. Among authors: grana x. Genes Cancer. 2010 Jan;1(1):69-80. doi: 10.1177/1947601909358105. Genes Cancer. 2010. PMID: 20634902 Free PMC article.

20

Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E.

Sotillo E, Garriga J, Padgaonkar A, Kurimchak A, Cook JG, Graña X. Sotillo E, et al. Among authors: grana x. J Biol Chem. 2009 May 22;284(21):14126-35. doi: 10.1074/jbc.M900687200. Epub 2009 Mar 25. J Biol Chem. 2009. PMID: 19321444 Free PMC article.

21

Downregulation of the phosphatase nuclear targeting subunit (PNUTS) triggers pRB dephosphorylation and apoptosis in pRB positive tumor cell lines.

Graña X. Graña X. Cancer Biol Ther. 2008 Jun;7(6):842-4. doi: 10.4161/cbt.7.6.6298. Epub 2008 May 14. Cancer Biol Ther. 2008. PMID: 18497566 Free article. No abstract available.

22

Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts.

Sotillo E, Garriga J, Kurimchak A, Graña X. Sotillo E, et al. Among authors: grana x. J Biol Chem. 2008 Apr 25;283(17):11280-92. doi: 10.1074/jbc.M709055200. Epub 2008 Feb 14. J Biol Chem. 2008. PMID: 18276582 Free PMC article.

23

Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes.

Salerno D, Hasham MG, Marshall R, Garriga J, Tsygankov AY, Graña X. Salerno D, et al. Among authors: grana x. Gene. 2007 Dec 15;405(1-2):65-78. doi: 10.1016/j.gene.2007.09.010. Epub 2007 Sep 19. Gene. 2007. PMID: 17949927 Free PMC article.

24

p21 loss cooperates with INK4 inactivation facilitating immortalization and Bcl-2-mediated anchorage-independent growth of oncogene-transduced primary mouse fibroblasts.

Carbone CJ, Graña X, Reddy EP, Haines DS. Carbone CJ, et al. Among authors: grana x. Cancer Res. 2007 May 1;67(9):4130-7. doi: 10.1158/0008-5472.CAN-07-0499. Cancer Res. 2007. PMID: 17483323

25

Mechanisms controlling CDK9 activity.

Marshall RM, Grana X. Marshall RM, et al. Among authors: grana x. Front Biosci. 2006 Sep 1;11:2598-613. doi: 10.2741/1994. Front Biosci. 2006. PMID: 16720337 Review.

26

Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis.

Reddy HK, Mettus RV, Rane SG, Graña X, Litvin J, Reddy EP. Reddy HK, et al. Among authors: grana x. Cancer Res. 2005 Nov 15;65(22):10174-8. doi: 10.1158/0008-5472.CAN-05-2639. Cancer Res. 2005. PMID: 16288002

27

Cyclin T1 expression is regulated by multiple signaling pathways and mechanisms during activation of human peripheral blood lymphocytes.

Marshall RM, Salerno D, Garriga J, Graña X. Marshall RM, et al. Among authors: grana x. J Immunol. 2005 Nov 15;175(10):6402-11. doi: 10.4049/jimmunol.175.10.6402. J Immunol. 2005. PMID: 16272292

28

A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130.

Garriga J, Jayaraman AL, Limón A, Jayadeva G, Sotillo E, Truongcao M, Patsialou A, Wadzinski BE, Graña X. Garriga J, et al. Among authors: grana x. Cell Cycle. 2004 Oct;3(10):1320-30. doi: 10.4161/cc.3.10.1183. Epub 2004 Oct 15. Cell Cycle. 2004. PMID: 15467457

29

Cellular control of gene expression by T-type cyclin/CDK9 complexes.

Garriga J, Graña X. Garriga J, et al. Among authors: grana x. Gene. 2004 Aug 4;337:15-23. doi: 10.1016/j.gene.2004.05.007. Gene. 2004. PMID: 15276198 Review.

30

CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2.

Garriga J, Bhattacharya S, Calbó J, Marshall RM, Truongcao M, Haines DS, Graña X. Garriga J, et al. Among authors: grana x. Mol Cell Biol. 2003 Aug;23(15):5165-73. doi: 10.1128/MCB.23.15.5165-5173.2003. Mol Cell Biol. 2003. PMID: 12861003 Free PMC article.

31

SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells.

Bhattacharya S, Garriga J, Calbó J, Yong T, Haines DS, Graña X. Bhattacharya S, et al. Among authors: grana x. Oncogene. 2003 Apr 24;22(16):2443-51. doi: 10.1038/sj.onc.1206339. Oncogene. 2003. PMID: 12717421

32

G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression.

Calbó J, Parreño M, Sotillo E, Yong T, Mazo A, Garriga J, Grana X. Calbó J, et al. Among authors: grana x. J Biol Chem. 2002 Dec 27;277(52):50263-74. doi: 10.1074/jbc.M209181200. Epub 2002 Oct 24. J Biol Chem. 2002. PMID: 12401786 Free article.

33

Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells.

Rane SG, Mangan JK, Amanullah A, Wong BC, Vora RK, Liebermann DA, Hoffman B, Graña X, Reddy EP. Rane SG, et al. Among authors: grana x. Blood. 2002 Oct 15;100(8):2753-62. doi: 10.1182/blood.V100.8.2753. Blood. 2002. PMID: 12351382 Free article.

34

E1A modulates phosphorylation of p130 and p107 by differentially regulating the activity of G1/S cyclin/CDK complexes.

Parreño M, Garriga J, Limón A, Albrecht JH, Graña X. Parreño M, et al. Among authors: grana x. Oncogene. 2001 Aug 9;20(35):4793-806. doi: 10.1038/sj.onc.1204644. Oncogene. 2001. PMID: 11521191

35

E1A blocks hyperphosphorylation of p130 and p107 without affecting the phosphorylation status of the retinoblastoma protein.

Parreño M, Garriga J, Limón A, Mayol X, Beck GR Jr, Moran E, Graña X. Parreño M, et al. Among authors: grana x. J Virol. 2000 Apr;74(7):3166-76. doi: 10.1128/jvi.74.7.3166-3176.2000. J Virol. 2000. PMID: 10708433 Free PMC article.

36

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth.

Graña X, Garriga J, Mayol X. Graña X, et al. Oncogene. 1998 Dec 24;17(25):3365-83. doi: 10.1038/sj.onc.1202575. Oncogene. 1998. PMID: 9916999 Review.

37

Upregulation of cyclin T1/CDK9 complexes during T cell activation.

Garriga J, Peng J, Parreño M, Price DH, Henderson EE, Graña X. Garriga J, et al. Among authors: grana x. Oncogene. 1998 Dec 17;17(24):3093-102. doi: 10.1038/sj.onc.1202548. Oncogene. 1998. PMID: 9872325

38

Differential regulation of the retinoblastoma family of proteins during cell proliferation and differentiation.

Garriga J, Limón A, Mayol X, Rane SG, Albrecht JH, Reddy EP, Andrés V, Graña X. Garriga J, et al. Among authors: grana x. Biochem J. 1998 Aug 1;333 ( Pt 3)(Pt 3):645-54. doi: 10.1042/bj3330645. Biochem J. 1998. PMID: 9677324 Free PMC article.

39

The p130 pocket protein: keeping order at cell cycle exit/re-entrance transitions.

Mayol X, Grana X. Mayol X, et al. Among authors: grana x. Front Biosci. 1998 Jan 1;3:d11-24. doi: 10.2741/a263. Front Biosci. 1998. PMID: 9405335 Review.

40

pRB, p107 and p130 as transcriptional regulators: role in cell growth and differentiation.

Mayol X, Graña X. Mayol X, et al. Among authors: grana x. Prog Cell Cycle Res. 1997;3:157-69. doi: 10.1007/978-1-4615-5371-7_13. Prog Cell Cycle Res. 1997. PMID: 9580269 Review.

41

Phosphorylation site specificity of the CDC2-related kinase PITALRE.

Garriga J, Segura E, Mayol X, Grubmeyer C, Graña X. Garriga J, et al. Among authors: grana x. Biochem J. 1996 Dec 15;320 ( Pt 3)(Pt 3):983-9. doi: 10.1042/bj3200983. Biochem J. 1996. PMID: 9003389 Free PMC article.

42

The CDC2-related kinase PITALRE is the catalytic subunit of active multimeric protein complexes.

Garriga J, Mayol X, Graña X. Garriga J, et al. Among authors: grana x. Biochem J. 1996 Oct 1;319 ( Pt 1)(Pt 1):293-8. doi: 10.1042/bj3190293. Biochem J. 1996. PMID: 8870681 Free PMC article.

43

G1 cyclin/CDK-independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with E2F-4.

Mayol X, Garriga J, Graña X. Mayol X, et al. Among authors: grana x. Oncogene. 1996 Jul 18;13(2):237-46. Oncogene. 1996. PMID: 8710362

44

Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130.

Mayol X, Garriga J, Graña X. Mayol X, et al. Among authors: grana x. Oncogene. 1995 Aug 17;11(4):801-8. Oncogene. 1995. PMID: 7651744

45

Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs).

Graña X, Reddy EP. Graña X, et al. Oncogene. 1995 Jul 20;11(2):211-9. Oncogene. 1995. PMID: 7624138 Review.

46

Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest.

Guillouf C, Graña X, Selvakumaran M, De Luca A, Giordano A, Hoffman B, Liebermann DA. Guillouf C, et al. Among authors: grana x. Blood. 1995 May 15;85(10):2691-8. Blood. 1995. PMID: 7742528 Free article.

47

PISSLRE, a human novel CDC2-related protein kinase.

Graña X, Claudio PP, De Luca A, Sang N, Giordano A. Graña X, et al. Oncogene. 1994 Jul;9(7):2097-103. Oncogene. 1994. PMID: 8208557

48

PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro.

Graña X, De Luca A, Sang N, Fu Y, Claudio PP, Rosenblatt J, Morgan DO, Giordano A. Graña X, et al. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3834-8. doi: 10.1073/pnas.91.9.3834. Proc Natl Acad Sci U S A. 1994. PMID: 8170997 Free PMC article.

49

Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain.

Mayol X, Graña X, Baldi A, Sang N, Hu Q, Giordano A. Mayol X, et al. Among authors: grana x. Oncogene. 1993 Sep;8(9):2561-6. Oncogene. 1993. PMID: 8361765

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