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Year Number of Results
1997 1
2001 1
2004 1
2007 1
2008 2
2010 1
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2012 1
2017 1
2018 3
2022 0
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Transglutaminase 2: Friend or foe? The discordant role in neurons and astrocytes.
Quinn BR, Yunes-Medina L, Johnson GVW. Quinn BR, et al. J Neurosci Res. 2018 Jul;96(7):1150-1158. doi: 10.1002/jnr.24239. Epub 2018 Mar 23. J Neurosci Res. 2018. PMID: 29570839 Free PMC article. Review.
Overexpression of TG2 in primary neurons protects against oxygen and glucose deprivation (OGD)-induced cell death and in vivo results in a reduction in infarct volume subsequent to a stroke. Knockdown of TG2 in primary neurons results in a loss of viability. ...
Overexpression of TG2 in primary neurons protects against oxygen and glucose deprivation (OGD)-induced cell death and in vivo results in a r …
Role of transglutaminase 2 in A1 adenosine receptor- and β2-adrenoceptor-mediated pharmacological pre- and post-conditioning against hypoxia-reoxygenation-induced cell death in H9c2 cells.
Vyas FS, Nelson CP, Dickenson JM. Vyas FS, et al. Eur J Pharmacol. 2018 Jan 15;819:144-160. doi: 10.1016/j.ejphar.2017.11.049. Epub 2017 Dec 5. Eur J Pharmacol. 2018. PMID: 29208472
Pharmacologically-induced pre- and post-conditioning represent attractive therapeutic strategies to reduce ischaemia/reperfusion injury during cardiac surgery and following myocardial infarction. We have previously reported that transglutaminase 2 (TG2) activity is modulat …
Pharmacologically-induced pre- and post-conditioning represent attractive therapeutic strategies to reduce ischaemia/reperfusion injury duri …
Transglutaminase 2 protects against ischemic stroke.
Filiano AJ, Tucholski J, Dolan PJ, Colak G, Johnson GV. Filiano AJ, et al. Neurobiol Dis. 2010 Sep;39(3):334-43. doi: 10.1016/j.nbd.2010.04.018. Epub 2010 May 6. Neurobiol Dis. 2010. PMID: 20451610 Free PMC article.
TG2 mRNA levels are increased after MCA ligations, and transgenic mice that express human TG2 in neurons had significantly smaller infarct volumes than wild type littermates. Further, TG2 translocates into the nucleus within 2h post ligation. ...
TG2 mRNA levels are increased after MCA ligations, and transgenic mice that express human TG2 in neurons had significantly smaller infarc
Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction.
Nahrendorf M, Aikawa E, Figueiredo JL, Stangenberg L, van den Borne SW, Blankesteijn WM, Sosnovik DE, Jaffer FA, Tung CH, Weissleder R. Nahrendorf M, et al. Eur Heart J. 2008 Feb;29(4):445-54. doi: 10.1093/eurheartj/ehm558. Eur Heart J. 2008. PMID: 18276618
AIMS: The transglutaminase factor XIII (FXIII) emerges as a key enzyme in healing after myocardial infarction (MI). Here we assess the impact of transglutaminase-modulating therapies on healing and evolution of heart failure using a novel, non-invasive molecular imaging te …
AIMS: The transglutaminase factor XIII (FXIII) emerges as a key enzyme in healing after myocardial infarction (MI). Here we assess th …
Localization of tissue transglutaminase in human carotid and coronary artery atherosclerosis: implications for plaque stability and progression.
Haroon ZA, Wannenburg T, Gupta M, Greenberg CS, Wallin R, Sane DC. Haroon ZA, et al. Lab Invest. 2001 Jan;81(1):83-93. doi: 10.1038/labinvest.3780214. Lab Invest. 2001. PMID: 11204277
Although atherosclerosis progresses in an indolent state for decades, the rupture of plaques creates acute ischemic syndromes that may culminate in myocardial infarction and stroke. Mechanical forces and matrix metalloproteinase activity initiate plaque rupture, whereas ti …
Although atherosclerosis progresses in an indolent state for decades, the rupture of plaques creates acute ischemic syndromes that may culmi …
Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor.
Wang Z, Stuckey DJ, Murdoch CE, Camelliti P, Lip GYH, Griffin M. Wang Z, et al. Cell Death Dis. 2018 Apr 27;9(6):613. doi: 10.1038/s41419-018-0573-2. Cell Death Dis. 2018. PMID: 29795262 Free PMC article.
Here we describe the use a highly selective TG2 small-molecule inhibitor to test the efficacy of TG2 inhibition as an anti-fibrotic therapy for heart failure employing two different in vivo models of cardiac fibrosis: Progressively induced interstitial cardiac fibrosis by pressur …
Here we describe the use a highly selective TG2 small-molecule inhibitor to test the efficacy of TG2 inhibition as an anti-fibrotic therapy …
Tissue transglutaminase is essential for integrin-mediated survival of bone marrow-derived mesenchymal stem cells.
Song H, Chang W, Lim S, Seo HS, Shim CY, Park S, Yoo KJ, Kim BS, Min BH, Lee H, Jang Y, Chung N, Hwang KC. Song H, et al. Stem Cells. 2007 Jun;25(6):1431-8. doi: 10.1634/stemcells.2006-0467. Epub 2007 Mar 8. Stem Cells. 2007. PMID: 17347495 Free article.
Downregulation of tTG by transfection of small interfering RNA specific to the tTG resulted in markedly decreased adhesion and spread of MSCs on Fn or cardiogel. tTG-MSCs on Fn significantly increased phosphorylation of focal adhesion related kinases FAK, Src, and PI3K. tTG-MSCs …
Downregulation of tTG by transfection of small interfering RNA specific to the tTG resulted in markedly decreased adhesion and spread of MSC …
Antitissue transglutaminase antibodies in acute coronary syndrome: an alert signal of myocardial tissue lesion?
Di Tola M, Barillà F, Trappolini M, Palumbo HF, Gaudio C, Picarelli A. Di Tola M, et al. J Intern Med. 2008 Jan;263(1):43-51. doi: 10.1111/j.1365-2796.2007.01881.x. J Intern Med. 2008. PMID: 18088251 Free article. Clinical Trial.
In patients at the second ACS, antibody levels were higher than in those at the first cardiac event. In patients with infarct Q, antitransglutaminase were higher than those in infarct non-Q, in which antibody levels were higher than those in unstable angina. ...
In patients at the second ACS, antibody levels were higher than in those at the first cardiac event. In patients with infarct Q, anti …
Complete transglutaminase 2 ablation results in reduced stroke volumes and astrocytes that exhibit increased survival in response to ischemia.
Colak G, Johnson GV. Colak G, et al. Neurobiol Dis. 2012 Mar;45(3):1042-50. doi: 10.1016/j.nbd.2011.12.023. Epub 2011 Dec 14. Neurobiol Dis. 2012. PMID: 22198379 Free PMC article.
For example in hTG2 transgenic mice, where TG2 is overexpressed only in neurons, middle cerebral artery ligation (MCAL) resulted in smaller infarct volumes compared to wild type mice. In this study TG2 knock out mice were used to determine how endogenous TG2 affected strok …
For example in hTG2 transgenic mice, where TG2 is overexpressed only in neurons, middle cerebral artery ligation (MCAL) resulted in smaller …
Immunohistochemical study on tissue transglutaminase and copper-zinc superoxide dismutase in human myocardium: its relevance to apoptosis detected by the nick end labelling method.
Kashima K, Yokoyama S, Daa T, Nakayama I, Iwaki T. Kashima K, et al. Virchows Arch. 1997 Apr;430(4):333-8. doi: 10.1007/BF01092757. Virchows Arch. 1997. PMID: 9134045
Positive nuclear reaction by NELM was only observed in myocardial cells showing contraction band necrosis or irregularly shaped nuclei surrounding recent or long-standing infarcted foci. In these the other two markers were negative. Since mucinous degeneration lacks the di …
Positive nuclear reaction by NELM was only observed in myocardial cells showing contraction band necrosis or irregularly shaped nuclei surro …
11 results