Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2016 4
2017 8
2018 5
2019 5
2020 6
2021 8
2022 7
2023 3
2024 8
2025 6
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

54 results

Results by year

Filters applied: . Clear all
Page 1
Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression.
Zhu GF, Xu YW, Li J, Niu HL, Ma WX, Xu J, Zhou PR, Liu X, Ye DL, Liu XR, Yan T, Zhai WK, Xu ZJ, Liu C, Wang L, Wang H, Luo JM, Liu L, Li XQ, Guo S, Jiang HP, Shen P, Lin HK, Yu DH, Ding YQ, Zhang QL. Zhu GF, et al. Nat Commun. 2019 Jan 10;10(1):112. doi: 10.1038/s41467-018-07998-x. Nat Commun. 2019. Retraction in: Nat Commun. 2023 Sep 18;14(1):5772. doi: 10.1038/s41467-023-41612-z. PMID: 30631060 Free PMC article. Retracted.
Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in Wilms tumor, but its expression and functions in other tumors are unclear. ...The aberrant upregulation of miR-20a/miR-106a were identified as the reason of WTX loss in CRC both in viv …
Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in Wilms tumor, but its expression and functions in ot …
Germline MBD4 deficiency causes a multi-tumor predisposition syndrome.
Palles C, West HD, Chew E, Galavotti S, Flensburg C, Grolleman JE, Jansen EAM, Curley H, Chegwidden L, Arbe-Barnes EH, Lander N, Truscott R, Pagan J, Bajel A, Sherwood K, Martin L, Thomas H, Georgiou D, Fostira F, Goldberg Y, Adams DJ, van der Biezen SAM, Christie M, Clendenning M, Thomas LE, Deltas C, Dimovski AJ, Dymerska D, Lubinski J, Mahmood K, van der Post RS, Sanders M, Weitz J, Taylor JC, Turnbull C, Vreede L, van Wezel T, Whalley C, Arnedo-Pac C, Caravagna G, Cross W, Chubb D, Frangou A, Gruber AJ, Kinnersley B, Noyvert B, Church D, Graham T, Houlston R, Lopez-Bigas N, Sottoriva A, Wedge D; Genomics England Research Consortium; CORGI Consortium; WGS500 Consortium; Jenkins MA, Kuiper RP, Roberts AW, Cheadle JP, Ligtenberg MJL, Hoogerbrugge N, Koelzer VH, Rivas AD, Winship IM, Ponte CR, Buchanan DD, Power DG, Green A, Tomlinson IPM, Sampson JR, Majewski IJ, de Voer RM. Palles C, et al. Am J Hum Genet. 2022 May 5;109(5):953-960. doi: 10.1016/j.ajhg.2022.03.018. Epub 2022 Apr 22. Am J Hum Genet. 2022. PMID: 35460607 Free PMC article.
MBD4-deficient polyps harbored somatic mutations in similar driver genes to sporadic colorectal tumors, although AMER1 mutations were more common and KRAS mutations less frequent. Our findings expand the role of BER deficiencies in tumor predisposition. ...
MBD4-deficient polyps harbored somatic mutations in similar driver genes to sporadic colorectal tumors, although AMER1 mutations were …
KIF23 activated Wnt/beta-catenin signaling pathway through direct interaction with Amer1 in gastric cancer.
Liu Y, Chen H, Dong P, Xie G, Zhou Y, Ma Y, Yuan X, Yang J, Han L, Chen L, Shen L. Liu Y, et al. Aging (Albany NY). 2020 May 4;12(9):8372-8396. doi: 10.18632/aging.103146. Epub 2020 May 4. Aging (Albany NY). 2020. PMID: 32365332 Free PMC article.
Mechanistic investigations confirmed that KIF23 activated the Wnt/beta-catenin signaling pathway by directly interacting with APC membrane recruitment 1 (Amer1). Furthermore, KIF23 exhibited competitive binding with Amer1 to block the association of Amer1 wit …
Mechanistic investigations confirmed that KIF23 activated the Wnt/beta-catenin signaling pathway by directly interacting with APC membrane r …
Clinical, Pathologic, and Genetic Features of Wilms Tumors With WTX Gene Mutation.
Alexandrescu S, Akhavanfard S, Harris MH, Vargas SO. Alexandrescu S, et al. Pediatr Dev Pathol. 2017 Mar-Apr;20(2):105-111. doi: 10.1177/1093526616683881. Epub 2017 Jan 26. Pediatr Dev Pathol. 2017. PMID: 28326956
Clinical and pathologic features of patients with WTX-mutated Wilms tumor (WT) have not been studied in detail. We characterize the clinical and pathologic findings in WT with WTX abnormalities and provide comparison with WT without WTX mutation. ...Our study …
Clinical and pathologic features of patients with WTX-mutated Wilms tumor (WT) have not been studied in detail. We characterize the c …
Molecular Profiling Provides Clinical Insights Into Targeted and Immunotherapies as Well as Colorectal Cancer Prognosis.
Guo L, Wang Y, Yang W, Wang C, Guo T, Yang J, Shao Z, Cai G, Cai S, Zhang L, Hu X, Xu Y. Guo L, et al. Gastroenterology. 2023 Aug;165(2):414-428.e7. doi: 10.1053/j.gastro.2023.04.029. Epub 2023 May 3. Gastroenterology. 2023. PMID: 37146911 Free article.
Functional studies suggested RBM10 acts as a tumor suppressor in CRC development. Co-mutations of KRAS/AMER1 or KRAS/APC were enriched in the metastatic cohort, which had poor progression-free survival and did not benefit from bevacizumab due to accelerated drug metabolism …
Functional studies suggested RBM10 acts as a tumor suppressor in CRC development. Co-mutations of KRAS/AMER1 or KRAS/APC were enriche …
A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.
Gadd S, Huff V, Walz AL, Ooms AHAG, Armstrong AE, Gerhard DS, Smith MA, Guidry Auvil JM, Meerzaman D, Chen QR, Hsu CH, Yan C, Nguyen C, Hu Y, Hermida LC, Davidsen T, Gesuwan P, Ma Y, Zong Z, Mungall AJ, Moore RA, Marra MA, Dome JS, Mullighan CG, Ma J, Wheeler DA, Hampton OA, Ross N, Gastier-Foster JM, Arold ST, Perlman EJ. Gadd S, et al. Nat Genet. 2017 Oct;49(10):1487-1494. doi: 10.1038/ng.3940. Epub 2017 Aug 21. Nat Genet. 2017. PMID: 28825729 Free PMC article.
In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, AMER1, DROSHA, DGCR8, XPO5, DICER1, SIX1, SIX2, MLLT1, MYCN, and TP53), we identified mutations in genes not previously recognized as recurrently involved in Wilms tumors, the most frequent being BCOR …
In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, AMER1, DROSHA, DGCR8, XPO5, DICER1, SIX1, SIX2, MLLT1, MYCN, …
Wilms Tumor in Children With AMER1/WTX Germline Pathogenic Variants: A Multicenter Case Series.
Campwala I, Schienda J, Murphy AJ, Hashimi B, Perry T, Cost N, Kamihara J, Mullen EA, Santiago T, Malek MM. Campwala I, et al. Pediatr Blood Cancer. 2025 Aug;72(8):e31798. doi: 10.1002/pbc.31798. Epub 2025 May 21. Pediatr Blood Cancer. 2025. PMID: 40399763
CONCLUSION: Our cohort of four patients, combined with the six patients with WT and AMER1 pathogenic variants previously reported, with 20% (two out of 10) collective incidence of bilateral tumors, support AMER1 as a WT predisposition gene warranting surveillance. . …
CONCLUSION: Our cohort of four patients, combined with the six patients with WT and AMER1 pathogenic variants previously reported, wi …
Current status and clinical usefulness of genomic panel testing using PleSSision-160 in resectable esophageal squamous cell carcinoma.
Matsui K, Kawakubo H, Matsuda S, Aimono E, Nakamura K, Fukuda K, Nakamura R, Nishihara H, Kitagawa Y. Matsui K, et al. Eur J Surg Oncol. 2025 Dec;51(12):110481. doi: 10.1016/j.ejso.2025.110481. Epub 2025 Sep 24. Eur J Surg Oncol. 2025. PMID: 41326213 Free article.
RESULTS: The top five mutations identified in surgical samples using PleSSision-160 were TP53 (80.4 %), KMT2D (13.0 %), NOTCH1 (13.0 %), EP300 (8.7 %), and AMER1 (8.7 %). Although individual mutations did not show significant associations with long-term survival, patients …
RESULTS: The top five mutations identified in surgical samples using PleSSision-160 were TP53 (80.4 %), KMT2D (13.0 %), NOTCH1 (13.0 %), EP3 …
Osteosclerosis and Meningioma: Implicating the Tumor Suppressor Gene AMER1/WTX.
Kumaria A, Weir P, Goldspring R, Scott I, Leggate A. Kumaria A, et al. Anticancer Res. 2025 Nov;45(11):5233-5237. doi: 10.21873/anticanres.17863. Anticancer Res. 2025. PMID: 41151894
CASE REPORT: We present a unique case of a 29-year-old female with osteosclerosis harboring a germline mutation in the AMER1 (also known as WTX) gene - a tumor suppressor known to regulate the Wnt/beta-catenin signaling pathway - who subsequently developed a large c …
CASE REPORT: We present a unique case of a 29-year-old female with osteosclerosis harboring a germline mutation in the AMER1 (also kn …
54 results