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341 results

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Page 1
Updates on eosinophilic disorders.
Tzankov A, Reichard KK, Hasserjian RP, Arber DA, Orazi A, Wang SA. Tzankov A, et al. Virchows Arch. 2023 Jan;482(1):85-97. doi: 10.1007/s00428-022-03402-8. Epub 2022 Sep 7. Virchows Arch. 2023. PMID: 36068374 Review.
This review addresses changes and updates in eosinophilic disorders under the International Consensus Classification (ICC). The previous category of myeloid/lymphoid neoplasm with eosinophilia (M/LN-eo) and a specific gene rearrangement is changed to M/LN-eo with tyrosine …
This review addresses changes and updates in eosinophilic disorders under the International Consensus Classification (ICC). The previ …
Histological types of breast cancer: how special are they?
Weigelt B, Geyer FC, Reis-Filho JS. Weigelt B, et al. Mol Oncol. 2010 Jun;4(3):192-208. doi: 10.1016/j.molonc.2010.04.004. Epub 2010 Apr 18. Mol Oncol. 2010. PMID: 20452298 Free PMC article. Review.
For instance, secretory carcinomas of the breast consistently harbour the t(12;15) translocation that leads to the formation of the ETV6-NTRK3 fusion gene, adenoid cystic carcinomas consistently display the t(6;9) MYB-NFIB translocation and lobular carcinomas consistently …
For instance, secretory carcinomas of the breast consistently harbour the t(12;15) translocation that leads to the formation of the ETV6 …
Advances in germline predisposition to acute leukaemias and myeloid neoplasms.
Klco JM, Mullighan CG. Klco JM, et al. Nat Rev Cancer. 2021 Feb;21(2):122-137. doi: 10.1038/s41568-020-00315-z. Epub 2020 Dec 16. Nat Rev Cancer. 2021. PMID: 33328584 Free PMC article. Review.
Although much work has focused on the elucidation of somatic alterations that drive the development of acute leukaemias and other haematopoietic diseases, it has become increasingly recognized that germline mutations are common in many of these neoplasms. In this Review, w …
Although much work has focused on the elucidation of somatic alterations that drive the development of acute leukaemias and other haematopoi …
Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N. Davis K, et al. Semin Diagn Pathol. 2023 May;40(3):202-215. doi: 10.1053/j.semdp.2023.04.003. Epub 2023 Apr 9. Semin Diagn Pathol. 2023. PMID: 37120350 Review.
This increased diagnostic and therapeutic complexity can be overwhelming, and this review compares nomenclature differences between the ICC and WHO 5th edition publications, compiles key features of each entity, and provides a diagnostic algorithmic approach. ...The establ …
This increased diagnostic and therapeutic complexity can be overwhelming, and this review compares nomenclature differences between t …
Precision medicine in acute lymphoblastic leukemia.
Pui CH. Pui CH. Front Med. 2020 Dec;14(6):689-700. doi: 10.1007/s11684-020-0759-8. Epub 2020 Oct 19. Front Med. 2020. PMID: 33074527 Free PMC article. Review.
Further improvement in outcome will need to rely more heavily on molecular therapeutic as well as immuno-and cellular-therapy approaches together with precise risk stratification. Children with ETV6-RUNX1 or hyperdiploid > 50 ALL who achieve negative minimal residual di …
Further improvement in outcome will need to rely more heavily on molecular therapeutic as well as immuno-and cellular-therapy approaches tog …
Molecular markers in ALL: Clinical implications.
Kimura S, Mullighan CG. Kimura S, et al. Best Pract Res Clin Haematol. 2020 Sep;33(3):101193. doi: 10.1016/j.beha.2020.101193. Epub 2020 Jun 7. Best Pract Res Clin Haematol. 2020. PMID: 33038982 Free PMC article. Review.
Several of these approaches have been validated in preclinical models and are now being formally evaluated in prospective clinical trials. In this review, we provide an overview of the recent advances in our knowledge of genomic bases of BCP-ALL, T-ALL, and relapsed ALL, a …
Several of these approaches have been validated in preclinical models and are now being formally evaluated in prospective clinical trials. I …
The international consensus classification of eosinophilic disorders and systemic mastocytosis.
Wang SA, Orazi A, Gotlib J, Reiter A, Tzankov A, Hasserjian RP, Arber DA, Tefferi A. Wang SA, et al. Am J Hematol. 2023 Aug;98(8):1286-1306. doi: 10.1002/ajh.26966. Epub 2023 Jun 7. Am J Hematol. 2023. PMID: 37283522 Free article. Review.
The category has been expanded to include ETV6::ABL1 and FLT3 fusions, and to accept PCM1::JAK2 and its genetic variants as formal members. ...The major diagnostic criteria for systemic mastocytosis (SM) in the ICC remain largely based on morphology, but several minor modi …
The category has been expanded to include ETV6::ABL1 and FLT3 fusions, and to accept PCM1::JAK2 and its genetic variants as formal me …
The International Consensus Classification (ICC) of hematologic neoplasms with germline predisposition, pediatric myelodysplastic syndrome, and juvenile myelomonocytic leukemia.
Rudelius M, Weinberg OK, Niemeyer CM, Shimamura A, Calvo KR. Rudelius M, et al. Virchows Arch. 2023 Jan;482(1):113-130. doi: 10.1007/s00428-022-03447-9. Epub 2022 Nov 29. Virchows Arch. 2023. PMID: 36445482 Review.
Advances in next-generation sequencing technology have led to the identification of an expanding group of genes that predispose to the development of hematolymphoid neoplasia when mutated in germline configuration and inherited. This review encompasses recent advances in t …
Advances in next-generation sequencing technology have led to the identification of an expanding group of genes that predispose to the devel …
How I treat myelodysplastic syndromes of childhood.
Locatelli F, Strahm B. Locatelli F, et al. Blood. 2018 Mar 29;131(13):1406-1414. doi: 10.1182/blood-2017-09-765214. Epub 2018 Feb 8. Blood. 2018. PMID: 29438960 Free article. Review.
Moreover, germ line syndromes predisposing individuals to develop MDS or acute myeloid leukemia have recently been identified, such as those caused by mutations in GATA2, ETV6, SRP72, and SAMD9/SAMD9-L Refractory cytopenia of childhood (RCC) is the most frequent pediatric …
Moreover, germ line syndromes predisposing individuals to develop MDS or acute myeloid leukemia have recently been identified, such as those …
Comparative features and outcomes between paediatric T-cell and B-cell acute lymphoblastic leukaemia.
Teachey DT, Pui CH. Teachey DT, et al. Lancet Oncol. 2019 Mar;20(3):e142-e154. doi: 10.1016/S1470-2045(19)30031-2. Lancet Oncol. 2019. PMID: 30842058 Free PMC article. Review.
Second, a higher proportion of patients with B-cell ALL have favourable genetic subtypes (eg, ETV6-RUNX1 and high hyperdiploidy), which confer a superior outcome compared with favourable subtypes of T-cell ALL. ...
Second, a higher proportion of patients with B-cell ALL have favourable genetic subtypes (eg, ETV6-RUNX1 and high hyperdiploidy), whi …
341 results