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Rare mature B-cell lymphomas in children and adolescents.
Woessmann W, Quintanilla-Martinez L. Woessmann W, et al. Hematol Oncol. 2019 Jun;37 Suppl 1:53-61. doi: 10.1002/hon.2585. Hematol Oncol. 2019. PMID: 31187530 Review.
The cells within the follicles of PTFL typically show high-grade cytology, IGH monoclonality and lack the t(14;18) chromosomal alteration. ...B-cell lymphomas presenting in the Waldeyer's ring are characterized by the expression of IRF4/MUM1 and often associated wit …
The cells within the follicles of PTFL typically show high-grade cytology, IGH monoclonality and lack the t(14;18) chromosomal altera …
Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Quintanilla-Martinez L, Laurent C, Soma L, Ng SB, Climent F, Ondrejka SL, Zamo A, Wotherspoon A, de Leval L, Dirnhofer S, Leoncini L. Quintanilla-Martinez L, et al. Virchows Arch. 2023 Sep;483(3):281-298. doi: 10.1007/s00428-023-03590-x. Epub 2023 Aug 9. Virchows Arch. 2023. PMID: 37555980 Free PMC article. Review.
It has a Burkitt-like immunophenotype (CD10+, BCL6+, BCL2-) but MYC expression is weak or negative, lacks MYC rearrangement, and is in contrast to Burkitt lymphoma 50% of the cases express LMO2. LBCL with IRF4 rearrangement (LBCL-IRF4) occurs mainly in the pediatric …
It has a Burkitt-like immunophenotype (CD10+, BCL6+, BCL2-) but MYC expression is weak or negative, lacks MYC rearrangement, and is in contr …
B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma.
Snuderl M, Kolman OK, Chen YB, Hsu JJ, Ackerman AM, Dal Cin P, Ferry JA, Harris NL, Hasserjian RP, Zukerberg LR, Abramson JS, Hochberg EP, Lee H, Lee AI, Toomey CE, Sohani AR. Snuderl M, et al. Am J Surg Pathol. 2010 Mar;34(3):327-40. doi: 10.1097/PAS.0b013e3181cd3aeb. Am J Surg Pathol. 2010. PMID: 20118770 Free PMC article.
Six patients had a history of grade 1 to 2 follicular lymphoma; review of the prior biopsy specimens in 2 of 5 cases revealed blastoid morphology. ...Distinguishing features from BL included expression of Bcl2 (P<0.0001), Mum1/IRF4 (P=0.006), Ki-67 <95% (P< …
Six patients had a history of grade 1 to 2 follicular lymphoma; review of the prior biopsy specimens in 2 of 5 cases revealed blastoi …
Primary Low-Grade B-Cell Lymphoma of Skull With Translocation Between Immunoglobulin and Interferon Regulatory Factor 4 Genes.
Nasim MM, Chalif DJ, Demopoulos AM, Brody J, Lee-Huang R, Spitzer SG, Kolitz JE, Zhang X. Nasim MM, et al. Int J Surg Pathol. 2020 May;28(3):330-335. doi: 10.1177/1066896919883013. Epub 2019 Oct 20. Int J Surg Pathol. 2020. PMID: 31631721
Low-grade B-cell lymphoma with immunoglobulin (IG) and interferon regulatory factor 4 (IRF4) gene rearrangement is extremely rare, with only 4 cases being previously reported. ...Fluorescence in situ hybridization analysis revealed del(13q) abnormality, but was negative fo …
Low-grade B-cell lymphoma with immunoglobulin (IG) and interferon regulatory factor 4 (IRF4) gene rearrangement is extremely rare, wi …