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2021 2
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ABCG8-mediated sterol efflux increases cancer cell progression via the LRP6/Wnt/beta-catenin signaling pathway in radiotherapy-resistant MDA-MB-231 triple-negative breast cancer cells.
Ko YS, Won JY, Jin H, Nguyen NB, Won Y, Nsanzimana V, Yun SP, Park SW, Kim HJ. Ko YS, et al. Int J Mol Med. 2025 May;55(5):80. doi: 10.3892/ijmm.2025.5521. Epub 2025 Mar 21. Int J Mol Med. 2025. PMID: 40116083 Free PMC article.
ABCG8 is involved in sterol efflux; however, its role in cancer is not well known. Therefore, the present study investigated the effect of ABCG8 on tumor progression in RT-R-TNBC cells. ...Additionally, RT-R-MDA-MB-231 cells exhibited increased levels of beta-cateni …
ABCG8 is involved in sterol efflux; however, its role in cancer is not well known. Therefore, the present study investigated the effe …
Genetic Heterogeneity of Familial Hypercholesterolemia: Repercussions for Molecular Diagnosis.
Di Taranto MD, Fortunato G. Di Taranto MD, et al. Int J Mol Sci. 2023 Feb 6;24(4):3224. doi: 10.3390/ijms24043224. Int J Mol Sci. 2023. PMID: 36834635 Free PMC article. Review.
In addition, variants in genes causing other dyslipidemias showing phenotypes overlapping with FH may mimic FH in patients without causative variants (FH-phenocopies; ABCG5, ABCG8, CYP27A1 and LIPA genes) or act as phenotype modifiers in patients with a pathogenic variant …
In addition, variants in genes causing other dyslipidemias showing phenotypes overlapping with FH may mimic FH in patients without causative …
Genetic variation and intestinal cholesterol absorption in humans: A systematic review and a gene network analysis.
Mokhtar FBA, Plat J, Mensink RP. Mokhtar FBA, et al. Prog Lipid Res. 2022 Apr;86:101164. doi: 10.1016/j.plipres.2022.101164. Epub 2022 Apr 4. Prog Lipid Res. 2022. PMID: 35390434 Free article.
Based on a systematic review, genetic variants in seven genes (ABCG5, ABCG8, ABO, APOE, MTTP, NPC1L1, and LDLR) were identified that were associated with intestinal cholesterol absorption. ...
Based on a systematic review, genetic variants in seven genes (ABCG5, ABCG8, ABO, APOE, MTTP, NPC1L1, and LDLR) were identified that …
Genetic association analysis of lipid-lowering drug target genes in chronic kidney disease.
Zhang Y, Ou G, Peng L, Pan J, Zhang S, Shi J. Zhang Y, et al. Front Endocrinol (Lausanne). 2025 Jan 14;15:1434145. doi: 10.3389/fendo.2024.1434145. eCollection 2024. Front Endocrinol (Lausanne). 2025. PMID: 39877840 Free PMC article.
METHODS: We extracted 11 genetic variants encoding targets of lipid-lowering drugs from published genome-wide association study (GWAS) summary statistics, encompassing LDLR, HMGCR, PCSK9, NPC1L1, APOB, ABCG5/ABCG8, LPL, APOC3, ANGPTL3, and PPARA. A Mendelian randomization …
METHODS: We extracted 11 genetic variants encoding targets of lipid-lowering drugs from published genome-wide association study (GWAS) summa …
Correlation of serum biochemical characteristics and ABCG8 genetic variant (rs 11887534) with gall stone compositions and risk of gallstone disease in Egyptian patients.
Aly DM, Fteah AM, Al Assaly NM, Elashry MA, Youssef YF, Hedaya MS. Aly DM, et al. Asian J Surg. 2023 Sep;46(9):3560-3567. doi: 10.1016/j.asjsur.2023.05.156. Epub 2023 Jun 19. Asian J Surg. 2023. PMID: 37344314 Free article.
BACKGROUND: The overexpression of the cholesterol transporter: ATP-binding cassette transporter (ABCG8) due to the effect of ABCG8 genetic variant (rs11887534) leads to the precipitation of cholesterol crystals and gallstone disease (GSD). ...CONCLUSION: The most pr …
BACKGROUND: The overexpression of the cholesterol transporter: ATP-binding cassette transporter (ABCG8) due to the effect of ABCG8 …
Lipid traits and lipid-lowering drug target genes and risk of melanoma: a mendelian randomization study.
Che Y, Yuan J, Tang D, Guo J. Che Y, et al. Arch Dermatol Res. 2024 May 31;316(6):301. doi: 10.1007/s00403-024-03100-2. Arch Dermatol Res. 2024. PMID: 38819656
We found that genetically proxied inhibition of HMGCR, ABCG5/ABCG8, and ANGPTL3 was associated with a reduced risk of melanoma. On the other hand, inhibition of LPL and Apo-B100 was significantly associated with an increased risk of melanoma. ...Our analysis also revealed …
We found that genetically proxied inhibition of HMGCR, ABCG5/ABCG8, and ANGPTL3 was associated with a reduced risk of melanoma. On th …
Cascade screening of a Pakistani consanguineous familial hypercholesterolemia cohort: Identification of seven new homozygous patients.
Ain Q, Sikonja J, Sadiq F, Shafi S, Kafol J, Gorjanc T, Sustar U, Kovac J, Khan MI, Ajmal M, Groselj U. Ain Q, et al. Atherosclerosis. 2025 Mar;402:119118. doi: 10.1016/j.atherosclerosis.2025.119118. Epub 2025 Feb 1. Atherosclerosis. 2025. PMID: 39903948 Free article.
Genetic screening was performed using next-generation sequencing to analyse all coding regions and exon-intron borders of the following genes: ALMS1, APOA1, APOB, APOA5, APOC2, APOC3, APOE, ABCA1, ABCG5, ABCG8, CREB3L3, GPIHBP1, LDLR, LDLRAP1, LIPA, LMF1, LPL, and PCSK9. T …
Genetic screening was performed using next-generation sequencing to analyse all coding regions and exon-intron borders of the following gene …
Genetic Analysis Reveals a Protective Effect of Sphingomyelin on Cholelithiasis.
Mao K, Li A, Liu H, Gao Y, Wang Z, Wang X, Liu S, Gao Z, Quan J, Shao M, Liu Y, Shi L, Zhang B, Zhang T. Mao K, et al. Genes (Basel). 2025 Apr 29;16(5):523. doi: 10.3390/genes16050523. Genes (Basel). 2025. PMID: 40428345 Free PMC article.
The following mediated MR analysis indicated that only LDL mediated a large part of the causal relationship (59.18%). Seven genes, including GCKR, SNX17, ABCG8, MARCH8, FUT2, APOH, and HNF1A, were revealed to be colocalized with the causal signal between sphingomyelin and …
The following mediated MR analysis indicated that only LDL mediated a large part of the causal relationship (59.18%). Seven genes, including …
Exploring the causal effect between lipid-modifying drugs and idiopathic pulmonary fibrosis: a drug-target Mendelian randomization study.
Cai G, Liu J, Cai M, Shao L. Cai G, et al. Lipids Health Dis. 2024 Aug 1;23(1):237. doi: 10.1186/s12944-024-02218-6. Lipids Health Dis. 2024. PMID: 39090671 Free PMC article.
The study's focus on lipid-regulatory genes encompassed PCSK9, NPC1L1, ABCG5, ABCG8, HMGCR, APOB, LDLR, CETP, ANGPTL3, APOC3, LPL, and PPARA. The primary effect estimates were determined using the inverse-variance-weighted method, with additional analyses employing the con …
The study's focus on lipid-regulatory genes encompassed PCSK9, NPC1L1, ABCG5, ABCG8, HMGCR, APOB, LDLR, CETP, ANGPTL3, APOC3, LPL, an …
High cholesterol absorption: A risk factor of atherosclerotic cardiovascular diseases?
Simonen P, Öörni K, Sinisalo J, Strandberg TE, Wester I, Gylling H. Simonen P, et al. Atherosclerosis. 2023 Jul;376:53-62. doi: 10.1016/j.atherosclerosis.2023.06.003. Epub 2023 Jun 2. Atherosclerosis. 2023. PMID: 37290267 Free article. Review.
According to these studies, loss-of-function genetic variations in the small intestinal sterol transporters ABCG5 and ABCG8 result in high cholesterol absorption associated with low cholesterol synthesis, low cholesterol elimination from the body, and a high risk of ASCVDs …
According to these studies, loss-of-function genetic variations in the small intestinal sterol transporters ABCG5 and ABCG8 result in …
38 results