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[Transglutaminase and neurodegenerative diseases].
Liu Z, Zeng J, Zeng S, Tang B, Wang J. Liu Z, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Aug;32(4):562-6. doi: 10.3760/cma.j.issn.1003-9406.2015.04.025. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015. PMID: 26252108 Review. Chinese.
Notably, neurodegenerative diseases such as Huntington's disease, spinocerebellar ataxia, Alzheimer's disease and Parkinson's disease, have a close connection with TGase's role in the human body....
Notably, neurodegenerative diseases such as Huntington's disease, spinocerebellar ataxia, Alzheimer's disease and Parkinson's disease …
Transglutaminase diseases: from biochemistry to the bedside.
Lorand L, Iismaa SE. Lorand L, et al. FASEB J. 2019 Jan;33(1):3-12. doi: 10.1096/fj.201801544R. FASEB J. 2019. PMID: 30593123
Loss of TG function is associated with numerous orphan diseases that affect a relatively small number of individuals: loss of FXIIIa (transamidase-activated form) crosslinking leads to defects in blood coagulation in FXIII deficiency; loss of TG1 and TG5 cross linking leads to de …
Loss of TG function is associated with numerous orphan diseases that affect a relatively small number of individuals: loss of FXIIIa (transa …
Transglutaminase-dependent formation of protein aggregates as possible biochemical mechanism for polyglutamine diseases.
Violante V, Luongo A, Pepe I, Annunziata S, Gentile V. Violante V, et al. Brain Res Bull. 2001 Oct-Nov 1;56(3-4):169-72. doi: 10.1016/s0361-9230(01)00576-7. Brain Res Bull. 2001. PMID: 11719247 Review.
Recently, the transglutaminase activity has been hypothesized to be involved in the pathogenetic mechanisms responsible for the formation of cellular inclusions present in Huntington disease and in all the other polyglutamine (polyQ) diseases hitherto identified, such as spinobul …
Recently, the transglutaminase activity has been hypothesized to be involved in the pathogenetic mechanisms responsible for the formation of …
Transglutaminase-6 is an autoantigen in progressive multiple sclerosis and is upregulated in reactive astrocytes.
Cristofanilli M, Gratch D, Pagano B, McDermott K, Huang J, Jian J, Bates D, Sadiq SA. Cristofanilli M, et al. Mult Scler. 2017 Nov;23(13):1707-1715. doi: 10.1177/1352458516684022. Epub 2016 Dec 22. Mult Scler. 2017. PMID: 28273770
It has been proposed as an autoimmune target in cerebral palsy, gluten-sensitive cerebellar ataxia, and schizophrenia. OBJECTIVE: To investigate TGM6 involvement in multiple sclerosis (MS). ...
It has been proposed as an autoimmune target in cerebral palsy, gluten-sensitive cerebellar ataxia, and schizophrenia. OBJECTIVE: To …
Spinocerebellar ataxia type 35 (SCA35)-associated transglutaminase 6 mutants sensitize cells to apoptosis.
Guan WJ, Wang JL, Liu YT, Ma YT, Zhou Y, Jiang H, Shen L, Guo JF, Xia K, Li JD, Tang BS. Guan WJ, et al. Biochem Biophys Res Commun. 2013 Jan 11;430(2):780-6. doi: 10.1016/j.bbrc.2012.11.069. Epub 2012 Dec 1. Biochem Biophys Res Commun. 2013. PMID: 23206699
Spinocerebellar ataxia type 35 (SCA35) is an autosomal dominant neurodegenerative disorder. ...
Spinocerebellar ataxia type 35 (SCA35) is an autosomal dominant neurodegenerative disorder. ...
Transglutaminase 6 Antibodies in the Serum of Patients With Amyotrophic Lateral Sclerosis.
Gadoth A, Nefussy B, Bleiberg M, Klein T, Artman I, Drory VE. Gadoth A, et al. JAMA Neurol. 2015 Jun;72(6):676-81. doi: 10.1001/jamaneurol.2015.48. JAMA Neurol. 2015. PMID: 25867286
Gluten sensitivity can cause neurologic manifestations, such as ataxia or neuropathy, with or without gastrointestinal symptoms. Many patients with gluten ataxia produce antibodies toward the newly identified neuronal transglutaminase 6 (TG6). ...
Gluten sensitivity can cause neurologic manifestations, such as ataxia or neuropathy, with or without gastrointestinal symptoms. Many …
Neurologic Deficits in Patients With Newly Diagnosed Celiac Disease Are Frequent and Linked With Autoimmunity to Transglutaminase 6.
Hadjivassiliou M, Croall ID, Zis P, Sarrigiannis PG, Sanders DS, Aeschlimann P, Grünewald RA, Armitage PA, Connolly D, Aeschlimann D, Hoggard N. Hadjivassiliou M, et al. Clin Gastroenterol Hepatol. 2019 Dec;17(13):2678-2686.e2. doi: 10.1016/j.cgh.2019.03.014. Epub 2019 Mar 16. Clin Gastroenterol Hepatol. 2019. PMID: 30885888
RESULTS: Gait instability was reported in 24% of the patients, persisting sensory symptoms in 12%, and frequent headaches in 42%. Gait ataxia was found in 29% of patients, nystagmus in 11%, and distal sensory loss in 10%. ...
RESULTS: Gait instability was reported in 24% of the patients, persisting sensory symptoms in 12%, and frequent headaches in 42%. Gait at
Distinct nuclear localization and activity of tissue transglutaminase.
Lesort M, Attanavanich K, Zhang J, Johnson GV. Lesort M, et al. J Biol Chem. 1998 May 15;273(20):11991-4. doi: 10.1074/jbc.273.20.11991. J Biol Chem. 1998. PMID: 9575137 Free article.
These findings may have important implications in the formation of the insoluble nuclear inclusions, which are characteristic of codon reiteration diseases such as Huntington's disease and the spinocerebellar ataxias....
These findings may have important implications in the formation of the insoluble nuclear inclusions, which are characteristic of codon reite …
Increased prevalence of transglutaminase 6 antibodies in sera from schizophrenia patients.
Cascella NG, Santora D, Gregory P, Kelly DL, Fasano A, Eaton WW. Cascella NG, et al. Schizophr Bull. 2013 Jul;39(4):867-71. doi: 10.1093/schbul/sbs064. Epub 2012 Apr 19. Schizophr Bull. 2013. PMID: 22516148 Free PMC article.
Organ-specific gluten reaction involves immune response toward other transglutaminase (TG) isoforms including tTG3 (expressed in the skin, leading to dermatitis herpetiformis) and tTG6 (expressed in the brain, causing gluten ataxia). This analysis focuses on tTG6 antibodie …
Organ-specific gluten reaction involves immune response toward other transglutaminase (TG) isoforms including tTG3 (expressed in the skin, l …
Transglutaminase 6: a protein associated with central nervous system development and motor function.
Thomas H, Beck K, Adamczyk M, Aeschlimann P, Langley M, Oita RC, Thiebach L, Hils M, Aeschlimann D. Thomas H, et al. Amino Acids. 2013 Jan;44(1):161-77. doi: 10.1007/s00726-011-1091-z. Epub 2011 Oct 8. Amino Acids. 2013. PMID: 21984379 Free PMC article.
Induction of differentiation in mouse Neuro 2a cells with NGF or dibutyryl cAMP is associated with an upregulation of TG6 expression. Familial ataxia has recently been linked to mutations in the TGM6 gene. Autoantibodies to TG6 were identified in immune-mediated ataxia
Induction of differentiation in mouse Neuro 2a cells with NGF or dibutyryl cAMP is associated with an upregulation of TG6 expression. Famili …
28 results