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Year Number of Results
2016 1
2017 5
2018 5
2019 5
2020 6
2021 5
2022 5
2023 3
2024 4
2025 7
2026 2

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Page 1
New classification and diagnostic criteria for insulin resistance syndrome.
Ogawa W, Araki E, Ishigaki Y, Hirota Y, Maegawa H, Yamauchi T, Yorifuji T, Katagiri H. Ogawa W, et al. Endocr J. 2022 Feb 28;69(2):107-113. doi: 10.1507/endocrj.EJ21-0725. Epub 2022 Feb 1. Endocr J. 2022. PMID: 35110500 Free article.
This syndrome is classified into two types: genetic insulin resistance syndrome, caused by gene abnormalities, and type B insulin resistance syndrome, caused by autoantibodies to the insulin receptor. ...Type B …
This syndrome is classified into two types: genetic insulin resistance syndrome, caused by gene abnormalities, and type …
Structure and function of the insulin receptor-a personal perspective.
Kasuga M. Kasuga M. Proc Jpn Acad Ser B Phys Biol Sci. 2019;95(10):581-589. doi: 10.2183/pjab.95.039. Proc Jpn Acad Ser B Phys Biol Sci. 2019. PMID: 31827016 Free PMC article. Review.
Immunoprecipitation with autoantibodies to the insulin receptor derived from patients with extreme insulin resistance and acanthosis nigricans revealed that the receptor is comprised of two subunits of 135 kDa (alpha subunit) and 95 kDa ( …
Immunoprecipitation with autoantibodies to the insulin receptor derived from patients with extreme insulin resistanc …
Insulin receptor variants: Extending the traditional Mendelian spectrum.
Collin-Chavagnac D, Saint-Martin C, Bedidi L, Lebreton L, Aslanzadeh V, Vigouroux C, Bellanné-Chantelot C, Semple RK, Lascols O, Jéru I. Collin-Chavagnac D, et al. Genet Med. 2025 Jun;27(6):101404. doi: 10.1016/j.gim.2025.101404. Epub 2025 Mar 13. Genet Med. 2025. PMID: 40094207 Free article.
PURPOSE: INSR encodes the insulin receptor, the essential entrainer of growth and metabolism to nutritional cues. INSR variants cause a spectrum of monogenic insulin resistance (IR) syndromes, namely, type A insulin resistance …
PURPOSE: INSR encodes the insulin receptor, the essential entrainer of growth and metabolism to nutritional cues. INSR variant …
Mecasermin in Insulin Receptor-Related Severe Insulin Resistance Syndromes: Case Report and Review of the Literature.
Plamper M, Gohlke B, Schreiner F, Woelfle J. Plamper M, et al. Int J Mol Sci. 2018 Apr 24;19(5):1268. doi: 10.3390/ijms19051268. Int J Mol Sci. 2018. PMID: 29695048 Free PMC article. Review.
Mutations in the insulin receptor (INSR) gene underlie rare severe INSR-related insulin resistance syndromes (SIR), including insulin resistance type A, Rabson-Mendenhall syndrome and Donohue syndrome (DS), with DS represent …
Mutations in the insulin receptor (INSR) gene underlie rare severe INSR-related insulin resistance syndromes (SI …
Clinical characteristics of insulin resistance syndromes: A nationwide survey in Japan.
Takeuchi T, Ishigaki Y, Hirota Y, Hasegawa Y, Yorifuji T, Kadowaki H, Akamizu T, Ogawa W, Katagiri H. Takeuchi T, et al. J Diabetes Investig. 2020 May;11(3):603-616. doi: 10.1111/jdi.13171. Epub 2019 Dec 5. J Diabetes Investig. 2020. PMID: 31677333 Free PMC article.
AIMS/INTRODUCTION: Insulin resistance syndrome (IRS) of type A or B is triggered by gene abnormalities of or autoantibodies to the insulin receptor, respectively. Rabson-Mendenhall/Donohue syndrome is also caused by defects of the insu …
AIMS/INTRODUCTION: Insulin resistance syndrome (IRS) of type A or B is triggered by gene abnormalities of or aut …
FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction.
Diener JL, Mowbray S, Huang WJ, Yowe D, Xu J, Caplan S, Misra A, Kapur A, Shapiro J, Ke X, Wu X, Bose A, Panza D, Chen M, Beaulieu V, Gao J. Diener JL, et al. Endocrinology. 2021 Sep 1;162(9):bqab092. doi: 10.1210/endocr/bqab092. Endocrinology. 2021. PMID: 33951176
In this paper, we revisited the original finding and found that insulin-independent glucose uptake in adipocytes is preserved in the presence of an insulin receptor antagonist. Using a 40-kDa PEGylated (PEG) and half-life extended form of FGF21 (FGF21-PEG), we exten …
In this paper, we revisited the original finding and found that insulin-independent glucose uptake in adipocytes is preserved in the presenc …
Utility of the C-Peptide/Insulin Molar Ratio for Distinguishing Type A Insulin Resistance Syndrome From Type 2 Diabetes.
Nishikage S, Hirota Y, Takayoshi T, Yoshimura K, Takeuchi T, Hamaguchi T, Ueda M, Yamamoto A, Sakaguchi K, Ogawa W. Nishikage S, et al. J Clin Endocrinol Metab. 2025 Sep 16;110(10):e3383-e3390. doi: 10.1210/clinem/dgaf043. J Clin Endocrinol Metab. 2025. PMID: 39873375
OBJECTIVE: Type A insulin resistance syndrome (IRS), characterized by impaired insulin receptor function due to variants of the insulin receptor gene, manifests as severe insulin-resistant diabetes. Differentia …
OBJECTIVE: Type A insulin resistance syndrome (IRS), characterized by impaired insulin receptor fu …
Structural Basis and Genotype-Phenotype Correlations of INSR Mutations Causing Severe Insulin Resistance.
Hosoe J, Kadowaki H, Miya F, Aizu K, Kawamura T, Miyata I, Satomura K, Ito T, Hara K, Tanaka M, Ishiura H, Tsuji S, Suzuki K, Takakura M, Boroevich KA, Tsunoda T, Yamauchi T, Shojima N, Kadowaki T. Hosoe J, et al. Diabetes. 2017 Oct;66(10):2713-2723. doi: 10.2337/db17-0301. Epub 2017 Aug 1. Diabetes. 2017. PMID: 28765322
The insulin receptor (INSR) gene was analyzed in four patients with severe insulin resistance, revealing five novel mutations and a deletion that removed exon 2. ...These results suggest the importance of the FnIII domains, provide insight into the mol …
The insulin receptor (INSR) gene was analyzed in four patients with severe insulin resistance, revealing five no …
Global hotspots and trends in Acanthosis nigricans research: A bibliometric and visualized analysis.
Zhang S, Yan H, Sun W, Li J, Xu J, Cao D, Song B, Wu X. Zhang S, et al. Skin Res Technol. 2024 Sep;30(9):e70054. doi: 10.1111/srt.70054. Skin Res Technol. 2024. PMID: 39258800 Free PMC article.
The most cited article is "Syndromes of Insulin Resistance and Acanthosis Nigricans: Insulin-Receptor Disorders in Man" (1976). The author Taylor, SI, has published the most papers. "Acanthosis nigricans" is the most frequen …
The most cited article is "Syndromes of Insulin Resistance and Acanthosis Nigricans: Insulin-Receptor …
Management of pregnancy with metformin: Case reports for genetic insulin resistance syndrome and a literature review for gestational and type 2 diabetes.
Yoshimura K, Hirota Y, Hamaguchi T, Takeuchi T, Takayoshi T, Saito S, Ueda M, Nishikage S, Yamamoto A, Hashimoto N, Ogawa W. Yoshimura K, et al. J Diabetes Investig. 2025 Sep;16(9):1663-1669. doi: 10.1111/jdi.70105. Epub 2025 Jun 30. J Diabetes Investig. 2025. PMID: 40587328 Free PMC article. Review.
INTRODUCTION: Genetic insulin resistance syndrome is characterized by severe insulin resistance due to functional abnormalities of the insulin receptor or downstream signaling molecules. ...MATERIALS AND METHODS: We describe prenatal care …
INTRODUCTION: Genetic insulin resistance syndrome is characterized by severe insulin resistance due to functiona …
40 results