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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
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1997 2
1999 3
2000 1
2001 4
2002 3
2003 5
2004 6
2005 6
2006 3
2007 3
2008 6
2009 11
2010 11
2011 6
2012 5
2013 3
2014 9
2015 6
2016 9
2017 10
2018 11
2019 9
2020 2
2022 0
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119 results
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Page 1
Inhibitors of tissue transglutaminase.
Keillor JW, Apperley KY, Akbar A. Keillor JW, et al. Trends Pharmacol Sci. 2015 Jan;36(1):32-40. doi: 10.1016/j.tips.2014.10.014. Epub 2014 Dec 12. Trends Pharmacol Sci. 2015. PMID: 25500711 Review.
Although TG2 is essential for the stabilization of the extracellular matrix, its unregulated activity has been implicated in celiac disease, fibrosis, and cancer metastasis, among other disorders. Given the importance and range of TG2-related pathologies, recent work has f …
Although TG2 is essential for the stabilization of the extracellular matrix, its unregulated activity has been implicated in celiac disease, …
Transglutaminase 2 limits the extravasation and the resultant myocardial fibrosis associated with factor XIII-A deficiency.
Griffin KJ, Newell LM, Simpson KR, Beckers CML, Drinkhill MJ, Standeven KF, Cheah LT, Iismaa SE, Grant PJ, Jackson CL, Pease RJ. Griffin KJ, et al. Atherosclerosis. 2020 Feb;294:1-9. doi: 10.1016/j.atherosclerosis.2019.12.013. Epub 2019 Dec 17. Atherosclerosis. 2020. PMID: 31874419 Free PMC article.
However, concomitant Tgm2 knockout markedly increased fibrosis, as apparent in both Apoe/Tgm2/F13a1 knockout and Tgm2/F13a1 knockout mice. ...The resulting fibrosis was interstitial in nature and caused only minor changes in cardiac function. ...
However, concomitant Tgm2 knockout markedly increased fibrosis, as apparent in both Apoe/Tgm2/F13a1 knockout and Tgm2/F13a1 knockout …
Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction.
Furini G, Verderio EAM. Furini G, et al. Med Sci (Basel). 2019 Jan 4;7(1):5. doi: 10.3390/medsci7010005. Med Sci (Basel). 2019. PMID: 30621228 Free PMC article. Review.
Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) in kidney and cardiac fibrosis, metastatic cancer, neurodegeneration and coeliac disease. The proposed role for HSPGs in the trafficki …
Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) i …
Transglutaminase inhibitors: a patent review.
Keillor JW, Apperley KY. Keillor JW, et al. Expert Opin Ther Pat. 2016;26(1):49-63. doi: 10.1517/13543776.2016.1115836. Epub 2015 Nov 24. Expert Opin Ther Pat. 2016. PMID: 26560530 Review.
INTRODUCTION: Transglutaminases (TGases) are a class of enzymes that play multifunctional roles. Their protein-crosslinking activity has been linked to fibrosis and Huntington's disease, their glutamine deamidation activity has been related to celiac disease and their GTP- …
INTRODUCTION: Transglutaminases (TGases) are a class of enzymes that play multifunctional roles. Their protein-crosslinking activity has bee …
Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney.
Lin CH, Chen J, Zhang Z, Johnson GV, Cooper AJ, Feola J, Bank A, Shein J, Ruotsalainen HJ, Pihlajaniemi TA, Goligorsky MS. Lin CH, et al. Kidney Int. 2016 Jun;89(6):1281-92. doi: 10.1016/j.kint.2016.01.030. Epub 2016 Apr 14. Kidney Int. 2016. PMID: 27165830 Free PMC article.
EST is also an interactive partner of transglutaminase 2 (TG2), an enzyme that cross-links extracellular matrix proteins. Here we tested whether EST and TG2 play a role in the fibrosis of aging. In wild-type mice, aging kidneys exhibited a 2- to 4-fold increase in TG2 para …
EST is also an interactive partner of transglutaminase 2 (TG2), an enzyme that cross-links extracellular matrix proteins. Here we tested whe …
Structural aspects of transglutaminase 2: functional, structural, and regulatory diversity.
Lee CS, Park HH. Lee CS, et al. Apoptosis. 2017 Sep;22(9):1057-1068. doi: 10.1007/s10495-017-1396-9. Apoptosis. 2017. PMID: 28677093 Review.
TG2 is linked to many human diseases such as inflammatory disease, celiac disease, neurodegenerative disease, diabetes, tissue fibrosis, and various cancers and is one of the most dynamic enzymes in terms of its functions, structures, and regulatory mechanisms. ...
TG2 is linked to many human diseases such as inflammatory disease, celiac disease, neurodegenerative disease, diabetes, tissue fibrosis
Transglutaminase 2 and its role in pulmonary fibrosis.
Olsen KC, Sapinoro RE, Kottmann RM, Kulkarni AA, Iismaa SE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ. Olsen KC, et al. Am J Respir Crit Care Med. 2011 Sep 15;184(6):699-707. doi: 10.1164/rccm.201101-0013OC. Epub 2011 Jun 23. Am J Respir Crit Care Med. 2011. PMID: 21700912 Free PMC article.
Transglutaminase 2 (TG2) is a multifunctional protein, but its function in pulmonary fibrosis is unknown. OBJECTIVES: To determine the role of TG2 in pulmonary fibrosis. ...MEASUREMENTS AND MAIN RESULTS: TG2 knockout mice developed significantly reduced fibrosis
Transglutaminase 2 (TG2) is a multifunctional protein, but its function in pulmonary fibrosis is unknown. OBJECTIVES: To determine th …
Cellular functions of tissue transglutaminase.
Nurminskaya MV, Belkin AM. Nurminskaya MV, et al. Int Rev Cell Mol Biol. 2012;294:1-97. doi: 10.1016/B978-0-12-394305-7.00001-X. Int Rev Cell Mol Biol. 2012. PMID: 22364871 Free PMC article. Review.
In turn, the impact of TG2 on these processes implicates this protein in various physiological responses and pathological states, contributing to wound healing, inflammation, autoimmunity, neurodegeneration, vascular remodeling, tumor growth and metastasis, and tissue fibrosis
In turn, the impact of TG2 on these processes implicates this protein in various physiological responses and pathological states, contributi …
Potential of transglutaminase 2 as a therapeutic target.
Caccamo D, Currò M, Ientile R. Caccamo D, et al. Expert Opin Ther Targets. 2010 Sep;14(9):989-1003. doi: 10.1517/14728222.2010.510134. Expert Opin Ther Targets. 2010. PMID: 20670177 Review.
WHAT THE READER WILL GAIN: Beneficial effects of enzyme activity inhibition have been observed in neurodegeneration and fibrosis in vivo models by delivery of the competitive inhibitor cystamine and more recently designed inhibitors, such as thiomidaziolium or norleucine d …
WHAT THE READER WILL GAIN: Beneficial effects of enzyme activity inhibition have been observed in neurodegeneration and fibrosis in v …
Glycolysis regulated transglutaminase 2 activation in cardiopulmonary fibrogenic remodeling.
Bhedi CD, Nasirova S, Toksoz D, Warburton RR, Morine KJ, Kapur NK, Galper JB, Preston IR, Hill NS, Fanburg BL, Penumatsa KC. Bhedi CD, et al. FASEB J. 2020 Jan;34(1):930-944. doi: 10.1096/fj.201902155R. Epub 2019 Nov 28. FASEB J. 2020. PMID: 31914588 Free PMC article.
Our findings support a novel role for glycolysis-mediated TG2 induction and tissue fibrosis associated with experimental PH, HF, and hyperglycemia....
Our findings support a novel role for glycolysis-mediated TG2 induction and tissue fibrosis associated with experimental PH, HF, and …
119 results