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Impacts of Caffeine during Pregnancy.
Qian J, Chen Q, Ward SM, Duan E, Zhang Y. Qian J, et al. Among authors: chen q. Trends Endocrinol Metab. 2020 Mar;31(3):218-227. doi: 10.1016/j.tem.2019.11.004. Epub 2019 Dec 6. Trends Endocrinol Metab. 2020. PMID: 31818639 Free PMC article. Review.
Recent animal studies with physiologically relevant dosages have begun to dissect adverse effects of caffeine during pregnancy with respect to oviduct contractility, embryo development, uterine receptivity, and placentation that jointly contribute to pregnancy complication …
Recent animal studies with physiologically relevant dosages have begun to dissect adverse effects of caffeine during pregnancy with respect …
Sperm RNA code programmes the metabolic health of offspring.
Zhang Y, Shi J, Rassoulzadegan M, Tuorto F, Chen Q. Zhang Y, et al. Among authors: chen q. Nat Rev Endocrinol. 2019 Aug;15(8):489-498. doi: 10.1038/s41574-019-0226-2. Epub 2019 Jun 24. Nat Rev Endocrinol. 2019. PMID: 31235802 Free PMC article. Review.
Our understanding of the categories of sperm RNAs (such as tRNA-derived small RNAs, microRNAs, ribosomal RNA-derived small RNAs and long non-coding RNAs) and associated RNA modifications is expanding and has begun to reveal the functional diversity and information capacity of the …
Our understanding of the categories of sperm RNAs (such as tRNA-derived small RNAs, microRNAs, ribosomal RNA-derived small RNAs and long non …
Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos.
Wang J, Wang L, Feng G, Wang Y, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W, Zhou Q. Wang J, et al. Among authors: chen q. Cell. 2018 Dec 13;175(7):1887-1901.e18. doi: 10.1016/j.cell.2018.11.039. Cell. 2018. PMID: 30550787 Free article.
In early mammalian embryos, it remains unclear how the first cell fate bias is initially triggered and amplified toward cell fate segregation. ...Thus, our data identify LincGET as one of the earliest known lineage regulators to bias cell fate in mammalian 2-cell embryo
In early mammalian embryos, it remains unclear how the first cell fate bias is initially triggered and amplified toward cell fate seg …
Rad9a is involved in chromatin decondensation and post-zygotic embryo development in mice.
Huang L, Meng TG, Ma XS, Wang ZB, Qi ST, Chen Q, Zhang QH, Liang QX, Wang ZW, Hu MW, Guo L, Ouyang YC, Hou Y, Zhao Y, Sun QY. Huang L, et al. Among authors: chen q. Cell Death Differ. 2019 May;26(5):969-980. doi: 10.1038/s41418-018-0181-9. Epub 2018 Aug 28. Cell Death Differ. 2019. PMID: 30154445 Free PMC article.
Here we report that maternal RAD9A, a key protein in DNA damage response pathway, is involved in post-zygotic embryo development, via a mouse model with conditional depletion of Rad9a alleles in oocytes of primordial follicles. ...Delayed zygotic chromatin decondensation c …
Here we report that maternal RAD9A, a key protein in DNA damage response pathway, is involved in post-zygotic embryo development, via …
Caffeine consumption during early pregnancy impairs oviductal embryo transport, embryonic development and uterine receptivity in mice.
Qian J, Zhang Y, Qu Y, Zhang L, Shi J, Zhang X, Liu S, Kim BH, Hwang SJ, Zhou T, Chen Q, Ward SM, Duan E, Zhang Y. Qian J, et al. Among authors: chen q. Biol Reprod. 2018 Dec 1;99(6):1266-1275. doi: 10.1093/biolre/ioy155. Biol Reprod. 2018. PMID: 29982366 Free PMC article.
In present study, we found that pregnant mice treated with moderate (5 mg/kg) or high (30 mg/kg) dosage of caffeine (intraperitoneally or orally) during preimplantation resulted in retention of early embryos in the oviduct, defective embryonic development, and impai …
In present study, we found that pregnant mice treated with moderate (5 mg/kg) or high (30 mg/kg) dosage of caffeine (intraperitoneally or or …
Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo.
Chen Q, Shi J, Tao Y, Zernicka-Goetz M. Chen Q, et al. Nat Commun. 2018 May 8;9(1):1819. doi: 10.1038/s41467-018-04155-2. Nat Commun. 2018. PMID: 29739935 Free PMC article. Review.
Instead of having prominent pre-patterning determinants as present in model organisms (worms, sea urchin, frog), we propose that the mammalian embryo takes advantage of more subtle cues such as compartmentalized intracellular reactions that generate micro-scale inhomogenei …
Instead of having prominent pre-patterning determinants as present in model organisms (worms, sea urchin, frog), we propose that the mammali …
GPR39 is region-specifically expressed in mouse oviduct correlating with the Zn2+ distribution.
Qiao J, Zhao H, Zhang Y, Peng H, Chen Q, Zhang H, Zheng X, Jin Y, Ni H, Duan E, Guo Y. Qiao J, et al. Among authors: chen q. Theriogenology. 2017 Jan 15;88:98-105. doi: 10.1016/j.theriogenology.2016.09.040. Epub 2016 Oct 1. Theriogenology. 2017. PMID: 27865419
Moreover, using ZnSe(AMG) staining, we found that Zn(2+), the putative ligand of GPR39, also found a distribution similar to GPR39 expression, suggesting that their potential interaction mediates fertilization and embryo transportation....
Moreover, using ZnSe(AMG) staining, we found that Zn(2+), the putative ligand of GPR39, also found a distribution similar to GPR39 expressio …
Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder.
Chen Q, Yan M, Cao Z, Li X, Zhang Y, Shi J, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E, Zhai Q, Zhou Q. Chen Q, et al. Science. 2016 Jan 22;351(6271):397-400. doi: 10.1126/science.aad7977. Epub 2015 Dec 31. Science. 2016. PMID: 26721680
Increasing evidence indicates that metabolic disorders in offspring can result from the father's diet, but the mechanism remains unclear. In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA-derived small RNAs (tsRNAs), mainl …
Increasing evidence indicates that metabolic disorders in offspring can result from the father's diet, but the mechanism remains uncl …
Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq.
Shi J, Chen Q, Li X, Zheng X, Zhang Y, Qiao J, Tang F, Tao Y, Zhou Q, Duan E. Shi J, et al. Among authors: chen q. Development. 2015 Oct 15;142(20):3468-77. doi: 10.1242/dev.123950. Epub 2015 Sep 22. Development. 2015. PMID: 26395495
During mammalian pre-implantation embryo development, when the first asymmetry emerges and how it develops to direct distinct cell fates remain longstanding questions. Here, by analyzing single-blastomere transcriptome data from mouse and human pre-implantation embryos
During mammalian pre-implantation embryo development, when the first asymmetry emerges and how it develops to direct distinct cell fa …
Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.
Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q, Duan E, Wang H. Zhang S, et al. Among authors: chen q. Cell Res. 2014 Aug;24(8):925-42. doi: 10.1038/cr.2014.82. Epub 2014 Jun 27. Cell Res. 2014. PMID: 24971735 Free PMC article.
Coordinated uterine-embryonic axis formation and decidual remodeling are hallmarks of mammalian post-implantation embryo development. ...These results demonstrate that uterine Rbpj is essential for normal embryo development via instructing the initial embr
Coordinated uterine-embryonic axis formation and decidual remodeling are hallmarks of mammalian post-implantation embryo devel …
Rotary suspension culture enhances mesendoderm differentiation of embryonic stem cells through modulation of Wnt/beta-catenin pathway.
Lei X, Deng Z, Zhang H, Zhao H, Zhou J, Liu S, Chen Q, Ning L, Cao Y, Wang X, Zhang X, Duan E. Lei X, et al. Among authors: chen q. Stem Cell Rev Rep. 2014 Aug;10(4):526-38. doi: 10.1007/s12015-014-9511-6. Stem Cell Rev Rep. 2014. PMID: 24793926
Despite the recent identification of the rotary cell culture system (RCCS) as a bioreactor for culturing stem cells, the underlying biological role provided by RCCS in the lineage differentiation of embryonic stem cells (ESCs) remains largely undefined. Here, we explored t …
Despite the recent identification of the rotary cell culture system (RCCS) as a bioreactor for culturing stem cells, the underlying biologic …
Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice.
Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F, Gao S, Wang H. Fu Z, et al. Among authors: chen q. Biol Reprod. 2014 Mar 13;90(3):52. doi: 10.1095/biolreprod.113.115337. Print 2014 Mar. Biol Reprod. 2014. PMID: 24451987
Among nearly 100 mammalian species, implantation can be suspended at blastocyst stage for a certain time and reactivated under favorable conditions, a phenomenon known as embryonic diapause. Until now, the underlying molecular mechanism governing embryonic diapause …
Among nearly 100 mammalian species, implantation can be suspended at blastocyst stage for a certain time and reactivated under favorable con …
Genetic deletion of Cxcl14 in mice alters uterine NK cells.
Cao Q, Chen H, Deng Z, Yue J, Chen Q, Cao Y, Ning L, Lei X, Duan E. Cao Q, et al. Among authors: chen q. Biochem Biophys Res Commun. 2013 Jun 14;435(4):664-70. doi: 10.1016/j.bbrc.2013.04.106. Epub 2013 May 18. Biochem Biophys Res Commun. 2013. PMID: 23688424
The uterine natural killer cells (uNK cells) are the major immune cells in pregnant uterus and the number of uNK cells is dramatically increased during placentation and embryo development. The uNK cells are necessary for the immune tolerance, cytokine secretion and angioge …
The uterine natural killer cells (uNK cells) are the major immune cells in pregnant uterus and the number of uNK cells is dramatically incre …
Navigating the site for embryo implantation: biomechanical and molecular regulation of intrauterine embryo distribution.
Chen Q, Zhang Y, Elad D, Jaffa AJ, Cao Y, Ye X, Duan E. Chen Q, et al. Mol Aspects Med. 2013 Oct;34(5):1024-42. doi: 10.1016/j.mam.2012.07.017. Epub 2012 Aug 14. Mol Aspects Med. 2013. PMID: 22921800 Review.
The distribution of intrauterine embryo implantation site(s) in most mammalian species shows remarkably constant patterns: in monotocous species such as humans, an embryo tends to implant in the uterine fundus; in polytocous species such as rodents, embryo
The distribution of intrauterine embryo implantation site(s) in most mammalian species shows remarkably constant patterns: in …
Transient {beta}2-adrenoceptor activation confers pregnancy loss by disrupting embryo spacing at implantation.
Chen Q, Zhang Y, Peng H, Lei L, Kuang H, Zhang L, Ning L, Cao Y, Duan E. Chen Q, et al. J Biol Chem. 2011 Feb 11;286(6):4349-56. doi: 10.1074/jbc.M110.197202. Epub 2010 Dec 9. J Biol Chem. 2011. PMID: 21148315 Free PMC article.
The abnormal embryo spacing could be prevented by pretreatment of beta(2)-AR antagonist or genetic ablation of beta-AR. Similar beta(2)-AR activation at day 5 postcoitus, when implantation sites have been established, did not affect embryo spacing or pregnancy outco …
The abnormal embryo spacing could be prevented by pretreatment of beta(2)-AR antagonist or genetic ablation of beta-AR. Similar beta( …
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