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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1987 1
1988 2
1989 1
1992 1
1997 4
1998 10
1999 21
2000 27
2001 31
2002 43
2003 36
2004 39
2005 32
2006 42
2007 33
2008 35
2009 36
2010 37
2011 35
2012 51
2013 31
2014 32
2015 29
2016 35
2017 41
2018 37
2019 32
2020 6
2022 0
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688 results
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Page 1
Microbial Transglutaminase Is Immunogenic and Potentially Pathogenic in Pediatric Celiac Disease.
Torsten M, Aaron L. Torsten M, et al. Front Pediatr. 2018 Dec 11;6:389. doi: 10.3389/fped.2018.00389. eCollection 2018. Front Pediatr. 2018. PMID: 30619787 Free PMC article. Review.
As a protein's glue, it cross-links gliadin peptides, creating neo-complexes that are immunogenic and potentially pathogenic to celiac disease communities. Even lacking sequence identity, it imitates functionally the endogenous tissue transglutaminase, known to be the auto …
As a protein's glue, it cross-links gliadin peptides, creating neo-complexes that are immunogenic and potentially pathogenic to celiac
Transglutaminase 2 and Transglutaminase 2 Autoantibodies in Celiac Disease: a Review.
Rauhavirta T, Hietikko M, Salmi T, Lindfors K. Rauhavirta T, et al. Clin Rev Allergy Immunol. 2019 Aug;57(1):23-38. doi: 10.1007/s12016-016-8557-4. Clin Rev Allergy Immunol. 2019. PMID: 27263022 Review.
Blocking the enzymatic activity of TG2 has thus been suggested as a suitable novel pharmacological approach to treat celiac disease. By virtue of its transamidation capacity, TG2 is also able to cross-link gliadin peptides to itself, this resulting in the generation of TG2 …
Blocking the enzymatic activity of TG2 has thus been suggested as a suitable novel pharmacological approach to treat celiac disease. …
Inhibitors of tissue transglutaminase.
Keillor JW, Apperley KY, Akbar A. Keillor JW, et al. Trends Pharmacol Sci. 2015 Jan;36(1):32-40. doi: 10.1016/j.tips.2014.10.014. Epub 2014 Dec 12. Trends Pharmacol Sci. 2015. PMID: 25500711 Review.
Although TG2 is essential for the stabilization of the extracellular matrix, its unregulated activity has been implicated in celiac disease, fibrosis, and cancer metastasis, among other disorders. ...
Although TG2 is essential for the stabilization of the extracellular matrix, its unregulated activity has been implicated in celiac d …
Transglutaminase as a therapeutic target for celiac disease.
Sulic AM, Kurppa K, Rauhavirta T, Kaukinen K, Lindfors K. Sulic AM, et al. Expert Opin Ther Targets. 2015 Mar;19(3):335-48. doi: 10.1517/14728222.2014.985207. Epub 2014 Nov 20. Expert Opin Ther Targets. 2015. PMID: 25410283 Review.
Here, the important role of transglutaminase 2 (TG2) in the pathogenesis of celiac disease makes it an attractive target for drug development. ...EXPERT OPINION: Activation of TG2 in the intestinal mucosa is central in celiac disease pathogenesis and researchers hav …
Here, the important role of transglutaminase 2 (TG2) in the pathogenesis of celiac disease makes it an attractive target for drug dev …
Transglutaminase inhibitors: a patent review.
Keillor JW, Apperley KY. Keillor JW, et al. Expert Opin Ther Pat. 2016;26(1):49-63. doi: 10.1517/13543776.2016.1115836. Epub 2015 Nov 24. Expert Opin Ther Pat. 2016. PMID: 26560530 Review.
Their protein-crosslinking activity has been linked to fibrosis and Huntington's disease, their glutamine deamidation activity has been related to celiac disease and their GTP-binding activity has been implicated in cancer. ...
Their protein-crosslinking activity has been linked to fibrosis and Huntington's disease, their glutamine deamidation activity has been rela …
Microbial transglutaminase: A new potential player in celiac disease.
Aaron L, Torsten M. Aaron L, et al. Clin Immunol. 2019 Feb;199:37-43. doi: 10.1016/j.clim.2018.12.008. Epub 2018 Dec 10. Clin Immunol. 2019. PMID: 30543926 Review.
Being a protein's glue, by cross-linking it creates neoepitope complexes that are immunogenic and potentially pathogenic in celiac disease. Despite low sequence identity, it imitates functionally its family member, the endogenous tissue transglutaminase, which is the autoa …
Being a protein's glue, by cross-linking it creates neoepitope complexes that are immunogenic and potentially pathogenic in celiac di …
Substrates, inhibitors, and probes of mammalian transglutaminase 2.
Zhuang R, Khosla C. Zhuang R, et al. Anal Biochem. 2020 Feb 15;591:113560. doi: 10.1016/j.ab.2019.113560. Epub 2019 Dec 24. Anal Biochem. 2020. PMID: 31874171 Free PMC article. Review.
Remarkably, the most definitive insights into the biology of TG2 stem from its pathophysiological role in gluten peptide deamidation in celiac disease. Meanwhile our understanding of TG2 chemistry has been leveraged to engineer a spectrum of inhibitors and other molecular …
Remarkably, the most definitive insights into the biology of TG2 stem from its pathophysiological role in gluten peptide deamidation in c
The function of tissue transglutaminase in celiac disease.
Di Sabatino A, Vanoli A, Giuffrida P, Luinetti O, Solcia E, Corazza GR. Di Sabatino A, et al. Autoimmun Rev. 2012 Aug;11(10):746-53. doi: 10.1016/j.autrev.2012.01.007. Epub 2012 Feb 3. Autoimmun Rev. 2012. PMID: 22326684 Review.
Gluten peptides are efficiently presented by celiac disease-specific HLA-DQ2- and HLA-DQ8-positive antigen presenting cells to CD4(+) T-cells that, once activated, drive a T helper cell type 1 response leading to the development of the typical celiac lesion-villous …
Gluten peptides are efficiently presented by celiac disease-specific HLA-DQ2- and HLA-DQ8-positive antigen presenting cells to CD4(+) …
Transglutaminase 2 in inflammation.
Kim SY. Kim SY. Front Biosci. 2006 Sep 1;11:3026-35. doi: 10.2741/2030. Front Biosci. 2006. PMID: 16720373 Review.
In most cases, TG 2 appears to form an inappropriate protein aggregate that may be cytotoxic enough to trigger inflammation and/or apoptosis. In some cases, such as celiac disease and rheumatoid arthritis, TG 2 is also associated with the pathogenic progression, as well as …
In most cases, TG 2 appears to form an inappropriate protein aggregate that may be cytotoxic enough to trigger inflammation and/or apoptosis …
[Gluten Ataxia: Anti-Transglutaminase-6 Antibody as a New Biomarker].
Sato K, Nanri K. Sato K, et al. Brain Nerve. 2017 Aug;69(8):933-940. doi: 10.11477/mf.1416200845. Brain Nerve. 2017. PMID: 28819077 Review. Japanese.
GRDs have been considered rare in Asian countries, including Japan, because of lower consumption of wheat products than in Europe and the U.S.A. and differences in genetic background. Recently, however, GRDs, such as celiac disease and gluten ataxia, have been reported in …
GRDs have been considered rare in Asian countries, including Japan, because of lower consumption of wheat products than in Europe and the U. …
688 results