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1981 2
1987 1
1991 1
1993 1
1995 2
1998 4
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2002 1
2004 3
2011 1
2014 1
2022 0
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Lens transglutaminase and cataract formation.
Lorand L, Hsu LK, Siefring GE Jr, Rafferty NS. Lorand L, et al. Proc Natl Acad Sci U S A. 1981 Mar;78(3):1356-60. doi: 10.1073/pnas.78.3.1356. Proc Natl Acad Sci U S A. 1981. PMID: 6112745 Free PMC article.
A protein polymer characteristically present in human cataract was shown to contain significant amounts of gamma-glutamyl-epsilon-lysine isopeptides. ...
A protein polymer characteristically present in human cataract was shown to contain significant amounts of gamma-glutamyl-epsilon-lys …
Localization of transglutaminase in human lenses.
Hidasi V, Adány R, Muszbek L. Hidasi V, et al. J Histochem Cytochem. 1995 Nov;43(11):1173-7. doi: 10.1177/43.11.7560900. J Histochem Cytochem. 1995. PMID: 7560900
Transglutaminase activity has been detected in the lenses of laboratory animals and in human cataracts. However, its distribution in the lens tissue has not been investigated. ...
Transglutaminase activity has been detected in the lenses of laboratory animals and in human cataracts. However, its distribution in …
Novel inhibitors against the transglutaminase-catalysed crosslinking of lens proteins.
Lorand L, Stern AM, Velasco PT. Lorand L, et al. Exp Eye Res. 1998 May;66(5):531-6. doi: 10.1006/exer.1997.0463. Exp Eye Res. 1998. PMID: 9628800
Post-translational modifications by transglutaminase may contribute to the remodeling of cellular architecture in the development of lens fiber cells, and there is evidence that the enzyme may also play a role in cataract formation. It catalyses hydrolytic deamidations as …
Post-translational modifications by transglutaminase may contribute to the remodeling of cellular architecture in the development of lens fi …
Transglutaminase activity in normal and hereditary cataractous rat lens and its partial purification.
Azari P, Rahim I, Clarkson DP. Azari P, et al. Curr Eye Res. 1981;1(8):463-9. doi: 10.3109/02713688109019987. Curr Eye Res. 1981. PMID: 6120797
Hereditary cataractous rat lenses showed significantly higher specific activity for transglutaminase than the normal lenses of comparable age. ...
Hereditary cataractous rat lenses showed significantly higher specific activity for transglutaminase than the normal lenses of compar …
Transglutaminase-mediated cross-linking of alpha-crystallin: structural and functional consequences.
Shridas P, Sharma Y, Balasubramanian D. Shridas P, et al. FEBS Lett. 2001 Jun 22;499(3):245-50. doi: 10.1016/s0014-5793(01)02565-0. FEBS Lett. 2001. PMID: 11423125 Free article.
Aggregation and covalent cross-linking of the crystallins, the major structural proteins of the eye lens, increase light scattering by the lens leading to opacification and cataract. Disturbance of calcium homeostasis in the tissue is one of the factors implicated in catar …
Aggregation and covalent cross-linking of the crystallins, the major structural proteins of the eye lens, increase light scattering by the l …
Enhanced expression of transglutaminase 2 in anterior polar cataracts and its induction by TGF-beta in vitro.
Wan XH, Lee EH, Koh HJ, Song J, Kim EK, Kim CY, Lee JB, Kim SY, Yao K, Lee JH. Wan XH, et al. Br J Ophthalmol. 2002 Nov;86(11):1293-8. doi: 10.1136/bjo.86.11.1293. Br J Ophthalmol. 2002. PMID: 12386092 Free PMC article.
BACKGROUND/AIMS: Transglutaminase activity has long been implicated in the cataract formation. However, the precise mechanism of how it is produced and involved in this process remains unclear. ...METHODS: Lens epithelial cells from anterior polar cataracts, nuclear …
BACKGROUND/AIMS: Transglutaminase activity has long been implicated in the cataract formation. However, the precise mechanism of how …
Expression and rapid purification of highly active hexahistidine-tagged guinea pig liver transglutaminase.
Gillet SM, Chica RA, Keillor JW, Pelletier JN. Gillet SM, et al. Protein Expr Purif. 2004 Feb;33(2):256-64. doi: 10.1016/j.pep.2003.10.003. Protein Expr Purif. 2004. PMID: 14711514
Tissue transglutaminase has been identified as a contributor to a wide variety of diseases, including cataract formation and Celiac disease. Guinea pig tissue transglutaminase has a very broad substrate specificity and therefore is useful for kinetic studies using substrat …
Tissue transglutaminase has been identified as a contributor to a wide variety of diseases, including cataract formation and Celiac d …
Transglutaminase activity in normal human lenses and in senile cataracts.
Hidasi V, Muszbek L. Hidasi V, et al. Ann Clin Lab Sci. 1995 May-Jun;25(3):236-40. Ann Clin Lab Sci. 1995. PMID: 7605105
Both the total and specific transglutaminase activity of highly cataractous lenses were less than those of normal lenses. During the progression of cataract (slightly moderately, and highly cataractous groups were compared), there was a substantial decrease i …
Both the total and specific transglutaminase activity of highly cataractous lenses were less than those of normal lenses. During the …
Properties of purified lens transglutaminase and regulation of its transamidase/crosslinking activity by GTP.
Murthy SN, Velasco PT, Lorand L. Murthy SN, et al. Exp Eye Res. 1998 Sep;67(3):273-81. doi: 10.1006/exer.1998.0509. Exp Eye Res. 1998. PMID: 9778408
On account of its protein crosslinking activity, the Ca2+-dependent transglutaminase of the lens is likely to be involved in the formation of cataracts. We have now purified the rabbit lens enzyme to near homogeneity as judged by SDS-PAGE (Mr approximately 78 kDa), and a k …
On account of its protein crosslinking activity, the Ca2+-dependent transglutaminase of the lens is likely to be involved in the formation o …
Endoplasmic reticulum stress activates transglutaminase 2 leading to protein aggregation.
Lee JH, Jeong J, Jeong EM, Cho SY, Kang JW, Lim J, Heo J, Kang H, Kim IG, Shin DM. Lee JH, et al. Int J Mol Med. 2014 Apr;33(4):849-55. doi: 10.3892/ijmm.2014.1640. Epub 2014 Jan 30. Int J Mol Med. 2014. PMID: 24481335 Free PMC article.
Aberrant activation of transglutaminase 2 (TGase2) contributes to a variety of protein conformational disorders such as neurodegenerative diseases and age-related cataracts. The accumulation of improperly folded proteins in the endoplasmic reticulum (ER) triggers the unfol …
Aberrant activation of transglutaminase 2 (TGase2) contributes to a variety of protein conformational disorders such as neurodegenerative di …
18 results