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Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-beta signaling as primary targets.
Bekhouche M, Leduc C, Dupont L, Janssen L, Delolme F, Vadon-Le Goff S, Smargiasso N, Baiwir D, Mazzucchelli G, Zanella-Cleon I, Dubail J, De Pauw E, Nusgens B, Hulmes DJ, Moali C, Colige A. Bekhouche M, et al. FASEB J. 2016 May;30(5):1741-56. doi: 10.1096/fj.15-279869. Epub 2016 Jan 6. FASEB J. 2016. PMID: 26740262 Free article.
Candidate substrates for the 3 ADAMTS have been biochemically validated in different contexts, and the implication of ADAMTS2 in the control of TGF-beta activity has been further demonstrated in human fibroblasts. ...Determination of the substrate repertoire of ADAMTS2 …
Candidate substrates for the 3 ADAMTS have been biochemically validated in different contexts, and the implication of ADAMTS2 in the …
Mutations in the TBX15-ADAMTS2 pathway associate with a novel soft palate dysplasia.
Zhang Y, Li J, Ji Y, Cheng Y, Fu X. Zhang Y, et al. Hum Mutat. 2022 Dec;43(12):2102-2115. doi: 10.1002/humu.24473. Epub 2022 Sep 30. Hum Mutat. 2022. PMID: 36124393
We reported de novo variants in specific exons of the TBX15 and ADAMTS2 genes in a hitherto undescribed class of patients with unique craniofacial developmental defects. ...Based on these data, we propose that the disruption of the TBX15-ADAMTS2 signaling pathway du …
We reported de novo variants in specific exons of the TBX15 and ADAMTS2 genes in a hitherto undescribed class of patients with unique …
ADAMTS proteins in human disorders.
Mead TJ, Apte SS. Mead TJ, et al. Matrix Biol. 2018 Oct;71-72:225-239. doi: 10.1016/j.matbio.2018.06.002. Epub 2018 Jun 6. Matrix Biol. 2018. PMID: 29885460 Free PMC article. Review.
Indeed, Mendelian disorders or birth defects resulting from naturally occurring ADAMTS2, ADAMTS3, ADAMTS10, ADAMTS13, ADAMTS17, ADAMTS20, ADAMTSL2 and ADAMTSL4 mutations as well as numerous phenotypes identified in genetically engineered mice have revealed ADAMTS participa …
Indeed, Mendelian disorders or birth defects resulting from naturally occurring ADAMTS2, ADAMTS3, ADAMTS10, ADAMTS13, ADAMTS17, ADAMT …
ADAMTS2 mediates epithelial-mesenchymal transition and inflammation in high-grade serous ovarian cancer: a study based on bioinformatic analyses and experiments.
Tian Y, Li J, Dong R, Guan Y, Wang Y, Yan L, Zhang J, Kang S. Tian Y, et al. BMC Cancer. 2025 Aug 26;25(1):1376. doi: 10.1186/s12885-025-14649-0. BMC Cancer. 2025. PMID: 40859223 Free PMC article.
Different machine learning algorithms identified MMP2, ADAMTS2, FN1, THBS2, C3ORF80, FAP and POSTN as key EMT-related signatures in HGSOC. Finally, qPCR, western blotting and IHC staining consistently revealed elevated expression of ADAMTS2 in five ovarian cancer ti …
Different machine learning algorithms identified MMP2, ADAMTS2, FN1, THBS2, C3ORF80, FAP and POSTN as key EMT-related signatures in H …
Critical Role of ADAMTS2 (A Disintegrin and Metalloproteinase With Thrombospondin Motifs 2) in Cardiac Hypertrophy Induced by Pressure Overload.
Wang X, Chen W, Zhang J, Khan A, Li L, Huang F, Qiu Z, Wang L, Chen X. Wang X, et al. Hypertension. 2017 Jun;69(6):1060-1069. doi: 10.1161/HYPERTENSIONAHA.116.08581. Epub 2017 Apr 3. Hypertension. 2017. PMID: 28373586
However, the role of ADAMTS2 in the heart has not yet been defined. Herein, we observed the upregulated expression of ADAMTS2 in failing human hearts and hypertrophic murine hearts. Mice lacking ADAMTS2 display exacerbated cardiac hypertrophy on pressure over …
However, the role of ADAMTS2 in the heart has not yet been defined. Herein, we observed the upregulated expression of ADAMTS2 …
Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain.
Rosell-García T, Paradela A, Bravo G, Dupont L, Bekhouche M, Colige A, Rodriguez-Pascual F. Rosell-García T, et al. J Biol Chem. 2019 Jul 19;294(29):11087-11100. doi: 10.1074/jbc.RA119.007806. Epub 2019 May 31. J Biol Chem. 2019. PMID: 31152061 Free PMC article.
In this study, using murine skin fibroblasts and HEK293 cells, along with immunoprecipitation, LOX enzymatic activity, solid-phase binding assays, and proteomics analyses, we report that the LOX precursor is proteolytically processed by the procollagen N-proteinases ADAMTS2 …
In this study, using murine skin fibroblasts and HEK293 cells, along with immunoprecipitation, LOX enzymatic activity, solid-phase binding a …
Prenatal diagnosis of a 5q35.3 microduplication involving part of the ADAMTS2 locus: a likely benign variant without apparent phenotypic abnormality: Case series.
Yue F, Yu Y, Xi Q, Zhang H, Jiang Y, Li S, Liu R, Wang R. Yue F, et al. Medicine (Baltimore). 2019 Dec;98(49):e18258. doi: 10.1097/MD.0000000000018258. Medicine (Baltimore). 2019. PMID: 31804359 Free PMC article.
Single-nucleotide polymorphism array results showed 177-269 kb duplications of 5q35.3 (chr5:178728830-178997692) in these cases. All shared similar localization of ADAMTS2. INTERVENTIONS: All pregnant women chose to continue the pregnancies. Follow-up analysis showed that …
Single-nucleotide polymorphism array results showed 177-269 kb duplications of 5q35.3 (chr5:178728830-178997692) in these cases. All shared …
ADAMTS genes and the risk of cerebral aneurysm.
Arning A, Jeibmann A, Köhnemann S, Brokinkel B, Ewelt C, Berger K, Wellmann J, Nowak-Göttl U, Stummer W, Stoll M, Holling M. Arning A, et al. J Neurosurg. 2016 Aug;125(2):269-74. doi: 10.3171/2015.7.JNS154. Epub 2016 Jan 8. J Neurosurg. 2016. PMID: 26745484
METHODS To identify susceptible genetic variants, the authors investigated 8 single nucleotide polymorphisms (SNPs) in 4 genes from the ADAMTS family (ADAMTS2, -7, -12, and -13) known to be associated with vascular diseases. The study included 353 patients with CAs and 105 …
METHODS To identify susceptible genetic variants, the authors investigated 8 single nucleotide polymorphisms (SNPs) in 4 genes from the ADAM …
ADAMTS12, a new candidate gene for pediatric stroke.
Witten A, Rühle F, de Witt M, Barysenka A, Stach M, Junker R, Nowak-Göttl U, Stoll M. Witten A, et al. PLoS One. 2020 Aug 20;15(8):e0237928. doi: 10.1371/journal.pone.0237928. eCollection 2020. PLoS One. 2020. PMID: 32817637 Free PMC article.
We recently reported a family-based genome wide association study (GWAS) for pediatric stroke pointing our attention to two significantly associated genes of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) gene family ADAMTS2 (rs469568, p = 8x10 …
We recently reported a family-based genome wide association study (GWAS) for pediatric stroke pointing our attention to two significantly as …
34 results