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NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights.
Gough SM, Slape CI, Aplan PD. Gough SM, et al. Blood. 2011 Dec 8;118(24):6247-57. doi: 10.1182/blood-2011-07-328880. Epub 2011 Sep 26. Blood. 2011. PMID: 21948299 Free PMC article. Review.
Several of the NUP98 fusions, including NUP98-homeobox (HOX)A9, NUP98-HOXD13, and NUP98-JARID1A, have been used to generate animal models of both lymphoid and myeloid malignancy; these models typically up-regulate HOXA cluster genes, including HOXA5, HOXA7, HOXA9, a …
Several of the NUP98 fusions, including NUP98-homeobox (HOX)A9, NUP98-HOXD13, and NUP98-JARID1A, have been used to generate an …
Hox genes: from leukemia to hematopoietic stem cell expansion.
Abramovich C, Pineault N, Ohta H, Humphries RK. Abramovich C, et al. Ann N Y Acad Sci. 2005 Jun;1044:109-16. doi: 10.1196/annals.1349.014. Ann N Y Acad Sci. 2005. PMID: 15958703 Review.
This phenomenon was also seen with NUP98 fusions containing only the homeodomain of the corresponding Hox protein. We then exploited the strong transforming potential of NUP98-HOXD13 and NUP98-HOXA10 to establish preleukemic myeloid lines composed of early myeloid p …
This phenomenon was also seen with NUP98 fusions containing only the homeodomain of the corresponding Hox protein. We then exploited the str …
Generation of the NUP98-HOXD13 fusion transcript by a rare translocation, t(2;11)(q31;p15), in a case of infant leukaemia.
Shimada H, Arai Y, Sekiguchi S, Ishii T, Tanitsu S, Sasaki M. Shimada H, et al. Br J Haematol. 2000 Jul;110(1):210-3. doi: 10.1046/j.1365-2141.2000.02172.x. Br J Haematol. 2000. PMID: 10931000 Free article. Review.
We report a case of de novo acute myelomonocytic leukaemia with the t(2;11)(q31;p15) translocation in a Japanese female infant. The NUP98-HOXD13 fusion transcript generated by the translocation was detected in the patient's bone marrow cells by reverse transcription …
We report a case of de novo acute myelomonocytic leukaemia with the t(2;11)(q31;p15) translocation in a Japanese female infant. The NUP98