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Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.
Hu Y, Wang Q, Yu J, Zhou Q, Deng Y, Liu J, Zhang L, Xu Y, Xiong W, Wang Y. Hu Y, et al. Nat Commun. 2022 Jan 10;13(1):114. doi: 10.1038/s41467-021-27684-9. Nat Commun. 2022. PMID: 35013220 Free PMC article.
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic options. Tartrate-resistant acid phosphatase 5 (ACP5) performs a variety of functions. However, its role in IPF remains unclear. Here, we demonstrate that the levels of ACP …
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic options. Tartrate-resistant acid phosphata …
Characterisation of ACP5 missense mutations encoding tartrate-resistant acid phosphatase associated with spondyloenchondrodysplasia.
Ramesh J, Parthasarathy LK, Janckila AJ, Begum F, Murugan R, Murthy BPSS, El-Mallakh RS, Parthasarathy RN, Venugopal B. Ramesh J, et al. PLoS One. 2020 Mar 26;15(3):e0230052. doi: 10.1371/journal.pone.0230052. eCollection 2020. PLoS One. 2020. PMID: 32214327 Free PMC article.
Biallelic mutations in ACP5, encoding tartrate-resistant acid phosphatase (TRACP), have recently been identified to cause the inherited immuno-osseous disorder, spondyloenchondrodysplasia (SPENCD). This study was undertaken to characterize the eight reported missense mutat …
Biallelic mutations in ACP5, encoding tartrate-resistant acid phosphatase (TRACP), have recently been identified to cause the inherit …
Non-bone metastatic cancers promote osteocyte-induced bone destruction.
Pin F, Prideaux M, Huot JR, Essex AL, Plotkin LI, Bonetto A, Bonewald LF. Pin F, et al. Cancer Lett. 2021 Nov 1;520:80-90. doi: 10.1016/j.canlet.2021.06.030. Epub 2021 Jul 4. Cancer Lett. 2021. PMID: 34233150 Free PMC article.
In addition, the expression of the osteoclastic markers, Acp5, CtsK, Atp6v0d2 and Mmp13, was elevated in IDG-SW3 osteocytes exposed to tumor factors, supporting the in vivo observations of increased lacunar size due to osteocytic osteolysis. ...
In addition, the expression of the osteoclastic markers, Acp5, CtsK, Atp6v0d2 and Mmp13, was elevated in IDG-SW3 osteocytes exposed t …
Detection of genetic mutations underlying early-onset systemic lupus erythematosus.
Sener S, Sag E, Han X, Bilginer Y, Zhou Q, Ozen S. Sener S, et al. Lupus. 2024 Aug;33(9):998-1003. doi: 10.1177/09612033241255011. Epub 2024 May 13. Lupus. 2024. PMID: 38739464
They are currently clinically inactive but have positive serological findings. Patient 3 with homozygous pathogenic ACP5 mutation [G109 R (c.325 G>A) variant] had arthritis, nephritis, short stature, and skeletal dysplasia. ...
They are currently clinically inactive but have positive serological findings. Patient 3 with homozygous pathogenic ACP5 mutation [G1 …
Two Amphioxus ApeC-Containing Proteins Bind to Microbes and Inhibit the TRAF6 Pathway.
Li J, Li Y, Fan Z, Chen S, Yan X, Yue Z, Huang G, Liu S, Zhang H, Chen S, Dong M, Xu A, Huang S. Li J, et al. Front Immunol. 2021 Jul 30;12:715245. doi: 10.3389/fimmu.2021.715245. eCollection 2021. Front Immunol. 2021. PMID: 34394119 Free PMC article.
Both ACP3 and ACP5 were mainly expressed in the intestine and hepatic cecum, and could be up-regulated after bacterial challenge. Both prokaryotic-expressed recombinant ACP3 and ACP5 could bind with several species of bacteria and yeasts, showing agglutinating activ …
Both ACP3 and ACP5 were mainly expressed in the intestine and hepatic cecum, and could be up-regulated after bacterial challenge. Bot …
Triple Culture of Primary Human Osteoblasts, Osteoclasts and Osteocytes as an In Vitro Bone Model.
Bernhardt A, Skottke J, von Witzleben M, Gelinsky M. Bernhardt A, et al. Int J Mol Sci. 2021 Jul 7;22(14):7316. doi: 10.3390/ijms22147316. Int J Mol Sci. 2021. PMID: 34298935 Free PMC article.
After 7 days of co-culture, the three cell species showed their typical morphology and gene expression of typical markers like ALPL, BSPII, BLGAP, E11, PHEX, MEPE, RANKL, ACP5, CAII and CTSK. Furthermore, relevant enzyme activities for osteoblasts (ALP) and osteoclasts (TR …
After 7 days of co-culture, the three cell species showed their typical morphology and gene expression of typical markers like ALPL, BSPII, …
Spondyloenchondrodysplasia in five new patients: identification of three novel ACP5 variants with variable neurological presentations.
Elhossini RM, Elbendary HM, Rafat K, Ghorab RM, Abdel-Hamid MS. Elhossini RM, et al. Mol Genet Genomics. 2023 May;298(3):709-720. doi: 10.1007/s00438-023-02009-1. Epub 2023 Apr 3. Mol Genet Genomics. 2023. PMID: 37010587 Free PMC article.
Spondyloenchondrodysplasia (SPENCD) is an immune-osseous disorder caused by biallelic variants in ACP5 gene and is less commonly associated with neurological abnormalities such as global developmental delay, spasticity and seizures. ...Whole exome sequencing was performed …
Spondyloenchondrodysplasia (SPENCD) is an immune-osseous disorder caused by biallelic variants in ACP5 gene and is less commonly asso …
Integration of transcriptomics and metabolomics reveals a novel gene signature guided by FN1 associated with immune response in oral squamous cell carcinoma tumorigenesis.
Peng Y, Yin D, Li X, Wang K, Li W, Huang Y, Liu X, Ren Z, Yang X, Zhang Z, Zhang S, Fan T. Peng Y, et al. J Cancer Res Clin Oncol. 2023 Aug;149(9):6097-6113. doi: 10.1007/s00432-023-04572-x. Epub 2023 Jan 19. J Cancer Res Clin Oncol. 2023. PMID: 36656379
RESULTS: These findings identified a FN1-mediated crucial network that was composed of immune-relevant genes (FN1, ACP5, CCL5, COL1A1, THBS1, BCAT1, PLAU, IGF2BP3, TNF, CSF2, CXCL1 and CXCL5) associated with immune infiltration and influences the tumour microenvironment, w …
RESULTS: These findings identified a FN1-mediated crucial network that was composed of immune-relevant genes (FN1, ACP5, CCL5, COL1A1 …
Single-Center Overview of Pediatric Monogenic Autoinflammatory Diseases in the Past Decade: A Summary and Beyond.
Wang W, Yu Z, Gou L, Zhong L, Li J, Ma M, Wang C, Zhou Y, Ru Y, Sun Z, Wei Q, Dong Y, Song H. Wang W, et al. Front Immunol. 2020 Sep 17;11:565099. doi: 10.3389/fimmu.2020.565099. eCollection 2020. Front Immunol. 2020. PMID: 33042144 Free PMC article.
Main clinical features were skin disorders (76%), musculoskeletal problems (66%), fever (62%), growth retardation (33%), gastrointestinal tract abnormalities (25%), central nervous system abnormalities (15%), eye disorders (16%), ear problems (9%), and cardiopulmonary disorders ( …
Main clinical features were skin disorders (76%), musculoskeletal problems (66%), fever (62%), growth retardation (33%), gastrointestinal tr …
Cross-talk between oxidative stress and lipid metabolism regulators reveals molecular clusters and immunological characterization in polycystic ovarian syndrome.
Tan C, Huang S, Xu L, Zhang T, Yuan X, Li Z, Chen M, Chen C, Yan Q. Tan C, et al. Lipids Health Dis. 2024 Aug 15;23(1):248. doi: 10.1186/s12944-024-02237-3. Lipids Health Dis. 2024. PMID: 39143634 Free PMC article.
Among the 19 OSLM-related genes, CXCR1, ACP5, CEACAM3, S1PR4, and TCF7 were identified by a Bayesian network and had a good fit with PCOS disease risk by the nomogram (AUC: 0.990 CI: 0.968-1.000). ...
Among the 19 OSLM-related genes, CXCR1, ACP5, CEACAM3, S1PR4, and TCF7 were identified by a Bayesian network and had a good fit with …
14 results