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2021 4
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Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.
Hu Y, Wang Q, Yu J, Zhou Q, Deng Y, Liu J, Zhang L, Xu Y, Xiong W, Wang Y. Hu Y, et al. Nat Commun. 2022 Jan 10;13(1):114. doi: 10.1038/s41467-021-27684-9. Nat Commun. 2022. PMID: 35013220 Free PMC article.
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic options. Tartrate-resistant acid phosphatase 5 (ACP5) performs a variety of functions. However, its role in IPF remains unclear. Here, we demonstrate that the levels of ACP …
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic options. Tartrate-resistant acid phosphata …
Metabolomic and transcriptomic analysis reveals metabolic-immune interactions in choroid neovascularization.
Zhang Y, Qi S, Shen W, Guo Y, Liang Y, Zhuo Q, Kong H, Zhang S, Zhao C. Zhang Y, et al. Exp Eye Res. 2025 Feb;251:110227. doi: 10.1016/j.exer.2024.110227. Epub 2024 Dec 26. Exp Eye Res. 2025. PMID: 39732424
Hub genes such as ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) and acid phosphatase 5, tartrate resistant (ACP5) emerged as potential central regulators of immune-metabolic crosstalk in CNV. The classification of the immune and metabolic landscape and their c …
Hub genes such as ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) and acid phosphatase 5, tartrate resistant (ACP5) emerge …
Trio Whole Exome Sequencing in Chinese Childhood-Onset Lupus Reveals Novel Candidate Genes.
Ma J, Qin Y, Hong SM, Ware T, Hou G, Tan J, Xie C, Zhang P, Wu X, Arsov T, Cao L, Andrews TD, Wu P, Shen Q, Ding H, Shen N, Vinuesa CG, He Y. Ma J, et al. Arthritis Rheumatol. 2025 Nov;77(11):1548-1559. doi: 10.1002/art.43243. Epub 2025 Jul 21. Arthritis Rheumatol. 2025. PMID: 40386946 Free PMC article.
At least two probands had monogenic disease, and one-third of probands carried novel or rare variants in genes well accepted to cause monogenic SLE: ACP5, C3, C4A, C4B, DNASE1, IFIH1, NRAS, RNASEH2B, RNASEH2C, and SAMHD1. Probands carried a median of one de novo, rare, cod …
At least two probands had monogenic disease, and one-third of probands carried novel or rare variants in genes well accepted to cause monoge …
Non-bone metastatic cancers promote osteocyte-induced bone destruction.
Pin F, Prideaux M, Huot JR, Essex AL, Plotkin LI, Bonetto A, Bonewald LF. Pin F, et al. Cancer Lett. 2021 Nov 1;520:80-90. doi: 10.1016/j.canlet.2021.06.030. Epub 2021 Jul 4. Cancer Lett. 2021. PMID: 34233150 Free PMC article.
In addition, the expression of the osteoclastic markers, Acp5, CtsK, Atp6v0d2 and Mmp13, was elevated in IDG-SW3 osteocytes exposed to tumor factors, supporting the in vivo observations of increased lacunar size due to osteocytic osteolysis. ...
In addition, the expression of the osteoclastic markers, Acp5, CtsK, Atp6v0d2 and Mmp13, was elevated in IDG-SW3 osteocytes exposed t …
Spondyloenchondrodysplasia in five new patients: identification of three novel ACP5 variants with variable neurological presentations.
Elhossini RM, Elbendary HM, Rafat K, Ghorab RM, Abdel-Hamid MS. Elhossini RM, et al. Mol Genet Genomics. 2023 May;298(3):709-720. doi: 10.1007/s00438-023-02009-1. Epub 2023 Apr 3. Mol Genet Genomics. 2023. PMID: 37010587 Free PMC article.
Spondyloenchondrodysplasia (SPENCD) is an immune-osseous disorder caused by biallelic variants in ACP5 gene and is less commonly associated with neurological abnormalities such as global developmental delay, spasticity and seizures. ...Whole exome sequencing was performed …
Spondyloenchondrodysplasia (SPENCD) is an immune-osseous disorder caused by biallelic variants in ACP5 gene and is less commonly asso …
Cross-talk between oxidative stress and lipid metabolism regulators reveals molecular clusters and immunological characterization in polycystic ovarian syndrome.
Tan C, Huang S, Xu L, Zhang T, Yuan X, Li Z, Chen M, Chen C, Yan Q. Tan C, et al. Lipids Health Dis. 2024 Aug 15;23(1):248. doi: 10.1186/s12944-024-02237-3. Lipids Health Dis. 2024. PMID: 39143634 Free PMC article.
Among the 19 OSLM-related genes, CXCR1, ACP5, CEACAM3, S1PR4, and TCF7 were identified by a Bayesian network and had a good fit with PCOS disease risk by the nomogram (AUC: 0.990 CI: 0.968-1.000). ...
Among the 19 OSLM-related genes, CXCR1, ACP5, CEACAM3, S1PR4, and TCF7 were identified by a Bayesian network and had a good fit with …
Genetic variability associates with ancestry, age at disease onset, organ involvement and disease severity in juvenile-onset systemic lupus erythematosus.
Natoli V, Charras A, Hasoon MSR, Jorgensen AL, Smith EMD, Caamaño Gutiérrez E, Beresford MW, Hedrich CM; UK JSLE Cohort Study Group. Natoli V, et al. Clin Immunol. 2025 Oct;279:110540. doi: 10.1016/j.clim.2025.110540. Epub 2025 Jun 15. Clin Immunol. 2025. PMID: 40527401 Free article.

Clinical variables, including severity of renal involvement (ACP5, ITGAM, LYN, p < 0.001; TNFAIP3, p = 0.007), associated with GAAS. Genetic variability likely contributes to early disease expression and severity in jSLE, supporting patient stratification and personalis

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Clinical variables, including severity of renal involvement (ACP5, ITGAM, LYN, p < 0.001; TNFAIP3, p = 0.007), associated with GAA

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Triple Culture of Primary Human Osteoblasts, Osteoclasts and Osteocytes as an In Vitro Bone Model.
Bernhardt A, Skottke J, von Witzleben M, Gelinsky M. Bernhardt A, et al. Int J Mol Sci. 2021 Jul 7;22(14):7316. doi: 10.3390/ijms22147316. Int J Mol Sci. 2021. PMID: 34298935 Free PMC article.
After 7 days of co-culture, the three cell species showed their typical morphology and gene expression of typical markers like ALPL, BSPII, BLGAP, E11, PHEX, MEPE, RANKL, ACP5, CAII and CTSK. Furthermore, relevant enzyme activities for osteoblasts (ALP) and osteoclasts (TR …
After 7 days of co-culture, the three cell species showed their typical morphology and gene expression of typical markers like ALPL, BSPII, …
Two Amphioxus ApeC-Containing Proteins Bind to Microbes and Inhibit the TRAF6 Pathway.
Li J, Li Y, Fan Z, Chen S, Yan X, Yue Z, Huang G, Liu S, Zhang H, Chen S, Dong M, Xu A, Huang S. Li J, et al. Front Immunol. 2021 Jul 30;12:715245. doi: 10.3389/fimmu.2021.715245. eCollection 2021. Front Immunol. 2021. PMID: 34394119 Free PMC article.
Both ACP3 and ACP5 were mainly expressed in the intestine and hepatic cecum, and could be up-regulated after bacterial challenge. Both prokaryotic-expressed recombinant ACP3 and ACP5 could bind with several species of bacteria and yeasts, showing agglutinating activ …
Both ACP3 and ACP5 were mainly expressed in the intestine and hepatic cecum, and could be up-regulated after bacterial challenge. Bot …
Detection of genetic mutations underlying early-onset systemic lupus erythematosus.
Sener S, Sag E, Han X, Bilginer Y, Zhou Q, Ozen S. Sener S, et al. Lupus. 2024 Aug;33(9):998-1003. doi: 10.1177/09612033241255011. Epub 2024 May 13. Lupus. 2024. PMID: 38739464
They are currently clinically inactive but have positive serological findings. Patient 3 with homozygous pathogenic ACP5 mutation [G109 R (c.325 G>A) variant] had arthritis, nephritis, short stature, and skeletal dysplasia. ...
They are currently clinically inactive but have positive serological findings. Patient 3 with homozygous pathogenic ACP5 mutation [G1 …
17 results