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2022 16
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Nr4a1 enhances Wnt4 transcription to promote mesenchymal stem cell osteogenesis and alleviates inflammation-inhibited bone regeneration.
Gao Y, Zou Y, Sokolowskei D, Xing X, Tower RJ, Lai Z, Shi J, Zhu L, Zheng Q, James AW, Xu J, Zhang Z. Gao Y, et al. Mol Ther. 2024 May 1;32(5):1479-1496. doi: 10.1016/j.ymthe.2024.02.034. Epub 2024 Mar 1. Mol Ther. 2024. PMID: 38429926 Free PMC article.
Transcriptomic and histologic analyses confirmed that upregulation of Nr4a1 increased the transcription of Wnt family member 4 (Wnt4) and activated Wnt pathway. Mechanistically, Nr4a1 bound to the promoter of Wnt4 and regulated its expression, thereby enhancing the …
Transcriptomic and histologic analyses confirmed that upregulation of Nr4a1 increased the transcription of Wnt family member 4 (Wnt4) …
Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses.
Pujol Gualdo N, Džigurski J, Rukins V, Pajuste FD, Wolford BN, Võsa M, Golob M, Haug L, Alver M, Läll K, Peters M, Brumpton BM; Estonian Biobank Research Team; Palta P, Mägi R, Laisk T. Pujol Gualdo N, et al. Nat Med. 2025 May;31(5):1626-1634. doi: 10.1038/s41591-025-03543-8. Epub 2025 Mar 11. Nat Med. 2025. PMID: 40069456
Finally, we identify pleiotropic loci and genes that function in genital tract development (WNT4, PAX8, WT1, SALL1), hormonal regulation (FSHB, GREB1, BMPR1B, SYNE1/ESR1) and folliculogenesis (CHEK2), underlining their integral roles in female reproductive health....
Finally, we identify pleiotropic loci and genes that function in genital tract development (WNT4, PAX8, WT1, SALL1), hormonal regulat …
WNT4 promotes the symmetric fission of crypt in radiation-induced intestinal epithelial regeneration.
Cheng J, Wu H, Cui Y. Cheng J, et al. Cell Mol Biol Lett. 2024 Dec 26;29(1):158. doi: 10.1186/s11658-024-00677-4. Cell Mol Biol Lett. 2024. PMID: 39725925 Free PMC article.
Three-dimensional (3D) reconstructed images of organoids were applied to assess the symmetry of crypt fission and Paneth cell localization upon manipulation of WNT4 expression. The effect of WNT4 on the expression of beta-catenin target genes was analyzed by real-ti …
Three-dimensional (3D) reconstructed images of organoids were applied to assess the symmetry of crypt fission and Paneth cell localization u …
Diagnosis and management of non-CAH 46,XX disorders/differences in sex development.
Yavas Abalı Z, Guran T. Yavas Abalı Z, et al. Front Endocrinol (Lausanne). 2024 May 15;15:1354759. doi: 10.3389/fendo.2024.1354759. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38812815 Free PMC article. Review.
Many genes are involved in the mechanisms of gonadal development, and genes associated with 46,XX T/OT-DSD include translocations of the SRY; copy number variants in NR2F2, NR0B1, SOX3, SOX9, SOX10, and FGF9, and sequence variants in NR5A1, NR2F2, RSPO1, SOX9, WNT2B, WNT4, …
Many genes are involved in the mechanisms of gonadal development, and genes associated with 46,XX T/OT-DSD include translocations of the SRY …
Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring.
Benonisdottir S, Straub VJ, Kong A, Mills MC. Benonisdottir S, et al. Nat Aging. 2024 Dec;4(12):1745-1759. doi: 10.1038/s43587-024-00733-w. Epub 2024 Dec 13. Nat Aging. 2024. PMID: 39672892 Review.
Using the GWAS Catalog as a basis, from 159 relevant studies, we isolate 37 genes that harbor association signals for four or more reproductive traits, more than half of which are linked to rare Mendelian disorders, including ten genes linked to reproductive-related disorders: FS …
Using the GWAS Catalog as a basis, from 159 relevant studies, we isolate 37 genes that harbor association signals for four or more reproduct …
The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms.
Chang CH, Liu F, Militi S, Hester S, Nibhani R, Deng S, Dunford J, Rendek A, Soonawalla Z, Fischer R, Oppermann U, Pauklin S. Chang CH, et al. Nat Commun. 2024 Apr 27;15(1):3580. doi: 10.1038/s41467-024-47680-z. Nat Commun. 2024. PMID: 38678032 Free PMC article.
E2F1 and E2F4 induce whereas pRb/RBL2 reduce WNT ligand expression (e.g. WNT7A, WNT7B, WNT10A, WNT4) thereby regulating self-renewal, chemoresistance and invasiveness of CSCs in both PDAC and breast cancer, and fibroblast proliferation. ...
E2F1 and E2F4 induce whereas pRb/RBL2 reduce WNT ligand expression (e.g. WNT7A, WNT7B, WNT10A, WNT4) thereby regulating self-renewal, …
The METTL3-PGR-WNT4 axis is critical for human endometrial stromal cell decidualization.
Hong YQ, Tang S, Yang XQ, Deng YT, Zhao JQ, Zhang QY, Ding CH, Zheng ZH, Xu YW, Yang SH, Liu JL. Hong YQ, et al. FEBS J. 2025 Dec;292(24):6576-6591. doi: 10.1111/febs.70200. Epub 2025 Jul 25. FEBS J. 2025. PMID: 40711993
Furthermore, we demonstrated that small interfering RNA (siRNA)-mediated knockdown of METTL3 in cultured human endometrial stromal cells (HESCs) resulted in impaired decidualization, which was primarily attributed to the downregulation of WNT4, a crucial factor for decidua …
Furthermore, we demonstrated that small interfering RNA (siRNA)-mediated knockdown of METTL3 in cultured human endometrial stromal cells (HE …
FOXL2 drives the differentiation of supporting gonadal cells in early ovarian development.
Danti L, Lundin K, Nedeczey-Ruzsák P, Tuuri T, Tapanainen JS. Danti L, et al. Reprod Biol Endocrinol. 2025 Mar 18;23(1):44. doi: 10.1186/s12958-025-01377-0. Reprod Biol Endocrinol. 2025. PMID: 40102860 Free PMC article.
RESULTS: Our results demonstrate that FOXL2 downregulates coelomic epithelial markers GATA4 and LHX9, female gonadal markers RSPO1 and WNT4, and male gonadal markers SOX9, NR0B1 and DHH. The differentially expressed genes were mostly associated with Kyoto encyclopaedia of …
RESULTS: Our results demonstrate that FOXL2 downregulates coelomic epithelial markers GATA4 and LHX9, female gonadal markers RSPO1 and WN …
WNT4 (rs7521902 and rs16826658) polymorphism and its association with endometriosis - A systematic review and meta-analysis.
Meidyana S, Isfandiary S, Primariawan RY. Meidyana S, et al. Eur J Obstet Gynecol Reprod Biol. 2024 Apr;295:111-117. doi: 10.1016/j.ejogrb.2024.01.038. Epub 2024 Feb 2. Eur J Obstet Gynecol Reprod Biol. 2024. PMID: 38354602
IMPORTANCE: This systematic review supports the involvement of the WNT4 gene in the pathophysiology of endometriosis. OBJECTIVE: To conduct a systematic review and meta-analysis on WNT4 rs7521902 and rs16826658 polymorphism associated with endometriosis based on mul …
IMPORTANCE: This systematic review supports the involvement of the WNT4 gene in the pathophysiology of endometriosis. OBJECTIVE: To c …
99 results