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Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma.
Juranic Z, Radic J, Konic-Ristic A, Jelic S, Mihaljevic B, Stankovic I, Matkovic S, Besu I, Gavrilović D. Juranic Z, et al. BMC Immunol. 2008 May 28;9:22. doi: 10.1186/1471-2172-9-22. BMC Immunol. 2008. PMID: 18507842 Free PMC article.
BACKGROUND: Multiple myeloma (MM) is a clonal B-cell disorder with many immunological disturbances. ...
BACKGROUND: Multiple myeloma (MM) is a clonal B-cell disorder with many immunological disturbances. ...
Evidence for the involvement of both retinoic acid receptor- and retinoic X receptor-dependent signaling pathways in the induction of tissue transglutaminase and apoptosis in the human myeloma cell line RPMI 8226.
Joseph B, Lefebvre O, Méreau-Richard C, Danzé PM, Belin-Plancot MT, Formstecher P. Joseph B, et al. Blood. 1998 Apr 1;91(7):2423-32. Blood. 1998. PMID: 9516142 Free article.
In this study, we show that both all-trans-retinoic acid (atRA) and 9-cis-retinoic acid (9-cis-RA) are potent inducers of tissue transglutaminase (TGase II), an enzyme involved in apoptosis, at the level of both enzyme activity and mRNA in the human myeloma cell line RPMI …
In this study, we show that both all-trans-retinoic acid (atRA) and 9-cis-retinoic acid (9-cis-RA) are potent inducers of tissue transglutam …
Low immunoglobulin A levels detected via the tissue transglutaminase assay can reveal previously undetected monoclonal proteins.
Wallage M, Dutton D, Lock RJ. Wallage M, et al. Ann Clin Biochem. 2016 May;53(Pt 3):409-11. doi: 10.1177/0004563215625692. Epub 2015 Dec 17. Ann Clin Biochem. 2016. PMID: 26684021
In one 3-month period, of 60 cases reviewed for low Immunoglobulin A, we found four new paraproteins through this testing route; one symptomatic multiple myeloma, one asymptomatic multiple myeloma, one monoclonal gammopathy of uncertain significance an …
In one 3-month period, of 60 cases reviewed for low Immunoglobulin A, we found four new paraproteins through this testing route; one symptom …