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Ciltacabtagene autoleucel in high-risk smoldering multiple myeloma: the CAR-PRISM phase 2 trial.
Nadeem O, Cordas Dos Santos DM, Nikiforow S, Bosch-Vilaseca A, O'Donnell E, Redd R, DeBraganca KC, Sperling AS, Liu Y, McEntire C, Arters F, O'Donnell C, Kineavy B, Marto M, Bergeron A, Swenson E, McHugh K, Caron A, Berry Q, Wei H, Durlacher E, Grimm E, Corrado F, Bidikian N, Montes de Oca R, Lengil T, De Wiest D, Gervais C, Panaro K, Smith EL, Anderson K, Jacobson C, Munshi NC, Richardson P, Madduri D, Schecter JM, Tendler C, Wildgust MA, Trippa L, Mateos MV, Ritz J, Ghobrial IM. Nadeem O, et al. Nat Med. 2026 Apr 20. doi: 10.1038/s41591-026-04365-y. Online ahead of print. Nat Med. 2026. PMID: 42010117
High-risk smoldering multiple myeloma (HR-SMM) carries an increased risk of progression to multiple myeloma, making it an ideal setting to test whether chimeric antigen receptor (CAR) T cell therapy can achieve curative outcomes. Here in this ph
High-risk smoldering multiple myeloma (HR-SMM) carries an increased risk of progression to multiple myelo
Chimeric antigen receptor T-cell therapy for multiple myeloma.
Liu L, Htut M. Liu L, et al. Curr Opin Oncol. 2025 Sep 1;37(5):499-505. doi: 10.1097/CCO.0000000000001167. Epub 2025 Jul 11. Curr Opin Oncol. 2025. PMID: 40671605 Review.
RECENT FINDINGS: Idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel) were initially approved in the fourth-line setting and quickly moved to the second-line and third-line settings due to efficacy. Delayed neurotoxicities remain …
RECENT FINDINGS: Idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel) were initially appro …