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Transglutaminase 2 exacerbates experimental autoimmune encephalomyelitis through positive regulation of encephalitogenic T cell differentiation and inflammation.
Oh K, Park HB, Seo MW, Byoun OJ, Lee DS. Oh K, et al. Clin Immunol. 2012 Nov;145(2):122-32. doi: 10.1016/j.clim.2012.08.009. Epub 2012 Aug 23. Clin Immunol. 2012. PMID: 23001131
The increased activity of transglutaminase 2 (TG2) in various inflammatory and fibrotic conditions results in the development of numerous disease processes. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, is an inflammatory and demye …
The increased activity of transglutaminase 2 (TG2) in various inflammatory and fibrotic conditions results in the development of numerous di …
Transglutaminase-6 is an autoantigen in progressive multiple sclerosis and is upregulated in reactive astrocytes.
Cristofanilli M, Gratch D, Pagano B, McDermott K, Huang J, Jian J, Bates D, Sadiq SA. Cristofanilli M, et al. Mult Scler. 2017 Nov;23(13):1707-1715. doi: 10.1177/1352458516684022. Epub 2016 Dec 22. Mult Scler. 2017. PMID: 28273770
TGM6 protein expression was analyzed in MS brain autopsy, murine experimental autoimmune encephalomyelitis (EAE), and cultured astrocytes. RESULTS: CSF levels of TGM6-IgG were significantly higher in PPMS and SPMS compared to RRMS and controls. ...
TGM6 protein expression was analyzed in MS brain autopsy, murine experimental autoimmune encephalomyelitis (EAE), and cultured astroc …
Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis.
Chrobok NL, Bol JGJM, Jongenelen CA, Brevé JJP, El Alaoui S, Wilhelmus MMM, Drukarch B, van Dam AM. Chrobok NL, et al. PLoS One. 2018 Apr 24;13(4):e0196433. doi: 10.1371/journal.pone.0196433. eCollection 2018. PLoS One. 2018. PMID: 29689097 Free PMC article.
The migration of leukocytes from the blood vessel is orchestrated by a multitude of factors whose determination is essential in reducing cellular influx in MS patients and the experimental autoimmune encephalomyelitis (EAE) animal model. The here studied enzyme tissue Tran …
The migration of leukocytes from the blood vessel is orchestrated by a multitude of factors whose determination is essential in reducing cel …
Tissue Transglutaminase contributes to experimental multiple sclerosis pathogenesis and clinical outcome by promoting macrophage migration.
van Strien ME, de Vries HE, Chrobok NL, Bol JGJM, Breve JJP, van der Pol SMP, Kooij G, van Buul JD, Karpuj M, Steinman L, Wilhelmus MM, Sestito C, Drukarch B, Van Dam AM. van Strien ME, et al. Brain Behav Immun. 2015 Nov;50:141-154. doi: 10.1016/j.bbi.2015.06.023. Epub 2015 Jun 29. Brain Behav Immun. 2015. PMID: 26133787
In human post-mortem material, we showed the appearance of TG2 immunoreactivity in leukocytes in MS lesions, and particular in macrophages in rat chronic-relapsing experimental autoimmune encephalomyelitis (cr-EAE), an experimental MS model. Clinical deficits as observed i …
In human post-mortem material, we showed the appearance of TG2 immunoreactivity in leukocytes in MS lesions, and particular in macrophages i …
Monocyte behaviour and tissue transglutaminase expression during experimental autoimmune encephalomyelitis in transgenic CX3CR1gfp/gfp mice.
Chrobok NL, Jaouen A, Fenrich KK, Bol JG, Wilhelmus MM, Drukarch B, Debarbieux F, van Dam AM. Chrobok NL, et al. Amino Acids. 2017 Mar;49(3):643-658. doi: 10.1007/s00726-016-2359-0. Epub 2016 Nov 9. Amino Acids. 2017. PMID: 27826792 Free PMC article.
Leukocyte infiltration into the central nervous system (CNS) is a key pathological feature in multiple sclerosis (MS) and the MS animal model experimental autoimmune encephalomyelitis (EAE). Recently, preventing leukocyte influx into the CNS of MS patients is the main targ …
Leukocyte infiltration into the central nervous system (CNS) is a key pathological feature in multiple sclerosis (MS) and the MS animal mode …