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Wnt10b regulates osteogenesis of adipose-derived stem cells through Wnt/beta-catenin signalling pathway in osteoporosis.
Huang K, Cai S, Fu T, Zhu Q, Liu L, Yao Z, Rao P, Lan X, Li Q, Xiao J. Huang K, et al. Cell Prolif. 2024 Jan;57(1):e13522. doi: 10.1111/cpr.13522. Epub 2023 Jun 20. Cell Prolif. 2024. PMID: 37340715 Free PMC article.
Our previous finding revealed that the Wnt10b RNA expression of osteoporotic adipose-derived stem cells (OP-ASCs) with impaired osteogenic capacity was significantly reduced than that of ASCs. ...The OP-ASCs and ASCs were harvested from the inguinal fa …
Our previous finding revealed that the Wnt10b RNA expression of osteoporotic adipose-derived stem cells (OP-ASCs …
OPG gene-modified adipose-derived stem cells improve bone formation around implants in osteoporotic rat maxillae.
Wan Y, Hu C, Hou Y, Si C, Zhao Q, Wang Z, Wang L, Guo X. Wan Y, et al. Heliyon. 2023 Sep 2;9(10):e19474. doi: 10.1016/j.heliyon.2023.e19474. eCollection 2023 Oct. Heliyon. 2023. PMID: 37817994 Free PMC article.
BACKGROUND: Osteoporosis is a significant barrier to the use of dental implants in the elderly for the treatment of tooth defects. Adipose derived stem cells (ADSCs) have demonstrated extensive potential for tissue repair and regeneration. ...
BACKGROUND: Osteoporosis is a significant barrier to the use of dental implants in the elderly for the treatment of tooth defects. …
Exosomes from Adipose-Derived Stem Cells Alleviate Dexamethasone-Induced Bone Loss by Regulating the Nrf2/HO-1 Axis.
Yao XW, Liu ZY, Ma NF, Jiang WK, Zhou Z, Chen B, Guan WG, Yan JJ, Yang M. Yao XW, et al. Oxid Med Cell Longev. 2023 Feb 1;2023:3602962. doi: 10.1155/2023/3602962. eCollection 2023. Oxid Med Cell Longev. 2023. PMID: 36778207 Free PMC article.
The widespread use of therapeutic glucocorticoids has increased the incidences of glucocorticoid-induced osteoporosis (GIOP). Oxidative stress and mitochondrial dysfunction are major causes of GIOP; therefore, alleviation of excess oxidative stress in osteoblasts is a pote …
The widespread use of therapeutic glucocorticoids has increased the incidences of glucocorticoid-induced osteoporosis (GIOP). Oxidati …
Osteoporotic Conditions Influence the Activity of Adipose-Derived Stem Cells.
Park JS, Piao J, Park G, Yoo KS, Hong HS. Park JS, et al. Tissue Eng Regen Med. 2020 Dec;17(6):875-885. doi: 10.1007/s13770-020-00289-x. Epub 2020 Sep 18. Tissue Eng Regen Med. 2020. PMID: 32946062 Free PMC article.
As bone marrow mesenchymal stem cell (BMSCs) lose viability and differentiation potential under osteoporotic conditions, it is impossible to use autologous BMSCs for osteoporosis treatment. As an alternative, adipose-derived stem cells (ADSCs) m …
As bone marrow mesenchymal stem cell (BMSCs) lose viability and differentiation potential under osteoporotic conditions, it is impossible to …
Efficacy of Human Adipose-Derived Stem Cells in Spinal Fusion in a Rat Ovariectomy Osteoporosis Model.
Na MK, Bae IS, Yi HJ, DO BR, Kim KD, Chun HJ. Na MK, et al. Turk Neurosurg. 2022;32(2):251-260. doi: 10.5137/1019-5149.JTN.33739-21.4. Turk Neurosurg. 2022. PMID: 34859827 Free article.
AIM: To evaluate the efficacy of human adipose-derived stem cells (h-ADSCs) in spinal fusion in an osteoporotic rat model. ...
AIM: To evaluate the efficacy of human adipose-derived stem cells (h-ADSCs) in spinal fusion in an osteoporotic …
Methyltransferase-like 3 modulates osteogenic differentiation of adipose-derived stem cells in osteoporotic rats.
Luo D, Peng S, Li Q, Rao P, Tao G, Wang L, Xiao J. Luo D, et al. J Gene Med. 2023 May;25(5):e3481. doi: 10.1002/jgm.3481. Epub 2023 Feb 26. J Gene Med. 2023. PMID: 36782035
BACKGROUND: Osteoporosis (OP) is a metabolic bone disease involving reduced bone mass. Adipose-derived stem cells (ASCs) play an important role in bone regeneration. ...
BACKGROUND: Osteoporosis (OP) is a metabolic bone disease involving reduced bone mass. Adipose-derived stem c
Electrical Stimulation of Adipose-Derived Stem Cells in 3D Nanofibrillar Cellulose Increases Their Osteogenic Potential.
Bicer M, Sheard J, Iandolo D, Boateng SY, Cottrell GS, Widera D. Bicer M, et al. Biomolecules. 2020 Dec 18;10(12):1696. doi: 10.3390/biom10121696. Biomolecules. 2020. PMID: 33353222 Free PMC article.
Due to the ageing population, there is a steadily increasing incidence of osteoporosis and osteoporotic fractures. As conventional pharmacological therapy options for osteoporosis are often associated with severe side effects, bone grafts are still considered the cl …
Due to the ageing population, there is a steadily increasing incidence of osteoporosis and osteoporotic fractures. As conventional ph …
Adipose-derived stem cells alleviate osteoporosis by enhancing osteogenesis and inhibiting adipogenesis in a rabbit model.
Ye X, Zhang P, Xue S, Xu Y, Tan J, Liu G. Ye X, et al. Cytotherapy. 2014 Dec;16(12):1643-55. doi: 10.1016/j.jcyt.2014.07.009. Epub 2014 Sep 16. Cytotherapy. 2014. PMID: 25231892
BACKGROUND AIMS: Osteoporosis (OP) is characterized by a reduction in bone quality, which is associated with inadequacies in bone marrow mesenchymal stromal cells (BMSCs). As an alternative cell source to BMSCs, adipose-derived stem cells (ASCs) …
BACKGROUND AIMS: Osteoporosis (OP) is characterized by a reduction in bone quality, which is associated with inadequacies in bone mar …
Photobiomodulation: An Effective Approach to Enhance Proliferation and Differentiation of Adipose-Derived Stem Cells into Osteoblasts.
Da Silva D, Crous A, Abrahamse H. Da Silva D, et al. Stem Cells Int. 2021 Mar 22;2021:8843179. doi: 10.1155/2021/8843179. eCollection 2021. Stem Cells Int. 2021. PMID: 33833810 Free PMC article. Review.
Osteoporosis is regarded as the most common chronic metabolic bone condition in humans. In osteoporosis, bone mesenchymal stem cells (MSCs) have reduced cellular function. ...
Osteoporosis is regarded as the most common chronic metabolic bone condition in humans. In osteoporosis, bone mesenchymal stem
Osteogenic differentiation potential of adipose-derived stem cells from ovariectomized mice.
Wang L, Huang C, Li Q, Xu X, Liu L, Huang K, Cai X, Xiao J. Wang L, et al. Cell Prolif. 2017 Apr;50(2):e12328. doi: 10.1111/cpr.12328. Epub 2017 Jan 16. Cell Prolif. 2017. PMID: 28090705 Free PMC article.
OBJECTIVES: Osteoporosis (OP) is a systemic disease caused by imbalance between bone resorption and bone formation, commonly resulting from post-menopausal oestrogen deficiency. Although osteogenic differentiation potential of adipose-derived stem c
OBJECTIVES: Osteoporosis (OP) is a systemic disease caused by imbalance between bone resorption and bone formation, commonly resultin …
Combined therapy of adipose-derived stem cells and photobiomodulation on accelerated bone healing of a critical size defect in an osteoporotic rat model.
Asgari M, Gazor R, Abdollahifar MA, Fadaei Fathabady F, Zare F, Norouzian M, Amini A, Khosravipour A, Kiani P, Atashgah RB, Rezaei F, Ghoreishi SK, Chien S, Hamblin MR, Bayat M. Asgari M, et al. Biochem Biophys Res Commun. 2020 Sep 10;530(1):173-180. doi: 10.1016/j.bbrc.2020.06.023. Epub 2020 Aug 12. Biochem Biophys Res Commun. 2020. PMID: 32828282
We investigated the impact of human demineralized bone matrix (hDBM) plus adipose-derived stem cells (hADS) plus photobiomodulation (PBM) on a critical-sized femoral defect (CSFD) in ovariectomy induced osteoporosis in rats. ...
We investigated the impact of human demineralized bone matrix (hDBM) plus adipose-derived stem cells (hADS) plus …
Priming with a Combination of FGF2 and HGF Restores the Impaired Osteogenic Differentiation of Adipose-Derived Stem Cells.
Park JS, Kim D, Hong HS. Park JS, et al. Cells. 2022 Jun 27;11(13):2042. doi: 10.3390/cells11132042. Cells. 2022. PMID: 35805126 Free PMC article.
Classical aging-associated diseases include osteoporosis, diabetes, hypertension, and arthritis. Osteoporosis causes the bone to become brittle, increasing fracture risk. ...
Classical aging-associated diseases include osteoporosis, diabetes, hypertension, and arthritis. Osteoporosis causes the bone …
SOST Gene Inhibits Osteogenesis from Adipose-Derived Mesenchymal Stem Cells by Inducing Th17 Cell Differentiation.
You L, Chen L, Pan L, Peng Y, Chen J. You L, et al. Cell Physiol Biochem. 2018;48(3):1030-1040. doi: 10.1159/000491971. Epub 2018 Jul 24. Cell Physiol Biochem. 2018. PMID: 30041240 Free article.
BACKGROUND/AIMS: Postmenopausal osteoporosis is considered to be an autoimmune and inflammatory process, and IL-17 plays important roles in the loss of bone mass. ...However, few studies have examined the role of SOST gene in the differentiation of T helper 17 (Th17) cells …
BACKGROUND/AIMS: Postmenopausal osteoporosis is considered to be an autoimmune and inflammatory process, and IL-17 plays important ro …
lncRNA-KCNQ1OT1: A Potential Target in Exosomes Derived from Adipose-Derived Stem Cells for the Treatment of Osteoporosis.
Wang SZ, Jia J, Chen CH. Wang SZ, et al. Stem Cells Int. 2021 Oct 19;2021:7690006. doi: 10.1155/2021/7690006. eCollection 2021. Stem Cells Int. 2021. PMID: 34712334 Free PMC article.
BACKGROUND: Osteoporosis is a worldwide medical and socioeconomic burden characterized by systemic impairment of bone strength and microstructure. Exosomes derived from adipose-derived stem cells (ADSCs-Exos) have been confirmed to play effectiv …
BACKGROUND: Osteoporosis is a worldwide medical and socioeconomic burden characterized by systemic impairment of bone strength and mi …
Decreased autophagy impairs osteogenic differentiation of adipose-derived stem cells via Notch signaling in diabetic osteoporosis mice.
Rao P, Lou F, Luo D, Huang C, Huang K, Yao Z, Xiao J. Rao P, et al. Cell Signal. 2021 Nov;87:110138. doi: 10.1016/j.cellsig.2021.110138. Epub 2021 Aug 28. Cell Signal. 2021. PMID: 34461277 Free article.
BACKGROUND: The osteogenic differentiation ability of adipose-derived stem cells (ASCs) is attenuated in type 2 diabetic osteoporosis (Dop) mice. ...Thus, it is meaningful to reveal potential correlations between autophagy, Notch signaling, and …
BACKGROUND: The osteogenic differentiation ability of adipose-derived stem cells (ASCs) is attenuated in type 2 …
Local implantation of autologous adipose-derived stem cells increases femoral strength and bone density in osteoporotic rats: A randomized controlled animal study.
Uri O, Behrbalk E, Folman Y. Uri O, et al. J Orthop Surg (Hong Kong). 2018 May-Aug;26(3):2309499018799534. doi: 10.1177/2309499018799534. J Orthop Surg (Hong Kong). 2018. PMID: 30235971 Free article.
BACKGROUND: Deficient osteogenic capacity of bone marrow stem cells plays a critical role in the pathophysiology of osteoporosis. Adipose-derived stem cells (ADSCs) have emerged as a promising source of skeletal progenitor cells. ...These findin …
BACKGROUND: Deficient osteogenic capacity of bone marrow stem cells plays a critical role in the pathophysiology of osteoporosis. …
Adipose-derived stem cells with miR-150-5p inhibition laden in hydroxyapatite/tricalcium phosphate ceramic powders promote osteogenesis via regulating Notch3 and activating FAK/ERK and RhoA.
Wang F, Wang Q, Zhao Y, Tian Z, Chang S, Tong H, Liu N, Bai S, Li X, Fan J. Wang F, et al. Acta Biomater. 2023 Jan 1;155:644-653. doi: 10.1016/j.actbio.2022.09.070. Epub 2022 Oct 4. Acta Biomater. 2023. PMID: 36206975
The combination of ADSCs with miR-150-5p inhibition and HA/TCP might be a promising strategy for bone damage repair. STATEMENT OF SIGNIFICANCE: Osteoporosis is a common chronic metabolic bone disease in humans. Bone tissue engineering based on mesenchymal stem cells, bioma …
The combination of ADSCs with miR-150-5p inhibition and HA/TCP might be a promising strategy for bone damage repair. STATEMENT OF SIGNIFICAN …
Multifunctional gold nanoparticles for osteoporosis: synthesis, mechanism and therapeutic applications.
Gao W, Liang C, Zhao K, Hou M, Wen Y. Gao W, et al. J Transl Med. 2023 Dec 7;21(1):889. doi: 10.1186/s12967-023-04594-6. J Transl Med. 2023. PMID: 38062495 Free PMC article. Review.
Osteoporosis is currently the most prevalent bone disorder worldwide and is characterized by low bone mineral density and an overall increased risk of fractures. ...Nanomaterials (particularly gold nanoparticles [AuNPs]), which have unique optical properties and excellent
Osteoporosis is currently the most prevalent bone disorder worldwide and is characterized by low bone mineral density and an overall
Role of Fzd6 in Regulating the Osteogenic Differentiation of Adipose-derived Stem Cells in Osteoporotic Mice.
Wu T, Yao Z, Tao G, Lou F, Tang H, Gao Y, Yang X, Xiao J. Wu T, et al. Stem Cell Rev Rep. 2021 Oct;17(5):1889-1904. doi: 10.1007/s12015-021-10182-2. Epub 2021 May 26. Stem Cell Rev Rep. 2021. PMID: 34041696
OBJECTIVE: Although it has been demonstrated that adipose-derived stem cells (ASCs) from osteoporotic mice (OP-ASCs) exhibited impaired osteogenic differentiation potential, the molecular mechanism has not yet been elucidated. ...Microscopic CT (Micro- …
OBJECTIVE: Although it has been demonstrated that adipose-derived stem cells (ASCs) from osteoporotic mice (OP-A …
RUNX3 derived hsa_circ_0005752 accelerates the osteogenic differentiation of adipose-derived stem cells via the miR-496/MDM2-p53 pathway.
Wang M, Huan Y, Li X, Li J, Lv G. Wang M, et al. Regen Ther. 2021 Oct 21;18:430-440. doi: 10.1016/j.reth.2021.09.006. eCollection 2021 Dec. Regen Ther. 2021. PMID: 34754888 Free PMC article.
CONCLUSION: Our study demonstrated that RUNX3 promoted osteogenic differentiation via regulating the hsa_circ_0005752/miR-496/MDM2 axis and thus provided a new therapeutic strategy for osteoporosis....
CONCLUSION: Our study demonstrated that RUNX3 promoted osteogenic differentiation via regulating the hsa_circ_0005752/miR-496/MDM2 axis and …
HSPB7 regulates osteogenic differentiation of human adipose derived stem cells via ERK signaling pathway.
Jin C, Shuai T, Tang Z. Jin C, et al. Stem Cell Res Ther. 2020 Oct 23;11(1):450. doi: 10.1186/s13287-020-01965-4. Stem Cell Res Ther. 2020. PMID: 33097082 Free PMC article.
However, whether HSPB7 regulates osteogenic differentiation of human adipose derived stem cells (hASCs) remains unexplored. METHODS: The expression level of HSPB7 during the osteogenesis of hASCs was examined by quantitative reverse transcription polym …
However, whether HSPB7 regulates osteogenic differentiation of human adipose derived stem cells (hASCs) remains …
LncRNA-AK137033 inhibits the osteogenic potential of adipose-derived stem cells in diabetic osteoporosis by regulating Wnt signaling pathway via DNA methylation.
Peng S, Gao Y, Shi S, Zhao D, Cao H, Fu T, Cai X, Xiao J. Peng S, et al. Cell Prolif. 2022 Jan;55(1):e13174. doi: 10.1111/cpr.13174. Epub 2021 Dec 24. Cell Prolif. 2022. PMID: 34953002 Free PMC article.
OBJECTIVES: Bone tissue engineering based on adipose-derived stem cells (ASCs) is expected to become a new treatment for diabetic osteoporosis (DOP) patients with bone defects. ...
OBJECTIVES: Bone tissue engineering based on adipose-derived stem cells (ASCs) is expected to become a new treat …
Downregulation of DNA methyltransferase-3a ameliorates the osteogenic differentiation ability of adipose-derived stem cells in diabetic osteoporosis via Wnt/beta-catenin signaling pathway.
Zhang M, Gao Y, Li Q, Cao H, Yang J, Cai X, Xiao J. Zhang M, et al. Stem Cell Res Ther. 2022 Aug 4;13(1):397. doi: 10.1186/s13287-022-03088-4. Stem Cell Res Ther. 2022. PMID: 35927735 Free PMC article.
The processes of bone defect repair and regeneration become extremely difficult with DOP. Adipose-derived stem cells (ASCs), as seed cells in bone tissue engineering technology, provide a promising therapeutic approach for bone regeneration in DOP pati …
The processes of bone defect repair and regeneration become extremely difficult with DOP. Adipose-derived stem cells
Knockdown of LAP2alpha inhibits osteogenic differentiation of human adipose-derived stem cells by activating NF-kappaB.
Tang Y, Zhang X, Ge W, Zhou Y. Tang Y, et al. Stem Cell Res Ther. 2020 Jul 1;11(1):263. doi: 10.1186/s13287-020-01774-9. Stem Cell Res Ther. 2020. PMID: 32611381 Free PMC article.
BACKGROUND: Lamina-associated polypeptide 2alpha (LAP2alpha) is a nucleoplasmic protein that has been involved in the regulation of the cell cycle, gene transcription, and adult stem cell function. LAP2alpha down-regulation is linked to age-related osteoporosis and bone de …
BACKGROUND: Lamina-associated polypeptide 2alpha (LAP2alpha) is a nucleoplasmic protein that has been involved in the regulation of the cell …
JKAMP inhibits the osteogenic capacity of adipose-derived stem cells in diabetic osteoporosis by modulating the Wnt signaling pathway through intragenic DNA methylation.
Peng S, Shi S, Tao G, Li Y, Xiao D, Wang L, He Q, Cai X, Xiao J. Peng S, et al. Stem Cell Res Ther. 2021 Feb 12;12(1):120. doi: 10.1186/s13287-021-02163-6. Stem Cell Res Ther. 2021. PMID: 33579371 Free PMC article.
BACKGROUND: Diabetic osteoporosis (DOP) is a systemic metabolic bone disease caused by diabetes mellitus (DM). Adipose-derived stem cells (ASCs) play an important role in bone regeneration. ...
BACKGROUND: Diabetic osteoporosis (DOP) is a systemic metabolic bone disease caused by diabetes mellitus (DM). Adipose-deri
[Osteogenic Capacity and Mettl14 and Notch1 Expression of Adipose-Derived Stem Cells from Osteoporotic Rats].
Feng MG, Yang SL, Luo DW, Peng SL, Lou FZ, Xiao JG. Feng MG, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2021 May;52(3):423-429. doi: 10.12182/20210560502. Sichuan Da Xue Xue Bao Yi Xue Ban. 2021. PMID: 34018360 Free PMC article. Chinese.
OBJECTIVE: To investigate the differences in the osteogenic capacity of osteoporotic adipose-derived stem cells (OP-ASCs) and normal control adipose-derived stem cells (Ctrl-ASCs), and to examine the expression levels of RNA …
OBJECTIVE: To investigate the differences in the osteogenic capacity of osteoporotic adipose-derived stem cells
Advanced glycation end products inhibit the osteogenic differentiation potential of adipose-derived stem cells in mice through autophagy.
Fu T, Zhu Q, Lou F, Cai S, Peng S, Xiao J. Fu T, et al. Cell Signal. 2023 Aug;108:110694. doi: 10.1016/j.cellsig.2023.110694. Epub 2023 May 2. Cell Signal. 2023. PMID: 37141927
BACKGROUND: Diabetes mellitus (DM) microenvironment will accelerate the accumulation of Advanced glycation end products (AGEs), adipose-derived stem cells (ASCs) have poor osteogenesis in the DM microenvironment. ...CONCLUSIONS: AGEs reduce the osteoge …
BACKGROUND: Diabetes mellitus (DM) microenvironment will accelerate the accumulation of Advanced glycation end products (AGEs), adipose
Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation in vitro.
Fink T, Rasmussen JG, Emmersen J, Pilgaard L, Fahlman Å, Brunberg S, Josefsson J, Arnemo JM, Zachar V, Swenson JE, Fröbert O. Fink T, et al. Stem Cell Res. 2011 Jul;7(1):89-95. doi: 10.1016/j.scr.2011.03.003. Epub 2011 Mar 24. Stem Cell Res. 2011. PMID: 21497574 Free article.
These findings could have implications for the use of hibernating brown bears as a model to study disuse osteoporosis....
These findings could have implications for the use of hibernating brown bears as a model to study disuse osteoporosis....
Bone formation in adipose-derived stem cells isolated from elderly patients with osteoporosis: a preliminary study.
Jiang M, Wang X, Liu H, Zhou L, Jiang T, Zhou H, Hao W. Jiang M, et al. Cell Biol Int. 2014 Jan;38(1):97-105. doi: 10.1002/cbin.10182. Epub 2013 Oct 15. Cell Biol Int. 2014. PMID: 24115596
We have explored the osteogenic potency of adipose-derived stem cells from osteoporotic patients (opASCs). opASCs were osteogenically induced in vitro with collagen I hydrogel or in culture plate. ...Thus opASCs with collagen I hydrogel have adequate o …
We have explored the osteogenic potency of adipose-derived stem cells from osteoporotic patients (opASCs). opASC …
Icariin promotes proliferation and osteogenic differentiation of rat adipose-derived stem cells by activating the RhoA-TAZ signaling pathway.
Ye Y, Jing X, Li N, Wu Y, Li B, Xu T. Ye Y, et al. Biomed Pharmacother. 2017 Apr;88:384-394. doi: 10.1016/j.biopha.2017.01.075. Epub 2017 Jan 22. Biomed Pharmacother. 2017. PMID: 28122303
Icariin, the main active flavonoid glucoside isolated from Herba epimedii, has been demonstrated to be a potential alternative therapy to prevent postmenopausal osteoporosis. Icariin has also been shown to regulate the proliferation and osteogenic differentiation of rat bo …
Icariin, the main active flavonoid glucoside isolated from Herba epimedii, has been demonstrated to be a potential alternative therapy to pr …
Metformin Rescues the Impaired Osteogenesis Differentiation Ability of Rat Adipose-Derived Stem Cells in High Glucose by Activating Autophagy.
Zhang M, Yang B, Peng S, Xiao J. Zhang M, et al. Stem Cells Dev. 2021 Oct 15;30(20):1017-1027. doi: 10.1089/scd.2021.0181. Epub 2021 Oct 8. Stem Cells Dev. 2021. PMID: 34486387
The incidence and morbidity of diabetes osteoporosis (DOP) are increasing with each passing year. Patients with DOP have a higher risk of bone fracture and poor healing of bone defects, which make a poor quality of their life. Bone tissue engineering based on autologous …
The incidence and morbidity of diabetes osteoporosis (DOP) are increasing with each passing year. Patients with DOP have a higher ris …
BMP-2 promotes chondrogenesis of rat adipose-derived stem cells by using a lentiviral system.
Fu HL, Diao ZY, Shao L, Yang DP. Fu HL, et al. Genet Mol Res. 2014 Oct 27;13(4):8620-31. doi: 10.4238/2014.October.27.1. Genet Mol Res. 2014. PMID: 25366751 Free article.
Osteoporosis poses a major public health threat in aging societies. Adipose-derived stem cells (ADSCs) are multipotent adult stem cells that have the ability to yield mesenchymal stem cells, and have the potential to undergo osteogenesis and bon
Osteoporosis poses a major public health threat in aging societies. Adipose-derived stem cells (ADSCs) ar
Enhanced Bone Formation in Osteoporotic Mice by a Novel Transplant Combined with Adipose-derived Stem Cells and Platelet-rich Fibrin Releasates.
Sheu SY, Hsu YK, Chuang MH, Chu CM, Lin PC, Liao JH, Lin SZ, Kuo TF. Sheu SY, et al. Cell Transplant. 2020 Jan-Dec;29:963689720927398. doi: 10.1177/0963689720927398. Cell Transplant. 2020. PMID: 32648485 Free PMC article.
Osteoporotic fracture is the main complication of osteoporosis (OP) and accounts for millions of injuries annually. Local intervention by intra-marrow injection has been a good option for preventing osteoporotic bone loss when the osteoporotic femoral fracture has been tre …
Osteoporotic fracture is the main complication of osteoporosis (OP) and accounts for millions of injuries annually. Local interventio …
Blockade of receptors of advanced glycation end products ameliorates diabetic osteogenesis of adipose-derived stem cells through DNA methylation and Wnt signalling pathway.
Zhang M, Li Y, Rao P, Huang K, Luo D, Cai X, Xiao J. Zhang M, et al. Cell Prolif. 2018 Oct;51(5):e12471. doi: 10.1111/cpr.12471. Epub 2018 Jul 16. Cell Prolif. 2018. PMID: 30014569 Free PMC article.
OBJECTIVES: Diabetes mellitus-related osteoporosis is caused by the imbalance between bone absorption and bone formation. Advanced glycation end products (AGEs) are considered a cause of diabetic osteoporosis. Although adipose-derived stem ce
OBJECTIVES: Diabetes mellitus-related osteoporosis is caused by the imbalance between bone absorption and bone formation. Advanced gl …
The effect of magnetic field exposure on differentiation of magnetite nanoparticle-loaded adipose-derived stem cells.
Labusca L, Herea DD, Danceanu CM, Minuti AE, Stavila C, Grigoras M, Gherca D, Stoian G, Ababei G, Chiriac H, Lupu N. Labusca L, et al. Mater Sci Eng C Mater Biol Appl. 2020 Apr;109:110652. doi: 10.1016/j.msec.2020.110652. Epub 2020 Jan 7. Mater Sci Eng C Mater Biol Appl. 2020. PMID: 32228923
Here we show that MNPs-mediated magneto-mechanical stimulation of human primary adipose derived stem cells (ADSCs) exposed to variable magnetic field (MF) influences their adipogenic and osteogenic differentiation. ...ADSCs-MNPs under MF exposure could …
Here we show that MNPs-mediated magneto-mechanical stimulation of human primary adipose derived stem cells (ADSC …
Simultaneous Treatment of Photobiomodulation and Demineralized Bone Matrix With Adipose-Derived Stem Cells Improve Bone Healing in an osteoporotic bone defect.
Gazor R, Asgari M, Abdollajhifar MA, Kiani P, Zare F, Fadaei Fathabady F, Norouzian M, Amini A, Khosravipour A, Atashgah RB, Kazemi M, Chien S, Bayat M. Gazor R, et al. J Lasers Med Sci. 2021 Aug 2;12:e41. doi: 10.34172/jlms.2021.41. eCollection 2021. J Lasers Med Sci. 2021. PMID: 34733764 Free PMC article.
Introduction: The ability of simultaneous treatment of critical-sized femoral defects (CSFDs) with photobiomodulation (PBM) and demineralized bone matrix (DBM) with or without seeded adipose-derived stem cells (ASCs) to induce bone reconstruction in ov …
Introduction: The ability of simultaneous treatment of critical-sized femoral defects (CSFDs) with photobiomodulation (PBM) and demineralize …
Impact of aging on the regenerative properties of bone marrow-, muscle-, and adipose-derived mesenchymal stem/stromal cells.
Beane OS, Fonseca VC, Cooper LL, Koren G, Darling EM. Beane OS, et al. PLoS One. 2014 Dec 26;9(12):e115963. doi: 10.1371/journal.pone.0115963. eCollection 2014. PLoS One. 2014. PMID: 25541697 Free PMC article.
MSCs have been investigated for the treatment of many musculoskeletal disorders, including osteoarthritis and osteoporosis. Due to the prevalence of these diseases in older populations, researchers have studied how aging affects MSC properties and have found that prolifera …
MSCs have been investigated for the treatment of many musculoskeletal disorders, including osteoarthritis and osteoporosis. Due to th …
FGF2/HGF priming facilitates adipose-derived stem cell-mediated bone formation in osteoporotic defects.
Park JS, Kim DY, Hong HS. Park JS, et al. Heliyon. 2024 Jan 17;10(2):e24554. doi: 10.1016/j.heliyon.2024.e24554. eCollection 2024 Jan 30. Heliyon. 2024. PMID: 38304814 Free PMC article.
AIMS: The activity of adipose-derived stem cells (ADSCs) is susceptible to the physiological conditions of the donor. ...This study aims to investigate the impact of supplementing Fibroblast Growth Factor 2 (FGF2) and Hepatocyte Growth Factor (HGF) on …
AIMS: The activity of adipose-derived stem cells (ADSCs) is susceptible to the physiological conditions of the d …
Effect of exogenous genistein on osteogenic differentiation of adipose-derived mesenchymal stem cells in laying hens.
Ahmadian F, Irani M, Mohammadi-Sangcheshmeh A. Ahmadian F, et al. Tissue Cell. 2024 Apr;87:102299. doi: 10.1016/j.tice.2023.102299. Epub 2024 Jan 4. Tissue Cell. 2024. PMID: 38228028
Previous literature revealed that genistein might play a preventive role in osteoporosis. Therefore, we aimed to evaluate the effect of genistein on the osteogenic potency of laying hens' adipose-derived stem cells (LHASCs). ...
Previous literature revealed that genistein might play a preventive role in osteoporosis. Therefore, we aimed to evaluate the effect …
Photobiomodulation and Stem Cell on Repair of Osteoporotic Bones.
Asgari M, Abdollahifar MA, Gazor R, Salmani T, Khosravipour A, Mahmoudi Y, Baniasadi F, Hamblin MR, Abrahamse H, Chien S, Bayat M. Asgari M, et al. Photobiomodul Photomed Laser Surg. 2022 Apr;40(4):261-272. doi: 10.1089/photob.2021.0127. Photobiomodul Photomed Laser Surg. 2022. PMID: 35452299
Objective: This study examined the use of photobiomodulation (PBM) plus adipose-derived stem cells (ASCs) to enhance the osteogenic properties of demineralized bone matrix (DBM) scaffold in a critical size femoral defect (CSFD) of ovariectomy-induced o …
Objective: This study examined the use of photobiomodulation (PBM) plus adipose-derived stem cells (ASCs) to enh …
The effect of diminished osteogenic signals on reduced osteoporosis recovery in aged mice and the potential therapeutic use of adipose-derived stem cells.
Liu HY, Chiou JF, Wu AT, Tsai CY, Leu JD, Ting LL, Wang MF, Chen HY, Lin CT, Williams DF, Deng WP. Liu HY, et al. Biomaterials. 2012 Sep;33(26):6105-12. doi: 10.1016/j.biomaterials.2012.05.024. Epub 2012 Jun 12. Biomaterials. 2012. PMID: 22698723
Adipose-derived stem cells (ADSCs) have been shown to be pluoripotent and explored for their usage in tissue engineering. Previously, we have established a cell-based approach comprised of platelet-enriched plasma and osteo-progenitor cells for treatin
Adipose-derived stem cells (ADSCs) have been shown to be pluoripotent and explored for their usage in tissue eng
Advanced glycation end products inhibit the osteogenic differentiation potential of adipose-derived stem cells by modulating Wnt/beta-catenin signalling pathway via DNA methylation.
Li Y, Wang L, Zhang M, Huang K, Yao Z, Rao P, Cai X, Xiao J. Li Y, et al. Cell Prolif. 2020 Jun;53(6):e12834. doi: 10.1111/cpr.12834. Epub 2020 May 28. Cell Prolif. 2020. PMID: 32468637 Free PMC article.
OBJECTIVES: Advanced glycation end products (AGEs) are considered a cause of diabetic osteoporosis. Although adipose-derived stem cells (ASCs) are widely used in the research of bone regeneration, the mechanisms of the osteogenic differentiation …
OBJECTIVES: Advanced glycation end products (AGEs) are considered a cause of diabetic osteoporosis. Although adipose-derive
Empagliflozin Ameliorates the Impaired Osteogenic Differentiation Ability of Adipose-Derived Stem Cells in Diabetic Osteoporosis by Activating Autophagy.
Yang S, Lin Y, Xie Y, Fu T, Wu T, Lan X, Lou F, Xiao J. Yang S, et al. Stem Cells. 2024 Jul 8;42(7):623-635. doi: 10.1093/stmcls/sxae019. Stem Cells. 2024. PMID: 38393380
Adipose-derived stem cells (ASCs) from diabetic osteoporosis (DOP) mice showed impaired osteogenic differentiation capacity. ...
Adipose-derived stem cells (ASCs) from diabetic osteoporosis (DOP) mice showed impaired osteogenic differ
Zinc finger protein 467 regulates Wnt signaling by modulating the expression of sclerostin in adipose derived stem cells.
You L, Chen L, Pan L, Gu WS, Chen JY. You L, et al. Biochem Biophys Res Commun. 2015 Jan 9;456(2):598-604. doi: 10.1016/j.bbrc.2014.11.120. Epub 2014 Dec 6. Biochem Biophys Res Commun. 2015. PMID: 25490389
Tissue engineering approaches to the treatment of osteoporosis depend on the identification of factors that promote the differentiation of progenitor cells towards an osteoblastic phenotype. In the present study, we expanded on prior findings on the role of zinc finger pro …
Tissue engineering approaches to the treatment of osteoporosis depend on the identification of factors that promote the differentiati …
The effect of age on osteogenic, adipogenic and proliferative potential of female adipose-derived stem cells.
Zhu M, Kohan E, Bradley J, Hedrick M, Benhaim P, Zuk P. Zhu M, et al. J Tissue Eng Regen Med. 2009 Jun;3(4):290-301. doi: 10.1002/term.165. J Tissue Eng Regen Med. 2009. PMID: 19309766
The stromal vascular fraction of adipose tissue contains a stem cell population, adipose-derived stem cells (ASCs), capable of adipogenic, osteogenic, myogenic and chondrogenic differentiation. ...These findings have important implications for emerging …
The stromal vascular fraction of adipose tissue contains a stem cell population, adipose-derived stem cells (ASC …
Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function.
Lee K, Kim H, Kim JM, Kim JR, Kim KJ, Kim YJ, Park SI, Jeong JH, Moon YM, Lim HS, Bae DW, Kwon J, Ko CY, Kim HS, Shin HI, Jeong D. Lee K, et al. J Cell Mol Med. 2011 Oct;15(10):2082-94. doi: 10.1111/j.1582-4934.2010.01230.x. J Cell Mol Med. 2011. PMID: 21159123 Free PMC article.
Systemic transplantation of adipose-derived stem cells (ASCs) is emerging as a novel therapeutic option for functional recovery of diverse damaged tissues. ...Overall, our findings suggest that paracrine factors secreted from hASCs improve bone repair …
Systemic transplantation of adipose-derived stem cells (ASCs) is emerging as a novel therapeutic option for func …
Suppression of zinc finger protein 467 alleviates osteoporosis through promoting differentiation of adipose derived stem cells to osteoblasts.
You L, Pan L, Chen L, Chen JY, Zhang X, Lv Z, Fu D. You L, et al. J Transl Med. 2012 Jan 17;10:11. doi: 10.1186/1479-5876-10-11. J Transl Med. 2012. PMID: 22252242 Free PMC article.
In this study, a comparative analysis of gene expression profiling using cDNA microarray and realtime-PCR indicated that Zinc finger protein 467 (Zfp467) involved in adipocyte and osteoblast differentiation of cultured adipose derived stem cells (ADSCs …
In this study, a comparative analysis of gene expression profiling using cDNA microarray and realtime-PCR indicated that Zinc finger protein …
Comparative study of osteogenic differentiation potential of mesenchymal stem cells derived from bone marrow and adipose tissue of osteoporotic female rats.
Boeloni JN, Ocarino NM, Goes AM, Serakides R. Boeloni JN, et al. Connect Tissue Res. 2014 Apr;55(2):103-14. doi: 10.3109/03008207.2013.860970. Epub 2014 Feb 12. Connect Tissue Res. 2014. PMID: 24175668
Osteoporosis causes reduction of osteogenic differentiation of mesenchymal stem cells (MSCs) from bone marrow and adipose tissue. This study was designed to compare the osteogenic potential of bone marrow mesenchymal stem cells (BMMSCs) and adipose-derived
Osteoporosis causes reduction of osteogenic differentiation of mesenchymal stem cells (MSCs) from bone marrow and adipose tissue. Thi
Potential probiotic Lactobacillus delbrueckii subsp. lactis KUMS-Y33 suppresses adipogenesis and promotes osteogenesis in human adipose-derived mesenchymal stem cell.
Goudarzi F, Kiani A, Nami Y, Shahmohammadi A, Mohammadalipour A, Karami A, Haghshenas B. Goudarzi F, et al. Sci Rep. 2024 Apr 27;14(1):9689. doi: 10.1038/s41598-024-60061-2. Sci Rep. 2024. PMID: 38678043 Free PMC article.
The present study aimed to investigate the effect of a new probiotic extract (Lactobacillus delbrueckii subsp. lactis KUMS Y33) on the differentiation process of human adipose-derived stem cells (hADSCs) into adipocytes and osteocytes and, as a result, …
The present study aimed to investigate the effect of a new probiotic extract (Lactobacillus delbrueckii subsp. lactis KUMS Y33) on the diffe …
Therapeutic effect of icariin combined with stem cells on postmenopausal osteoporosis in rats.
Tang D, Ju C, Liu Y, Xu F, Wang Z, Wang D. Tang D, et al. J Bone Miner Metab. 2018 Mar;36(2):180-188. doi: 10.1007/s00774-017-0831-x. Epub 2017 Jul 5. J Bone Miner Metab. 2018. PMID: 28681147
Osteoporosis is characterized by skeletal fragility and microarchitectural deterioration. The side effects of drugs to treat osteoporosis will negatively affect the health of patients. This study aimed to investigate the therapeutic effects of icariin combined with
Osteoporosis is characterized by skeletal fragility and microarchitectural deterioration. The side effects of drugs to treat osteo
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