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Year Number of Results
1985 1
1987 1
1988 2
1989 1
1992 1
1997 4
1998 10
1999 21
2000 27
2001 31
2002 43
2003 36
2004 39
2005 32
2006 42
2007 33
2008 35
2009 36
2010 37
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2012 51
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688 results

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Page 1
Microbial Transglutaminase Is Immunogenic and Potentially Pathogenic in Pediatric Celiac Disease.
Torsten M, Aaron L. Torsten M, et al. Front Pediatr. 2018 Dec 11;6:389. doi: 10.3389/fped.2018.00389. eCollection 2018. Front Pediatr. 2018. PMID: 30619787 Free PMC article. Review.
As a protein's glue, it cross-links gliadin peptides, creating neo-complexes that are immunogenic and potentially pathogenic to celiac disease communities. Even lacking sequence identity, it imitates functionally the endogenous tissue transglutaminase, known to be the auto …
As a protein's glue, it cross-links gliadin peptides, creating neo-complexes that are immunogenic and potentially pathogenic to celiac
Transglutaminase 2 and Transglutaminase 2 Autoantibodies in Celiac Disease: a Review.
Rauhavirta T, Hietikko M, Salmi T, Lindfors K. Rauhavirta T, et al. Clin Rev Allergy Immunol. 2019 Aug;57(1):23-38. doi: 10.1007/s12016-016-8557-4. Clin Rev Allergy Immunol. 2019. PMID: 27263022 Review.
Blocking the enzymatic activity of TG2 has thus been suggested as a suitable novel pharmacological approach to treat celiac disease. By virtue of its transamidation capacity, TG2 is also able to cross-link gliadin peptides to itself, this resulting in the generation of TG2 …
Blocking the enzymatic activity of TG2 has thus been suggested as a suitable novel pharmacological approach to treat celiac disease. …
Inhibitors of tissue transglutaminase.
Keillor JW, Apperley KY, Akbar A. Keillor JW, et al. Trends Pharmacol Sci. 2015 Jan;36(1):32-40. doi: 10.1016/j.tips.2014.10.014. Epub 2014 Dec 12. Trends Pharmacol Sci. 2015. PMID: 25500711 Review.
Although TG2 is essential for the stabilization of the extracellular matrix, its unregulated activity has been implicated in celiac disease, fibrosis, and cancer metastasis, among other disorders. ...
Although TG2 is essential for the stabilization of the extracellular matrix, its unregulated activity has been implicated in celiac d …
Transglutaminase as a therapeutic target for celiac disease.
Sulic AM, Kurppa K, Rauhavirta T, Kaukinen K, Lindfors K. Sulic AM, et al. Expert Opin Ther Targets. 2015 Mar;19(3):335-48. doi: 10.1517/14728222.2014.985207. Epub 2014 Nov 20. Expert Opin Ther Targets. 2015. PMID: 25410283 Review.
Here, the important role of transglutaminase 2 (TG2) in the pathogenesis of celiac disease makes it an attractive target for drug development. ...EXPERT OPINION: Activation of TG2 in the intestinal mucosa is central in celiac disease pathogenesis and researchers hav …
Here, the important role of transglutaminase 2 (TG2) in the pathogenesis of celiac disease makes it an attractive target for drug dev …
Microbial transglutaminase: A new potential player in celiac disease.
Aaron L, Torsten M. Aaron L, et al. Clin Immunol. 2019 Feb;199:37-43. doi: 10.1016/j.clim.2018.12.008. Epub 2018 Dec 10. Clin Immunol. 2019. PMID: 30543926 Review.
Being a protein's glue, by cross-linking it creates neoepitope complexes that are immunogenic and potentially pathogenic in celiac disease. Despite low sequence identity, it imitates functionally its family member, the endogenous tissue transglutaminase, which is the autoa …
Being a protein's glue, by cross-linking it creates neoepitope complexes that are immunogenic and potentially pathogenic in celiac di …
Transglutaminase inhibitors: a patent review.
Keillor JW, Apperley KY. Keillor JW, et al. Expert Opin Ther Pat. 2016;26(1):49-63. doi: 10.1517/13543776.2016.1115836. Epub 2015 Nov 24. Expert Opin Ther Pat. 2016. PMID: 26560530 Review.
Their protein-crosslinking activity has been linked to fibrosis and Huntington's disease, their glutamine deamidation activity has been related to celiac disease and their GTP-binding activity has been implicated in cancer. ...
Their protein-crosslinking activity has been linked to fibrosis and Huntington's disease, their glutamine deamidation activity has been rela …
Substrates, inhibitors, and probes of mammalian transglutaminase 2.
Zhuang R, Khosla C. Zhuang R, et al. Anal Biochem. 2020 Feb 15;591:113560. doi: 10.1016/j.ab.2019.113560. Epub 2019 Dec 24. Anal Biochem. 2020. PMID: 31874171 Free PMC article. Review.
Remarkably, the most definitive insights into the biology of TG2 stem from its pathophysiological role in gluten peptide deamidation in celiac disease. Meanwhile our understanding of TG2 chemistry has been leveraged to engineer a spectrum of inhibitors and other molecular …
Remarkably, the most definitive insights into the biology of TG2 stem from its pathophysiological role in gluten peptide deamidation in c
Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction.
Furini G, Verderio EAM. Furini G, et al. Med Sci (Basel). 2019 Jan 4;7(1):5. doi: 10.3390/medsci7010005. Med Sci (Basel). 2019. PMID: 30621228 Free PMC article. Review.
Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) in kidney and cardiac fibrosis, metastatic cancer, neurodegeneration and coeliac disease. The proposed role for HSPGs in the trafficki …
Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) i …
Role of transglutaminase 2 in celiac disease pathogenesis.
Klöck C, Diraimondo TR, Khosla C. Klöck C, et al. Semin Immunopathol. 2012 Jul;34(4):513-22. doi: 10.1007/s00281-012-0305-0. Epub 2012 Mar 22. Semin Immunopathol. 2012. PMID: 22437759 Free PMC article. Review.
A number of lines of evidence suggest that transglutaminase 2 (TG2) may be one of the earliest disease-relevant proteins to encounter immunotoxic gluten in the celiac gut. These and other investigations also suggest that the reaction catalyzed by TG2 on dietary gluten pept …
A number of lines of evidence suggest that transglutaminase 2 (TG2) may be one of the earliest disease-relevant proteins to encounter immuno …
The industrial food additive, microbial transglutaminase, mimics tissue transglutaminase and is immunogenic in celiac disease patients.
Matthias T, Jeremias P, Neidhöfer S, Lerner A. Matthias T, et al. Autoimmun Rev. 2016 Dec;15(12):1111-1119. doi: 10.1016/j.autrev.2016.09.011. Epub 2016 Sep 15. Autoimmun Rev. 2016. PMID: 27640315 Review.
The serological activity of mTg, tTg, gliadin complexed mTg (mTg neo-epitope) and gliadin complexed tTg (tTg neo-epitope) were studied in 95 pediatric celiac patients (CD), 99 normal children (NC), 79 normal adults (NA) and 45 children with nonspecific abdominal pain (AP). …
The serological activity of mTg, tTg, gliadin complexed mTg (mTg neo-epitope) and gliadin complexed tTg (tTg neo-epitope) were studied in 95 …
688 results