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Transglutaminase 2 and neuroinflammation.
Ientile R, Currò M, Caccamo D. Ientile R, et al. Amino Acids. 2015 Jan;47(1):19-26. doi: 10.1007/s00726-014-1864-2. Epub 2014 Nov 15. Amino Acids. 2015. PMID: 25398223 Review.
Several findings emphasize the possible role of the TG2/NF-kappaB activation pathway in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis. Although further studies are needed t …
Several findings emphasize the possible role of the TG2/NF-kappaB activation pathway in neurodegenerative diseases, including Alzheimer's di …
Transglutaminase-6 is an autoantigen in progressive multiple sclerosis and is upregulated in reactive astrocytes.
Cristofanilli M, Gratch D, Pagano B, McDermott K, Huang J, Jian J, Bates D, Sadiq SA. Cristofanilli M, et al. Mult Scler. 2017 Nov;23(13):1707-1715. doi: 10.1177/1352458516684022. Epub 2016 Dec 22. Mult Scler. 2017. PMID: 28273770
It has been proposed as an autoimmune target in cerebral palsy, gluten-sensitive cerebellar ataxia, and schizophrenia. OBJECTIVE: To investigate TGM6 involvement in multiple sclerosis (MS). METHODS: Antibody levels against TGM6 (TGM6-IgG) were measured in the cerebr …
It has been proposed as an autoimmune target in cerebral palsy, gluten-sensitive cerebellar ataxia, and schizophrenia. OBJECTIVE: To investi …
Is monocyte- and macrophage-derived tissue transglutaminase involved in inflammatory processes?
Chrobok NL, Sestito C, Wilhelmus MM, Drukarch B, van Dam AM. Chrobok NL, et al. Amino Acids. 2017 Mar;49(3):441-452. doi: 10.1007/s00726-016-2334-9. Epub 2016 Sep 22. Amino Acids. 2017. PMID: 27659795 Free PMC article. Review.
In addition, we discuss the role of TG2 in certain pathological conditions, in which inflammation and monocytes and/or macrophages are prominently present, including atherosclerosis, sepsis, and multiple sclerosis. Based on the studies and considerations reported in …
In addition, we discuss the role of TG2 in certain pathological conditions, in which inflammation and monocytes and/or macrophages are promi …
Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis.
Chrobok NL, Bol JGJM, Jongenelen CA, Brevé JJP, El Alaoui S, Wilhelmus MMM, Drukarch B, van Dam AM. Chrobok NL, et al. PLoS One. 2018 Apr 24;13(4):e0196433. doi: 10.1371/journal.pone.0196433. eCollection 2018. PLoS One. 2018. PMID: 29689097 Free PMC article.
The neurodegenerative disease multiple sclerosis (MS) is pathologically characterized by the massive influx of immune cells into the central nervous system. ...
The neurodegenerative disease multiple sclerosis (MS) is pathologically characterized by the massive influx of immune cells in …
Tissue Transglutaminase Promotes Early Differentiation of Oligodendrocyte Progenitor Cells.
Espitia Pinzon N, van Mierlo H, de Jonge JC, Brevé JJP, Bol JGJM, Drukarch B, van Dam AM, Baron W. Espitia Pinzon N, et al. Front Cell Neurosci. 2019 Jul 2;13:281. doi: 10.3389/fncel.2019.00281. eCollection 2019. Front Cell Neurosci. 2019. PMID: 31312122 Free PMC article.
Demyelinated lesions of the central nervous system are characteristic for multiple sclerosis (MS). Remyelination is not very effective, particular at later stages of the disease, which results in a chronic neurodegenerative character with worsening of symptoms. ...
Demyelinated lesions of the central nervous system are characteristic for multiple sclerosis (MS). Remyelination is not very e …
Tissue Transglutaminase contributes to experimental multiple sclerosis pathogenesis and clinical outcome by promoting macrophage migration.
van Strien ME, de Vries HE, Chrobok NL, Bol JGJM, Breve JJP, van der Pol SMP, Kooij G, van Buul JD, Karpuj M, Steinman L, Wilhelmus MM, Sestito C, Drukarch B, Van Dam AM. van Strien ME, et al. Brain Behav Immun. 2015 Nov;50:141-154. doi: 10.1016/j.bbi.2015.06.023. Epub 2015 Jun 29. Brain Behav Immun. 2015. PMID: 26133787
Multiple sclerosis is a serious neurological disorder, resulting in e.g., sensory, motor and cognitive deficits. A critical pathological aspect of multiple sclerosis (MS) is the influx of immunomodulatory cells into the central nervous system (CNS). ..
Multiple sclerosis is a serious neurological disorder, resulting in e.g., sensory, motor and cognitive deficits. A critical pa
Monocyte-derived tissue transglutaminase in multiple sclerosis patients: reflecting an anti-inflammatory status and function of the cells?
Sestito C, Brevé JJP, van Eggermond MCJA, Killestein J, Teunissen CE, van Rossum J, Wilhelmus MMM, Drukarch B, van den Elsen PJ, van Dam AM. Sestito C, et al. J Neuroinflammation. 2017 Dec 21;14(1):257. doi: 10.1186/s12974-017-1035-y. J Neuroinflammation. 2017. PMID: 29268771 Free PMC article.
BACKGROUND: Leukocyte infiltration into the central nervous system is an important feature of multiple sclerosis (MS) pathology. Among the infiltrating cells, monocytes comprise the largest population and are considered to play a dual role in the course of the disea …
BACKGROUND: Leukocyte infiltration into the central nervous system is an important feature of multiple sclerosis (MS) patholog …
Recent advances in the development of tissue transglutaminase (TG2) inhibitors.
Badarau E, Collighan RJ, Griffin M. Badarau E, et al. Amino Acids. 2013 Jan;44(1):119-27. doi: 10.1007/s00726-011-1188-4. Epub 2011 Dec 13. Amino Acids. 2013. PMID: 22160259 Review.
However, upregulated levels of TG2 are associated with many disease states like celiac sprue, certain types of cancer, fibrosis, cystic fibrosis, multiple sclerosis, Alzheimer's, Huntington's and Parkinson's disease. ...
However, upregulated levels of TG2 are associated with many disease states like celiac sprue, certain types of cancer, fibrosis, cystic fibr …
Tissue Transglutaminase Appears in Monocytes and Macrophages but Not in Lymphocytes in White Matter Multiple Sclerosis Lesions.
Chrobok NL, Bol JGJM, Wilhelmus MMM, Drukarch B, van Dam AM. Chrobok NL, et al. J Neuropathol Exp Neurol. 2019 Jun 1;78(6):492-500. doi: 10.1093/jnen/nlz030. J Neuropathol Exp Neurol. 2019. PMID: 31058279 Free PMC article.
Leukocyte infiltration is an important pathological hallmark of multiple sclerosis (MS) and is therefore targeted by current MS therapies. ...
Leukocyte infiltration is an important pathological hallmark of multiple sclerosis (MS) and is therefore targeted by current M …
Tissue transglutaminase in marmoset experimental multiple sclerosis: discrepancy between white and grey matter.
Espitia Pinzon N, Stroo E, 't Hart BA, Bol JG, Drukarch B, Bauer J, van Dam AM. Espitia Pinzon N, et al. PLoS One. 2014 Jun 24;9(6):e100574. doi: 10.1371/journal.pone.0100574. eCollection 2014. PLoS One. 2014. PMID: 24959868 Free PMC article.
Infiltration of leukocytes is a major pathological event in white matter lesion formation in the brain of multiple sclerosis (MS) patients. In grey matter lesions, less infiltration of these cells occur, but microglial activation is present. ...
Infiltration of leukocytes is a major pathological event in white matter lesion formation in the brain of multiple sclerosis ( …
22 results