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Recent advances in the development of tissue transglutaminase (TG2) inhibitors.
Badarau E, Collighan RJ, Griffin M. Badarau E, et al. Amino Acids. 2013 Jan;44(1):119-27. doi: 10.1007/s00726-011-1188-4. Epub 2011 Dec 13. Amino Acids. 2013. PMID: 22160259 Review.
However, upregulated levels of TG2 are associated with many disease states like celiac sprue, certain types of cancer, fibrosis, cystic fibrosis, multiple sclerosis, Alzheimer's, Huntington's and Parkinson's disease. ...
However, upregulated levels of TG2 are associated with many disease states like celiac sprue, certain types of cancer, fibrosis, c
A novel regulatory role for tissue transglutaminase in epithelial-mesenchymal transition in cystic fibrosis.
Nyabam S, Wang Z, Thibault T, Oluseyi A, Basar R, Marshall L, Griffin M. Nyabam S, et al. Biochim Biophys Acta. 2016 Sep;1863(9):2234-44. doi: 10.1016/j.bbamcr.2016.05.012. Epub 2016 May 24. Biochim Biophys Acta. 2016. PMID: 27234323 Free article.
Cystic fibrosis (CF) is a genetic disorder caused by mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) for which there is no overall effective treatment. ...Our data indicate that selective inhibition of TG2 provides a potentia
Cystic fibrosis (CF) is a genetic disorder caused by mutation of the cystic fibrosis transmembrane conductance r
Tissue transglutaminase activation modulates inflammation in cystic fibrosis via PPARgamma down-regulation.
Maiuri L, Luciani A, Giardino I, Raia V, Villella VR, D'Apolito M, Pettoello-Mantovani M, Guido S, Ciacci C, Cimmino M, Cexus ON, Londei M, Quaratino S. Maiuri L, et al. J Immunol. 2008 Jun 1;180(11):7697-705. doi: 10.4049/jimmunol.180.11.7697. J Immunol. 2008. PMID: 18490773 Free article.
Cystic fibrosis (CF), the most common life-threatening inherited disease in Caucasians, is due to mutations in the CF transmembrane conductance regulator (CFTR) gene and is characterized by airways chronic inflammation and pulmonary infections. ...
Cystic fibrosis (CF), the most common life-threatening inherited disease in Caucasians, is due to mutations in the CF transmem
Transglutaminase 2 and nucleoside diphosphate kinase activity are correlated in epithelial membranes and are abnormal in cystic fibrosis.
Treharne KJ, Giles Best O, Mehta A. Treharne KJ, et al. FEBS Lett. 2009 Sep 3;583(17):2789-92. doi: 10.1016/j.febslet.2009.07.026. Epub 2009 Jul 18. FEBS Lett. 2009. PMID: 19619546 Free PMC article.
In the epithelial cell membrane, we show that manipulation of tgase2 function by monodansylcadaverine or retinoic acid (RA) alters the activity of a membrane-bound protein kinase, nucleoside diphosphate kinase (NDPK, nm23-H1/H2) that is known to control G-protein function. We fin …
In the epithelial cell membrane, we show that manipulation of tgase2 function by monodansylcadaverine or retinoic acid (RA) alters the activ …
SUMOylation of tissue transglutaminase as link between oxidative stress and inflammation.
Luciani A, Villella VR, Vasaturo A, Giardino I, Raia V, Pettoello-Mantovani M, D'Apolito M, Guido S, Leal T, Quaratino S, Maiuri L. Luciani A, et al. J Immunol. 2009 Aug 15;183(4):2775-84. doi: 10.4049/jimmunol.0900993. Epub 2009 Jul 22. J Immunol. 2009. PMID: 19625650 Free article.
Cystic fibrosis (CF) is a monogenic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. ...
Cystic fibrosis (CF) is a monogenic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. ...
Transglutaminase 2 is dispensable but required for the survival of mice in dextran sulfate sodium-induced colitis.
Jeong EM, Son YH, Choi Y, Kim JH, Lee JH, Cho SY, Kim IG. Jeong EM, et al. Exp Mol Med. 2016 Nov 4;48(11):e267. doi: 10.1038/emm.2016.95. Exp Mol Med. 2016. PMID: 27811936 Free PMC article.
It has been reported that TG2 is involved in the pathogenesis of various inflammatory diseases including celiac disease, pulmonary fibrosis, cystic fibrosis, multiple sclerosis and sepsis. Recently, using a mouse model of bleomycin-induced lung fibrosis
It has been reported that TG2 is involved in the pathogenesis of various inflammatory diseases including celiac disease, pulmonary fibros
Production of recombinant human tissue transglutaminase using the baculovirus expression system, and its application for serological diagnosis of coeliac disease.
Osman AA, Richter T, Stern M, Conrad K, Henker J, Brandsch C, Zimmer KP, Mothes T. Osman AA, et al. Eur J Gastroenterol Hepatol. 2002 Nov;14(11):1217-23. doi: 10.1097/00042737-200211000-00009. Eur J Gastroenterol Hepatol. 2002. PMID: 12439116
For this, 35 patients with active CD were compared with 144 controls (18 patients with bioptically excluded CD, 89 blood donors, 30 patients with inflammatory bowel disease, and seven patients with cystic fibrosis). RESULTS: The ELISA using hu-tTG showed a sensitivi …
For this, 35 patients with active CD were compared with 144 controls (18 patients with bioptically excluded CD, 89 blood donors, 30 patients …
TgpA, a protein with a eukaryotic-like transglutaminase domain, plays a critical role in the viability of Pseudomonas aeruginosa.
Milani A, Vecchietti D, Rusmini R, Bertoni G. Milani A, et al. PLoS One. 2012;7(11):e50323. doi: 10.1371/journal.pone.0050323. Epub 2012 Nov 27. PLoS One. 2012. PMID: 23209712 Free PMC article.
The Gram-negative bacterium Pseudomonas aeruginosa is an important opportunistic pathogen in compromised individuals, such as patients with cystic fibrosis, severe burns or impaired immunity. In this work we aimed to screen novel essential genes of P. aeruginosa by …
The Gram-negative bacterium Pseudomonas aeruginosa is an important opportunistic pathogen in compromised individuals, such as patients with …
11 results