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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 2
1997 2
1998 3
1999 2
2000 5
2001 2
2002 10
2003 6
2004 6
2005 7
2006 10
2007 4
2008 8
2009 10
2010 8
2011 10
2012 9
2013 8
2014 10
2015 5
2016 11
2017 12
2018 8
2019 2
2024 0

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141 results

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Page 1
New insight into transglutaminase 2 and link to neurodegenerative diseases.
Min B, Chung KC. Min B, et al. BMB Rep. 2018 Jan;51(1):5-13. doi: 10.5483/bmbrep.2018.51.1.227. BMB Rep. 2018. PMID: 29187283 Free PMC article. Review.
Formation of toxic protein aggregates is a common feature and mainly contributes to the pathogenesis of neurodegenerative diseases (NDDs), which include amyotrophic lateral sclerosis (ALS), Alzheimer's, Parkinson's, Huntington's, and prion diseases. ...
Formation of toxic protein aggregates is a common feature and mainly contributes to the pathogenesis of neurodegenerative diseases (N …
[Transglutaminase and neurodegenerative diseases].
Liu Z, Zeng J, Zeng S, Tang B, Wang J. Liu Z, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Aug;32(4):562-6. doi: 10.3760/cma.j.issn.1003-9406.2015.04.025. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015. PMID: 26252108 Review. Chinese.
TGase has been found to contribute to a variety of important physiological and pathological processes and play a role in the pathogenesis of multiple diseases. Notably, neurodegenerative diseases such as Huntington's disease, spinocerebellar ataxia, Alzheimer's disease and …
TGase has been found to contribute to a variety of important physiological and pathological processes and play a role in the pathogenesis of …
Tissue transglutaminase (TG2) and mitochondrial function and dysfunction.
Lai TS, Lin CJ, Wu YT, Wu CJ. Lai TS, et al. Front Biosci (Landmark Ed). 2017 Mar 1;22(7):1114-1137. doi: 10.2741/4536. Front Biosci (Landmark Ed). 2017. PMID: 28199195 Free article. Review.
Here, we summarize dysfunctional mitochondria in diseases such as in neurodegenerative disorders can modulate TG2's activity and function. TG2 is also important for normal function of mitochondria....
Here, we summarize dysfunctional mitochondria in diseases such as in neurodegenerative disorders can modulate TG2's activity and func …
Transglutaminase 2 and neuroinflammation.
Ientile R, Currò M, Caccamo D. Ientile R, et al. Amino Acids. 2015 Jan;47(1):19-26. doi: 10.1007/s00726-014-1864-2. Epub 2014 Nov 15. Amino Acids. 2015. PMID: 25398223 Review.
Neuroinflammatory processes seem to play a pivotal role in various chronic neurodegenerative diseases, characterized also by the pathogenetic accumulation of specific protein aggregates. ...Several findings emphasize the possible role of the TG2/NF-kappaB activation pathwa …
Neuroinflammatory processes seem to play a pivotal role in various chronic neurodegenerative diseases, characterized also by the path …
Transglutaminase 2: biology, relevance to neurodegenerative diseases and therapeutic implications.
Grosso H, Mouradian MM. Grosso H, et al. Pharmacol Ther. 2012 Mar;133(3):392-410. doi: 10.1016/j.pharmthera.2011.12.003. Epub 2011 Dec 22. Pharmacol Ther. 2012. PMID: 22212614 Review.
Neurodegenerative disorders are characterized by progressive neuronal loss and the aggregation of disease-specific pathogenic proteins in hallmark neuropathologic lesions. ...
Neurodegenerative disorders are characterized by progressive neuronal loss and the aggregation of disease-specific pathogenic protein
Structural aspects of transglutaminase 2: functional, structural, and regulatory diversity.
Lee CS, Park HH. Lee CS, et al. Apoptosis. 2017 Sep;22(9):1057-1068. doi: 10.1007/s10495-017-1396-9. Apoptosis. 2017. PMID: 28677093 Review.
TG2 is linked to many human diseases such as inflammatory disease, celiac disease, neurodegenerative disease, diabetes, tissue fibrosis, and various cancers and is one of the most dynamic enzymes in terms of its functions, structures, and regulatory mechanisms. ...
TG2 is linked to many human diseases such as inflammatory disease, celiac disease, neurodegenerative disease, diabetes, tissue fibros …
Possible involvement of transglutaminase-catalyzed reactions in the physiopathology of neurodegenerative diseases.
Martin A, Giuliano A, Collaro D, De Vivo G, Sedia C, Serretiello E, Gentile V. Martin A, et al. Amino Acids. 2013 Jan;44(1):111-8. doi: 10.1007/s00726-011-1081-1. Epub 2011 Sep 22. Amino Acids. 2013. PMID: 21938398 Review.
Transglutaminase activity has been hypothesized to be involved also in the pathogenetic mechanisms responsible for human neurodegenerative diseases. Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, supranuclear palsy, Huntington's diseas …
Transglutaminase activity has been hypothesized to be involved also in the pathogenetic mechanisms responsible for human neurodegenerativ
New Insights into Development of Transglutaminase 2 Inhibitors as Pharmaceutical Lead Compounds.
Kim SY. Kim SY. Med Sci (Basel). 2018 Oct 8;6(4):87. doi: 10.3390/medsci6040087. Med Sci (Basel). 2018. PMID: 30297644 Free PMC article. Review.
Consistent with this, TGase 2 knockout mice exhibit reversal of disease phenotypes in neurodegenerative and chronic inflammatory disease models. Accordingly, TGase 2 is considered to be a potential therapeutic target. ...
Consistent with this, TGase 2 knockout mice exhibit reversal of disease phenotypes in neurodegenerative and chronic inflammatory dise …
Transglutaminase 2 in inflammation.
Kim SY. Kim SY. Front Biosci. 2006 Sep 1;11:3026-35. doi: 10.2741/2030. Front Biosci. 2006. PMID: 16720373 Review.
Aberrant activation of TG 2 activity in tissues contributes to a variety of diseases including neurodegenerative diseases, autoimmune diseases, and cancers. In most cases, TG 2 appears to form an inappropriate protein aggregate that may be cytotoxic enough to trigger infla …
Aberrant activation of TG 2 activity in tissues contributes to a variety of diseases including neurodegenerative diseases, autoimmune …
Type 2 transglutaminase in neurodegenerative diseases: the mitochondrial connection.
Malorni W, Farrace MG, Rodolfo C, Piacentini M. Malorni W, et al. Curr Pharm Des. 2008;14(3):278-88. Curr Pharm Des. 2008. PMID: 18220838 Review.
Multiple lines of evidence suggest an involvement of the enzyme in neurodegenerative diseases, such as Huntington's (HD) and Parkinson (PD), and that its inhibition, either via drug treatments or genetic approaches, might be beneficial for the treatment of these syndromes. …
Multiple lines of evidence suggest an involvement of the enzyme in neurodegenerative diseases, such as Huntington's (HD) and Parkinso …
141 results