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Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer.
Taraborrelli L, Şenbabaoğlu Y, Wang L, Lim J, Blake K, Kljavin N, Gierke S, Scherl A, Ziai J, McNamara E, Owyong M, Rao S, Calviello AK, Oreper D, Jhunjhunwala S, Argiles G, Bendell J, Kim TW, Ciardiello F, Wongchenko MJ, de Sauvage FJ, de Sousa E Melo F, Yan Y, West NR, Murthy A. Taraborrelli L, et al. Nat Commun. 2023 Sep 23;14(1):5945. doi: 10.1038/s41467-023-41618-7. Nat Commun. 2023. PMID: 37741832 Free PMC article.
The V-ATPase/ATG16L1 axis is controlled by the V(1)H subunit.
Timimi L, Wrobel AG, Chiduza GN, Maslen SL, Torres-Méndez A, Montaner B, Davis C, Minckley T, Hole KL, Serio A, Devine MJ, Skehel JM, Rubinstein JL, Schreiber A, Beale R. Timimi L, et al. Mol Cell. 2024 Aug 8;84(15):2966-2983.e9. doi: 10.1016/j.molcel.2024.07.003. Epub 2024 Jul 31. Mol Cell. 2024. PMID: 39089251 Free article.
ATG16L1 induces the formation of phagophore-like membrane cups.
Mohan J, Moparthi SB, Girard-Blanc C, Campisi D, Blanchard S, Nugues C, Rama S, Salles A, Pénard E, Vassilopoulos S, Wollert T. Mohan J, et al. Nat Struct Mol Biol. 2024 Sep;31(9):1448-1459. doi: 10.1038/s41594-024-01300-y. Epub 2024 Jun 4. Nat Struct Mol Biol. 2024. PMID: 38834913
76 results