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26 results

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Page 1
High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase.
Garcia AM, Davis AK, Martinez-Ramos C, Morishima Y, Lau M, Xu E, Sunil A, Zhang H, Alt A, Lieberman AP, Osawa Y. Garcia AM, et al. Among authors: alt a. Mol Pharmacol. 2025 Feb;107(2):100008. doi: 10.1016/j.molpha.2024.100008. Epub 2024 Dec 12. Mol Pharmacol. 2025. PMID: 40023517 Free PMC article.
Identification of a TNIK-CDK9 Axis as a Targetable Strategy for Platinum-Resistant Ovarian Cancer.
Puleo N, Ram H, Dziubinski ML, Carvette D, Teitel J, Sekhar SC, Bedi K, Robida A, Nakashima MM, Farsinejad S, Iwanicki M, Senkowski W, Ray A, Bollerman TJ, Dunbar J, Richardson P, Taddei A, Hudson C, DiFeo A. Puleo N, et al. Among authors: robida a. Mol Cancer Ther. 2025 Apr 2;24(4):639-656. doi: 10.1158/1535-7163.MCT-24-0785. Mol Cancer Ther. 2025. PMID: 39873147 Free PMC article.
N-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels.
Denomme N, Hernandez CC, Bock HA, Ohana RF, Bakshi S, Sherwood AM, McCorvy JD, Daley PF, Callaway WB, Hull JM, Alt A, Isom LL, Cozzi NV. Denomme N, et al. Among authors: alt a. Mol Pharmacol. 2024 Jul 17;106(2):92-106. doi: 10.1124/molpharm.123.000837. Mol Pharmacol. 2024. PMID: 38821630
An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3.
Thompson AD, Wagner MJ, Rodriguez J, Malhotra A, Vander Roest S, Lilienthal U, Shao H, Vignesh M, Weber K, Yob JM, Prosser BL, Helms AS, Gestwicki JE, Ginsburg D, Day SM. Thompson AD, et al. Among authors: vander roest s. JACC Basic Transl Sci. 2023 Aug 2;8(9):1198-1211. doi: 10.1016/j.jacbts.2023.04.009. eCollection 2023 Sep. JACC Basic Transl Sci. 2023. PMID: 37791314 Free PMC article.
Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2-(Pyrrolidin-1-ylmethyl)pyrrole-Based Stimulation-2 (ST2) Inhibitors.
Yuan X, Jiang H, Fu D, Rech JC, Robida A, Rajanayake K, Yuan H, He M, Wen B, Sun D, Liu C, Chinnaswamy K, Stuckey JA, Paczesny S, Yang CY. Yuan X, et al. Among authors: robida a. ACS Pharmacol Transl Sci. 2023 Aug 16;6(9):1275-1287. doi: 10.1021/acsptsci.3c00122. eCollection 2023 Sep 8. ACS Pharmacol Transl Sci. 2023. PMID: 37705593 Free PMC article.
Targeting Lymphoma-associated Macrophage Expansion via CSF1R/JAK Inhibition is a Therapeutic Vulnerability in Peripheral T-cell Lymphomas.
Gao X, Kady N, Wang C, Abdelrahman S, Gann P, Sverdlov M, Wolfe A, Brown N, Reneau J, Robida AM, Murga-Zamalloa C, Wilcox RA. Gao X, et al. Among authors: robida am. Cancer Res Commun. 2022 Dec 30;2(12):1727-1737. doi: 10.1158/2767-9764.CRC-22-0336. eCollection 2022 Dec. Cancer Res Commun. 2022. PMID: 36970721 Free PMC article.
Repurposing HDAC inhibitors to enhance ribonuclease 4 and 7 expression and reduce urinary tract infection.
Schwartz L, Bochter MS, Simoni A, Bender K, de Dios Ruiz Rosado J, Cotzomi-Ortega I, Sanchez-Zamora YI, Becknell B, Linn S, Li B, Santoro N, Eichler T, Spencer JD. Schwartz L, et al. Among authors: santoro n. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2213363120. doi: 10.1073/pnas.2213363120. Epub 2023 Jan 18. Proc Natl Acad Sci U S A. 2023. PMID: 36652479 Free PMC article.
Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease.
Yuan X, Jiang H, Fu D, Robida A, Rajanayake K, Yuan H, Wen B, Sun D, Watch BT, Chinnaswamy K, Stuckey JA, Paczesny S, Rech JC, Yang CY. Yuan X, et al. Among authors: robida a. Bioorg Med Chem. 2022 Oct 1;71:116942. doi: 10.1016/j.bmc.2022.116942. Epub 2022 Jul 22. Bioorg Med Chem. 2022. PMID: 35930851 Free PMC article.
Soluble CD13 induces inflammatory arthritis by activating the bradykinin receptor B1.
Tsou PS, Lu C, Gurrea-Rubio M, Muraoka S, Campbell PL, Wu Q, Model EN, Lind ME, Vichaikul S, Mattichak MN, Brodie WD, Hervoso JL, Ory S, Amarista CI, Pervez R, Junginger L, Ali M, Hodish G, O'Mara MM, Ruth JH, Robida AM, Alt AJ, Zhang C, Urquhart AG, Lawton JN, Chung KC, Maerz T, Saunders TL, Groppi VE, Fox DA, Amin MA. Tsou PS, et al. Among authors: robida am, alt aj. J Clin Invest. 2022 Jun 1;132(11):e151827. doi: 10.1172/JCI151827. J Clin Invest. 2022. PMID: 35439173 Free PMC article.
Development of a specific live-cell assay for native autophagic flux.
Safren N, Tank EM, Malik AM, Chua JP, Santoro N, Barmada SJ. Safren N, et al. Among authors: santoro n. J Biol Chem. 2021 Sep;297(3):101003. doi: 10.1016/j.jbc.2021.101003. Epub 2021 Jul 23. J Biol Chem. 2021. PMID: 34303705 Free PMC article.
Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects.
Kandasamy R, Hillhouse TM, Livingston KE, Kochan KE, Meurice C, Eans SO, Li MH, White AD, Roques BP, McLaughlin JP, Ingram SL, Burford NT, Alt A, Traynor JR. Kandasamy R, et al. Among authors: alt a. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2000017118. doi: 10.1073/pnas.2000017118. Proc Natl Acad Sci U S A. 2021. PMID: 33846240 Free PMC article.
Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.
Zwicker JD, Smith D, Guerra AJ, Hitchens JR, Haug N, Vander Roest S, Lee P, Wen B, Sun D, Wang L, Keep RF, Xiang J, Carruthers VB, Larsen SD. Zwicker JD, et al. Among authors: vander roest s. ACS Chem Neurosci. 2020 Aug 19;11(16):2450-2463. doi: 10.1021/acschemneuro.9b00674. Epub 2020 Feb 18. ACS Chem Neurosci. 2020. PMID: 32027110 Free PMC article.
From proteomics to discovery of first-in-class ST2 inhibitors active in vivo.
Ramadan AM, Daguindau E, Rech JC, Chinnaswamy K, Zhang J, Hura GL, Griesenauer B, Bolten Z, Robida A, Larsen M, Stuckey JA, Yang CY, Paczesny S. Ramadan AM, et al. Among authors: robida a. JCI Insight. 2018 Jul 26;3(14):e99208. doi: 10.1172/jci.insight.99208. eCollection 2018 Jul 26. JCI Insight. 2018. PMID: 30046004 Free PMC article.
Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor.
Burford NT, Livingston KE, Canals M, Ryan MR, Budenholzer LM, Han Y, Shang Y, Herbst JJ, O'Connell J, Banks M, Zhang L, Filizola M, Bassoni DL, Wehrman TS, Christopoulos A, Traynor JR, Gerritz SW, Alt A. Burford NT, et al. Among authors: alt a. J Med Chem. 2015 May 28;58(10):4220-9. doi: 10.1021/acs.jmedchem.5b00007. Epub 2015 May 7. J Med Chem. 2015. PMID: 25901762 Free PMC article.