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96 results

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Page 1
Cellular functions of tissue transglutaminase.
Nurminskaya MV, Belkin AM. Nurminskaya MV, et al. Int Rev Cell Mol Biol. 2012;294:1-97. doi: 10.1016/B978-0-12-394305-7.00001-X. Int Rev Cell Mol Biol. 2012. PMID: 22364871 Free PMC article. Review.
In turn, the impact of TG2 on these processes implicates this protein in various physiological responses and pathological states, contributing to wound healing, inflammation, autoimmunity, neurodegeneration, vascular remodeling, tumor growth and metastasis, and tissue fibr …
In turn, the impact of TG2 on these processes implicates this protein in various physiological responses and pathological states, contributi …
Inhibitors of tissue transglutaminase.
Keillor JW, Apperley KY, Akbar A. Keillor JW, et al. Trends Pharmacol Sci. 2015 Jan;36(1):32-40. doi: 10.1016/j.tips.2014.10.014. Epub 2014 Dec 12. Trends Pharmacol Sci. 2015. PMID: 25500711 Review.
Although TG2 is essential for the stabilization of the extracellular matrix, its unregulated activity has been implicated in celiac disease, fibrosis, and cancer metastasis, among other disorders. Given the importance and range of TG2-related pathologies, recent work has f …
Although TG2 is essential for the stabilization of the extracellular matrix, its unregulated activity has been implicated in celiac disease, …
Tissue transglutaminase, inflammation, and cancer: how intimate is the relationship?
Kumar S, Mehta K. Kumar S, et al. Amino Acids. 2013 Jan;44(1):81-8. doi: 10.1007/s00726-011-1139-0. Epub 2011 Nov 15. Amino Acids. 2013. PMID: 22083892 Review.
Despite significant advances in surgery and biology, cancer remains a major health problem. It is now well accepted that metastasis and cancer cells' acquired or inherent resistance to conventional therapies are major roadblocks to successful treatment. ...According to the …
Despite significant advances in surgery and biology, cancer remains a major health problem. It is now well accepted that metastasis a …
Tissue transglutaminase-mediated chemoresistance in cancer cells.
Verma A, Mehta K. Verma A, et al. Drug Resist Updat. 2007 Aug-Oct;10(4-5):144-51. doi: 10.1016/j.drup.2007.06.002. Epub 2007 Jul 27. Drug Resist Updat. 2007. PMID: 17662645 Review.
Drug resistance and metastasis are major impediments for the successful treatment of cancer. ...This review discusses the current thinking and implications of increased TG2 expression in development of drug resistance and metastasis by cancer cells....
Drug resistance and metastasis are major impediments for the successful treatment of cancer. ...This review discusses the current thi …
Transglutaminase 2 in cancer.
Huang L, Xu AM, Liu W. Huang L, et al. Am J Cancer Res. 2015 Aug 15;5(9):2756-76. eCollection 2015. Am J Cancer Res. 2015. PMID: 26609482 Free PMC article.
TG2 also plays an important role in tumor progression and may serve as a novel prognostic biomarker and therapeutic target in various cancer types. TG2 promotes malignant cell mobility, invasion, and metastasis, and induces chemo-resistance of cancer cells, mainly through …
TG2 also plays an important role in tumor progression and may serve as a novel prognostic biomarker and therapeutic target in various cancer …
Transglutaminase 2: The Maestro of the Oncogenic Mediators in Renal Cell Carcinoma.
Nezir AE, Ulukan B, Telci D. Nezir AE, et al. Med Sci (Basel). 2019 Feb 6;7(2):24. doi: 10.3390/medsci7020024. Med Sci (Basel). 2019. PMID: 30736384 Free PMC article. Review.
Von Hippel-Lindau mutations leading to the subsequent activation of Hypoxia Inducible Factor (HIF)-1-mediated signaling pathways, survival signaling via the PI3K/Akt pathway resulting in Epithelial Mesenchymal Transition (EMT) metastasis and angiogenesis are the main facto …
Von Hippel-Lindau mutations leading to the subsequent activation of Hypoxia Inducible Factor (HIF)-1-mediated signaling pathways, survival s …
Tissue transglutaminase promotes or suppresses tumors depending on cell context.
Chhabra A, Verma A, Mehta K. Chhabra A, et al. Anticancer Res. 2009 Jun;29(6):1909-19. Anticancer Res. 2009. PMID: 19528447 Free article. Review.
Therefore, elucidation of tumor-encoded genes whose expression contribute to the development of drug resistance and metastasis can be of great significance in revealing novel therapeutic targets for the effective control and treatment of cancer. ...In this review, the cont …
Therefore, elucidation of tumor-encoded genes whose expression contribute to the development of drug resistance and metastasis can be …
Tissue transglutaminase as a central mediator in inflammation-induced progression of breast cancer.
Agnihotri N, Kumar S, Mehta K. Agnihotri N, et al. Breast Cancer Res. 2013 Feb 25;15(1):202. doi: 10.1186/bcr3371. Breast Cancer Res. 2013. PMID: 23673317 Free PMC article. Review.
TG2 expression is able to induce the developmentally regulated program of epithelial-to-mesenchymal transition (EMT) and to confer cancer stem cell (CSC) traits in mammary epithelial cells; both EMT and CSCs have been implicated in cancer metastasis and resistance to stand …
TG2 expression is able to induce the developmentally regulated program of epithelial-to-mesenchymal transition (EMT) and to confer cancer st …
Transglutaminase 2: a multi-tasking protein in the complex circuitry of inflammation and cancer.
Mehta K, Kumar A, Kim HI. Mehta K, et al. Biochem Pharmacol. 2010 Dec 15;80(12):1921-9. doi: 10.1016/j.bcp.2010.06.029. Epub 2010 Jun 25. Biochem Pharmacol. 2010. PMID: 20599779 Review.
Metastasis of primary tumors to distant sites and their inherent or acquired resistance to currently available therapies pose major clinical challenge to the successful treatment of cancer. ...Recently, cells that have undergone the epithelial-mesenchymal transition (EMT),
Metastasis of primary tumors to distant sites and their inherent or acquired resistance to currently available therapies pose major c
96 results