((schmitz-ml[Author]) NOT (Rock) NOT (children) NOT (stoner) NOT (aarhus) NOT (Atlanta) NOT (Zurich) ) OR (Lienhard Schmitz[Author]) - Search Results

Year	Number of Results
1989	1
1991	2
1993	1
1994	2
1995	4
1996	4
1997	6
1998	6
1999	6
2000	9
2001	5
2002	9
2003	6
2004	7
2005	6
2006	8
2007	6
2008	6
2009	8
2010	4
2011	6
2012	8
2013	6
2014	9
2015	5
2016	6
2017	4
2018	6
2019	8
2020	8
2021	8
2022	7
2023	8
2024	7
2025	2

1

The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA.

Leib L, Juli J, Jurida L, Mayr-Buro C, Priester J, Weiser H, Wirth S, Hanel S, Heylmann D, Weber A, Schmitz ML, Papantonis A, Bartkuhn M, Wilhelm J, Linne U, Meier-Soelch J, Kracht M. Leib L, et al. Among authors: schmitz ml. EMBO Rep. 2025 Feb;26(4):1144-1183. doi: 10.1038/s44319-024-00339-8. Epub 2025 Jan 3. EMBO Rep. 2025. PMID: 39753783 Free PMC article.

2

SIAH3 is frequently epigenetically silenced in cancer and regulates mitochondrial metabolism.

Deutschmeyer VE, Schlaudraff NA, Walesch SK, Moyer J, Sokol AM, Graumann J, Meissner W, Schneider M, Muley T, Helmbold P, Schwinn M, Richter AM, Schmitz ML, Dammann RH. Deutschmeyer VE, et al. Among authors: schmitz ml. Int J Cancer. 2025 Jan 15;156(2):353-367. doi: 10.1002/ijc.35202. Epub 2024 Sep 30. Int J Cancer. 2025. PMID: 39344659 Free PMC article.

3

Distinct negative-sense RNA viruses induce a common set of transcripts encoding proteins forming an extensive network.

Hofmann N, Bartkuhn M, Becker S, Biedenkopf N, Böttcher-Friebertshäuser E, Brinkrolf K, Dietzel E, Fehling SK, Goesmann A, Heindl MR, Hoffmann S, Karl N, Maisner A, Mostafa A, Kornecki L, Müller-Kräuter H, Müller-Ruttloff C, Nist A, Pleschka S, Sauerhering L, Stiewe T, Strecker T, Wilhelm J, Wuerth JD, Ziebuhr J, Weber F, Schmitz ML. Hofmann N, et al. Among authors: schmitz ml. J Virol. 2024 Oct 22;98(10):e0093524. doi: 10.1128/jvi.00935-24. Epub 2024 Sep 16. J Virol. 2024. PMID: 39283124 Free PMC article.

4

A common gene signature of the right ventricle in failing rat and human hearts.

Jurida L, Werner S, Knapp F, Niemann B, Li L, Grün D, Wirth S, Weber A, Beuerlein K, Liebetrau C, Wiedenroth CB, Guth S, Kojonazarov B, Jafari L, Weissmann N, Günther S, Braun T, Bartkuhn M, Schermuly RT, Dorfmüller P, Yin X, Mayr M, Schmitz ML, Czech L, Schlüter KD, Schulz R, Rohrbach S, Kracht M. Jurida L, et al. Among authors: schmitz ml. Nat Cardiovasc Res. 2024 Jul;3(7):819-840. doi: 10.1038/s44161-024-00485-1. Epub 2024 Jul 5. Nat Cardiovasc Res. 2024. PMID: 39196177 Free PMC article.

5

The Aurora B-controlled PP1/RepoMan complex determines the spatial and temporal distribution of mitotic H2B S6 phosphorylation.

Pfisterer M, Robert R, Saul VV, Pritz A, Seibert M, Feederle R, Schmitz ML. Pfisterer M, et al. Among authors: schmitz ml. Open Biol. 2024 May;14(5):230460. doi: 10.1098/rsob.230460. Epub 2024 May 29. Open Biol. 2024. PMID: 38806145 Free PMC article.

6

Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat.

Li L, Niemann B, Knapp F, Werner S, Mühlfeld C, Schneider JP, Jurida LM, Molenda N, Schmitz ML, Yin X, Mayr M, Schulz R, Kracht M, Rohrbach S. Li L, et al. Among authors: schmitz ml. Basic Res Cardiol. 2024 Aug;119(4):587-611. doi: 10.1007/s00395-024-01051-3. Epub 2024 May 17. Basic Res Cardiol. 2024. PMID: 38758338

7

A reductionist perspective on HIF-1α's role in cell proliferation under non-hypoxic conditions.

Dreute J, Pfisterer M, Schmitz ML. Dreute J, et al. Among authors: schmitz ml. Biochim Biophys Acta Mol Cell Res. 2024 Mar;1871(3):119683. doi: 10.1016/j.bbamcr.2024.119683. Epub 2024 Feb 1. Biochim Biophys Acta Mol Cell Res. 2024. PMID: 38301905 Free article. Review.

8

Open questions in the NF-κB field.

Bacher S, Schmitz ML. Bacher S, et al. Among authors: schmitz ml. Biochim Biophys Acta Mol Cell Res. 2024 Feb;1871(2):119469. doi: 10.1016/j.bbamcr.2023.119469. Epub 2023 Nov 9. Biochim Biophys Acta Mol Cell Res. 2024. PMID: 37951506 Free article. Review.

9

Understanding and Therapeutic Targeting of the p53 Network.

Bacher S, Schmitz ML. Bacher S, et al. Among authors: schmitz ml. Cancers (Basel). 2023 Sep 7;15(18):4461. doi: 10.3390/cancers15184461. Cancers (Basel). 2023. PMID: 37760430 Free PMC article.

10

A transient increase of HIF-1α during the G1 phase (G1-HIF) ensures cell survival under nutritional stress.

Belapurkar R, Pfisterer M, Dreute J, Werner S, Zukunft S, Fleming I, Kracht M, Schmitz ML. Belapurkar R, et al. Among authors: schmitz ml. Cell Death Dis. 2023 Jul 27;14(7):477. doi: 10.1038/s41419-023-06012-7. Cell Death Dis. 2023. PMID: 37500648 Free PMC article.

11

Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5'-termini of RNA and polymerase function.

Liu L, Madhugiri R, Saul VV, Bacher S, Kracht M, Pleschka S, Schmitz ML. Liu L, et al. Among authors: schmitz ml. Sci Rep. 2023 Apr 29;13(1):7042. doi: 10.1038/s41598-023-34285-7. Sci Rep. 2023. PMID: 37120635 Free PMC article.

12

Introducing the Special Issue on "Emerging Concepts & Non-Canonical Pathways in Cellular Signaling".

Bultynck G, Khan S, Schmitz ML. Bultynck G, et al. Among authors: schmitz ml. Biochim Biophys Acta Mol Cell Res. 2023 Jun;1870(5):119478. doi: 10.1016/j.bbamcr.2023.119478. Epub 2023 Apr 18. Biochim Biophys Acta Mol Cell Res. 2023. PMID: 37080361 Free article. No abstract available.

13

Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation.

Yang X, Wu ST, Gao R, Wang R, Wang Y, Dong Z, Wang L, Qi C, Wang X, Schmitz ML, Liu R, Han Z, Wang L, Zheng X. Yang X, et al. Among authors: schmitz ml. JCI Insight. 2023 Mar 8;8(5):e160372. doi: 10.1172/jci.insight.160372. JCI Insight. 2023. PMID: 36692953 Free PMC article.

14

Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex.

Liu L, Weber A, Linne U, Shehata M, Pleschka S, Kracht M, Schmitz ML. Liu L, et al. Among authors: schmitz ml. mBio. 2023 Feb 28;14(1):e0323122. doi: 10.1128/mbio.03231-22. Epub 2023 Jan 5. mBio. 2023. PMID: 36602306 Free PMC article.

15

Reply to: The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein.

Shaban MS, Müller C, Mayr-Buro C, Weiser H, Schmitz ML, Ziebuhr J, Kracht M. Shaban MS, et al. Among authors: schmitz ml. Nat Commun. 2022 Nov 14;13(1):6550. doi: 10.1038/s41467-022-34066-2. Nat Commun. 2022. PMID: 36376283 Free PMC article. No abstract available.

16

Testing the Effect of Histone Acetyltransferases on Local Chromatin Compaction.

Pfisterer M, Schmitz ML. Pfisterer M, et al. Among authors: schmitz ml. Methods Mol Biol. 2023;2589:361-376. doi: 10.1007/978-1-0716-2788-4_24. Methods Mol Biol. 2023. PMID: 36255637

17

Post-Transcriptional Control of mRNA Metabolism and Protein Secretion: The Third Level of Regulation within the NF-κB System.

Priester J, Dreute J, Kracht M, Schmitz ML. Priester J, et al. Among authors: schmitz ml. Biomedicines. 2022 Aug 29;10(9):2108. doi: 10.3390/biomedicines10092108. Biomedicines. 2022. PMID: 36140209 Free PMC article. Review.

18

Therapeutic induction of Bcl2-associated athanogene 3-mediated autophagy in idiopathic pulmonary fibrosis.

Chillappagari S, Schwarz J, Kesireddy V, Knoell J, Korfei M, Hoetzenecker K, Schmitz ML, Behl C, Bellusci S, Guenther A, Mahavadi P. Chillappagari S, et al. Among authors: schmitz ml. Clin Transl Med. 2022 Jul;12(7):e935. doi: 10.1002/ctm2.935. Clin Transl Med. 2022. PMID: 35834635 Free PMC article.

19

Comparative kinase activity profiling of pathogenic influenza A viruses reveals new anti- and pro-viral protein kinases.

Liu L, Weiß A, Saul VV, Schermuly RT, Pleschka S, Schmitz ML. Liu L, et al. Among authors: schmitz ml. J Gen Virol. 2022 Jun;103(6). doi: 10.1099/jgv.0.001762. J Gen Virol. 2022. PMID: 35771598

20

Thapsigargin: key to new host-directed coronavirus antivirals?

Shaban MS, Mayr-Buro C, Meier-Soelch J, Albert BV, Schmitz ML, Ziebuhr J, Kracht M. Shaban MS, et al. Among authors: schmitz ml. Trends Pharmacol Sci. 2022 Jul;43(7):557-568. doi: 10.1016/j.tips.2022.04.004. Epub 2022 Apr 18. Trends Pharmacol Sci. 2022. PMID: 35534355 Free PMC article. Review.

21

SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression.

Schmitz ML, Dreute J, Pfisterer M, Günther S, Kracht M, Chillappagari S. Schmitz ML, et al. Heliyon. 2022 Mar 1;8(3):e09029. doi: 10.1016/j.heliyon.2022.e09029. eCollection 2022 Mar. Heliyon. 2022. PMID: 35284677 Free PMC article.

22

Monitoring the Levels of Cellular NF-κB Activation States.

Meier-Soelch J, Mayr-Buro C, Juli J, Leib L, Linne U, Dreute J, Papantonis A, Schmitz ML, Kracht M. Meier-Soelch J, et al. Among authors: schmitz ml. Cancers (Basel). 2021 Oct 26;13(21):5351. doi: 10.3390/cancers13215351. Cancers (Basel). 2021. PMID: 34771516 Free PMC article. Review.

23

Multi-level inhibition of coronavirus replication by chemical ER stress.

Shaban MS, Müller C, Mayr-Buro C, Weiser H, Meier-Soelch J, Albert BV, Weber A, Linne U, Hain T, Babayev I, Karl N, Hofmann N, Becker S, Herold S, Schmitz ML, Ziebuhr J, Kracht M. Shaban MS, et al. Among authors: schmitz ml. Nat Commun. 2021 Sep 20;12(1):5536. doi: 10.1038/s41467-021-25551-1. Nat Commun. 2021. PMID: 34545074 Free PMC article.

24

A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival.

Lara-Chica M, Correa-Sáez A, Jiménez-Izquierdo R, Garrido-Rodríguez M, Ponce FJ, Moreno R, Morrison K, Di Vona C, Arató K, Jiménez-Jiménez C, Morrugares R, Schmitz ML, de la Luna S, de la Vega L, Calzado MA. Lara-Chica M, et al. Among authors: schmitz ml. Cell Death Differ. 2022 Jan;29(1):105-117. doi: 10.1038/s41418-021-00845-5. Epub 2021 Aug 6. Cell Death Differ. 2022. PMID: 34363019 Free PMC article.

25

TRAF6 Phosphorylation Prevents Its Autophagic Degradation and Re-Shapes LPS-Triggered Signaling Networks.

Busch J, Moreno R, de la Vega L, Saul VV, Bacher S, von Zweydorf F, Ueffing M, Weber A, Gloeckner CJ, Linne U, Kracht M, Schmitz ML. Busch J, et al. Among authors: schmitz ml. Cancers (Basel). 2021 Jul 19;13(14):3618. doi: 10.3390/cancers13143618. Cancers (Basel). 2021. PMID: 34298830 Free PMC article.

26

MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival.

Bacher S, Stekman H, Farah CM, Karger A, Kracht M, Schmitz ML. Bacher S, et al. Among authors: schmitz ml. Mol Cell Biol. 2021 Sep 24;41(10):e0008121. doi: 10.1128/MCB.00081-21. Epub 2021 Jul 12. Mol Cell Biol. 2021. PMID: 34251884 Free PMC article.

27

Regulation of Transcription Factor NF-κB in Its Natural Habitat: The Nucleus.

Bacher S, Meier-Soelch J, Kracht M, Schmitz ML. Bacher S, et al. Among authors: schmitz ml. Cells. 2021 Mar 29;10(4):753. doi: 10.3390/cells10040753. Cells. 2021. PMID: 33805563 Free PMC article. Review.

28

Corrigendum to "NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation" [Biochim. Biophys. Acta Mol. Cell Res., 1864 (2017): 1785-1798].

Riedlinger T, Dommerholt MB, Wijshake T, Kruit JK, Huijkman N, Dekker D, Koster M, Kloosterhuis N, Koonen DPY, de Bruin A, Baker D, Hofker MH, van Deursen J, Jonker JW, Lienhard Schmitz M, van de Sluis B. Riedlinger T, et al. Among authors: lienhard schmitz m. Biochim Biophys Acta Mol Cell Res. 2021 May;1868(6):119008. doi: 10.1016/j.bbamcr.2021.119008. Epub 2021 Mar 11. Biochim Biophys Acta Mol Cell Res. 2021. PMID: 33715857 Free article. No abstract available.

29

Chromatin Targeting of HIPK2 Leads to Acetylation-Dependent Chromatin Decondensation.

Haas J, Bloesel D, Bacher S, Kracht M, Schmitz ML. Haas J, et al. Among authors: schmitz ml. Front Cell Dev Biol. 2020 Sep 1;8:852. doi: 10.3389/fcell.2020.00852. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32984337 Free PMC article.

30

Dynamic mRNP Remodeling in Response to Internal and External Stimuli.

Zarnack K, Balasubramanian S, Gantier MP, Kunetsky V, Kracht M, Schmitz ML, Sträßer K. Zarnack K, et al. Among authors: schmitz ml. Biomolecules. 2020 Sep 11;10(9):1310. doi: 10.3390/biom10091310. Biomolecules. 2020. PMID: 32932892 Free PMC article. Review.

31

Mutual regulation of metabolic processes and proinflammatory NF-κB signaling.

Kracht M, Müller-Ladner U, Schmitz ML. Kracht M, et al. Among authors: schmitz ml. J Allergy Clin Immunol. 2020 Oct;146(4):694-705. doi: 10.1016/j.jaci.2020.07.027. Epub 2020 Aug 6. J Allergy Clin Immunol. 2020. PMID: 32771559 Free article. Review.

32

Defective BACH1/HO-1 regulatory circuits in cystic fibrosis bronchial epithelial cells.

Chillappagari S, Garapati V, Mahavadi P, Naehrlich L, Schmeck BT, Schmitz ML, Guenther A. Chillappagari S, et al. Among authors: schmitz ml. J Cyst Fibros. 2021 Jan;20(1):140-148. doi: 10.1016/j.jcf.2020.05.006. Epub 2020 Jun 11. J Cyst Fibros. 2021. PMID: 32534959 Free article.

33

SIAH2-mediated and organ-specific restriction of HO-1 expression by a dual mechanism.

Chillappagari S, Belapurkar R, Möller A, Molenda N, Kracht M, Rohrbach S, Schmitz ML. Chillappagari S, et al. Among authors: schmitz ml. Sci Rep. 2020 Feb 10;10(1):2268. doi: 10.1038/s41598-020-59005-3. Sci Rep. 2020. PMID: 32042051 Free PMC article.

34

Porphyromonas gingivalis Cell Wall Components Induce Programmed Death Ligand 1 (PD-L1) Expression on Human Oral Carcinoma Cells by a Receptor-Interacting Protein Kinase 2 (RIP2)-Dependent Mechanism.

Groeger S, Denter F, Lochnit G, Schmitz ML, Meyle J. Groeger S, et al. Among authors: schmitz ml. Infect Immun. 2020 Apr 20;88(5):e00051-20. doi: 10.1128/IAI.00051-20. Print 2020 Apr 20. Infect Immun. 2020. PMID: 32041789 Free PMC article.

35

Priming chromatin for segregation: functional roles of mitotic histone modifications.

Schmitz ML, Higgins JMG, Seibert M. Schmitz ML, et al. Cell Cycle. 2020 Mar;19(6):625-641. doi: 10.1080/15384101.2020.1719585. Epub 2020 Jan 28. Cell Cycle. 2020. PMID: 31992120 Free PMC article. Review.

36

Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner.

Weiterer SS, Meier-Soelch J, Georgomanolis T, Mizi A, Beyerlein A, Weiser H, Brant L, Mayr-Buro C, Jurida L, Beuerlein K, Müller H, Weber A, Tenekeci U, Dittrich-Breiholz O, Bartkuhn M, Nist A, Stiewe T, van IJcken WF, Riedlinger T, Schmitz ML, Papantonis A, Kracht M. Weiterer SS, et al. Among authors: schmitz ml. EMBO J. 2020 Jan 2;39(1):e101533. doi: 10.15252/embj.2019101533. Epub 2019 Nov 7. EMBO J. 2020. PMID: 31701553 Free PMC article.

37

ULK1/2 Restricts the Formation of Inducible SINT-Speckles, Membraneless Organelles Controlling the Threshold of TBK1 Activation.

Saul VV, Seibert M, Krüger M, Jeratsch S, Kracht M, Schmitz ML. Saul VV, et al. Among authors: schmitz ml. iScience. 2019 Sep 27;19:527-544. doi: 10.1016/j.isci.2019.08.001. Epub 2019 Aug 6. iScience. 2019. PMID: 31442668 Free PMC article.

38

Single-Cell Analysis of Multiple Steps of Dynamic NF-κB Regulation in Interleukin-1α-Triggered Tumor Cells Using Proximity Ligation Assays.

Mayr-Buro C, Schlereth E, Beuerlein K, Tenekeci U, Meier-Soelch J, Schmitz ML, Kracht M. Mayr-Buro C, et al. Among authors: schmitz ml. Cancers (Basel). 2019 Aug 16;11(8):1199. doi: 10.3390/cancers11081199. Cancers (Basel). 2019. PMID: 31426445 Free PMC article.

39

Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression.

Riedlinger T, Bartkuhn M, Zimmermann T, Hake SB, Nist A, Stiewe T, Kracht M, Schmitz ML. Riedlinger T, et al. Among authors: schmitz ml. Cancers (Basel). 2019 Jun 25;11(6):883. doi: 10.3390/cancers11060883. Cancers (Basel). 2019. PMID: 31242600 Free PMC article.

40

Differential intracellular localization and dynamic nucleocytoplasmic shuttling of homeodomain-interacting protein kinase family members.

Ritter O, Schmitz ML. Ritter O, et al. Among authors: schmitz ml. Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1676-1686. doi: 10.1016/j.bbamcr.2019.04.009. Epub 2019 Apr 25. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 31029697 Free article.

41

Phosphoproteome Analysis of Cells Infected with Adapted and Nonadapted Influenza A Virus Reveals Novel Pro- and Antiviral Signaling Networks.

Weber A, Dam S, Saul VV, Kuznetsova I, Müller C, Fritz-Wolf K, Becker K, Linne U, Gu H, Stokes MP, Pleschka S, Kracht M, Schmitz ML. Weber A, et al. Among authors: schmitz ml. J Virol. 2019 Jun 14;93(13):e00528-19. doi: 10.1128/JVI.00528-19. Print 2019 Jul 1. J Virol. 2019. PMID: 30996098 Free PMC article.

42

CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation.

Seibert M, Krüger M, Watson NA, Sen O, Daum JR, Slotman JA, Braun T, Houtsmuller AB, Gorbsky GJ, Jacob R, Kracht M, Higgins JMG, Schmitz ML. Seibert M, et al. Among authors: schmitz ml. J Cell Biol. 2019 Apr 1;218(4):1164-1181. doi: 10.1083/jcb.201806057. Epub 2019 Feb 14. J Cell Biol. 2019. PMID: 30765437 Free PMC article.

43

NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression.

Riedlinger T, Liefke R, Meier-Soelch J, Jurida L, Nist A, Stiewe T, Kracht M, Schmitz ML. Riedlinger T, et al. Among authors: schmitz ml. FASEB J. 2019 Mar;33(3):4188-4202. doi: 10.1096/fj.201801638R. Epub 2018 Dec 7. FASEB J. 2019. PMID: 30526044 Free PMC article.

44

The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection.

Schmitz ML, Shaban MS, Albert BV, Gökçen A, Kracht M. Schmitz ML, et al. Biomedicines. 2018 May 16;6(2):58. doi: 10.3390/biomedicines6020058. Biomedicines. 2018. PMID: 29772680 Free PMC article. Review.

45

Correction: Riedlinger, T. et al. The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-In Mice. Biomedicines, 2018, 6, 36.

Riedlinger T, Haas J, Busch J, van de Sluis B, Kracht M, Schmitz ML. Riedlinger T, et al. Among authors: schmitz ml. Biomedicines. 2018 May 16;6(2):57. doi: 10.3390/biomedicines6020057. Biomedicines. 2018. PMID: 29772656 Free PMC article. No abstract available.

46

RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes.

Meier-Soelch J, Jurida L, Weber A, Newel D, Kim J, Braun T, Schmitz ML, Kracht M. Meier-Soelch J, et al. Among authors: schmitz ml. Front Immunol. 2018 Apr 27;9:775. doi: 10.3389/fimmu.2018.00775. eCollection 2018. Front Immunol. 2018. PMID: 29755455 Free PMC article.

47

Formaldehyde-assisted Isolation of Regulatory Elements to Measure Chromatin Accessibility in Mammalian Cells.

Rodríguez-Gil A, Riedlinger T, Ritter O, Saul VV, Schmitz ML. Rodríguez-Gil A, et al. Among authors: schmitz ml. J Vis Exp. 2018 Apr 2;(134):57272. doi: 10.3791/57272. J Vis Exp. 2018. PMID: 29658938 Free PMC article.

48

The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice.

Riedlinger T, Haas J, Busch J, van de Sluis B, Kracht M, Schmitz ML. Riedlinger T, et al. Among authors: schmitz ml. Biomedicines. 2018 Mar 19;6(1):36. doi: 10.3390/biomedicines6010036. Biomedicines. 2018. PMID: 29562713 Free PMC article. Review.

49

NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.

Riedlinger T, Dommerholt MB, Wijshake T, Kruit JK, Huijkman N, Dekker D, Koster M, Kloosterhuis N, Koonen DPY, de Bruin A, Baker D, Hofker MH, van Deursen J, Jonker JW, Schmitz ML, van de Sluis B. Riedlinger T, et al. Among authors: schmitz ml. Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1785-1798. doi: 10.1016/j.bbamcr.2017.07.005. Epub 2017 Jul 16. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28723419 Free article.

50

The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription.

Rodríguez-Gil A, Ritter O, Saul VV, Wilhelm J, Yang CY, Grosschedl R, Imai Y, Kuba K, Kracht M, Schmitz ML. Rodríguez-Gil A, et al. Among authors: schmitz ml. Sci Rep. 2017 Jun 14;7(1):3547. doi: 10.1038/s41598-017-03708-7. Sci Rep. 2017. PMID: 28615693 Free PMC article.

51

The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells.

Poppe M, Wittig S, Jurida L, Bartkuhn M, Wilhelm J, Müller H, Beuerlein K, Karl N, Bhuju S, Ziebuhr J, Schmitz ML, Kracht M. Poppe M, et al. Among authors: schmitz ml. PLoS Pathog. 2017 Mar 29;13(3):e1006286. doi: 10.1371/journal.ppat.1006286. eCollection 2017 Mar. PLoS Pathog. 2017. PMID: 28355270 Free PMC article.

52

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping.

Tenekeci U, Poppe M, Beuerlein K, Buro C, Müller H, Weiser H, Kettner-Buhrow D, Porada K, Newel D, Xu M, Chen ZJ, Busch J, Schmitz ML, Kracht M. Tenekeci U, et al. Among authors: schmitz ml. Mol Cell. 2016 Aug 4;63(3):540. doi: 10.1016/j.molcel.2016.07.009. Epub 2016 Aug 4. Mol Cell. 2016. PMID: 27494559 Free article. No abstract available.

53

Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases.

Hagenbucher J, Stekman H, Rodriguez-Gil A, Kracht M, Schmitz ML. Hagenbucher J, et al. Among authors: schmitz ml. Methods Mol Biol. 2017;1510:297-312. doi: 10.1007/978-1-4939-6527-4_22. Methods Mol Biol. 2017. PMID: 27761830

54

The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB.

Dam S, Kracht M, Pleschka S, Schmitz ML. Dam S, et al. Among authors: schmitz ml. J Virol. 2016 Aug 12;90(17):7980-90. doi: 10.1128/JVI.00946-16. Print 2016 Sep 1. J Virol. 2016. PMID: 27356900 Free PMC article.

55

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping.

Tenekeci U, Poppe M, Beuerlein K, Buro C, Müller H, Weiser H, Kettner-Buhrow D, Porada K, Newel D, Xu M, Chen ZJ, Busch J, Schmitz ML, Kracht M. Tenekeci U, et al. Among authors: schmitz ml. Mol Cell. 2016 Jun 16;62(6):943-957. doi: 10.1016/j.molcel.2016.05.017. Mol Cell. 2016. PMID: 27315556 Free article.

56

SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies.

Liang YC, Lee CC, Yao YL, Lai CC, Schmitz ML, Yang WM. Liang YC, et al. Among authors: schmitz ml. Sci Rep. 2016 May 23;6:26509. doi: 10.1038/srep26509. Sci Rep. 2016. PMID: 27211601 Free PMC article.

57

HIPK family kinases bind and regulate the function of the CCR4-NOT complex.

Rodriguez-Gil A, Ritter O, Hornung J, Stekman H, Krüger M, Braun T, Kremmer E, Kracht M, Schmitz ML. Rodriguez-Gil A, et al. Among authors: schmitz ml. Mol Biol Cell. 2016 Jun 15;27(12):1969-80. doi: 10.1091/mbc.E15-09-0629. Epub 2016 Apr 27. Mol Biol Cell. 2016. PMID: 27122605 Free PMC article.

58

Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression.

Schmitz ML, Kracht M. Schmitz ML, et al. Trends Pharmacol Sci. 2016 Feb;37(2):101-113. doi: 10.1016/j.tips.2015.10.004. Epub 2015 Dec 22. Trends Pharmacol Sci. 2016. PMID: 26719217 Review.

59

Mutations of c-Cbl in myeloid malignancies.

Katzav S, Schmitz ML. Katzav S, et al. Among authors: schmitz ml. Oncotarget. 2015 May 10;6(13):10689-96. doi: 10.18632/oncotarget.3986. Oncotarget. 2015. PMID: 26028666 Free PMC article. Review.

60

The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65.

Jurida L, Soelch J, Bartkuhn M, Handschick K, Müller H, Newel D, Weber A, Dittrich-Breiholz O, Schneider H, Bhuju S, Saul VV, Schmitz ML, Kracht M. Jurida L, et al. Among authors: schmitz ml. Cell Rep. 2015 Feb 10;10(5):726-739. doi: 10.1016/j.celrep.2015.01.001. Epub 2015 Feb 5. Cell Rep. 2015. PMID: 25660023 Free article.

61

SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity.

Saul VV, Niedenthal R, Pich A, Weber F, Schmitz ML. Saul VV, et al. Among authors: schmitz ml. Biochim Biophys Acta. 2015 Jan;1853(1):136-43. doi: 10.1016/j.bbamcr.2014.10.008. Epub 2014 Oct 14. Biochim Biophys Acta. 2015. PMID: 25409927 Free article.

62

The intricate interplay between RNA viruses and NF-κB.

Schmitz ML, Kracht M, Saul VV. Schmitz ML, et al. Biochim Biophys Acta. 2014 Nov;1843(11):2754-2764. doi: 10.1016/j.bbamcr.2014.08.004. Epub 2014 Aug 10. Biochim Biophys Acta. 2014. PMID: 25116307 Free PMC article. Review.

63

Thrombin selectively induces transcription of genes in human monocytes involved in inflammation and wound healing.

López ML, Bruges G, Crespo G, Salazar V, Deglesne PA, Schneider H, Cabrera-Fuentes H, Schmitz ML, Preissner KT. López ML, et al. Among authors: schmitz ml. Thromb Haemost. 2014 Nov;112(5):992-1001. doi: 10.1160/TH14-01-0034. Epub 2014 Jul 24. Thromb Haemost. 2014. PMID: 25057055

64

SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells.

Müller S, Chen Y, Ginter T, Schäfer C, Buchwald M, Schmitz LM, Klitzsch J, Schütz A, Haitel A, Schmid K, Moriggl R, Kenner L, Friedrich K, Haan C, Petersen I, Heinzel T, Krämer OH. Müller S, et al. Among authors: schmitz lm. Oncotarget. 2014 May 30;5(10):3184-96. doi: 10.18632/oncotarget.1899. Oncotarget. 2014. PMID: 24833526 Free PMC article.

65

Expression pattern of protease activated receptors in lymphoid cells.

López ML, Soriano-Sarabia N, Bruges G, Marquez ME, Preissner KT, Schmitz ML, Hackstein H. López ML, et al. Among authors: schmitz ml. Cell Immunol. 2014 Mar-Apr;288(1-2):47-52. doi: 10.1016/j.cellimm.2014.02.004. Epub 2014 Feb 28. Cell Immunol. 2014. PMID: 24637088

66

Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-κB-dependent gene expression.

Handschick K, Beuerlein K, Jurida L, Bartkuhn M, Müller H, Soelch J, Weber A, Dittrich-Breiholz O, Schneider H, Scharfe M, Jarek M, Stellzig J, Schmitz ML, Kracht M. Handschick K, et al. Among authors: schmitz ml. Mol Cell. 2014 Jan 23;53(2):193-208. doi: 10.1016/j.molcel.2013.12.002. Epub 2014 Jan 2. Mol Cell. 2014. PMID: 24389100 Free article.

67

New Insights into the Role of Histone Deacetylases as Coactivators of Inflammatory Gene Expression.

Schmitz ML, de la Vega L. Schmitz ML, et al. Antioxid Redox Signal. 2015 Jul 1;23(1):85-98. doi: 10.1089/ars.2013.5750. Epub 2014 Mar 13. Antioxid Redox Signal. 2015. PMID: 24359078 Review.

68

Integration of stress signals by homeodomain interacting protein kinases.

Schmitz ML, Rodriguez-Gil A, Hornung J. Schmitz ML, et al. Biol Chem. 2014 Apr;395(4):375-86. doi: 10.1515/hsz-2013-0264. Biol Chem. 2014. PMID: 24225127 Free article. Review.

69

Deregulated expression of TANK in glioblastomas triggers pro-tumorigenic ERK1/2 and AKT signaling pathways.

Stellzig J, Chariot A, Shostak K, Ismail Göktuna S, Renner F, Acker T, Pagenstecher A, Schmitz ML. Stellzig J, et al. Among authors: schmitz ml. Oncogenesis. 2013 Nov 11;2(11):e79. doi: 10.1038/oncsis.2013.42. Oncogenesis. 2013. PMID: 24217713 Free PMC article.

70

The cytokine-induced conformational switch of nuclear factor κB p65 is mediated by p65 phosphorylation.

Milanovic M, Kracht M, Schmitz ML. Milanovic M, et al. Among authors: schmitz ml. Biochem J. 2014 Feb 1;457(3):401-13. doi: 10.1042/BJ20130780. Biochem J. 2014. PMID: 24175631

71

Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons.

Klenke C, Widera D, Engelen T, Müller J, Noll T, Niehaus K, Schmitz ML, Kaltschmidt B, Kaltschmidt C. Klenke C, et al. Among authors: schmitz ml. PLoS One. 2013 Jun 7;8(6):e65280. doi: 10.1371/journal.pone.0065280. Print 2013. PLoS One. 2013. PMID: 23762333 Free PMC article.

72

Homeodomain-interacting protein kinase 2-dependent repression of myogenic differentiation is relieved by its caspase-mediated cleavage.

de la Vega L, Hornung J, Kremmer E, Milanovic M, Schmitz ML. de la Vega L, et al. Among authors: schmitz ml. Nucleic Acids Res. 2013 Jun;41(11):5731-45. doi: 10.1093/nar/gkt262. Epub 2013 Apr 24. Nucleic Acids Res. 2013. PMID: 23620283 Free PMC article.

73

Posttranslational modifications regulate HIPK2, a driver of proliferative diseases.

Saul VV, Schmitz ML. Saul VV, et al. Among authors: schmitz ml. J Mol Med (Berl). 2013 Sep;91(9):1051-8. doi: 10.1007/s00109-013-1042-0. Epub 2013 Apr 25. J Mol Med (Berl). 2013. PMID: 23616089 Review.

74

Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression.

Buss H, Handschick K, Jurrmann N, Pekkonen P, Beuerlein K, Müller H, Wait R, Saklatvala J, Ojala PM, Schmitz ML, Naumann M, Kracht M. Buss H, et al. Among authors: schmitz ml. PLoS One. 2012;7(12):e51847. doi: 10.1371/journal.pone.0051847. Epub 2012 Dec 26. PLoS One. 2012. PMID: 23300567 Free PMC article.

75

Regulation of the tumor suppressor PML by sequential post-translational modifications.

Schmitz ML, Grishina I. Schmitz ML, et al. Front Oncol. 2012 Dec 31;2:204. doi: 10.3389/fonc.2012.00204. eCollection 2012. Front Oncol. 2012. PMID: 23293771 Free PMC article.

76

The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.

Ziesché E, Kettner-Buhrow D, Weber A, Wittwer T, Jurida L, Soelch J, Müller H, Newel D, Kronich P, Schneider H, Dittrich-Breiholz O, Bhaskara S, Hiebert SW, Hottiger MO, Li H, Burstein E, Schmitz ML, Kracht M. Ziesché E, et al. Among authors: schmitz ml. Nucleic Acids Res. 2013 Jan 7;41(1):90-109. doi: 10.1093/nar/gks916. Epub 2012 Oct 19. Nucleic Acids Res. 2013. PMID: 23087373 Free PMC article.

77

SIAH-mediated ubiquitination and degradation of acetyl-transferases regulate the p53 response and protein acetylation.

Grishina I, Debus K, García-Limones C, Schneider C, Shresta A, García C, Calzado MA, Schmitz ML. Grishina I, et al. Among authors: schmitz ml. Biochim Biophys Acta. 2012 Dec;1823(12):2287-96. doi: 10.1016/j.bbamcr.2012.09.011. Epub 2012 Oct 6. Biochim Biophys Acta. 2012. PMID: 23044042 Free article.

78

HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop.

Saul VV, de la Vega L, Milanovic M, Krüger M, Braun T, Fritz-Wolf K, Becker K, Schmitz ML. Saul VV, et al. Among authors: schmitz ml. J Mol Cell Biol. 2013 Feb;5(1):27-38. doi: 10.1093/jmcb/mjs053. Epub 2012 Sep 20. J Mol Cell Biol. 2013. PMID: 23000554

79

Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways.

Pérez M, García-Limones C, Zapico I, Marina A, Schmitz ML, Muñoz E, Calzado MA. Pérez M, et al. Among authors: schmitz ml. J Mol Cell Biol. 2012 Oct;4(5):316-30. doi: 10.1093/jmcb/mjs047. Epub 2012 Aug 9. J Mol Cell Biol. 2012. PMID: 22878263

80

A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress.

de la Vega L, Grishina I, Moreno R, Krüger M, Braun T, Schmitz ML. de la Vega L, et al. Among authors: schmitz ml. Mol Cell. 2012 May 25;46(4):472-83. doi: 10.1016/j.molcel.2012.03.003. Epub 2012 Apr 12. Mol Cell. 2012. PMID: 22503103 Free article.

81

Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines.

Schmitz ML, Weber A, Roxlau T, Gaestel M, Kracht M. Schmitz ML, et al. Biochim Biophys Acta. 2011 Dec;1813(12):2165-75. doi: 10.1016/j.bbamcr.2011.06.019. Epub 2011 Jul 20. Biochim Biophys Acta. 2011. PMID: 21787809 Free article. Review.

82

The dual function cytokine IL-33 interacts with the transcription factor NF-κB to dampen NF-κB-stimulated gene transcription.

Ali S, Mohs A, Thomas M, Klare J, Ross R, Schmitz ML, Martin MU. Ali S, et al. Among authors: schmitz ml. J Immunol. 2011 Aug 15;187(4):1609-16. doi: 10.4049/jimmunol.1003080. Epub 2011 Jul 6. J Immunol. 2011. PMID: 21734074

83

Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination.

Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine GN, Kracht M, Schmitz ML, Burstein E. Li H, et al. Among authors: schmitz ml. Oncogene. 2012 Feb 2;31(5):611-23. doi: 10.1038/onc.2011.253. Epub 2011 Jun 27. Oncogene. 2012. PMID: 21706061 Free PMC article.

84

Improved intraportal islet transplantation outcome by systemic IKK-beta inhibition: NF-κB activity in pancreatic islets depends on oxygen availability.

Chen C, Moreno R, Samikannu B, Bretzel RG, Schmitz ML, Linn T. Chen C, et al. Among authors: schmitz ml. Am J Transplant. 2011 Feb;11(2):215-24. doi: 10.1111/j.1600-6143.2010.03390.x. Epub 2011 Jan 10. Am J Transplant. 2011. PMID: 21219576 Free article.

85

Inducible SUMO modification of TANK alleviates its repression of TLR7 signalling.

Renner F, Saul VV, Pagenstecher A, Wittwer T, Schmitz ML. Renner F, et al. Among authors: schmitz ml. EMBO Rep. 2011 Feb;12(2):129-35. doi: 10.1038/embor.2010.207. Epub 2011 Jan 7. EMBO Rep. 2011. PMID: 21212807 Free PMC article.

86

Control of nuclear HIPK2 localization and function by a SUMO interaction motif.

de la Vega L, Fröbius K, Moreno R, Calzado MA, Geng H, Schmitz ML. de la Vega L, et al. Among authors: schmitz ml. Biochim Biophys Acta. 2011 Feb;1813(2):283-97. doi: 10.1016/j.bbamcr.2010.11.022. Epub 2010 Dec 8. Biochim Biophys Acta. 2011. PMID: 21145359 Free article.

87

The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions.

Ritterhoff S, Farah CM, Grabitzki J, Lochnit G, Skurat AV, Schmitz ML. Ritterhoff S, et al. Among authors: schmitz ml. EMBO J. 2010 Nov 17;29(22):3750-61. doi: 10.1038/emboj.2010.251. Epub 2010 Oct 12. EMBO J. 2010. PMID: 20940704 Free PMC article.

88

Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon.

Moreno R, Sobotzik JM, Schultz C, Schmitz ML. Moreno R, et al. Among authors: schmitz ml. Nucleic Acids Res. 2010 Oct;38(18):6029-44. doi: 10.1093/nar/gkq439. Epub 2010 May 27. Nucleic Acids Res. 2010. PMID: 20507904 Free PMC article.

89

SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death.

Renner F, Moreno R, Schmitz ML. Renner F, et al. Among authors: schmitz ml. Mol Cell. 2010 Feb 26;37(4):503-15. doi: 10.1016/j.molcel.2010.01.018. Mol Cell. 2010. PMID: 20188669 Free article.

90

Autoregulatory control of the p53 response by Siah-1L-mediated HIPK2 degradation.

Calzado MA, de la Vega L, Muñoz E, Schmitz ML. Calzado MA, et al. Among authors: schmitz ml. Biol Chem. 2009 Oct;390(10):1079-83. doi: 10.1515/BC.2009.112. Biol Chem. 2009. PMID: 19642869

91

Activation of T cells: releasing the brakes by proteolytic elimination of Cbl-b.

Schmitz ML. Schmitz ML. Sci Signal. 2009 Jun 23;2(76):pe38. doi: 10.1126/scisignal.276pe38. Sci Signal. 2009. PMID: 19549983 Review.

92

The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4.

Yamada D, Pérez-Torrado R, Filion G, Caly M, Jammart B, Devignot V, Sasai N, Ravassard P, Mallet J, Sastre-Garau X, Schmitz ML, Defossez PA. Yamada D, et al. Among authors: schmitz ml. Oncogene. 2009 Jul 9;28(27):2535-44. doi: 10.1038/onc.2009.109. Epub 2009 May 18. Oncogene. 2009. PMID: 19448668

93

From top to bottom: the two faces of HIPK2 for regulation of the hypoxic response.

Calzado MA, De La Vega L, Munoz E, Schmitz ML. Calzado MA, et al. Among authors: schmitz ml. Cell Cycle. 2009 Jun 1;8(11):1659-64. doi: 10.4161/cc.8.11.8597. Cell Cycle. 2009. PMID: 19448429

94

Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination.

Geng H, Wittwer T, Dittrich-Breiholz O, Kracht M, Schmitz ML. Geng H, et al. Among authors: schmitz ml. EMBO Rep. 2009 Apr;10(4):381-6. doi: 10.1038/embor.2009.10. Epub 2009 Mar 6. EMBO Rep. 2009. PMID: 19270718 Free PMC article.

95

Autoregulatory feedback loops terminating the NF-kappaB response.

Renner F, Schmitz ML. Renner F, et al. Among authors: schmitz ml. Trends Biochem Sci. 2009 Mar;34(3):128-35. doi: 10.1016/j.tibs.2008.12.003. Epub 2009 Feb 21. Trends Biochem Sci. 2009. PMID: 19233657 Review.

96

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.

Calzado MA, de la Vega L, Möller A, Bowtell DD, Schmitz ML. Calzado MA, et al. Among authors: schmitz ml. Nat Cell Biol. 2009 Jan;11(1):85-91. doi: 10.1038/ncb1816. Epub 2008 Nov 30. Nat Cell Biol. 2009. PMID: 19043406

97

PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage.

Gresko E, Ritterhoff S, Sevilla-Perez J, Roscic A, Fröbius K, Kotevic I, Vichalkovski A, Hess D, Hemmings BA, Schmitz ML. Gresko E, et al. Among authors: schmitz ml. Oncogene. 2009 Feb 5;28(5):698-708. doi: 10.1038/onc.2008.420. Epub 2008 Nov 17. Oncogene. 2009. PMID: 19015637

98

Functional architecture of the cell nucleus.

Schmitz ML, Herrmann H. Schmitz ML, et al. Biochim Biophys Acta. 2008 Nov;1783(11):2041-3. doi: 10.1016/j.bbamcr.2008.09.007. Biochim Biophys Acta. 2008. PMID: 18929934 Free article. No abstract available.

99

A bacterial small molecule undermining immune response signaling.

Schmitz ML, de la Vega L. Schmitz ML, et al. Chembiochem. 2008 Nov 3;9(16):2575-7. doi: 10.1002/cbic.200800562. Chembiochem. 2008. PMID: 18823058 No abstract available.

100

NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation.

Wittwer T, Schmitz ML. Wittwer T, et al. Among authors: schmitz ml. Biochem Biophys Res Commun. 2008 Jun 27;371(2):294-7. doi: 10.1016/j.bbrc.2008.04.069. Epub 2008 Apr 23. Biochem Biophys Res Commun. 2008. PMID: 18439422

101

Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii.

Moussaieff A, Shein NA, Tsenter J, Grigoriadis S, Simeonidou C, Alexandrovich AG, Trembovler V, Ben-Neriah Y, Schmitz ML, Fiebich BL, Munoz E, Mechoulam R, Shohami E. Moussaieff A, et al. Among authors: schmitz ml. J Cereb Blood Flow Metab. 2008 Jul;28(7):1341-52. doi: 10.1038/jcbfm.2008.28. Epub 2008 Apr 16. J Cereb Blood Flow Metab. 2008. PMID: 18414499

102

Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation.

Moussaieff A, Shohami E, Kashman Y, Fride E, Schmitz ML, Renner F, Fiebich BL, Munoz E, Ben-Neriah Y, Mechoulam R. Moussaieff A, et al. Among authors: schmitz ml. Mol Pharmacol. 2007 Dec;72(6):1657-64. doi: 10.1124/mol.107.038810. Epub 2007 Sep 25. Mol Pharmacol. 2007. PMID: 17895408

103

The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein.

de la Vega L, Sánchez-Duffhues G, Fresno M, Schmitz ML, Muñoz E, Calzado MA. de la Vega L, et al. Among authors: schmitz ml. J Mol Biol. 2007 Sep 14;372(2):317-30. doi: 10.1016/j.jmb.2007.06.075. Epub 2007 Jul 3. J Mol Biol. 2007. PMID: 17669424

104

Integration of the activation of the human hyaluronan synthase 2 gene promoter by common cofactors of the transcription factors retinoic acid receptor and nuclear factor kappaB.

Saavalainen K, Tammi MI, Bowen T, Schmitz ML, Carlberg C. Saavalainen K, et al. Among authors: schmitz ml. J Biol Chem. 2007 Apr 13;282(15):11530-9. doi: 10.1074/jbc.M607871200. Epub 2007 Feb 15. J Biol Chem. 2007. PMID: 17307735 Free article.

105

NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer.

Calzado MA, Bacher S, Schmitz ML. Calzado MA, et al. Among authors: schmitz ml. Curr Med Chem. 2007;14(3):367-76. doi: 10.2174/092986707779941113. Curr Med Chem. 2007. PMID: 17305539 Review.

106

HIPK2: a versatile switchboard regulating the transcription machinery and cell death.

Calzado MA, Renner F, Roscic A, Schmitz ML. Calzado MA, et al. Among authors: schmitz ml. Cell Cycle. 2007 Jan 15;6(2):139-43. doi: 10.4161/cc.6.2.3788. Epub 2007 Jan 29. Cell Cycle. 2007. PMID: 17245128 Review.

107

Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells.

Wesierska-Gadek J, Schmitz ML, Ranftler C. Wesierska-Gadek J, et al. Among authors: schmitz ml. J Cell Biochem. 2007 Mar 1;100(4):865-74. doi: 10.1002/jcb.21211. J Cell Biochem. 2007. PMID: 17203463

108

Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.

Roscic A, Möller A, Calzado MA, Renner F, Wimmer VC, Gresko E, Lüdi KS, Schmitz ML. Roscic A, et al. Among authors: schmitz ml. Mol Cell. 2006 Oct 6;24(1):77-89. doi: 10.1016/j.molcel.2006.08.004. Mol Cell. 2006. PMID: 17018294 Free article.

109

The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway.

López-Antón N, Rudy A, Barth N, Schmitz ML, Pettit GR, Schulze-Osthoff K, Dirsch VM, Vollmar AM. López-Antón N, et al. Among authors: schmitz ml. J Biol Chem. 2006 Nov 3;281(44):33078-86. doi: 10.1074/jbc.M607904200. Epub 2006 Aug 31. J Biol Chem. 2006. PMID: 16945918 Free article.

110

Electrophysiology studies without fluoroscopy.

Zabala LM, Schmitz ML, Ullah S, Watkins WB, Tuzcu V. Zabala LM, et al. Among authors: schmitz ml. Anesth Analg. 2006 Sep;103(3):780; author reply 780. doi: 10.1213/01.ANE.0000227144.84027.4E. Anesth Analg. 2006. PMID: 16931700 No abstract available.

111

Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.

Aikawa Y, Nguyen LA, Isono K, Takakura N, Tagata Y, Schmitz ML, Koseki H, Kitabayashi I. Aikawa Y, et al. Among authors: schmitz ml. EMBO J. 2006 Sep 6;25(17):3955-65. doi: 10.1038/sj.emboj.7601273. Epub 2006 Aug 17. EMBO J. 2006. PMID: 16917507 Free PMC article.

112

Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

Gresko E, Roscic A, Ritterhoff S, Vichalkovski A, del Sal G, Schmitz ML. Gresko E, et al. Among authors: schmitz ml. EMBO J. 2006 May 3;25(9):1883-94. doi: 10.1038/sj.emboj.7601077. Epub 2006 Apr 6. EMBO J. 2006. PMID: 16601678 Free PMC article.

113

Controlling NF-kappaB activation in T cells by costimulatory receptors.

Schmitz ML, Krappmann D. Schmitz ML, et al. Cell Death Differ. 2006 May;13(5):834-42. doi: 10.1038/sj.cdd.4401845. Cell Death Differ. 2006. PMID: 16410801 Review.

114

Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon.

Mattioli I, Geng H, Sebald A, Hodel M, Bucher C, Kracht M, Schmitz ML. Mattioli I, et al. Among authors: schmitz ml. J Biol Chem. 2006 Mar 10;281(10):6175-83. doi: 10.1074/jbc.M508045200. Epub 2006 Jan 3. J Biol Chem. 2006. PMID: 16407239 Free article.

115

Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB.

Waschbisch A, Fiebich BL, Akundi RS, Schmitz ML, Hoozemans JJ, Candelario-Jalil E, Virtainen N, Veerhuis R, Slawik H, Yrjänheikki J, Hüll M. Waschbisch A, et al. Among authors: schmitz ml. J Neurochem. 2006 Feb;96(3):680-93. doi: 10.1111/j.1471-4159.2005.03599.x. Epub 2006 Jan 9. J Neurochem. 2006. PMID: 16405508 Free article.

116

IL-17 reduces TNF-induced Rantes and VCAM-1 expression.

Schnyder B, Schnyder-Candrian S, Pansky A, Schmitz ML, Heim M, Ryffel B, Moser R. Schnyder B, et al. Among authors: schmitz ml. Cytokine. 2005 Aug 7;31(3):191-202. doi: 10.1016/j.cyto.2005.02.012. Cytokine. 2005. PMID: 15975820

117

Inhibition of NF-kappaB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus.

Calzado MA, Lüdi KS, Fiebich B, Ben-Neriah Y, Bacher S, Munoz E, Ballero M, Prosperini S, Appendino G, Schmitz ML. Calzado MA, et al. Among authors: schmitz ml. Biochim Biophys Acta. 2005 Jun 30;1729(2):88-93. doi: 10.1016/j.bbaexp.2005.04.007. Biochim Biophys Acta. 2005. PMID: 15949852

118

Inhibition of mitosis by glycopeptide dendrimer conjugates of colchicine.

Lagnoux D, Darbre T, Schmitz ML, Reymond JL. Lagnoux D, et al. Among authors: schmitz ml. Chemistry. 2005 Jun 20;11(13):3941-50. doi: 10.1002/chem.200401294. Chemistry. 2005. PMID: 15861378

119

Role of CREB1 and NF{kappa}B-p65 in the down-regulation of renin gene expression by tumor necrosis factor {alpha}.

Todorov VT, Völkl S, Friedrich J, Kunz-Schughart LA, Hehlgans T, Vermeulen L, Haegeman G, Schmitz ML, Kurtz A. Todorov VT, et al. Among authors: schmitz ml. J Biol Chem. 2005 Jul 1;280(26):24356-62. doi: 10.1074/jbc.M502968200. Epub 2005 Apr 27. J Biol Chem. 2005. PMID: 15857826 Free article.

120

Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability.

Gresko E, Möller A, Roscic A, Schmitz ML. Gresko E, et al. Among authors: schmitz ml. Biochem Biophys Res Commun. 2005 Apr 22;329(4):1293-9. doi: 10.1016/j.bbrc.2005.02.113. Biochem Biophys Res Commun. 2005. PMID: 15766567

121

T cell receptor-induced lipid raft recruitment of the I kappa B kinase complex is necessary and sufficient for NF-kappa B activation occurring in the cytosol.

Sebald A, Mattioli I, Schmitz ML. Sebald A, et al. Among authors: schmitz ml. Eur J Immunol. 2005 Jan;35(1):318-25. doi: 10.1002/eji.200425024. Eur J Immunol. 2005. PMID: 15597322 Free article.

122

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.

Buss H, Dörrie A, Schmitz ML, Hoffmann E, Resch K, Kracht M. Buss H, et al. Among authors: schmitz ml. J Biol Chem. 2004 Dec 31;279(53):55633-43. doi: 10.1074/jbc.M409825200. Epub 2004 Oct 15. J Biol Chem. 2004. PMID: 15489227 Free article.

123

Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity.

Buss H, Dörrie A, Schmitz ML, Frank R, Livingstone M, Resch K, Kracht M. Buss H, et al. Among authors: schmitz ml. J Biol Chem. 2004 Nov 26;279(48):49571-4. doi: 10.1074/jbc.C400442200. Epub 2004 Oct 1. J Biol Chem. 2004. PMID: 15465828 Free article.

124

NF-kappaB: a multifaceted transcription factor regulated at several levels.

Schmitz ML, Mattioli I, Buss H, Kracht M. Schmitz ML, et al. Chembiochem. 2004 Oct 4;5(10):1348-58. doi: 10.1002/cbic.200400144. Chembiochem. 2004. PMID: 15457532 Review.

125

The NF-kappaB pathway as a potential target for autoimmune disease therapy.

Bacher S, Schmitz ML. Bacher S, et al. Among authors: schmitz ml. Curr Pharm Des. 2004;10(23):2827-37. doi: 10.2174/1381612043383584. Curr Pharm Des. 2004. PMID: 15379671 Review.

126

Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes.

Mattioli I, Dittrich-Breiholz O, Livingstone M, Kracht M, Schmitz ML. Mattioli I, et al. Among authors: schmitz ml. Blood. 2004 Nov 15;104(10):3302-4. doi: 10.1182/blood-2004-04-1536. Epub 2004 Jul 27. Blood. 2004. PMID: 15280197 Free article.

127

Of mice and men.

Ben-Neriah Y, Schmitz ML. Ben-Neriah Y, et al. Among authors: schmitz ml. EMBO Rep. 2004 Jul;5(7):668-73. doi: 10.1038/sj.embor.7400187. Epub 2004 Jun 25. EMBO Rep. 2004. PMID: 15218526 Free PMC article.

128

Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import.

Mattioli I, Sebald A, Bucher C, Charles RP, Nakano H, Doi T, Kracht M, Schmitz ML. Mattioli I, et al. Among authors: schmitz ml. J Immunol. 2004 May 15;172(10):6336-44. doi: 10.4049/jimmunol.172.10.6336. J Immunol. 2004. PMID: 15128824

129

HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells.

Hofmann TG, Stollberg N, Schmitz ML, Will H. Hofmann TG, et al. Among authors: schmitz ml. Cancer Res. 2003 Dec 1;63(23):8271-7. Cancer Res. 2003. PMID: 14678985

130

NF-kappaB activation pathways induced by T cell costimulation.

Schmitz ML, Bacher S, Dienz O. Schmitz ML, et al. FASEB J. 2003 Dec;17(15):2187-93. doi: 10.1096/fj.02-1100rev. FASEB J. 2003. PMID: 14656980 Review.

131

Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression.

Möller A, Sirma H, Hofmann TG, Staege H, Gresko E, Lüdi KS, Klimczak E, Dröge W, Will H, Schmitz ML. Möller A, et al. Among authors: schmitz ml. Oncogene. 2003 Nov 27;22(54):8731-7. doi: 10.1038/sj.onc.1207079. Oncogene. 2003. PMID: 14647468

132

Viruses as hijackers of PML nuclear bodies.

Möller A, Schmitz ML. Möller A, et al. Among authors: schmitz ml. Arch Immunol Ther Exp (Warsz). 2003;51(5):295-300. Arch Immunol Ther Exp (Warsz). 2003. PMID: 14626429 Review.

133

PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.

Möller A, Sirma H, Hofmann TG, Rueffer S, Klimczak E, Dröge W, Will H, Schmitz ML. Möller A, et al. Among authors: schmitz ml. Cancer Res. 2003 Aug 1;63(15):4310-4. Cancer Res. 2003. PMID: 12907596

134

Prohibitin and prohibitone are contained in high-molecular weight complexes and interact with alpha-actinin and annexin A2.

Bacher S, Achatz G, Schmitz ML, Lamers MC. Bacher S, et al. Among authors: schmitz ml. Biochimie. 2002 Dec;84(12):1207-20. doi: 10.1016/s0300-9084(02)00027-5. Biochimie. 2002. PMID: 12628297

135

The promoter context determines mutual repression or synergism between NF-kappaB and the glucocorticoid receptor.

Hofmann TG, Schmitz ML. Hofmann TG, et al. Among authors: schmitz ml. Biol Chem. 2002 Dec;383(12):1947-51. doi: 10.1515/BC.2002.219. Biol Chem. 2002. PMID: 12553732

136

Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and phospholipase C gamma 1 are required for NF-kappa B activation and lipid raft recruitment of protein kinase C theta induced by T cell costimulation.

Dienz O, Möller A, Strecker A, Stephan N, Krammer PH, Dröge W, Schmitz ML. Dienz O, et al. Among authors: schmitz ml. J Immunol. 2003 Jan 1;170(1):365-72. doi: 10.4049/jimmunol.170.1.365. J Immunol. 2003. PMID: 12496421

137

Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness.

Bantel H, Schmitz ML, Raible A, Gregor M, Schulze-Osthoff K. Bantel H, et al. Among authors: schmitz ml. FASEB J. 2002 Nov;16(13):1832-4. doi: 10.1096/fj.02-0223fje. Epub 2002 Sep 5. FASEB J. 2002. PMID: 12223450

138

The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants.

Nheu TV, He H, Hirokawa Y, Tamaki K, Florin L, Schmitz ML, Suzuki-Takahashi I, Jorissen RN, Burgess AW, Nishimura S, Wood J, Maruta H. Nheu TV, et al. Among authors: schmitz ml. Cancer J. 2002 Jul-Aug;8(4):328-36. doi: 10.1097/00130404-200207000-00009. Cancer J. 2002. PMID: 12184411

139

Molecular analysis of mitogen-activated protein kinase signaling pathways induced by reactive oxygen intermediates.

Schmitz ML, Bacher S, Dröge W. Schmitz ML, et al. Methods Enzymol. 2002;352:53-61. doi: 10.1016/s0076-6879(02)52006-1. Methods Enzymol. 2002. PMID: 12125376 No abstract available.

140

Lipoteichoic acid selectively induces the ERK signaling pathway in the cornea.

You L, Kruse FE, Bacher S, Schmitz ML. You L, et al. Among authors: schmitz ml. Invest Ophthalmol Vis Sci. 2002 Jul;43(7):2272-7. Invest Ophthalmol Vis Sci. 2002. PMID: 12091427

141

Phenotype and regulation of persistent intracerebral T cells in murine Toxoplasma encephalitis.

Schlüter D, Meyer T, Kwok LY, Montesinos-Rongen M, Lütjen S, Strack A, Schmitz ML, Deckert M. Schlüter D, et al. Among authors: schmitz ml. J Immunol. 2002 Jul 1;169(1):315-22. doi: 10.4049/jimmunol.169.1.315. J Immunol. 2002. PMID: 12077260

142

The human papillomavirus oncoprotein E7 attenuates NF-kappa B activation by targeting the Ikappa B kinase complex.

Spitkovsky D, Hehner SP, Hofmann TG, Möller A, Schmitz ML. Spitkovsky D, et al. Among authors: schmitz ml. J Biol Chem. 2002 Jul 12;277(28):25576-82. doi: 10.1074/jbc.M201884200. Epub 2002 May 1. J Biol Chem. 2002. PMID: 11986318 Free article.

143

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.

Hofmann TG, Möller A, Sirma H, Zentgraf H, Taya Y, Dröge W, Will H, Schmitz ML. Hofmann TG, et al. Among authors: schmitz ml. Nat Cell Biol. 2002 Jan;4(1):1-10. doi: 10.1038/ncb715. Nat Cell Biol. 2002. PMID: 11740489

144

CD95-induced JNK activation signals are transmitted by the death-inducing signaling complex (DISC), but not by Daxx.

Hofmann TG, Möller A, Hehner SP, Welsch D, Dröge W, Schmitz ML. Hofmann TG, et al. Among authors: schmitz ml. Int J Cancer. 2001 Jul 15;93(2):185-91. doi: 10.1002/ijc.1316. Int J Cancer. 2001. PMID: 11410864

145

The Drosophila proteins Pelle and Tube induce JNK/AP-1 activity in mammalian cells.

Bacher S, Grosshans J, Dröge W, Schmitz ML. Bacher S, et al. Among authors: schmitz ml. FEBS Lett. 2001 May 25;497(2-3):153-8. doi: 10.1016/s0014-5793(01)02454-1. FEBS Lett. 2001. PMID: 11377431 Free article.

146

Pheophorbide A from Solanum diflorum interferes with NF-kappa B activation.

Heinrich M, Bork PM, Schmitz ML, Rimpler H, Frei B, Sticher O. Heinrich M, et al. Among authors: schmitz ml. Planta Med. 2001 Mar;67(2):156-7. doi: 10.1055/s-2001-11496. Planta Med. 2001. PMID: 11301864

147

Protein kinase C theta cooperates with Vav1 to induce JNK activity in T-cells.

Möller A, Dienz O, Hehner SP, Dröge W, Schmitz ML. Möller A, et al. Among authors: schmitz ml. J Biol Chem. 2001 Jun 8;276(23):20022-8. doi: 10.1074/jbc.M011139200. Epub 2001 Mar 23. J Biol Chem. 2001. PMID: 11274147 Free article.

148

I kappa B-independent control of NF-kappa B activity by modulatory phosphorylations.

Schmitz ML, Bacher S, Kracht M. Schmitz ML, et al. Trends Biochem Sci. 2001 Mar;26(3):186-90. doi: 10.1016/s0968-0004(00)01753-9. Trends Biochem Sci. 2001. PMID: 11246025 Review.

149

Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34.

Hofmann TG, Mincheva A, Lichter P, Dröge W, Schmitz ML. Hofmann TG, et al. Among authors: schmitz ml. Biochimie. 2000 Dec;82(12):1123-7. doi: 10.1016/s0300-9084(00)01196-2. Biochimie. 2000. PMID: 11120354

150

Enhancement of T cell receptor signaling by a mild oxidative shift in the intracellular thiol pool.

Hehner SP, Breitkreutz R, Shubinsky G, Unsoeld H, Schulze-Osthoff K, Schmitz ML, Dröge W. Hehner SP, et al. Among authors: schmitz ml. J Immunol. 2000 Oct 15;165(8):4319-28. doi: 10.4049/jimmunol.165.8.4319. J Immunol. 2000. PMID: 11035067

151

End-of-life decisions in the neonatal intensive care unit: medical infanticide or palliative terminal care?

Schmitz ML, Taylor BJ, Anand KJ. Schmitz ML, et al. Crit Care Med. 2000 Jul;28(7):2668-71. doi: 10.1097/00003246-200007000-00092. Crit Care Med. 2000. PMID: 10921623 No abstract available.

152

Synergistic activation of NF-kappa B by functional cooperation between vav and PKCtheta in T lymphocytes.

Dienz O, Hehner SP, Droge W, Schmitz ML. Dienz O, et al. Among authors: schmitz ml. J Biol Chem. 2000 Aug 11;275(32):24547-51. doi: 10.1074/jbc.C000177200. J Biol Chem. 2000. PMID: 10862755 Free article.

153

Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription.

Hehner SP, Hofmann TG, Dienz O, Droge W, Schmitz ML. Hehner SP, et al. Among authors: schmitz ml. J Biol Chem. 2000 Jun 16;275(24):18160-71. doi: 10.1074/jbc.275.24.18160. J Biol Chem. 2000. PMID: 10849438 Free article.

154

The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus.

Kaltschmidt B, Kaltschmidt C, Hofmann TG, Hehner SP, Dröge W, Schmitz ML. Kaltschmidt B, et al. Among authors: schmitz ml. Eur J Biochem. 2000 Jun;267(12):3828-35. doi: 10.1046/j.1432-1327.2000.01421.x. Eur J Biochem. 2000. PMID: 10849002 Free article.

155

Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells.

Hehner SP, Li-Weber M, Giaisi M, Dröge W, Krammer PH, Schmitz ML. Hehner SP, et al. Among authors: schmitz ml. J Immunol. 2000 Apr 1;164(7):3829-36. doi: 10.4049/jimmunol.164.7.3829. J Immunol. 2000. PMID: 10725744

156

Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription.

Hofmann TG, Hehner SP, Dröge W, Schmitz ML. Hofmann TG, et al. Among authors: schmitz ml. Oncogene. 2000 Feb 24;19(9):1153-63. doi: 10.1038/sj.onc.1203406. Oncogene. 2000. PMID: 10713703

157

Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex.

Hehner SP, Hofmann TG, Ushmorov A, Dienz O, Wing-Lan Leung I, Lassam N, Scheidereit C, Dröge W, Schmitz ML. Hehner SP, et al. Among authors: schmitz ml. Mol Cell Biol. 2000 Apr;20(7):2556-68. doi: 10.1128/MCB.20.7.2556-2568.2000. Mol Cell Biol. 2000. PMID: 10713178 Free PMC article.

158

The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.

Hehner SP, Hofmann TG, Dröge W, Schmitz ML. Hehner SP, et al. Among authors: schmitz ml. J Immunol. 1999 Nov 15;163(10):5617-23. J Immunol. 1999. PMID: 10553091

159

Inhibition of tyrosine phosphatases induces apoptosis independent from the CD95 system.

Hehner SP, Hofmann TG, Dröge W, Schmitz ML. Hehner SP, et al. Among authors: schmitz ml. Cell Death Differ. 1999 Sep;6(9):833-41. doi: 10.1038/sj.cdd.4400559. Cell Death Differ. 1999. PMID: 10510465

160

Inhibition of tyrosine phosphatases antagonizes CD95-mediated apoptosis.

Hehner SP, Hofmann TG, Ratter F, Dröge W, Schmitz ML. Hehner SP, et al. Among authors: schmitz ml. Eur J Biochem. 1999 Aug;264(1):132-9. doi: 10.1046/j.1432-1327.1999.00587.x. Eur J Biochem. 1999. PMID: 10447681 Free article.

161

Hypericin as a non-antioxidant inhibitor of NF-kappa B.

Bork PM, Bacher S, Schmitz ML, Kaspers U, Heinrich M. Bork PM, et al. Among authors: schmitz ml. Planta Med. 1999 May;65(4):297-300. doi: 10.1055/s-1999-13989. Planta Med. 1999. PMID: 10364831

162

Repression of NF-kappaB impairs HeLa cell proliferation by functional interference with cell cycle checkpoint regulators.

Kaltschmidt B, Kaltschmidt C, Hehner SP, Dröge W, Schmitz ML. Kaltschmidt B, et al. Among authors: schmitz ml. Oncogene. 1999 May 27;18(21):3213-25. doi: 10.1038/sj.onc.1202657. Oncogene. 1999. PMID: 10359527

163

Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-kappaB.

Dumont A, Hehner SP, Hofmann TG, Ueffing M, Dröge W, Schmitz ML. Dumont A, et al. Among authors: schmitz ml. Oncogene. 1999 Jan 21;18(3):747-57. doi: 10.1038/sj.onc.1202325. Oncogene. 1999. PMID: 9989825

164

Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription.

Hofmann TG, Hehner SP, Bacher S, Dröge W, Schmitz ML. Hofmann TG, et al. Among authors: schmitz ml. FEBS Lett. 1998 Dec 28;441(3):441-6. doi: 10.1016/s0014-5793(98)01609-3. FEBS Lett. 1998. PMID: 9891987 Free article.

165

Co-stimulatory effect of nitric oxide on endothelial NF-kappaB implies a physiological self-amplifying mechanism.

Umansky V, Hehner SP, Dumont A, Hofmann TG, Schirrmacher V, Dröge W, Schmitz ML. Umansky V, et al. Among authors: schmitz ml. Eur J Immunol. 1998 Aug;28(8):2276-82. doi: 10.1002/(SICI)1521-4141(199808)28:08<2276::AID-IMMU2276>3.0.CO;2-H. Eur J Immunol. 1998. PMID: 9710205 Free article.

166

Cross-talk between steroids and NF-kappa B: what language?

Dumont A, Hehner SP, Schmitz ML, Gustafsson JA, Lidén J, Okret S, van der Saag PT, Wissink S, van der Burg B, Herrlich P, Haegeman G, De Bosscher K, Fiers W. Dumont A, et al. Among authors: schmitz ml. Trends Biochem Sci. 1998 Jul;23(7):233-5. doi: 10.1016/s0968-0004(98)01212-2. Trends Biochem Sci. 1998. PMID: 9697408 Review. No abstract available.

167

Tumor necrosis factor-alpha-induced cell killing and activation of transcription factor NF-kappaB are uncoupled in L929 cells.

Hehner SP, Hofmann TG, Ratter F, Dumont A, Dröge W, Schmitz ML. Hehner SP, et al. Among authors: schmitz ml. J Biol Chem. 1998 Jul 17;273(29):18117-21. doi: 10.1074/jbc.273.29.18117. J Biol Chem. 1998. PMID: 9660769 Free article.

168

p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.

Vanden Berghe W, Plaisance S, Boone E, De Bosscher K, Schmitz ML, Fiers W, Haegeman G. Vanden Berghe W, et al. Among authors: schmitz ml. J Biol Chem. 1998 Feb 6;273(6):3285-90. doi: 10.1074/jbc.273.6.3285. J Biol Chem. 1998. PMID: 9452444 Free article.

169

Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation.

De Bosscher K, Schmitz ML, Vanden Berghe W, Plaisance S, Fiers W, Haegeman G. De Bosscher K, et al. Among authors: schmitz ml. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13504-9. doi: 10.1073/pnas.94.25.13504. Proc Natl Acad Sci U S A. 1997. PMID: 9391055 Free PMC article.

170

Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta.

Hehner SP, Heinrich M, Bork PM, Vogt M, Ratter F, Lehmann V, Schulze-Osthoff K, Dröge W, Schmitz ML. Hehner SP, et al. Among authors: schmitz ml. J Biol Chem. 1998 Jan 16;273(3):1288-97. doi: 10.1074/jbc.273.3.1288. J Biol Chem. 1998. PMID: 9430659 Free article.

171

Distinct domains of the RelA NF-kappaB subunit are required for negative cross-talk and direct interaction with the glucocorticoid receptor.

Wissink S, van Heerde EC, Schmitz ML, Kalkhoven E, van der Burg B, Baeuerle PA, van der Saag PT. Wissink S, et al. Among authors: schmitz ml. J Biol Chem. 1997 Aug 29;272(35):22278-84. doi: 10.1074/jbc.272.35.22278. J Biol Chem. 1997. PMID: 9268377 Free article.

172

Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways.

Wesselborg S, Bauer MK, Vogt M, Schmitz ML, Schulze-Osthoff K. Wesselborg S, et al. Among authors: schmitz ml. J Biol Chem. 1997 May 9;272(19):12422-9. doi: 10.1074/jbc.272.19.12422. J Biol Chem. 1997. PMID: 9139689 Free article.

173

Basal transcription factors TBP and TFIIB and the viral coactivator E1A 13S bind with distinct affinities and kinetics to the transactivation domain of NF-kappaB p65.

Paal K, Baeuerle PA, Schmitz ML. Paal K, et al. Among authors: schmitz ml. Nucleic Acids Res. 1997 Mar 1;25(5):1050-5. doi: 10.1093/nar/25.5.1050. Nucleic Acids Res. 1997. PMID: 9023117 Free PMC article.

174

Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB.

Bork PM, Schmitz ML, Kuhnt M, Escher C, Heinrich M. Bork PM, et al. Among authors: schmitz ml. FEBS Lett. 1997 Jan 27;402(1):85-90. doi: 10.1016/s0014-5793(96)01502-5. FEBS Lett. 1997. PMID: 9013864 Free article.

175

Bacterial expression, purification, and potential use of His-tagged GAL4 fusion proteins.

Schmitz ML, Baeuerle PA. Schmitz ML, et al. Methods Mol Biol. 1997;63:129-37. doi: 10.1385/0-89603-481-X:129. Methods Mol Biol. 1997. PMID: 9113647 No abstract available.

176

Nahua indian medicinal plants (Mexico): Inhibitory activity on NF-κB as an anti-inflammatory model and antibacterial effects.

Bork PM, Schmitz ML, Weimann C, Kist M, Heinrich M. Bork PM, et al. Among authors: schmitz ml. Phytomedicine. 1996 Nov;3(3):263-9. doi: 10.1016/S0944-7113(96)80064-X. Phytomedicine. 1996. PMID: 23195081

177

A hydrophobic region within the adenovirus E1B 19 kDa protein is necessary for the transient inhibition of NF-kappaB activated by different stimuli.

Limbourg FP, Städtler H, Chinnadurai G, Baeuerle PA, Schmitz ML. Limbourg FP, et al. Among authors: schmitz ml. J Biol Chem. 1996 Aug 23;271(34):20392-8. doi: 10.1074/jbc.271.34.20392. J Biol Chem. 1996. PMID: 8702775 Free article.

178

The dual effect of adenovirus type 5 E1A 13S protein on NF-kappaB activation is antagonized by E1B 19K.

Schmitz ML, Indorf A, Limbourg FP, Städtler H, Traenckner EB, Baeuerle PA. Schmitz ML, et al. Mol Cell Biol. 1996 Aug;16(8):4052-63. doi: 10.1128/MCB.16.8.4052. Mol Cell Biol. 1996. PMID: 8754803 Free PMC article.

179

Sex reversal by loss of the C-terminal transactivation domain of human SOX9.

Südbeck P, Schmitz ML, Baeuerle PA, Scherer G. Südbeck P, et al. Among authors: schmitz ml. Nat Genet. 1996 Jun;13(2):230-2. doi: 10.1038/ng0696-230. Nat Genet. 1996. PMID: 8640233

180

Function and activation of the transcription factor NF-kappa B in the response to toxins and pathogens.

Schmitz ML. Schmitz ML. Toxicol Lett. 1995 Dec;82-83:407-11. doi: 10.1016/0378-4274(95)03491-9. Toxicol Lett. 1995. PMID: 8597085 Review.

181

Multi-step activation of NF-kappa B/Rel transcription factors.

Schmitz ML, Baeuerle PA. Schmitz ML, et al. Immunobiology. 1995 Jul;193(2-4):116-27. doi: 10.1016/s0171-2985(11)80534-6. Immunobiology. 1995. PMID: 8530134 Review.

182

Transactivation domain 2 (TA2) of p65 NF-kappa B. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells.

Schmitz ML, dos Santos Silva MA, Baeuerle PA. Schmitz ML, et al. J Biol Chem. 1995 Jun 30;270(26):15576-84. doi: 10.1074/jbc.270.26.15576. J Biol Chem. 1995. PMID: 7797554 Free article.

183

Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators.

Schmitz ML, Stelzer G, Altmann H, Meisterernst M, Baeuerle PA. Schmitz ML, et al. J Biol Chem. 1995 Mar 31;270(13):7219-26. doi: 10.1074/jbc.270.13.7219. J Biol Chem. 1995. PMID: 7706261 Free article.

184

Structural and functional analysis of the NF-kappa B p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation.

Schmitz ML, dos Santos Silva MA, Altmann H, Czisch M, Holak TA, Baeuerle PA. Schmitz ML, et al. J Biol Chem. 1994 Oct 14;269(41):25613-20. J Biol Chem. 1994. PMID: 7929265 Free article.

185

A vector, pHisGal, allowing bacterial production of proteins fused to a hexahistidine-tagged Gal4 DNA-binding domain.

Schmitz ML, Baeuerle PA. Schmitz ML, et al. Biotechniques. 1994 Oct;17(4):714-6, 718. Biotechniques. 1994. PMID: 7833034

186

Rapid characterization of lambda cDNA clones after amplification and radioactive labeling with the PCR technique.

Henkel T, Schmitz ML, Baeuerle PA. Henkel T, et al. Among authors: schmitz ml. Biotechniques. 1993 Jun;14(6):906-8. Biotechniques. 1993. PMID: 8333956 No abstract available.

187

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

Schmitz ML, Baeuerle PA. Schmitz ML, et al. EMBO J. 1991 Dec;10(12):3805-17. doi: 10.1002/j.1460-2075.1991.tb04950.x. EMBO J. 1991. PMID: 1935902 Free PMC article.

188

Proteins controlling the nuclear uptake of NF-kappa B, Rel and dorsal.

Schmitz ML, Henkel T, Baeuerle PA. Schmitz ML, et al. Trends Cell Biol. 1991 Nov;1(5):130-7. doi: 10.1016/0962-8924(91)90118-s. Trends Cell Biol. 1991. PMID: 14731544

189

Specific binding of nuclear proteins to the promoter region of a maize nuclear rRNA gene unit.

Schmitz ML, Maier UG, Brown JW, Feix G. Schmitz ML, et al. J Biol Chem. 1989 Jan 25;264(3):1467-72. J Biol Chem. 1989. PMID: 2912967 Free article.

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