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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2006 1
2007 1
2009 1
2010 2
2011 2
2012 2
2013 6
2014 7
2015 4
2016 2
2017 3
2018 2
2019 2
2020 1
2022 0
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29 results
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Page 1
Transglutaminase is a Critical Link Between Inflammation and Hypertension.
Luo R, Liu C, Elliott SE, Wang W, Parchim N, Iriyama T, Daugherty PS, Tao L, Eltzschig HK, Blackwell SC, Sibai BM, Kellems RE, Xia Y. Luo R, et al. J Am Heart Assoc. 2016 Jun 30;5(7):e003730. doi: 10.1161/JAHA.116.003730. J Am Heart Assoc. 2016. PMID: 27364991 Free PMC article.
BACKGROUND: The pathogenesis of essential hypertension is multifactorial with different underlying mechanisms contributing to disease. ...Our findings establish TGase as a critical link between inflammation, hypertension, and autoimmunity....
BACKGROUND: The pathogenesis of essential hypertension is multifactorial with different underlying mechanisms contributing to disease …
Inflammation, Autoimmunity, and Hypertension: The Essential Role of Tissue Transglutaminase.
Liu C, Kellems RE, Xia Y. Liu C, et al. Am J Hypertens. 2017 Aug 1;30(8):756-764. doi: 10.1093/ajh/hpx027. Am J Hypertens. 2017. PMID: 28338973 Free PMC article. Review.
Extensive evidence shows that these autoantibodies, termed AT1-AA, contribute to hypertension. We review here recent studies showing that cytokine-induced hypertension and AT1-AA production require the ubiquitous enzyme, tissue transglutaminase (TG2). ...Based on th …
Extensive evidence shows that these autoantibodies, termed AT1-AA, contribute to hypertension. We review here recent studies showing …
Transglutaminase 2-mediated serotonylation in pulmonary hypertension.
Penumatsa KC, Fanburg BL. Penumatsa KC, et al. Am J Physiol Lung Cell Mol Physiol. 2014 Feb 15;306(4):L309-15. doi: 10.1152/ajplung.00321.2013. Epub 2013 Dec 27. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 24375797 Free PMC article. Review.
The basic mechanism by which TG2 is activated and the potential role(s) of serotonylated proteins in pulmonary hypertension remain a mystery. In the present review we have tried to address the current understanding of 5-HT metabolism in pulmonary hypertension
The basic mechanism by which TG2 is activated and the potential role(s) of serotonylated proteins in pulmonary hypertension re …
Transglutaminase 2 in pulmonary and cardiac tissue remodeling in experimental pulmonary hypertension.
Penumatsa KC, Toksoz D, Warburton RR, Kharnaf M, Preston IR, Kapur NK, Khosla C, Hill NS, Fanburg BL. Penumatsa KC, et al. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L752-L762. doi: 10.1152/ajplung.00170.2017. Epub 2017 Aug 3. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 28775095 Free PMC article.
Tissue matrix remodeling and fibrosis leading to loss of pulmonary arterial and right ventricular compliance are important features of both experimental and clinical pulmonary hypertension (PH). We have previously reported that transglutaminase 2 (TG2) is involved in PH de …
Tissue matrix remodeling and fibrosis leading to loss of pulmonary arterial and right ventricular compliance are important features of both …
Glycolysis regulated transglutaminase 2 activation in cardiopulmonary fibrogenic remodeling.
Bhedi CD, Nasirova S, Toksoz D, Warburton RR, Morine KJ, Kapur NK, Galper JB, Preston IR, Hill NS, Fanburg BL, Penumatsa KC. Bhedi CD, et al. FASEB J. 2020 Jan;34(1):930-944. doi: 10.1096/fj.201902155R. Epub 2019 Nov 28. FASEB J. 2020. PMID: 31914588 Free PMC article.
The pathophysiology of pulmonary hypertension (PH) and heart failure (HF) includes fibrogenic remodeling associated with the loss of pulmonary arterial (PA) and cardiac compliance. ...
The pathophysiology of pulmonary hypertension (PH) and heart failure (HF) includes fibrogenic remodeling associated with the loss of …
Activation of extracellular transglutaminase 2 by mechanical force in the arterial wall.
Huelsz-Prince G, Belkin AM, VanBavel E, Bakker EN. Huelsz-Prince G, et al. J Vasc Res. 2013;50(5):383-95. doi: 10.1159/000354222. Epub 2013 Aug 24. J Vasc Res. 2013. PMID: 23988702 Review.
Inward remodeling of small arteries occurs after prolonged vasoconstriction, low blood flow, and in several models of hypertension. The cross-linking enzyme, transglutaminases 2 (TG2), is able to induce inward remodeling and stiffening of arteries. ...
Inward remodeling of small arteries occurs after prolonged vasoconstriction, low blood flow, and in several models of hypertension. T …
Tissue Transglutaminase-Mediated AT1 Receptor Sensitization Underlies Pro-inflammatory Cytokine LIGHT-Induced Hypertension.
Liu C, Luo R, Wang W, Peng Z, Johnson GVW, Kellems RE, Xia Y. Liu C, et al. Am J Hypertens. 2019 Apr 22;32(5):476-485. doi: 10.1093/ajh/hpz018. Am J Hypertens. 2019. PMID: 30715101 Free PMC article.
BACKGROUND: Although numerous recent studies have shown a strong link between inflammation and hypertension, the underlying mechanisms by which inflammatory cytokines induce hypertension remain to be fully elucidated. Hypertensive disorders are also associate …
BACKGROUND: Although numerous recent studies have shown a strong link between inflammation and hypertension, the underlying mechanism …
Tissue Transglutaminase Elevates Intraocular Pressure in Mice.
Raychaudhuri U, Millar JC, Clark AF. Raychaudhuri U, et al. Invest Ophthalmol Vis Sci. 2017 Dec 1;58(14):6197-6211. doi: 10.1167/iovs.17-22236. Invest Ophthalmol Vis Sci. 2017. PMID: 29222550
CONCLUSIONS: The increased expression of TGM2 in the TM increases N-epsilon(gamma-glutamyl) lysine crosslinking in the TM, increases aqueous outflow resistance, and elevates IOP in mice. TGM2 may be at least partially responsible for ocular hypertension in POAG....
CONCLUSIONS: The increased expression of TGM2 in the TM increases N-epsilon(gamma-glutamyl) lysine crosslinking in the TM, increases aqueous …
S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes.
Jeong EM, Jin CZ, Jang JH, Zhao ZH, Jin CL, Lee JH, Lee KB, Kim SJ, Kim IG, Zhang YH. Jeong EM, et al. Exp Mol Med. 2018 Apr 6;50(4):1-11. doi: 10.1038/s12276-017-0021-x. Exp Mol Med. 2018. PMID: 29622788 Free PMC article.
By contrast, in cardiac myocytes from angiotensin-II-treated rats and mice, the effects of fatty acid supplementation on TG2 activity, ATP level, and myocyte contraction were abolished. We found that TG2 was inhibited by S-nitrosylation and its level increased in hypert
By contrast, in cardiac myocytes from angiotensin-II-treated rats and mice, the effects of fatty acid supplementation on TG2 activity, ATP l …
Novel roles for biogenic monoamines: from monoamines in transglutaminase-mediated post-translational protein modification to monoaminylation deregulation diseases.
Walther DJ, Stahlberg S, Vowinckel J. Walther DJ, et al. FEBS J. 2011 Dec;278(24):4740-55. doi: 10.1111/j.1742-4658.2011.08347.x. Epub 2011 Nov 21. FEBS J. 2011. PMID: 21923757 Free article. Review.
Multiple physiological roles have been identified since its description in 2003 and, importantly, deregulated serotonylation was shown in the etiology of bleeding disorders, primary pulmonary hypertension and diabetes. The PBMAs 5-HT, histamine, dopamine, and norepinephrin …
Multiple physiological roles have been identified since its description in 2003 and, importantly, deregulated serotonylation was shown in th …
29 results