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2018 18
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2020 21
2021 1
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Opioid Addiction, Genetic Susceptibility, and Medical Treatments: A Review.
Wang SC, Chen YC, Lee CH, Cheng CM. Wang SC, et al. Int J Mol Sci. 2019 Sep 2;20(17):4294. doi: 10.3390/ijms20174294. Int J Mol Sci. 2019. PMID: 31480739 Free PMC article. Review.
Opioid addiction is a chronic and complex disease characterized by relapse and remission. ...In this article, we summarized the biological mechanisms of opioid addiction and medical treatments, and we reviewed articles about the genetics of opioid addictio
Opioid addiction is a chronic and complex disease characterized by relapse and remission. ...In this article, we summarized the biolo …
Untangling the complexity of opioid receptor function.
Valentino RJ, Volkow ND. Valentino RJ, et al. Neuropsychopharmacology. 2018 Dec;43(13):2514-2520. doi: 10.1038/s41386-018-0225-3. Epub 2018 Sep 24. Neuropsychopharmacology. 2018. PMID: 30250308 Free PMC article. Review.
Yet many questions remain and the development of non-addictive opioid analgesics has not been achieved. However, access to new molecular, genetic and computational tools have begun to elucidate the structural dynamics of opioid receptors, the scaffolding that links them to …
Yet many questions remain and the development of non-addictive opioid analgesics has not been achieved. However, access to new molecular, …
Epigenetic Mechanisms of Opioid Addiction.
Browne CJ, Godino A, Salery M, Nestler EJ. Browne CJ, et al. Biol Psychiatry. 2020 Jan 1;87(1):22-33. doi: 10.1016/j.biopsych.2019.06.027. Epub 2019 Jul 8. Biol Psychiatry. 2020. PMID: 31477236 Free PMC article. Review.
The persistence of these neuroadaptations is mediated in part by epigenetic remodeling of gene expression programs in discrete brain regions. Although the majority of work examining how epigenetic modifications contribute to addiction has focused on psychostimulants …
The persistence of these neuroadaptations is mediated in part by epigenetic remodeling of gene expression programs in discrete brain …
Molecular Genetics and New Medication Strategies for Opioid Addiction.
Hurd YL, O'Brien CP. Hurd YL, et al. Am J Psychiatry. 2018 Oct 1;175(10):935-942. doi: 10.1176/appi.ajp.2018.18030352. Epub 2018 Aug 2. Am J Psychiatry. 2018. PMID: 30068261 Free PMC article. Review.
Opioid antagonists are now evolving in their use, not only to prevent acute overdoses but as extended-use treatment options. Strategies that target specific genetic and epigenetic factors, along with novel nonopioid medications, hold promise as future therapeutic intervent …
Opioid antagonists are now evolving in their use, not only to prevent acute overdoses but as extended-use treatment options. Strategies that …
Current status of opioid addiction treatment and related preclinical research.
Kreek MJ, Reed B, Butelman ER. Kreek MJ, et al. Sci Adv. 2019 Oct 2;5(10):eaax9140. doi: 10.1126/sciadv.aax9140. eCollection 2019 Oct. Sci Adv. 2019. PMID: 31616793 Free PMC article. Review.
Opioid use disorders (OUDs) are diseases of the brain with behavioral, psychological, neurobiological, and medical manifestations. Vulnerability to OUDs can be affected by factors such as genetic background, environment, stress, and prolonged exposure to mu-opioid agonists …
Opioid use disorders (OUDs) are diseases of the brain with behavioral, psychological, neurobiological, and medical manifestations. Vulnerabi …
A review of opioid addiction genetics.
Crist RC, Reiner BC, Berrettini WH. Crist RC, et al. Curr Opin Psychol. 2019 Jun;27:31-35. doi: 10.1016/j.copsyc.2018.07.014. Epub 2018 Aug 9. Curr Opin Psychol. 2019. PMID: 30118972 Free PMC article. Review.
Opioid use disorder (OUD) affects millions of people worldwide and the risk of developing the disorder has a significant genetic component according to twin and family studies. Identification of the genetic variants underlying this inherited risk has focused on two …
Opioid use disorder (OUD) affects millions of people worldwide and the risk of developing the disorder has a significant genetic comp …
Risk Factors and Prevention Strategies for Postoperative Opioid Abuse.
Zhao S, Chen F, Feng A, Han W, Zhang Y. Zhao S, et al. Pain Res Manag. 2019 Jul 10;2019:7490801. doi: 10.1155/2019/7490801. eCollection 2019. Pain Res Manag. 2019. PMID: 31360271 Free PMC article. Review.
However, the irrational use of opioids leads to excessive drug dependence and drug abuse, resulting in an increased mortality rate and huge economic loss. ...In this review, we summarize several key factors in opioid abuse, including race, region, income, genetic fa …
However, the irrational use of opioids leads to excessive drug dependence and drug abuse, resulting in an increased mortality rate an …
Analgesia, Opioids, and Other Drug Use During Pregnancy and Neonatal Abstinence Syndrome.
Jones HE, Kraft WK. Jones HE, et al. Clin Perinatol. 2019 Jun;46(2):349-366. doi: 10.1016/j.clp.2019.02.013. Epub 2019 Mar 30. Clin Perinatol. 2019. PMID: 31010564 Review.
A summary of the neonatal abstinence syndrome definition, its assessment tools, treatment approaches, and future genetic directions are provided....
A summary of the neonatal abstinence syndrome definition, its assessment tools, treatment approaches, and future genetic directions a …
New opioid receptor modulators and agonists.
Kaye AD, Cornett EM, Patil SS, Gennuso SA, Colontonio MM, Latimer DR, Kaye AJ, Urman RD, Vadivelu N. Kaye AD, et al. Best Pract Res Clin Anaesthesiol. 2018 Jun;32(2):125-136. doi: 10.1016/j.bpa.2018.06.009. Epub 2018 Jul 2. Best Pract Res Clin Anaesthesiol. 2018. PMID: 30322454 Review.
In summary, the structural elucidation of opioid receptors, allosteric modulation of opioid receptors, new opioid modulators and agonists, the employment of optogenetics, optopharmacology, and next-generation sequencing of opioid receptor genes and related functionality sh …
In summary, the structural elucidation of opioid receptors, allosteric modulation of opioid receptors, new opioid modulators and agonists, t …
Metabolism and metabolomics of opiates: A long way of forensic implications to unravel.
Dinis-Oliveira RJ. Dinis-Oliveira RJ. J Forensic Leg Med. 2019 Feb;61:128-140. doi: 10.1016/j.jflm.2018.12.005. Epub 2018 Dec 19. J Forensic Leg Med. 2019. PMID: 30621882 Review.
Heroin, a semi-synthetic drug produced from morphine is a worldwide serious cause of morbidity and mortality. Heroin dependence is complex phenomenon with environmental and genetic influence, and several biomarkers of exposure have been proposed. ...Profound alterat …
Heroin, a semi-synthetic drug produced from morphine is a worldwide serious cause of morbidity and mortality. Heroin dependence is co …
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