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Genetic susceptibility of delta-ALAD associated with lead (Pb) intoxication: sources of exposure, preventive measures, and treatment interventions.
Qader A, Rehman K, Akash MSH. Qader A, et al. Environ Sci Pollut Res Int. 2021 Sep;28(33):44818-44832. doi: 10.1007/s11356-021-15323-1. Epub 2021 Jul 9. Environ Sci Pollut Res Int. 2021. PMID: 34244947 Review.
Delta-aminolevulinic acid dehydratase (delta-ALAD) is involved in the synthesis of haem and exhibits a polymorphic nature. delta-ALAD polymorphism produces two alleles, namely delta-ALAD-1 and delta-ALAD-2, which in turn pro …
Delta-aminolevulinic acid dehydratase (delta-ALAD) is involved in the synthesis of haem and exhibits a po …
Genetic Polymorphism of Delta Aminolevulinic Acid Dehydratase (ALAD) Gene and Symptoms of Chronic Mercury Exposure in Munduruku Indigenous Children within the Brazilian Amazon.
Perini JA, Silva MC, Vasconcellos ACS, Viana PVS, Lima MO, Jesus IM, Kempton JW, Oliveira RAA, Hacon SS, Basta PC. Perini JA, et al. Int J Environ Res Public Health. 2021 Aug 19;18(16):8746. doi: 10.3390/ijerph18168746. Int J Environ Res Public Health. 2021. PMID: 34444495 Free PMC article.
This study aimed to investigate the impact of an ALAD polymorphism on chronic mercury exposure and the health situation of indigenous children from the Brazilian Amazon. ...The mean age was 6.6 4.5 years old, 60% were female, 49% presented with anemia, and the mean hair me …
This study aimed to investigate the impact of an ALAD polymorphism on chronic mercury exposure and the health situation of indigenous …
5-Aminolevulinate dehydratase porphyria: Update on hepatic 5-aminolevulinic acid synthase induction and long-term response to hemin.
Lahiji AP, Anderson KE, Chan A, Simon A, Desnick RJ, Ramanujam VMS. Lahiji AP, et al. Mol Genet Metab. 2020 Dec;131(4):418-423. doi: 10.1016/j.ymgme.2020.10.011. Epub 2020 Oct 26. Mol Genet Metab. 2020. PMID: 33199206
BACKGROUND: 5-Aminolevulinic acid dehydratase (ALAD) porphyria (ADP) is an ultrarare autosomal recessive disease, with only eight documented cases, all of whom were males. ...Gain of function mutation of erythroid specific ALAS2 - an X-linked mo …
BACKGROUND: 5-Aminolevulinic acid dehydratase (ALAD) porphyria (ADP) is an ultrarare autosomal recessive …
Maternal delta-aminolevulinic acid dehydratase 1-2 genotype enhances fetal lead exposure and increases the susceptibility to the development of cerebral palsy.
Abdel Hamid OI, Khayal EEH, Tolba SAR, Orabi EE. Abdel Hamid OI, et al. Environ Sci Pollut Res Int. 2020 Dec;27(36):44709-44723. doi: 10.1007/s11356-020-10182-8. Epub 2020 Jul 24. Environ Sci Pollut Res Int. 2020. PMID: 32710353
Limited epidemiologic studies questioned the association between pre- and postnatal lead exposure and the development of cerebral palsy (CP). Moreover, the genotypes of delta-aminolevulinic acid dehydratase (delta-ALAD) in CP patients and their …
Limited epidemiologic studies questioned the association between pre- and postnatal lead exposure and the development of cerebral palsy (CP) …
Genetic susceptibility to low-level lead exposure in men: Insights from ALAD polymorphisms.
Stajnko A, Palir N, Snoj Tratnik J, Mazej D, Sešek Briški A, Runkel AA, Horvat M, Falnoga I. Stajnko A, et al. Int J Hyg Environ Health. 2024 Mar;256:114315. doi: 10.1016/j.ijheh.2023.114315. Epub 2024 Jan 1. Int J Hyg Environ Health. 2024. PMID: 38168581 Free article.
The genetic susceptibility to low-level lead (Pb) exposure in general populations has been poorly investigated and is limited to the single nucleotide polymorphism (SNP) rs1800435 in the delta-aminolevulinic acid dehydratase gene (ALAD). …
The genetic susceptibility to low-level lead (Pb) exposure in general populations has been poorly investigated and is limited to the single …
Role of Ape1 in Impaired DNA Repair Capacity in Battery Recycling Plant Workers Exposed to Lead.
Hernández-Franco P, Maldonado-Vega M, Calderón-Salinas JV, Rojas E, Valverde M. Hernández-Franco P, et al. Int J Environ Res Public Health. 2022 Jun 29;19(13):7961. doi: 10.3390/ijerph19137961. Int J Environ Res Public Health. 2022. PMID: 35805621 Free PMC article.
Lead intoxication was characterized by high blood lead concentration, high lipid peroxidation and low activity of delta-aminolevulinic acid dehydratase (delta-ALAD). Relevantly, we found a loss of DNA repair capacity related with down-regulation …
Lead intoxication was characterized by high blood lead concentration, high lipid peroxidation and low activity of delta-aminolevul …