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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2003 1
2004 2
2008 2
2010 1
2011 1
2012 2
2013 1
2015 1
2018 2
2022 0
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13 results
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Transglutaminase 2: Friend or foe? The discordant role in neurons and astrocytes.
Quinn BR, Yunes-Medina L, Johnson GVW. Quinn BR, et al. J Neurosci Res. 2018 Jul;96(7):1150-1158. doi: 10.1002/jnr.24239. Epub 2018 Mar 23. J Neurosci Res. 2018. PMID: 29570839 Free PMC article. Review.
Overexpression of TG2 in primary neurons protects against oxygen and glucose deprivation (OGD)-induced cell death and in vivo results in a reduction in infarct volume subsequent to a stroke. Knockdown of TG2 in primary neurons results in a loss of viability. ...
Overexpression of TG2 in primary neurons protects against oxygen and glucose deprivation (OGD)-induced cell death and in vivo results in a r …
Transglutaminase is a therapeutic target for oxidative stress, excitotoxicity and stroke: a new epigenetic kid on the CNS block.
Basso M, Ratan RR. Basso M, et al. J Cereb Blood Flow Metab. 2013 Jun;33(6):809-18. doi: 10.1038/jcbfm.2013.53. Epub 2013 Apr 10. J Cereb Blood Flow Metab. 2013. PMID: 23571278 Free PMC article. Review.
Here, we review the evidence that supports principally a role for one isoform of this family, TG2, in cell injury and death associated with hemorrhagic or ischemic stroke. We also outline an evolving model in which TG2 is a critical mediator between pathologic signaling an …
Here, we review the evidence that supports principally a role for one isoform of this family, TG2, in cell injury and death associated with …
Transglutaminase 2 protects against ischemic stroke.
Filiano AJ, Tucholski J, Dolan PJ, Colak G, Johnson GV. Filiano AJ, et al. Neurobiol Dis. 2010 Sep;39(3):334-43. doi: 10.1016/j.nbd.2010.04.018. Epub 2010 May 6. Neurobiol Dis. 2010. PMID: 20451610 Free PMC article.
TG2 binds to the hypoxia inducible factor (HIF) 1beta and decreases the upregulation of hypoxic-induced proapoptotic genes. To investigate the role of TG2 in ischemic stroke in vivo, we used the murine, permanent middle cerebral artery (MCA) ligation model. ...Further, TG2 …
TG2 binds to the hypoxia inducible factor (HIF) 1beta and decreases the upregulation of hypoxic-induced proapoptotic genes. To investigate t …
Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls.
Petersen-Jones HG, Johnson KB, Hitomi K, Tykocki NR, Thompson JM, Watts SW. Petersen-Jones HG, et al. Am J Physiol Heart Circ Physiol. 2015 Mar 15;308(6):H592-602. doi: 10.1152/ajpheart.00402.2014. Epub 2015 Jan 16. Am J Physiol Heart Circ Physiol. 2015. PMID: 25599570 Free PMC article.
Because hypertension is characterized by arterial remodeling, we hypothesized that TG activity, expression, and functionality would be increased in the aorta, but not in the vena cava (which does not undergo remodeling), from hypertensive rats relative to normotensive rats. Spont …
Because hypertension is characterized by arterial remodeling, we hypothesized that TG activity, expression, and functionality would be incre …
Complete transglutaminase 2 ablation results in reduced stroke volumes and astrocytes that exhibit increased survival in response to ischemia.
Colak G, Johnson GV. Colak G, et al. Neurobiol Dis. 2012 Mar;45(3):1042-50. doi: 10.1016/j.nbd.2011.12.023. Epub 2011 Dec 14. Neurobiol Dis. 2012. PMID: 22198379 Free PMC article.
In this study TG2 knock out mice were used to determine how endogenous TG2 affected stroke volumes. Intriguingly, infarct volumes in TG2 knock out mice were significantly smaller compared to wild type mice. ...Both wild type and knock out neurons were protected against oxy …
In this study TG2 knock out mice were used to determine how endogenous TG2 affected stroke volumes. Intriguingly, infarct volumes in …
Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling.
Filiano AJ, Bailey CD, Tucholski J, Gundemir S, Johnson GV. Filiano AJ, et al. FASEB J. 2008 Aug;22(8):2662-75. doi: 10.1096/fj.07-097709. Epub 2008 Mar 28. FASEB J. 2008. PMID: 18375543 Free PMC article.
Transglutaminase 2 (TG2) is a multifunctional enzyme that has been implicated in the pathogenesis of neurodegenerative diseases, ischemia, and stroke. The mechanism by which TG2 modulates disease progression have not been elucidated. ...These results indicate that TG2 may …
Transglutaminase 2 (TG2) is a multifunctional enzyme that has been implicated in the pathogenesis of neurodegenerative diseases, ischemia, a …
Localization of tissue transglutaminase in human carotid and coronary artery atherosclerosis: implications for plaque stability and progression.
Haroon ZA, Wannenburg T, Gupta M, Greenberg CS, Wallin R, Sane DC. Haroon ZA, et al. Lab Invest. 2001 Jan;81(1):83-93. doi: 10.1038/labinvest.3780214. Lab Invest. 2001. PMID: 11204277
Although atherosclerosis progresses in an indolent state for decades, the rupture of plaques creates acute ischemic syndromes that may culminate in myocardial infarction and stroke. Mechanical forces and matrix metalloproteinase activity initiate plaque rupture, whereas ti …
Although atherosclerosis progresses in an indolent state for decades, the rupture of plaques creates acute ischemic syndromes that may culmi …
Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.
Basso M, Berlin J, Xia L, Sleiman SF, Ko B, Haskew-Layton R, Kim E, Antonyak MA, Cerione RA, Iismaa SE, Willis D, Cho S, Ratan RR. Basso M, et al. J Neurosci. 2012 May 9;32(19):6561-9. doi: 10.1523/JNEUROSCI.3353-11.2012. J Neurosci. 2012. PMID: 22573678 Free PMC article.
Molecular deletion of transglutaminase 2 (TG2) has been shown to improve function and survival in a host of neurological conditions including stroke, Huntington's disease, and Parkinson's disease. However, unifying schemes by which these cross-linking or poly …
Molecular deletion of transglutaminase 2 (TG2) has been shown to improve function and survival in a host of neurological conditions includin …
Tissue transglutaminase catalyzes the formation of alpha-synuclein crosslinks in Parkinson's disease.
Andringa G, Lam KY, Chegary M, Wang X, Chase TN, Bennett MC. Andringa G, et al. FASEB J. 2004 May;18(7):932-4. doi: 10.1096/fj.03-0829fje. Epub 2004 Mar 4. FASEB J. 2004. PMID: 15001552
In Parkinson's disease (PD), conformational changes in the alpha-synuclein monomer precede the formation of Lewy bodies. ...
In Parkinson's disease (PD), conformational changes in the alpha-synuclein monomer precede the formation of Lewy bodies. ...
13 results