Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2022 2
2023 17
2024 22
2025 19
2026 3

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

53 results

Results by year

Filters applied: . Clear all
Page 1
The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases.
Sumida TS, Cheru NT, Hafler DA. Sumida TS, et al. Nat Rev Immunol. 2024 Jul;24(7):503-517. doi: 10.1038/s41577-024-00994-x. Epub 2024 Feb 19. Nat Rev Immunol. 2024. PMID: 38374298 Free PMC article. Review.
FOXP3 mutations in humans cause lethal fulminant systemic autoinflammation (IPEX syndrome). However, it remains unclear to what degree T(reg) cell dysfunction is contributing to the pathophysiology of common autoimmune diseases. ...Further, we examine evidence for T …
FOXP3 mutations in humans cause lethal fulminant systemic autoinflammation (IPEX syndrome). However, it remains unclear to what degre …
IPEX syndrome from diagnosis to cure, learning along the way.
Bacchetta R, Roncarolo MG. Bacchetta R, et al. J Allergy Clin Immunol. 2024 Mar;153(3):595-605. doi: 10.1016/j.jaci.2023.11.021. Epub 2023 Nov 30. J Allergy Clin Immunol. 2024. PMID: 38040040 Free article. Review.
In the past 2 decades, a significant number of studies have been published describing the molecular and clinical aspects of immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome. These studies have refined ou …
In the past 2 decades, a significant number of studies have been published describing the molecular and clinical aspects of immune …
FOXP3 deficiency, from the mechanisms of the disease to curative strategies.
Borna S, Meffre E, Bacchetta R. Borna S, et al. Immunol Rev. 2024 Mar;322(1):244-258. doi: 10.1111/imr.13289. Epub 2023 Nov 23. Immunol Rev. 2024. PMID: 37994657 Review.
FOXP3 gene is a key transcription factor driving immune tolerance and its deficiency causes immune dysregulation, polyendocrinopathy, enteropathy X-linked syndrome (IPEX), a prototypic primary immune regulatory disord …
FOXP3 gene is a key transcription factor driving immune tolerance and its deficiency causes immune dysregulation, po …
Expanding IPEX: Inborn Errors of Regulatory T Cells.
Wobma H, Janssen E. Wobma H, et al. Rheum Dis Clin North Am. 2023 Nov;49(4):825-840. doi: 10.1016/j.rdc.2023.06.009. Epub 2023 Jul 28. Rheum Dis Clin North Am. 2023. PMID: 37821198 Review.
Expanding the spectrum of IPEX: from new clinical findings to novel treatments.
Voarino M, Consonni F, Gambineri E. Voarino M, et al. Curr Opin Allergy Clin Immunol. 2024 Dec 1;24(6):457-463. doi: 10.1097/ACI.0000000000001033. Epub 2024 Oct 11. Curr Opin Allergy Clin Immunol. 2024. PMID: 39475830 Free PMC article. Review.
PURPOSE OF REVIEW: This review aims to provide an overview of recent research findings regarding immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, focusing on clinical and immunological novelties, as …
PURPOSE OF REVIEW: This review aims to provide an overview of recent research findings regarding immune dysregulation, poly …
Inborn errors of regulatory T-cell differentiation and function.
Oktelik FB, Luo Y, Benamar M, Chatila TA. Oktelik FB, et al. J Allergy Clin Immunol. 2025 Dec;156(6):1441-1455. doi: 10.1016/j.jaci.2025.07.001. Epub 2025 Jul 7. J Allergy Clin Immunol. 2025. PMID: 40633593 Review.
Regulatory T (Treg) cells play an essential role in enforcing peripheral immune tolerance and promoting tissue homeostasis and repair. Our understanding of their pivotal role in immune regulation has critically benefited from the identification of a growing number o …
Regulatory T (Treg) cells play an essential role in enforcing peripheral immune tolerance and promoting tissue homeostasis and repair …
IL-27 Gene Therapy Ameliorates IPEX Syndrome Caused by Germline Mutation of Foxp3 Gene: A Major Role for Induction of IL-10.
Liu JQ, Jabbari A, Lin CH, Akkanapally V, Frankel WL, Basu S, He K, Zheng P, Liu Y, Bai XF. Liu JQ, et al. J Immunol. 2024 Sep 1;213(5):559-566. doi: 10.4049/jimmunol.2400056. J Immunol. 2024. PMID: 38975727 Free PMC article.
Inactivating mutations of Foxp3, the master regulator of regulatory T cell development and function, lead to immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome in mice and humans. IPEX is a fatal …
Inactivating mutations of Foxp3, the master regulator of regulatory T cell development and function, lead to immune dysregulation …
CTLA4-related primary immune dysregulatory disorders.
Baris S. Baris S. Curr Opin Allergy Clin Immunol. 2025 Dec 1;25(6):435-443. doi: 10.1097/ACI.0000000000001117. Epub 2025 Oct 1. Curr Opin Allergy Clin Immunol. 2025. PMID: 41158012 Review.
PURPOSE OF REVIEW: CTLA4-related immune disorders are primary immune dysregulation characterized by susceptibility to infections, autoimmunity, hyperinflammation, and malignancies. ...Clinically, phenotypic heterogeneity spans susceptibility to infections wit …
PURPOSE OF REVIEW: CTLA4-related immune disorders are primary immune dysregulation characterized by susceptibility to i …
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy.
Ghanim HY, Porteus MH. Ghanim HY, et al. Immunol Rev. 2024 Mar;322(1):157-177. doi: 10.1111/imr.13305. Epub 2024 Jan 17. Immunol Rev. 2024. PMID: 38233996 Review.
Inborn errors of immunity (IEI) present a unique paradigm in the realm of gene therapy, emphasizing the need for precision in therapeutic design. ...The review uses four specific IEIs to highlight key issues in gene therapy strategies: X-linked agammaglobulin …
Inborn errors of immunity (IEI) present a unique paradigm in the realm of gene therapy, emphasizing the need for precision in therape …
Clonal hematopoiesis meets an autoinflammatory disease: the new paradigm of VEXAS syndrome.
Fiumara M, Molteni R, Scorpio G, Tomelleri A, Bergonzi GM, Ferrari S, Matucci-Cerinic M, Cenci S, Dagna L, Ciceri F, Diral E, Campochiaro C. Fiumara M, et al. Expert Rev Hematol. 2025 Jul;18(7):509-519. doi: 10.1080/17474086.2025.2508505. Epub 2025 May 30. Expert Rev Hematol. 2025. PMID: 40396343 Free article. Review.
INTRODUCTION: VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is an acquired autoinflammatory disorder caused by somatic mutations in the UBA1 gene. ...
INTRODUCTION: VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is an acquired autoinflammatory disord …
53 results